{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:02:51Z","timestamp":1790704971496,"version":"4.1.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K08803"],"award-info":[{"award-number":["16K08803"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H05805"],"award-info":[{"award-number":["16H05805"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16H06429"],"award-info":[{"award-number":["16H06429"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16H06431"],"award-info":[{"award-number":["16H06431"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16K21723"],"award-info":[{"award-number":["16K21723"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virus Genes"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s11262-019-01683-x","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T06:49:23Z","timestamp":1562741363000},"page":"630-642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Upregulated expression of the antioxidant sestrin 2 identified by transcriptomic analysis of Japanese encephalitis virus-infected SH-SY5Y neuroblastoma cells"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-6209","authenticated-orcid":false,"given":"Michael","family":"Carr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christida E.","family":"Wastika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihito","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Orba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihito","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"1683_CR1","unstructured":"Takayama J. Japanese encephalitis. WHO, 2015"},{"key":"1683_CR2","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.4269\/ajtmh.14-0148","volume":"92","author":"Z Yin","year":"2015","unstructured":"Yin Z, Wang X, Li L, Li H, Zhang X, Li J, Ning G, Li F, Liang X, Gao L, Liang X, Li Y (2015) Neurological sequelae of hospitalized Japanese encephalitis cases in Gansu province, China. Am J Trop Med Hyg 92:1125\u20131129. \n                    https:\/\/doi.org\/10.4269\/ajtmh.14-0148","journal-title":"Am J Trop Med Hyg"},{"key":"1683_CR3","doi-asserted-by":"publisher","first-page":"e437","DOI":"10.1371\/journal.pntd.0000437","volume":"3","author":"D Ghosh","year":"2009","unstructured":"Ghosh D, Basu A (2009) Japanese encephalitis-a pathological and clinical perspective. PLoS Negl Trop Dis 3:e437. \n                    https:\/\/doi.org\/10.1371\/journal.pntd.0000437","journal-title":"PLoS Negl Trop Dis"},{"key":"1683_CR4","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1056\/NEJMra030476","volume":"351","author":"T Solomon","year":"2004","unstructured":"Solomon T (2004) Flavivirus encephalitis. N Engl J Med 351:370\u2013378. \n                    https:\/\/doi.org\/10.1056\/NEJMra030476","journal-title":"N Engl J Med"},{"issue":"766\u2013774","key":"1683_CR5","doi-asserted-by":"publisher","first-page":"774A","DOI":"10.2471\/BLT.10.085233","volume":"89","author":"GL Campbell","year":"2011","unstructured":"Campbell GL, Hills SL, Fischer M, Jacobson JA, Hoke CH, Hombach JM, Marfin AA, Solomon T, Tsai TF, Tsu VD, Ginsburg AS (2011) Estimated global incidence of Japanese encephalitis: a systematic review. Bull World Health Organ 89(766\u2013774):774A\u2013774E. \n                    https:\/\/doi.org\/10.2471\/BLT.10.085233","journal-title":"Bull World Health Organ"},{"key":"1683_CR6","doi-asserted-by":"publisher","first-page":"e2980","DOI":"10.1371\/journal.pntd.0002980","volume":"8","author":"KS Myint","year":"2014","unstructured":"Myint KS, Kipar A, Jarman RG, Gibbons RV, Perng GC, Flanagan B, Mongkolsirichaikul D, Van Gessel Y, Solomon T (2014) Neuropathogenesis of Japanese encephalitis in a primate model. PLoS Negl Trop Dis 8:e2980. \n                    https:\/\/doi.org\/10.1371\/journal.pntd.0002980","journal-title":"PLoS Negl Trop Dis"},{"key":"1683_CR7","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/ana.410180510","volume":"18","author":"RT Johnson","year":"1985","unstructured":"Johnson RT, Burke DS, Elwell M, Leake CJ, Nisalak A, Hoke CH, Lorsomrudee W (1985) Japanese encephalitis: immunocytochemical studies of viral antigen and inflammatory cells in fatal cases. Ann Neurol 18:567\u2013573. \n                    https:\/\/doi.org\/10.1002\/ana.410180510","journal-title":"Ann Neurol"},{"key":"1683_CR8","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/BF00309631","volume":"89","author":"A Desai","year":"1995","unstructured":"Desai A, Shankar SK, Ravi V, Chandramuki A, Gourie-Devi M (1995) Japanese encephalitis virus antigen in the human brain and its topographic distribution. Acta Neuropathol 89:368\u2013373","journal-title":"Acta Neuropathol"},{"key":"1683_CR9","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.trstmh.2006.02.008","volume":"100","author":"AC German","year":"2006","unstructured":"German AC, Myint KS, Mai NT, Pomeroy I, Phu NH, Tzartos J, Winter P, Collett J, Farrar J, Barrett A, Kipar A, Esiri MM, Solomon T (2006) A preliminary neuropathological study of Japanese encephalitis in humans and a mouse model. Trans R Soc Trop Med Hyg 100:1135\u20131145. \n                    https:\/\/doi.org\/10.1016\/j.trstmh.2006.02.008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"1683_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.virusres.2009.10.018","volume":"147","author":"N Gupta","year":"2010","unstructured":"Gupta N, Santhosh SR, Babu JP, Parida MM, Rao PV (2010) Chemokine profiling of Japanese encephalitis virus-infected mouse neuroblastoma cells by microarray and real-time RT-PCR: implication in neuropathogenesis. Virus Res 147:107\u2013112. \n                    https:\/\/doi.org\/10.1016\/j.virusres.2009.10.018","journal-title":"Virus Res"},{"key":"1683_CR11","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.virol.2005.01.009","volume":"333","author":"MD Trottier Jr","year":"2005","unstructured":"Trottier MD Jr, Palian BM, Reiss CS (2005) VSV replication in neurons is inhibited by type I IFN at multiple stages of infection. Virology 333:215\u2013225","journal-title":"Virology"},{"key":"1683_CR12","doi-asserted-by":"publisher","first-page":"13350","DOI":"10.1128\/JVI.79.21.13350-13361.2005","volume":"79","author":"MA Samuel","year":"2005","unstructured":"Samuel MA, Diamond MS (2005) Alpha\/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J Virol 79:13350\u201313361. \n                    https:\/\/doi.org\/10.1128\/JVI.79.21.13350-13361.2005","journal-title":"J Virol"},{"key":"1683_CR13","doi-asserted-by":"publisher","first-page":"10349","DOI":"10.1128\/JVI.00935-08","volume":"82","author":"S Daffis","year":"2008","unstructured":"Daffis S, Samuel MA, Suthar MS, Gale M, Diamond MS (2008) Toll-like receptor 3 has a protective role against West Nile virus infection. J Virol 82:10349\u201310358. \n                    https:\/\/doi.org\/10.1128\/Jvi.00935-08","journal-title":"J Virol"},{"issue":"4","key":"1683_CR14","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/nm.3108","volume":"19","author":"H Cho","year":"2013","unstructured":"Cho H, Proll SC, Szretter KJ, Katze MG, Gale M, Diamond MS (2013) Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses. Nat Med 19(4):458. \n                    https:\/\/doi.org\/10.1038\/nm.3108","journal-title":"Nat Med"},{"issue":"1","key":"1683_CR15","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1371\/journal.ppat.1005028","volume":"11","author":"PC Rosato","year":"2015","unstructured":"Rosato PC, Leib DA (2015) Neuronal interferon signaling is required for protection against herpes simplex virus replication and pathogenesis. PLoS Pathog 11(1):456. \n                    https:\/\/doi.org\/10.1371\/journal.ppat.1005028","journal-title":"PLoS Pathog"},{"key":"1683_CR16","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1126\/science.1095569","volume":"304","author":"AV Budanov","year":"2004","unstructured":"Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM (2004) Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304:596\u2013600. \n                    https:\/\/doi.org\/10.1126\/science.1095569","journal-title":"Science"},{"key":"1683_CR17","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1126\/science.1182228","volume":"327","author":"JH Lee","year":"2010","unstructured":"Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327:1223\u20131228. \n                    https:\/\/doi.org\/10.1126\/science.1182228","journal-title":"Science"},{"key":"1683_CR18","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","volume":"124","author":"S Wullschleger","year":"2006","unstructured":"Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471\u2013484. \n                    https:\/\/doi.org\/10.1016\/j.cell.2006.01.016","journal-title":"Cell"},{"key":"1683_CR19","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","volume":"168","author":"RA Saxton","year":"2017","unstructured":"Saxton RA, Sabatini DM (2017) mTOR signaling in growth, metabolism, and disease. Cell 168:960\u2013976. \n                    https:\/\/doi.org\/10.1016\/j.cell.2017.02.004","journal-title":"Cell"},{"key":"1683_CR20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrm3025","volume":"12","author":"R Zoncu","year":"2011","unstructured":"Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21\u201335. \n                    https:\/\/doi.org\/10.1038\/nrm3025","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1683_CR21","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.cmet.2012.08.004","volume":"16","author":"JH Lee","year":"2012","unstructured":"Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab 16:311\u2013321. \n                    https:\/\/doi.org\/10.1016\/j.cmet.2012.08.004","journal-title":"Cell Metab"},{"key":"1683_CR22","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.cell.2008.06.028","volume":"134","author":"AV Budanov","year":"2008","unstructured":"Budanov AV, Karin M (2008) p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling. Cell 134:451\u2013460. \n                    https:\/\/doi.org\/10.1016\/j.cell.2008.06.028","journal-title":"Cell"},{"key":"1683_CR23","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.4161\/cc.8.10.8498","volume":"8","author":"MC Maiuri","year":"2009","unstructured":"Maiuri MC, Malik SA, Morselli E, Kepp O, Criollo A, Mouchel PL, Carnuccio R, Kroemer G (2009) Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle 8:1571\u20131576. \n                    https:\/\/doi.org\/10.4161\/cc.8.10.8498","journal-title":"Cell Cycle"},{"issue":"1","key":"1683_CR24","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1371\/journal.pone.0032035","volume":"7","author":"T Sanli","year":"2012","unstructured":"Sanli T, Linher-Melville K, Tsakiridis T, Singh G (2012) Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells. PLoS ONE 7(1):789. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0032035","journal-title":"PLoS ONE"},{"key":"1683_CR25","doi-asserted-by":"publisher","first-page":"6017","DOI":"10.1038\/sj.onc.1205877","volume":"21","author":"AV Budanov","year":"2002","unstructured":"Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chumakov PM, Feinstein E (2002) Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 21:6017\u20136031. \n                    https:\/\/doi.org\/10.1038\/sj.onc.1205877","journal-title":"Oncogene"},{"key":"1683_CR26","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1080\/15548627.2016.1183081","volume":"12","author":"MJ Kim","year":"2016","unstructured":"Kim MJ, Bae SH, Ryu JC, Kwon Y, Oh JH, Kwon J, Moon JS, Kim K, Miyawaki A, Lee MG, Shin J, Kim YS, Kim CH, Ryter SW, Choi AMK, Rhee SG, Ryu JH, Yoon JH (2016) SESN2\/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages. Autophagy 12:1272\u20131291. \n                    https:\/\/doi.org\/10.1080\/15548627.2016.1183081","journal-title":"Autophagy"},{"key":"1683_CR27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.copbio.2012.09.004","volume":"24","author":"KO Mutz","year":"2013","unstructured":"Mutz KO, Heilkenbrinker A, Lonne M, Walter JG, Stahl F (2013) Transcriptome analysis using next-generation sequencing. Curr Opin Biotech 24:22\u201330. \n                    https:\/\/doi.org\/10.1016\/j.copbio.2012.09.004","journal-title":"Curr Opin Biotech"},{"key":"1683_CR28","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1099\/vir.0.031237-0","volume":"92","author":"Y Yamaguchi","year":"2011","unstructured":"Yamaguchi Y, Nukui Y, Tajima S, Nerome R, Kato F, Watanabe H, Takasaki T, Kurane I (2011) An amino acid substitution (V3I) in the Japanese encephalitis virus NS4A protein increases its virulence in mice, but not its growth rate in vitro. J Gen Virol 92:1601\u20131606. \n                    https:\/\/doi.org\/10.1099\/vir.0.031237-0","journal-title":"J Gen Virol"},{"key":"1683_CR29","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nbt.3519","volume":"34","author":"NL Bray","year":"2016","unstructured":"Bray NL, Pimentel H, Melsted P, Pachter L (2016) Near-optimal probabilistic RNA-seq quantification. Nat Biotechnol 34:525\u2013527. \n                    https:\/\/doi.org\/10.1038\/nbt.3519","journal-title":"Nat Biotechnol"},{"key":"1683_CR30","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1093\/nar\/gkt214","volume":"41","author":"Y Liao","year":"2013","unstructured":"Liao Y, Smyth GK, Shi W (2013) The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote. Nucleic Acids Res 41:e108. \n                    https:\/\/doi.org\/10.1093\/nar\/gkt214","journal-title":"Nucleic Acids Res"},{"key":"1683_CR31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK (2010) edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26:139\u2013140. \n                    https:\/\/doi.org\/10.1093\/bioinformatics\/btp616","journal-title":"Bioinformatics"},{"key":"1683_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. \n                    https:\/\/doi.org\/10.1186\/s13059-014-0550-8","journal-title":"Genome Biol"},{"key":"1683_CR33","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1177\/0300985810372507","volume":"47","author":"T Kimura","year":"2010","unstructured":"Kimura T, Sasaki M, Okumura M, Kim E, Sawa H (2010) Flavivirus encephalitis: pathological aspects of mouse and other animal models. Vet Pathol 47:806\u2013818. \n                    https:\/\/doi.org\/10.1177\/0300985810372507","journal-title":"Vet Pathol"},{"key":"1683_CR34","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1016\/j.bbamcr.2013.03.007","volume":"1833","author":"T Gidalevitz","year":"2013","unstructured":"Gidalevitz T, Stevens F, Argon Y (2013) Orchestration of secretory protein folding by ER chaperones. Biochim Biophys Acta 1833:2410\u20132424. \n                    https:\/\/doi.org\/10.1016\/j.bbamcr.2013.03.007","journal-title":"Biochim Biophys Acta"},{"key":"1683_CR35","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.gene.2018.01.023","volume":"647","author":"D Lin","year":"2018","unstructured":"Lin D, Liang Y, Zheng D, Chen Y, Jing X, Lei M, Zeng Z, Zhou T, Wu X, Peng S, Huang K, Yang L, Xiao S, Liu J, Tao E (2018) Novel biomolecular information in rotenone-induced cellular model of Parkinson\u2019s disease. Gene 647:244\u2013260. \n                    https:\/\/doi.org\/10.1016\/j.gene.2018.01.023","journal-title":"Gene"},{"key":"1683_CR36","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/978-3-319-75402-4_52","volume":"1074","author":"T McLaughlin","year":"2018","unstructured":"McLaughlin T, Falkowski M, Wang JJ, Zhang SX (2018) Molecular chaperone ERp29: a potential target for cellular protection in retinal and neurodegenerative diseases. Adv Exp Med Biol 1074:421\u2013427. \n                    https:\/\/doi.org\/10.1007\/978-3-319-75402-4_52","journal-title":"Adv Exp Med Biol"},{"key":"1683_CR37","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.celrep.2015.06.049","volume":"12","author":"H Ma","year":"2015","unstructured":"Ma H, Dang Y, Wu Y, Jia G, Anaya E, Zhang J, Abraham S, Choi JG, Shi G, Qi L, Manjunath N, Wu H (2015) A CRISPR-based screen identifies genes essential for west-nile-virus-induced cell death. Cell Rep 12:673\u2013683. \n                    https:\/\/doi.org\/10.1016\/j.celrep.2015.06.049","journal-title":"Cell Rep"},{"key":"1683_CR38","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.1523\/JNEUROSCI.5478-10.2011","volume":"31","author":"T Hoshino","year":"2011","unstructured":"Hoshino T, Murao N, Namba T, Takehara M, Adachi H, Katsuno M, Sobue G, Matsushima T, Suzuki T, Mizushima T (2011) Suppression of Alzheimer\u2019s disease-related phenotypes by expression of heat shock protein 70 in mice. J Neurosci 31:5225\u20135234. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.5478-10.2011","journal-title":"J Neurosci"},{"key":"1683_CR39","doi-asserted-by":"publisher","first-page":"333","DOI":"10.2379\/Npx08162","volume":"28","author":"H Slodzinski","year":"2009","unstructured":"Slodzinski H, Moran LB, Michael GJ, Wang B, Novoselov S, Cheetham ME, Pearce RKB, Graeber MB (2009) Homocysteine-induced endoplasmic reticulum protein (Herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies. Clin Neuropathol 28:333\u2013343. \n                    https:\/\/doi.org\/10.2379\/Npx08162","journal-title":"Clin Neuropathol"},{"key":"1683_CR40","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1242\/jcs.153643","volume":"127","author":"D Eletto","year":"2014","unstructured":"Eletto D, Chevet E, Argon Y, Appenzeller-Herzog C (2014) Redox controls UPR to control redox. J Cell Sci 127:3649\u20133658. \n                    https:\/\/doi.org\/10.1242\/jcs.153643","journal-title":"J Cell Sci"},{"key":"1683_CR41","doi-asserted-by":"publisher","first-page":"e33208","DOI":"10.1371\/journal.pone.0033208","volume":"7","author":"A Jauhiainen","year":"2012","unstructured":"Jauhiainen A, Thomsen C, Strombom L, Grundevik P, Andersson C, Danielsson A, Andersson MK, Nerman O, Rorkvist L, Stahlberg A, Aman P (2012) Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3\/CHOP\/GADD153. PLoS ONE 7:e33208. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0033208","journal-title":"PLoS ONE"},{"key":"1683_CR42","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1099\/vir.0.82941-0","volume":"88","author":"R Nerome","year":"2007","unstructured":"Nerome R, Tajima S, Takasaki T, Yoshida T, Kotaki A, Lim CK, Ito M, Sugiyama A, Yamauchi A, Yano T, Kameyama T, Morishita I, Kuwayama M, Ogawa T, Sahara K, Ikegaya A, Kanda M, Hosoya Y, Itokazu K, Onishi H, Chiya S, Yoshida Y, Tabei Y, Katsuki K, Tabata K, Harada S, Kurane I (2007) Molecular epidemiological analyses of Japanese encephalitis virus isolates from swine in Japan from 2002 to 2004. J Gen Virol 88:2762\u20132768. \n                    https:\/\/doi.org\/10.1099\/vir.0.82941-0","journal-title":"J Gen Virol"},{"key":"1683_CR43","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1089\/ars.2011.4391","volume":"18","author":"J Lewerenz","year":"2013","unstructured":"Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P (2013) The cystine\/glutamate antiporter system x\u2212c in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Sign 18:522\u2013555. \n                    https:\/\/doi.org\/10.1089\/ars.2011.4391","journal-title":"Antioxid Redox Sign"},{"key":"1683_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15074","author":"CS Shin","year":"2017","unstructured":"Shin CS, Mishra P, Watrous JD, Carelli V, D\u2019Aurelio M, Jain M, Chan DC (2017) The glutamate\/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nat Commun. \n                    https:\/\/doi.org\/10.1038\/ncomms15074","journal-title":"Nat Commun"},{"key":"1683_CR45","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3296294","author":"M Pasha","year":"2017","unstructured":"Pasha M, Eid AH, Eid AA, Gorin Y, Munusamy S (2017) Sestrin2 as a novel biomarker and therapeutic target for various diseases. Oxid Med Cell Longev. \n                    https:\/\/doi.org\/10.1155\/2017\/3296294","journal-title":"Oxid Med Cell Longev"},{"key":"1683_CR46","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1128\/JVI.76.9.4162-4171.2002","volume":"76","author":"HL Su","year":"2002","unstructured":"Su HL, Liao CL, Lin YL (2002) Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response. J Virol 76:4162\u20134171","journal-title":"J Virol"},{"key":"1683_CR47","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1099\/jgv.0.000792","volume":"98","author":"M Sharma","year":"2017","unstructured":"Sharma M, Bhattacharyya S, Sharma KB, Chauhan S, Asthana S, Abdin MZ, Vrati S, Kalia M (2017) Japanese encephalitis virus activates autophagy through XBP1 and ATF6 ER stress sensors in neuronal cells. J Gen Virol 98:1027\u20131039. \n                    https:\/\/doi.org\/10.1099\/jgv.0.000792","journal-title":"J Gen Virol"},{"key":"1683_CR48","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s11481-012-9357-0","volume":"7","author":"V Soontornniyomkij","year":"2012","unstructured":"Soontornniyomkij V, Soontornniyomkij B, Moore DJ, Gouaux B, Masliah E, Tung S, Vinters HV, Grant I, Achim CL (2012) Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders. J Neuroimmune Pharmacol 7:579\u2013590. \n                    https:\/\/doi.org\/10.1007\/s11481-012-9357-0","journal-title":"J Neuroimmune Pharmacol"},{"key":"1683_CR49","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s12031-013-0081-x","volume":"51","author":"D Zhou","year":"2013","unstructured":"Zhou D, Zhan C, Zhong Q, Li S (2013) Upregulation of sestrin-2 expression via P53 protects against 1-methyl-4-phenylpyridinium (MPP\u2009+) neurotoxicity. J Mol Neurosci 51:967\u2013975. \n                    https:\/\/doi.org\/10.1007\/s12031-013-0081-x","journal-title":"J Mol Neurosci"},{"key":"1683_CR50","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.3233\/JAD-160479","volume":"54","author":"N Rai","year":"2016","unstructured":"Rai N, Kumar R, Desai GR, Venugopalan G, Shekhar S, Chatterjee P, Tripathi M, Upadhyay AD, Dwivedi S, Dey AB, Dey S (2016) Relative alterations in blood-based levels of sestrin in alzheimer\u2019s disease and mild cognitive impairment patients. J Alzheimers Dis 54:1147\u20131155. \n                    https:\/\/doi.org\/10.3233\/JAD-160479","journal-title":"J Alzheimers Dis"},{"key":"1683_CR51","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1212\/WNL.53.8.1781","volume":"53","author":"S Pradhan","year":"1999","unstructured":"Pradhan S, Pandey N, Shashank S, Gupta RK, Mathur A (1999) Parkinsonism due to predominant involvement of substantia nigra in Japanese encephalitis. Neurology 53:1781\u20131786. \n                    https:\/\/doi.org\/10.1212\/Wnl.53.8.1781","journal-title":"Neurology"},{"key":"1683_CR52","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1212\/WNL.55.4.602","volume":"55","author":"A Ogata","year":"2000","unstructured":"Ogata A, Tashiro K (2000) Parkinsonism due to predominant involvement of substantia nigra in Japanese encephalitis. Neurology 55:602. \n                    https:\/\/doi.org\/10.1212\/Wnl.55.4.602","journal-title":"Neurology"},{"issue":"1","key":"1683_CR53","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/s41598-017-19102-2","volume":"8","author":"A Kumar","year":"2018","unstructured":"Kumar A, Shaha C (2018) SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation. Sci Rep 8(1):615. \n                    https:\/\/doi.org\/10.1038\/s41598-017-19102-2","journal-title":"Sci Rep"},{"key":"1683_CR54","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/33416","volume":"392","author":"T Kitada","year":"1998","unstructured":"Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:605\u2013608","journal-title":"Nature"},{"key":"1683_CR55","doi-asserted-by":"publisher","first-page":"7231","DOI":"10.1128\/JVI.00326-16","volume":"90","author":"SC Tran","year":"2016","unstructured":"Tran SC, Pham TM, Nguyen LN, Park EM, Lim YS, Hwang SB (2016) Nonstructural 3 protein of hepatitis C virus modulates the tribbles homolog 3\/AKT signaling pathway for persistent viral infection. J Virol 90:7231\u20137247. \n                    https:\/\/doi.org\/10.1128\/JVI.00326-16","journal-title":"J Virol"},{"issue":"1","key":"1683_CR56","doi-asserted-by":"publisher","first-page":"e2556","DOI":"10.1038\/cddis.2016.394","volume":"8","author":"S Mukherjee","year":"2017","unstructured":"Mukherjee S, Singh N, Sengupta N, Fatima M, Seth P, Mahadevan A, Shankar SK, Bhattacharyya A, Basu A (2017) Japanese encephalitis virus induces human neural stem\/progenitor cell death by elevating GRP78, PHB and hnRNPC through ER stress. Cell Death Dis 8(1):e2556. \n                    https:\/\/doi.org\/10.1038\/cddis.2016.394","journal-title":"Cell Death Dis"},{"key":"1683_CR57","doi-asserted-by":"publisher","first-page":"9429","DOI":"10.1128\/JVI.00511-14","volume":"88","author":"L Giffin","year":"2014","unstructured":"Giffin L, Yan F, Ben Major M, Damania B (2014) Modulation of kaposi\u2019s sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1. J Virol 88:9429\u20139441. \n                    https:\/\/doi.org\/10.1128\/Jvi.00511-14","journal-title":"J Virol"},{"key":"1683_CR58","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","volume":"18","author":"HL Tang","year":"2016","unstructured":"Tang HL, Hammack C, Ogden SC, Wen ZX, Qian XY, Li YJ, Yao B, Shin J, Zhang FR, Lee EM, Christian KM, Didier RA, Jin P, Song HJ, Ming GL (2016) Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 18:587\u2013590. \n                    https:\/\/doi.org\/10.1016\/j.stem.2016.02.016","journal-title":"Cell Stem Cell"},{"key":"1683_CR59","doi-asserted-by":"publisher","first-page":"13472","DOI":"10.1523\/JNEUROSCI.2282-14.2014","volume":"34","author":"Y Zhou","year":"2014","unstructured":"Zhou Y, Wang X, Tzingounis AV, Danbolt NC, Larsson HP (2014) EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake. J Neurosci 34:13472\u201313485. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.2282-14.2014","journal-title":"J Neurosci"},{"key":"1683_CR60","doi-asserted-by":"publisher","first-page":"e240","DOI":"10.1038\/cddis.2011.117","volume":"2","author":"D Nguyen","year":"2011","unstructured":"Nguyen D, Alavi MV, Kim KY, Kang T, Scott RT, Noh YH, Lindsey JD, Wissinger B, Ellisman MH, Weinreb RN, Perkins GA, Ju WK (2011) A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics. Cell Death Dis 2:e240. \n                    https:\/\/doi.org\/10.1038\/cddis.2011.117","journal-title":"Cell Death Dis"},{"key":"1683_CR61","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1002\/glia.21113","volume":"59","author":"J de Groot","year":"2011","unstructured":"de Groot J, Sontheimer H (2011) Glutamate and the biology of gliomas. Glia 59:1181\u20131189. \n                    https:\/\/doi.org\/10.1002\/glia.21113","journal-title":"Glia"},{"key":"1683_CR62","first-page":"303","volume":"9","author":"S Singh","year":"2012","unstructured":"Singh S, Khan AR, Gupta AK (2012) Role of glutathione in cancer pathophysiology and therapeutic interventions. J Exp Ther Oncol 9:303\u2013316","journal-title":"J Exp Ther Oncol"},{"key":"1683_CR63","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2837-5","author":"B Pal","year":"2018","unstructured":"Pal B (2018) Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability. Cell Mol Life Sci. \n                    https:\/\/doi.org\/10.1007\/s00018-018-2837-5","journal-title":"Cell Mol Life Sci"},{"key":"1683_CR64","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1089\/ars.2013.5455","volume":"20","author":"J Lewerenz","year":"2014","unstructured":"Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, Massie A, Hardingham GE, Maher P (2014) Phosphoinositide 3-kinases upregulate system X\u2212c via eukaryotic initiation factor 2 alpha and activating transcription factor 4\u2014A pathway active in glioblastomas and epilepsy. Antioxid Redox Signal 20:2907\u20132922. \n                    https:\/\/doi.org\/10.1089\/ars.2013.5455","journal-title":"Antioxid Redox Signal"}],"container-title":["Virus Genes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11262-019-01683-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11262-019-01683-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11262-019-01683-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T23:15:34Z","timestamp":1594250134000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11262-019-01683-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,10]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["1683"],"URL":"https:\/\/doi.org\/10.1007\/s11262-019-01683-x","relation":{},"ISSN":["0920-8569","1572-994X"],"issn-type":[{"value":"0920-8569","type":"print"},{"value":"1572-994X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,10]]},"assertion":[{"value":"18 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any study involving either human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants or animals"}}]}}