{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:34:28Z","timestamp":1761744868497,"version":"3.37.3"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T00:00:00Z","timestamp":1543017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81500471","81700544"],"award-info":[{"award-number":["81500471","81700544"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province","award":["UNPYSCT-2016112"],"award-info":[{"award-number":["UNPYSCT-2016112"]}]},{"name":"Basic Scientific Research Project of University belongs to Heilongjiang in 2017 under Grant","award":["2017-KYYWF-0649","2017-KYYWF-0640"],"award-info":[{"award-number":["2017-KYYWF-0649","2017-KYYWF-0640"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s11274-018-2565-x","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T23:49:37Z","timestamp":1543016977000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Expression, purification, and evaluation of in vivo anti-fibrotic activity for soluble truncated TGF-\u03b2 receptor II as a cleavable His-SUMO fusion protein"],"prefix":"10.1007","volume":"34","author":[{"given":"Xiaohua","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijie","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinqiu","family":"Gui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,24]]},"reference":[{"key":"2565_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s12033-017-0032-9","volume":"59","author":"G Antoniou","year":"2017","unstructured":"Antoniou G, Papakyriacou I, Papaneophytou C (2017) Optimization of soluble expression and purification of recombinant human rhinovirus Type-14 3C protease using statistically designed experiments: isolation and characterization of the enzyme. Mol Biotechnol 59:407\u2013424","journal-title":"Mol Biotechnol"},{"key":"2565_CR2","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.3892\/or.2016.5078","volume":"36","author":"G Bai","year":"2016","unstructured":"Bai G, Yan G, Wang G, Wan P, Zhang R (2016) Anti-hepatic fibrosis effects of a novel turtle shell decoction by inhibiting hepatic stellate cell proliferation and blocking TGF-beta1\/Smad signaling pathway in rats. Oncol Rep 36:2902\u20132910","journal-title":"Oncol Rep"},{"key":"2565_CR3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"2565_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pep.2005.03.016","volume":"43","author":"TR Butt","year":"2005","unstructured":"Butt TR, Edavettal SC, Hall JP, Mattern MR (2005) SUMO fusion technology for difficult-to-express proteins. Protein Expr Purif 43:1\u20139","journal-title":"Protein Expr Purif"},{"key":"2565_CR5","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s12072-008-9093-y","volume":"2","author":"A Douglass","year":"2008","unstructured":"Douglass A, Wallace K, Koruth M, Barelle C, Porter AJ, Wright MC (2008) Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy. Hepatol Int 2:405\u2013415","journal-title":"Hepatol Int"},{"key":"2565_CR6","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1148\/radiol.2017170595","volume":"287","author":"CT Farrar","year":"2017","unstructured":"Farrar CT, Gale EM, Kennan R, Ramsay I, Masia R, Arora G, Looby K, Wei L, Kalpathy-Cramer J, Bunzel MM, Zhang C, Zhu Y, Akiyama TE, Klimas M, Pinto S, Diyabalanage H, Tanabe KK, Humblet V, Fuchs BC, Caravan P (2017) CM-101: type I collagen-targeted MR imaging probe for detection of liver fibrosis. Radiology 287:581\u2013589","journal-title":"Radiology"},{"key":"2565_CR7","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s00253-009-2078-5","volume":"85","author":"X Gao","year":"2010","unstructured":"Gao X, Chen W, Guo C, Qian C, Liu G, Ge F, Huang Y, Kitazato K, Wang Y, Xiong S (2010) Soluble cytoplasmic expression, rapid purification, and characterization of cyanovirin-N as a His-SUMO fusion. Appl Microbiol Biotechnol 85:1051\u20131060","journal-title":"Appl Microbiol Biotechnol"},{"key":"2565_CR8","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1093\/cvr\/cvt083","volume":"99","author":"MA Hagler","year":"2013","unstructured":"Hagler MA, Hadley TM, Zhang H, Mehra K, Roos CM, Schaff HV, Suri RM, Miller JD (2013) TGF-beta signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves. Cardiovasc Res 99:175\u2013184","journal-title":"Cardiovasc Res"},{"key":"2565_CR9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s41038-016-0055-7","volume":"4","author":"JM Hahn","year":"2016","unstructured":"Hahn JM, McFarland KL, Combs KA, Supp DM (2016) Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-beta1. Burns Trauma 4:30","journal-title":"Burns Trauma"},{"key":"2565_CR10","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1440-1746.2003.03292.x","volume":"19","author":"I Hernandez-Canaveral","year":"2004","unstructured":"Hernandez-Canaveral I, Gonzalez J, Lopez-Casillas F, Armendariz-Borunda J (2004) Amplified expression of dominant-negative transforming growth factor-beta type II receptor inhibits collagen type I production via reduced Smad-3 activity. J Gastroenterol Hepatol 19:380\u2013387","journal-title":"J Gastroenterol Hepatol"},{"key":"2565_CR11","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/exd.13366","volume":"26","author":"M Ide","year":"2017","unstructured":"Ide M, Jinnin M, Tomizawa Y, Wang Z, Kajihara I, Fukushima S, Hashizume Y, Asano Y, Ihn H (2017) Transforming growth factor beta-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis. Exp Dermatol 26:1139\u20131143","journal-title":"Exp Dermatol"},{"key":"2565_CR12","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1038\/ncomms3562","volume":"4","author":"SM Jung","year":"2013","unstructured":"Jung SM, Lee JH, Park J, Oh YS, Lee SK, Park JS, Lee YS, Kim JH, Lee JY, Bae YS, Koo SH, Kim SJ, Park SH (2013) Smad6 inhibits non-canonical TGF-beta1 signalling by recruiting the deubiquitinase A20 to TRAF6. Nat Commun 4:2562","journal-title":"Nat Commun"},{"key":"2565_CR13","doi-asserted-by":"publisher","first-page":"10391","DOI":"10.1128\/MCB.25.23.10391-10406.2005","volume":"25","author":"I Lamsoul","year":"2005","unstructured":"Lamsoul I, Lodewick J, Lebrun S, Brasseur R, Burny A, Gaynor RB, Bex F (2005) Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein. Mol Cell Biol 25:10391\u201310406","journal-title":"Mol Cell Biol"},{"key":"2565_CR14","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1111\/liv.12638","volume":"35","author":"J Li","year":"2015","unstructured":"Li J, Li X, Xu W, Wang S, Hu Z, Zhang Q, Deng X, Wang J, Zhang J, Guo C (2015) Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT\/mTOR\/p70S6K and TGFbeta\/Smad signalling pathways. Liver Int 35:1222\u20131233","journal-title":"Liver Int"},{"key":"2565_CR15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.biomaterials.2016.02.017","volume":"87","author":"H Li","year":"2016","unstructured":"Li H, Hicks JJ, Wang L, Oyster N, Philippon MJ, Hurwitz S, Hogan MV, Huard J (2016) Customized platelet-rich plasma with transforming growth factor beta1 neutralization antibody to reduce fibrosis in skeletal muscle. Biomaterials 87:147\u2013156","journal-title":"Biomaterials"},{"key":"2565_CR16","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/0092-8674(92)90152-3","volume":"68","author":"HY Lin","year":"1992","unstructured":"Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF (1992) Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine\/threonine kinase. Cell 68:775\u2013785","journal-title":"Cell"},{"key":"2565_CR17","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00253-011-3864-4","volume":"96","author":"X Liu","year":"2012","unstructured":"Liu X, Chen Y, Wu X, Li H, Jiang C, Tian H, Tang L, Wang D, Yu T, Li X (2012) SUMO fusion system facilitates soluble expression and high production of bioactive human fibroblast growth factor 23 (FGF23). Appl Microbiol Biotechnol 96:103\u2013111","journal-title":"Appl Microbiol Biotechnol"},{"key":"2565_CR18","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1002\/jor.22890","volume":"33","author":"AE Loiselle","year":"2015","unstructured":"Loiselle AE, Yukata K, Geary MB, Kondabolu S, Shi S, Jonason JH, Awad HA, O\u2019Keefe RJ (2015) Development of antisense oligonucleotide (ASO) technology against Tgf-beta signaling to prevent scarring during flexor tendon repair. J Orthop Res 33:859\u2013866","journal-title":"J Orthop Res"},{"key":"2565_CR19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.tox.2016.07.018","volume":"365","author":"C Lu","year":"2016","unstructured":"Lu C, Xu W, Zhang F, Shao J, Zheng S (2016) Nrf2 knockdown attenuates the ameliorative effects of ligustrazine on hepatic fibrosis by targeting hepatic stellate cell transdifferentiation. Toxicology 365:35\u201347","journal-title":"Toxicology"},{"key":"2565_CR20","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1681\/ASN.2017050574","volume":"29","author":"C Luo","year":"2018","unstructured":"Luo C, Zhou S, Zhou Z, Liu Y, Yang L, Liu J, Zhang Y, Li H, Liu Y, Hou FF, Zhou L (2018) Wnt9a promotes renal fibrosis by accelerating cellular senescence in tubular epithelial cells. J Am Soc Nephrol 29:1238\u20131256","journal-title":"J Am Soc Nephrol"},{"key":"2565_CR21","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12967-017-1198-4","volume":"15","author":"LA Morales-Garza","year":"2017","unstructured":"Morales-Garza LA, Puche JE, Aguirre GA, Munoz U, Garcia-Magarino M, De la Garza RG, Castilla-Cortazar I (2017) Experimental approach to IGF-1 therapy in CCl4-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency. J Transl Med 15:96","journal-title":"J Transl Med"},{"key":"2565_CR22","doi-asserted-by":"publisher","first-page":"50833","DOI":"10.1074\/jbc.M307533200","volume":"278","author":"T Ohshima","year":"2003","unstructured":"Ohshima T, Shimotohno K (2003) Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4. J Biol Chem 278:50833\u201350842","journal-title":"J Biol Chem"},{"key":"2565_CR23","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/nm.3777","volume":"21","author":"K Palumbo-Zerr","year":"2015","unstructured":"Palumbo-Zerr K, Zerr P, Distler A, Fliehr J, Mancuso R, Huang J, Mielenz D, Tomcik M, Furnrohr BG, Scholtysek C, Dees C, Beyer C, Kronke G, Metzger D, Distler O, Schett G, Distler JH (2015) Orphan nuclear receptor NR4A1 regulates transforming growth factor-beta signaling and fibrosis. Nat Med 21:150\u2013158","journal-title":"Nat Med"},{"key":"2565_CR24","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1053\/j.gastro.2011.12.006","volume":"142","author":"J Ross","year":"2012","unstructured":"Ross J, Gherardi E, Mallorqui-Fernandez N, Bocci M, Sobkowicz A, Rees M, Rowe A, Ellmerich S, Massie I, Soeda J, Selden C, Hodgson H (2012) Protein engineered variants of hepatocyte growth factor\/scatter factor promote proliferation of primary human hepatocytes and in rodent liver. Gastroenterology 142:897\u2013906","journal-title":"Gastroenterology"},{"key":"2565_CR25","doi-asserted-by":"publisher","first-page":"18961","DOI":"10.1074\/jbc.M117.793794","volume":"292","author":"M Sato-Matsubara","year":"2017","unstructured":"Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N (2017) Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling. J Biol Chem 292:18961\u201318972","journal-title":"J Biol Chem"},{"key":"2565_CR26","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1042\/CS20170218","volume":"131","author":"F Schueller","year":"2017","unstructured":"Schueller F, Roy S, Loosen SH, Alder J, Koppe C, Schneider AT, Wandrer F, Bantel H, Vucur M, Mi QS, Trautwein C, Luedde T, Roderburg C (2017) miR-223 represents a biomarker in acute and chronic liver injury. Clin Sci (Lond) 131:1971\u20131987","journal-title":"Clin Sci (Lond)"},{"key":"2565_CR27","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/hep.28644","volume":"64","author":"W Seo","year":"2016","unstructured":"Seo W, Eun HS, Kim SY, Yi HS, Lee YS, Park SH, Jang MJ, Jo E, Kim SC, Han YM, Park KG, Jeong WI (2016) Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by gammadelta T cells in liver fibrosis. Hepatology 64:616\u2013631","journal-title":"Hepatology"},{"key":"2565_CR28","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s13205-017-0895-2","volume":"7","author":"RK Shah","year":"2017","unstructured":"Shah RK, Patel AK, Davla DM, Parikh IK, Subramanian RB, Patel KC, Jakhesara SJ, Joshi CG (2017) Molecular cloning, heterologous expression, and functional characterization of a cellulolytic enzyme (Cel PRII) from buffalo rumen metagenome. 3 Biotech 7:257","journal-title":"3 Biotech"},{"key":"2565_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.pep.2018.01.010","volume":"146","author":"W Shen","year":"2018","unstructured":"Shen W, Han J, Yan P, Zheng J, Zhang L, Li X, Tuo D, Zhou P (2018) Soluble expression of biologically active methionine sulfoxide reductase B1 (PaMsrB1) from Carica papaya in Escherichia coli and isolation of its protein targets. Protein Expr Purif 146:17\u201322","journal-title":"Protein Expr Purif"},{"key":"2565_CR30","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00418-008-0544-2","volume":"131","author":"E Rossen Van","year":"2009","unstructured":"Van Rossen E, Vander Borght S, van Grunsven LA, Reynaert H, Bruggeman V, Blomhoff R, Roskams T, Geerts A (2009) Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver. Histochem Cell Biol 131:313\u2013325","journal-title":"Histochem Cell Biol"},{"key":"2565_CR31","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.ijbiomac.2017.12.145","volume":"110","author":"SK Vettath","year":"2018","unstructured":"Vettath SK, Shivashankar G, Menon KN, Vijayachandran LS (2018) Recombinant expression of extracellular domain of mutant epidermal growth factor receptor in prokaryotic and baculovirus expression systems. Int J Biol Macromol 110:582\u2013587","journal-title":"Int J Biol Macromol"},{"key":"2565_CR32","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.bbadis.2013.02.004","volume":"1832","author":"R Vivar","year":"2013","unstructured":"Vivar R, Humeres C, Ayala P, Olmedo I, Catalan M, Garcia L, Lavandero S, Diaz-Araya G (2013) TGF-beta1 prevents simulated ischemia\/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways. Biochim Biophys Acta 1832:754\u2013762","journal-title":"Biochim Biophys Acta"},{"key":"2565_CR33","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1007\/s11274-014-1711-3","volume":"30","author":"X Wang","year":"2014","unstructured":"Wang X, Liu H, Zhang Z, Liu Y, Li Y, Gui J, Chu Y (2014) High-level expression and characterization of bioactive human truncated variant of hepatocyte growth factor in Escherichia coli. World J Microbiol Biotechnol 30:2851\u20132859","journal-title":"World J Microbiol Biotechnol"},{"key":"2565_CR34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10930-016-9654-1","volume":"35","author":"X Wang","year":"2016","unstructured":"Wang X, Liu H, Liu Y, Li Y, Yan L, Yuan X, Zhang Y, Wu Y, Liu J, Zhang C, Chu Y (2016) A novel strategy for the preparation of codon-optimized truncated Ulp1 and its simplified application to cleavage the SUMO fusion protein. Protein J 35:115\u2013123","journal-title":"Protein J"},{"key":"2565_CR35","first-page":"919","volume":"28","author":"T Watanabe","year":"2011","unstructured":"Watanabe T, Tajima H, Hironori H, Nakagawara H, Ohnishi I, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Tani T, Fujimura T, Ota T, Wakayama T, Iseki S, Harada S (2011) Sodium valproate blocks the transforming growth factor (TGF)-beta1 autocrine loop and attenuates the TGF-beta1-induced collagen synthesis in a human hepatic stellate cell line. Int J Mol Med 28:919\u2013925","journal-title":"Int J Mol Med"},{"key":"2565_CR36","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1073\/pnas.0637114100","volume":"100","author":"LD Wood","year":"2003","unstructured":"Wood LD, Irvin BJ, Nucifora G, Luce KS, Hiebert SW (2003) Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor. Proc Natl Acad Sci USA 100:3257\u20133262","journal-title":"Proc Natl Acad Sci USA"},{"key":"2565_CR37","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/370341a0","volume":"370","author":"JL Wrana","year":"1994","unstructured":"Wrana JL, Attisano L, Wieser R, Ventura F, Massague J (1994) Mechanism of activation of the TGF-beta receptor. Nature 370:341\u2013347","journal-title":"Nature"},{"key":"2565_CR38","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1038\/labinvest.2012.113","volume":"92","author":"H Xu","year":"2012","unstructured":"Xu H, Zhou Y, Lu C, Ping J, Xu LM (2012) Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway. Lab Invest 92:1738\u20131748","journal-title":"Lab Invest"},{"key":"2565_CR39","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1136\/gutjnl-2013-305507","volume":"63","author":"G Zhao","year":"2014","unstructured":"Zhao G, Hatting M, Nevzorova YA, Peng J, Hu W, Boekschoten MV, Roskams T, Muller M, Gassler N, Liedtke C, Davis RJ, Cubero FJ, Trautwein C (2014) Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis. Gut 63:1159\u20131172","journal-title":"Gut"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11274-018-2565-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-018-2565-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-018-2565-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T19:11:20Z","timestamp":1574536280000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11274-018-2565-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,24]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2565"],"URL":"https:\/\/doi.org\/10.1007\/s11274-018-2565-x","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"type":"print","value":"0959-3993"},{"type":"electronic","value":"1573-0972"}],"subject":[],"published":{"date-parts":[[2018,11,24]]},"assertion":[{"value":"19 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"181"}}