{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T10:11:13Z","timestamp":1742379073648,"version":"3.40.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K18476","21H02972"],"award-info":[{"award-number":["24K18476","21H02972"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24km0405209"],"award-info":[{"award-number":["24km0405209"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virus Genes"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s11262-025-02134-6","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T17:54:41Z","timestamp":1738346081000},"page":"239-243","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pooled screening for endogenous HHV-6 in subjects with coronary artery disease"],"prefix":"10.1007","volume":"61","author":[{"given":"Rie","family":"Koide","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Sotomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas F.","family":"Parrish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"2134_CR1","doi-asserted-by":"publisher","first-page":"8040","DOI":"10.1128\/JVI.73.10.8040-8052.1999","volume":"73","author":"G Dominguez","year":"1999","unstructured":"Dominguez G, Dambaugh TR, Stamey FR, Dewhurst S, Inoue N, Pellett PE (1999) Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J Virol 73:8040\u20138052","journal-title":"J Virol"},{"key":"2134_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1128\/CMR.00122-14","volume":"28","author":"H Agut","year":"2015","unstructured":"Agut H, Bonnafous P, Gautheret-Dejean A (2015) Laboratory and clinical aspects of human herpesvirus 6 infections. Clin Microbiol Rev 28:313\u2013335","journal-title":"Clin Microbiol Rev"},{"key":"2134_CR3","doi-asserted-by":"publisher","first-page":"117954762091295","DOI":"10.1177\/1179547620912952","volume":"13","author":"F Kim","year":"2020","unstructured":"Kim F, Reichman V, Hooven TA (2020) Human herpesvirus-6 meningitis in a premature infant with fevers: a case and literature review. Clin Med Insights Case Rep 13:1179547620912952","journal-title":"Clin Med Insights Case Rep"},{"key":"2134_CR4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3201\/eid0503.990306","volume":"5","author":"G Campadelli-Fiume","year":"1999","unstructured":"Campadelli-Fiume G, Mirandola P, Menotti L (1999) Human herpesvirus 6: an emerging pathogen. Emerg Infect Dis 5:353\u2013366","journal-title":"Emerg Infect Dis"},{"key":"2134_CR5","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1086\/339411","volume":"185","author":"T Yoshikawa","year":"2002","unstructured":"Yoshikawa T, Asano Y, Ihira M, Suzuki K, Ohashi M, Suga S, Kudo K, Horibe K, Kojima S, Kato K, Matsuyama T, Nishiyama Y (2002) Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors. J Infect Dis 185:847\u2013853","journal-title":"J Infect Dis"},{"key":"2134_CR6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.coviro.2014.09.016","volume":"9","author":"EC Leibovitch","year":"2014","unstructured":"Leibovitch EC, Jacobson S (2014) Evidence linking HHV-6 with multiple sclerosis: an update. Curr Opin Virol 9:127\u2013133","journal-title":"Curr Opin Virol"},{"key":"2134_CR7","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.neuron.2018.05.023","volume":"99","author":"B Readhead","year":"2018","unstructured":"Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS, Beckmann ND, Price ND, Reiman EM, Schadt EE, Ehrlich ME, Gandy S, Dudley JT (2018) Multiscale analysis of independent Alzheimer\u2019s Cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus. Neuron 99:64\u201382","journal-title":"Neuron"},{"key":"2134_CR8","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1159\/000066172","volume":"48","author":"M Montejo","year":"2002","unstructured":"Montejo M, Ramon Fernandez J, Testillano M, Valdivieso A, Aguirrebengoa K, Varas C, Olaizola A, de Urbina JO (2002) Encephalitis caused by human herpesvirus-6 in a liver transplant recipient. Eur Neurol 48:234\u2013235","journal-title":"Eur Neurol"},{"key":"2134_CR9","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1182\/blood-2017-03-775759","volume":"130","author":"JA Hill","year":"2017","unstructured":"Hill JA, Magaret AS, Hall-Sedlak R, Mikhaylova A, Huang ML, Sandmaier BM, Hansen JA, Jerome KR, Zerr DM, Boeckh DMM (2017) Outcomes of hematopoietic cell transplantation using donors or recipients with inherited chromosomally integrated HHV-6. Blood 130:1062\u20131069","journal-title":"Blood"},{"key":"2134_CR10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1352","volume":"137","author":"HE Stefanski","year":"2016","unstructured":"Stefanski HE, Thibert KA, Pritchett J, Prusty BK, Wagner JE, Lund TC (2016) Fatal myocarditis associated with HHV-6 following immunosuppression in two children. Pediatrics 137:e20151352","journal-title":"Pediatrics"},{"key":"2134_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3390\/v14020299","volume":"14","author":"A Elsanhoury","year":"2022","unstructured":"Elsanhoury A, K\u00fchl U, Stautner B, Klein O, Krannich A, Morris D, Willner M, Jankowska E, Klingel K, Van Linthout S, Tsch\u00f6pe C (2022) The spontaneous course of human herpesvirus 6 DNA-associated myocarditis and the effect of immunosuppressive intervention. Viruses 14:299","journal-title":"Viruses"},{"key":"2134_CR12","doi-asserted-by":"publisher","first-page":"5563","DOI":"10.1073\/pnas.0913586107","volume":"107","author":"JH Arbuckle","year":"2010","unstructured":"Arbuckle JH, Medveczky MM, Luka J, Hadley SH, Luegmayr A, Ablashi D, Lund TC, Tolar J, De Meirleir K, Montoya JG, Komaroff AL, Ambros PF, Medveczky PG (2010) The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc Natl Acad Sci USA 107:5563\u20135568","journal-title":"Proc Natl Acad Sci USA"},{"key":"2134_CR13","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/nar\/gkt840","volume":"42","author":"Y Huang","year":"2014","unstructured":"Huang Y, Hidalgo-Bravo A, Zhang E, Cotton VE, Mendez-Bermudez A, Wig G, Medina-Calzada Z, Neumann R, Jeffreys AJ, Winney B, Wilson JF, Clark DA, Dyer MJ, Royle NJ (2014) Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome. Nucleic Acids Res 42:315\u2013327","journal-title":"Nucleic Acids Res"},{"key":"2134_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004033","volume":"9","author":"BK Prusty","year":"2013","unstructured":"Prusty BK, Krohne G, Rudel T (2013) Reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation. PloS Genet 9:e1004033. https:\/\/doi.org\/10.1371\/journal.pgen.1004033","journal-title":"PloS Genet"},{"key":"2134_CR15","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70452","volume":"10","author":"ML Wood","year":"2021","unstructured":"Wood ML, Veal CD, Neumann R, Su\u00e1rez NM, Nichols J, Parker AJ, Martin D, Romaine SP, Codd V, Samani NJ, Voors AA, Tomaszewski M, Flamand L, Davison AJ, Royle NJ (2021) Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals. Elife 10:e70452. https:\/\/doi.org\/10.7554\/eLife.70452","journal-title":"Elife"},{"key":"2134_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008915","volume":"16","author":"X Liu","year":"2020","unstructured":"Liu X, Kosugi S, Koide R, Kawamura Y, Ito J, Miura H, Matoba N, Matsuzaki M, Fujita M, Kamada AJ, Nakagawa H, Tamiya G, Matsuda K, Murakami Y, Kubo M, Aswad A, Sato K, Momozawa Y, Ohashi J, Terao C, Yoshikawa T, Parrish NF, Kamatani Y (2020) Endogenization and excision of human herpesvirus 6 in human genomes. PLoS Genet 16:e1008915. https:\/\/doi.org\/10.1371\/journal.pgen.1008915","journal-title":"PLoS Genet"},{"key":"2134_CR17","doi-asserted-by":"publisher","first-page":"8058","DOI":"10.1073\/pnas.1502741112","volume":"112","author":"A Gravel","year":"2015","unstructured":"Gravel A, Dubuc I, Morissette G, Sedlak RH, Jerome KR, Flamand L (2015) Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris. Proc Natl Acad Sci U S A 112:8058\u20138063","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2134_CR18","doi-asserted-by":"publisher","first-page":"e022258","DOI":"10.1161\/JAHA.121.022258","volume":"10","author":"Y Sotomi","year":"2021","unstructured":"Sotomi Y, Ueda Y, Hikoso S, Nakatani D, Suna S, Dohi T, Mizuno H, Okada K, Kida H, Oeun B, Sunaga A, Sato T, Kitamura T, Sakata Y, Sato H, Hori M, Komuro I, Sakata Y, Osaka Acute Coronary Insufficiency Study (OACIS) Group (2021) Manual thrombus aspiration and its procedural stroke risk in myocardial infarction. J Am Heart Assoc 10:e022258. https:\/\/doi.org\/10.1161\/JAHA.121.022258","journal-title":"J Am Heart Assoc"},{"key":"2134_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104656","volume":"132","author":"Y Kawamura","year":"2020","unstructured":"Kawamura Y, Hashimoto T, Miura H, Kozawa K, Yoshikawa A, Ikeda N, Yatsuya H, Yasuoka H, Yoshikawa T (2020) Inherited chromosomally integrated human herpesvirus 6 and autoimmune connective tissue diseases. J Clin Virol 132:104656. https:\/\/doi.org\/10.1016\/j.jcv.2020.104656","journal-title":"J Clin Virol"},{"key":"2134_CR20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jcv.2016.02.016","volume":"77","author":"JA Hill","year":"2016","unstructured":"Hill JA, HallSedlak R, Magaret A, Huang ML, Zerr DM, Jerome KR, Boeckh M (2016) Efficient identification of inherited chromosomally integrated human herpesvirus 6 using specimen pooling. J Clin Virol 77:71\u201376","journal-title":"J Clin Virol"},{"key":"2134_CR21","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41586-020-2885-5","volume":"589","author":"L Mutesa","year":"2021","unstructured":"Mutesa L, Ndishimye P, Butera Y, Souopgui J, Uwineza A, Rutayisire R, Ndoricimpaye EL, Musoni E, Rujeni N, Nyatanyi T, Ntagwabira E, Semakula M, Musanabaganwa C, Nyamwasa D, Ndashimye M, Ujeneza E, Mwikarago IE, Muvunyi CM, Mazarati JB, Nsanzimana S, Turok N, Ndifon W (2021) A pooled testing strategy for identifying SARS-CoV-2 at low prevalence. Nature 589:276\u2013280","journal-title":"Nature"},{"key":"2134_CR22","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/jmv.20113","volume":"73","author":"K Tanaka-Taya","year":"2004","unstructured":"Tanaka-Taya K, Sashihara J, Kurahashi H, Amo K, Miyagawa H, Kondo K, Okada S, Yamanishi K (2004) Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA. J Med Virol 73:465\u2013473","journal-title":"J Med Virol"},{"key":"2134_CR23","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1002\/jmv.25244","volume":"90","author":"H Miura","year":"2018","unstructured":"Miura H, Kawamura Y, Hattori F, Kozawa K, Ihira M, Ohye T, Kurahashi H, Yoshikawa T (2018) Chromosomally integrated human herpesvirus 6 in the Japanese population. J Med Virol 90:1636\u20131642","journal-title":"J Med Virol"},{"key":"2134_CR24","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1136\/jmedgenet-2014-102423","volume":"51","author":"C Terao","year":"2014","unstructured":"Terao C, Terada N, Matsuo K, Kawaguchi T, Yoshimura K, Hayashi N, Shimizu M, Soga N, Takahashi M, Kotoura Y, Yamada R, Ogawa O, Matsuda F, Nagahama Cohort Study Group (2014) A genome-wide association study of serum levels of prostate-specific antigen in the Japanese population. J Med Genet 51:530\u2013536","journal-title":"J Med Genet"}],"container-title":["Virus Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11262-025-02134-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11262-025-02134-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11262-025-02134-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:18:24Z","timestamp":1742375904000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11262-025-02134-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["2134"],"URL":"https:\/\/doi.org\/10.1007\/s11262-025-02134-6","relation":{},"ISSN":["0920-8569","1572-994X"],"issn-type":[{"type":"print","value":"0920-8569"},{"type":"electronic","value":"1572-994X"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"19 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}