{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:38:48Z","timestamp":1740123528972,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Biotechnology, Govt. of India","award":["BT\/NBM0095\/02\/18"],"award-info":[{"award-number":["BT\/NBM0095\/02\/18"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virus Genes"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s11262-021-01826-z","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T09:04:51Z","timestamp":1615194291000},"page":"245-249","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Isolation and genetic characterization of SARS-CoV-2 from Indian patients in a single family without H\/O travel abroad"],"prefix":"10.1007","volume":"57","author":[{"given":"Shubham","family":"Shrivastava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshad P.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhas T.","family":"Mhaske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Palkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Lalwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhilesh Chandra","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-3437","authenticated-orcid":false,"given":"Vidya A.","family":"Arankalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"issue":"7798","key":"1826_CR1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","volume":"579","author":"F Wu","year":"2020","unstructured":"Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG et al (2020) A new coronavirus associated with human respiratory disease in China. Nature 579(7798):265\u2013269. https:\/\/doi.org\/10.1038\/s41586-020-2008-3","journal-title":"Nature"},{"issue":"10223","key":"1826_CR2","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/S0140-6736(20)30154-9","volume":"395","author":"JFW Chan","year":"2020","unstructured":"Chan JFW, Yuan S, Kok KH, To KKW, Chu H, Yang J et al (2020) A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 395(10223):514\u2013523. https:\/\/doi.org\/10.1016\/S0140-6736(20)30154-9","journal-title":"Lancet"},{"issue":"4","key":"1826_CR3","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","volume":"5","author":"AE Gorbalenya","year":"2020","unstructured":"Gorbalenya AE et al (2020) The Species Severe Acute Respiratory Syndrome-Related Coronavirus: Classifying 2019-NCoV and Naming It SARS-CoV-2. Nat Microbiol 5(4):536\u2013544. https:\/\/doi.org\/10.1038\/s41564-020-0695-z","journal-title":"Nat Microbiol"},{"key":"1826_CR4","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200092","author":"SKP Lau","year":"2020","unstructured":"Lau SKP, Luk HKH, Wong ACP, Li KSM, Zhu L, He Z et al (2020) Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2. Emerg Infect Dis. https:\/\/doi.org\/10.3201\/eid2607.200092","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"1826_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.24171\/j.phrp.2020.11.1.02","volume":"11","author":"J-M Kim","year":"2020","unstructured":"Kim J-M, Chung Y-S, Jo HJ, Lee N-J, Kim MS, Woo SH et al (2020) Identification of Coronavirus Isolated from a Patient in Korea with COVID-19. Osong Public Health Res Perspect 11(1):3\u20137. https:\/\/doi.org\/10.24171\/j.phrp.2020.11.1.02","journal-title":"Osong Public Health Res Perspect"},{"issue":"6","key":"1826_CR6","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.3201\/eid2606.200516","volume":"26","author":"J Harcourt","year":"2020","unstructured":"Harcourt J, Tamin A, Lu X, Kamili S, Sakthivel SK, Murray J et al (2020) Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with 2019 Novel Coronavirus Disease. United States Emerg Infect Dis 26(6):1266\u20131273. https:\/\/doi.org\/10.3201\/eid2606.200516","journal-title":"United States Emerg Infect Dis"},{"issue":"11","key":"1826_CR7","doi-asserted-by":"publisher","first-page":"e00543","DOI":"10.1128\/JVI.00543-20","volume":"94","author":"D Licastro","year":"2020","unstructured":"Licastro D, Rajasekharan S, Dal Monego S, Segat L, D\u2019Agaro P, Marcello A (2020) Isolation and full-length genome characterization of SARS-CoV-2 from COVID-19 cases in Northern Italy. J Virol 94(11):e00543-e620. https:\/\/doi.org\/10.1128\/JVI.00543-20","journal-title":"J Virol"},{"issue":"10","key":"1826_CR8","doi-asserted-by":"publisher","first-page":"459","DOI":"10.5694\/mja2.50569","volume":"212","author":"L Caly","year":"2020","unstructured":"Caly L, Druce J, Roberts J, Bond K, Tran T, Kostecki R et al (2020) Isolation and Rapid Sharing of the 2019 Novel Coronavirus (SARS-CoV-2) From the First Patient Diagnosed With COVID-19 in Australia. Med J Aust 212(10):459\u2013462. https:\/\/doi.org\/10.5694\/mja2.50569","journal-title":"Med J Aust"},{"issue":"8","key":"1826_CR9","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/NEJMoa2001017","volume":"382","author":"N Zhu","year":"2020","unstructured":"Zhu N, Zhang D, Wang W, Li X, Yang B, Song J et al (2020) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382(8):727\u2013733. https:\/\/doi.org\/10.1056\/NEJMoa2001017","journal-title":"N Engl J Med"},{"issue":"13","key":"1826_CR10","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1056\/NEJMc2001899","volume":"382","author":"S Hoehl","year":"2020","unstructured":"Hoehl S, Rabenau H, Berger A, Kortenbusch M, Cinatl J, Bojkova D et al (2020) Evidence of SARS-CoV-2 infection in returning travelers from Wuhan. China N Engl J Med 382(13):1278\u20131280. https:\/\/doi.org\/10.1056\/NEJMc2001899","journal-title":"China N Engl J Med"},{"key":"1826_CR11","doi-asserted-by":"publisher","DOI":"10.7326\/M20-1176","author":"F Colavita","year":"2020","unstructured":"Colavita F, Lapa D, Carletti F, Lalle E, Bordi L, Marsella P et al (2020) SARS-CoV-2 Isolation From Ocular Secretions of a Patient With COVID-19 in Italy With Prolonged Viral RNA Detection. Ann Intern Med. https:\/\/doi.org\/10.7326\/M20-1176","journal-title":"Ann Intern Med"},{"issue":"2","key":"1826_CR12","doi-asserted-by":"publisher","first-page":"e0192672","DOI":"10.1371\/journal.pone.0192672","volume":"13","author":"S Shrivastava","year":"2018","unstructured":"Shrivastava S, Tiraki D, Diwan A, Lalwani SK, Modak M, Mishra AC et al (2018) Co-circulation of all the four dengue virus serotypes and detection of a novel clade of DENV-4 (genotype I) virus in Pune, India during 2016 season. PLoS ONE 13(2):e0192672. https:\/\/doi.org\/10.1371\/journal.pone.0192672","journal-title":"PLoS ONE"},{"key":"1826_CR13","doi-asserted-by":"crossref","unstructured":"Rut W, Groborz K, Zhang L, Sun X, Zmudzinski M, Hilgenfeld R, et al (2020) Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design. bioRxiv;2020.03.07.981928.","DOI":"10.1101\/2020.03.07.981928"},{"issue":"1","key":"1826_CR14","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12967-020-02344-6","volume":"18","author":"M Pachetti","year":"2020","unstructured":"Pachetti M, Marini B, Benedetti F, Giudici F, Mauro E, Storici P et al (2020) (2020) Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. J Transl Med 18(1):179. https:\/\/doi.org\/10.1186\/s12967-020-02344-6","journal-title":"J Transl Med"},{"issue":"2","key":"1826_CR15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4103\/ijmr.IJMR_1058_20","volume":"151","author":"V Potdar","year":"2020","unstructured":"Potdar V, Cherian S, Deshpande G, Ullas P, Yadav P, Choudhary M et al (2020) Genomic analysis of SARS-CoV-2 strains among Indians returning from Italy, Iran & China, & Italian tourists in India. Indian J Med Res 151(2):255\u2013260. https:\/\/doi.org\/10.4103\/ijmr.IJMR_1058_20","journal-title":"Indian J Med Res"},{"key":"1826_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa036","author":"X Tang","year":"2020","unstructured":"Tang X, Wu C, Li X, Song Y, Yao X, Wu X et al (2020) On the origin and continuing evolution of SARS-CoV-2. Natl Sci Rev. https:\/\/doi.org\/10.1093\/nsr\/nwaa036","journal-title":"Natl Sci Rev"},{"key":"1826_CR17","doi-asserted-by":"crossref","unstructured":"Bhattacharyya C, Das C, Ghosh A, Singh AK (2020) Global Spread of SARS-CoV-2 Subtype with Spike Protein Mutation D614G is Shaped by Human Genomic Variations that Regulate Expression of TMPRSS2 and MX1 Genes. BioRxiv.","DOI":"10.1101\/2020.05.04.075911"},{"issue":"1","key":"1826_CR18","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1080\/22221751.2020.1756700","volume":"9","author":"S-Y Lau","year":"2020","unstructured":"Lau S-Y, Wang P, Mok BW-Y, Zhang AJ, Chu H, Lee AC-Y et al (2020) Attenuated SARS-CoV-2 variants with deletions at the S1\/S2 junction. Emerg Microbes Infect 9(1):837\u2013842. https:\/\/doi.org\/10.1080\/22221751.2020.1756700","journal-title":"Emerg Microbes Infect"},{"key":"1826_CR19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00790-20","author":"Z Liu","year":"2020","unstructured":"Liu Z, Zheng H, Yuan R, Li M, Lin H, Peng J et al (2020) Identification of a common deletion in the spike protein of SARS-CoV-2. J Virol. https:\/\/doi.org\/10.1128\/JVI.00790-20","journal-title":"J Virol"},{"key":"1826_CR20","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00711-20","author":"L Holland","year":"2020","unstructured":"Holland L, Kaelin E, Maqsood R, Estifanos B, LI W, Varsani A, et al (2020) An 81 nucleotide deletion in SARS-CoV-2 ORF7a identified from sentinel surveillance in Arizona (Jan-Mar 2020). J Virol. https:\/\/doi.org\/10.1128\/JVI.00711-20","journal-title":"J Virol"},{"issue":"2","key":"1826_CR21","doi-asserted-by":"publisher","first-page":"200","DOI":"10.4103\/ijmr.IJMR_663_20","volume":"151","author":"P Yadav","year":"2020","unstructured":"Yadav P, Potdar V, Choudhary M, Nyayanit D, Agrawal M, Jadhav S et al (2020) Full-genome sequences of the first two SARS-CoV-2 viruses from India. Indian J Med Res 151(2):200\u2013209. https:\/\/doi.org\/10.4103\/ijmr.IJMR_663_20","journal-title":"Indian J Med Res"},{"key":"1826_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.03.025","author":"MR Capobianchi","year":"2020","unstructured":"Capobianchi MR, Rueca M, Messina F, Giombini E, Carletti F, Colavita F et al (2020) Molecular characterization of SARS-CoV-2 from the first case of COVID-19 in Italy. Clin Microbiol Infect. https:\/\/doi.org\/10.1016\/j.cmi.2020.03.025","journal-title":"Clin Microbiol Infect"},{"key":"1826_CR23","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.13.2000305","author":"P Stefanelli","year":"2020","unstructured":"Stefanelli P, Faggioni G, Lo Presti A, Fiore S, Marchi A, Benedetti E et al (2020) Whole genome and phylogenetic analysis of two SARSCoV-2 strains isolated in Italy in January and February 2020: Additional clues on multiple introductions and further circulation in Europe. Euro Surveill. https:\/\/doi.org\/10.2807\/1560-7917.ES.2020.25.13.2000305","journal-title":"Euro Surveill"}],"container-title":["Virus Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11262-021-01826-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11262-021-01826-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11262-021-01826-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T09:28:43Z","timestamp":1622280523000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11262-021-01826-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["1826"],"URL":"https:\/\/doi.org\/10.1007\/s11262-021-01826-z","relation":{},"ISSN":["0920-8569","1572-994X"],"issn-type":[{"type":"print","value":"0920-8569"},{"type":"electronic","value":"1572-994X"}],"subject":[],"published":{"date-parts":[[2021,3,8]]},"assertion":[{"value":"16 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors have any conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by Institutional Ethics Committee of Bharati Hospital & Research Centre at Bharati Vidyapeeth Deemed University (IEC\/2020\/25).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed written consent was obtained from each participant before enrolment in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}