{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:24:53Z","timestamp":1793121893667,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470226"],"award-info":[{"award-number":["31470226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s11274-019-2689-7","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T08:03:56Z","timestamp":1563782636000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Efflux proteins MacAB confer resistance to arsenite and penicillin\/macrolide-type antibiotics in Agrobacterium tumefaciens 5A"],"prefix":"10.1007","volume":"35","author":[{"given":"Kaixiang","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixue","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gejiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"2689_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrmicro2312","volume":"8","author":"HK Allen","year":"2010","unstructured":"Allen HK, Donato J, Wang HH, Cloud-Hansen KA, Davies J, Handelsman J (2010) Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Microbiol 8:251\u2013259","journal-title":"Nat Rev Microbiol"},{"key":"2689_CR2","doi-asserted-by":"publisher","first-page":"4369","DOI":"10.1128\/AEM.00503-13","volume":"79","author":"RG Amachawadi","year":"2013","unstructured":"Amachawadi RG, Scott HM, Alvarado CA, Mainini TR, Vinasco J, Drouillard JS, Nagaraja TG (2013) Occurrence of the transferable copper resistance gene tcrB among fecal enterococci of U.S. feedlot cattle fed copper-supplemented diets. Appl Environ Microbiol 79:4369\u20134375","journal-title":"Appl Environ Microbiol"},{"key":"2689_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.tim.2006.02.006","volume":"14","author":"C Baker-Austin","year":"2006","unstructured":"Baker-Austin C, Wright MS, Stepanauskas R, McArthur JV (2006) Co-selection of antibiotic and metal resistance. Trends Microbiol 14:176\u2013182","journal-title":"Trends Microbiol"},{"key":"2689_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2180-9-4","volume":"9","author":"L Cai","year":"2009","unstructured":"Cai L, Liu G, Rensing C, Wang G (2009) Genes involved in arsenic transformation and resistance associated with different levels of arsenic-contaminated soils. BMC Microbiol 9:4","journal-title":"BMC Microbiol"},{"key":"2689_CR5","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1128\/jb.177.4.981-986.1995","volume":"177","author":"A Carlin","year":"1995","unstructured":"Carlin A, Shi W, Dey S, Rosen BP (1995) The ars operon of Escherichia coli confers arsenical and antimonial resistance. J Bacteriol 177:981\u2013986","journal-title":"J Bacteriol"},{"key":"2689_CR6","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1289\/ehp.1510209","volume":"124","author":"DJ Carlin","year":"2015","unstructured":"Carlin DJ et al (2015) Arsenic and environmental health: state of the science and future research opportunities. Environ Health Perspect 124:890\u2013899","journal-title":"Environ Health Perspect"},{"key":"2689_CR7","first-page":"923","volume":"6","author":"F Chen","year":"2015","unstructured":"Chen F, Cao Y, Wei S, Li Y, Li X, Wang Q, Wang G (2015a) Regulation of arsenite oxidation by the phosphate two-component system PhoBR in Halomonas sp. HAL1. Front Microbiol 6:923","journal-title":"Front Microbiol"},{"key":"2689_CR8","doi-asserted-by":"publisher","first-page":"23390","DOI":"10.3390\/ijms161023390","volume":"16","author":"S Chen","year":"2015","unstructured":"Chen S, Li X, Sun G, Zhang Y, Su J, Ye J (2015b) Heavy metal induced antibiotic resistance in bacterium LSJC7. Int J Mol Sci 16:23390\u201323404","journal-title":"Int J Mol Sci"},{"key":"2689_CR9","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/mmi.14169","volume":"111","author":"J Chen","year":"2019","unstructured":"Chen J, Yoshinaga M, Rosen BP (2019) The antibiotic action of methylarsenite is an emergent property of microbial communities. Mol Microbiol 111:487\u2013494","journal-title":"Mol Microbiol"},{"key":"2689_CR10","doi-asserted-by":"publisher","first-page":"14446","DOI":"10.1073\/pnas.93.25.14446","volume":"93","author":"J Cheng","year":"1996","unstructured":"Cheng J, Hicks DB, Krulwich TA (1996) The purified Bacillus subtilis tetracycline efflux protein TetA(L) reconstitutes both tetracycline-cobalt\/H+ and Na+(K+)\/H+ exchange. Proc Natl Acad Sci USA 93:14446\u201314451","journal-title":"Proc Natl Acad Sci USA"},{"key":"2689_CR11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neuro.2016.02.002","volume":"53","author":"C Escudero-Lourdes","year":"2016","unstructured":"Escudero-Lourdes C (2016) Toxicity mechanisms of arsenic that are shared with neurodegenerative diseases and cognitive impairment: Role of oxidative stress and inflammatory responses. Neurotoxicology 53:223\u2013235","journal-title":"Neurotoxicology"},{"key":"2689_CR12","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.1365-2672.2008.03790.x","volume":"105","author":"H Fan","year":"2008","unstructured":"Fan H, Su C, Wang Y, Yao J, Zhao K, Wang Y, Wang G (2008) Sedimentary arsenite-oxidizing and arsenate-reducing bacteria associated with high arsenic groundwater from Shanyin, Northwestern China. J Appl Microbiol 105:529\u2013539","journal-title":"J Appl Microbiol"},{"key":"2689_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/bs.pmbts.2016.05.010","volume":"142","author":"N German","year":"2016","unstructured":"German N, Luthje F, Hao X, Ronn R, Rensing C (2016) Microbial virulence and interactions with metals. Prog Mol Biol Transl Sci 142:27\u201349","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2689_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.chemosphere.2014.03.068","volume":"112","author":"X Guo","year":"2014","unstructured":"Guo X, Liu S, Wang Z, Zhang XX, Li M, Wu B (2014) Metagenomic profiles and antibiotic resistance genes in gut microbiota of mice exposed to arsenic and iron. Chemosphere 112:1\u20138","journal-title":"Chemosphere"},{"key":"2689_CR15","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.marpolbul.2016.05.031","volume":"109","author":"I Henriques","year":"2016","unstructured":"Henriques I, Tacao M, Leite L, Fidalgo C, Araujo S, Oliveira C, Alves A (2016) Co-selection of antibiotic and metal(loid) resistance in gram-negative epiphytic bacteria from contaminated salt marshes. Mar Pollut Bull 109:427\u2013434","journal-title":"Mar Pollut Bull"},{"key":"2689_CR16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.envint.2011.03.001","volume":"42","author":"JJ Huang","year":"2012","unstructured":"Huang JJ, Hu HY, Lu SQ, Li Y, Tang F, Lu Y, Wei B (2012) Monitoring and evaluation of antibiotic-resistant bacteria at a municipal wastewater treatment plant in China. Environ Int 42:31\u201336","journal-title":"Environ Int"},{"key":"2689_CR17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1128\/CMR.00036-08","volume":"22","author":"GA Jacoby","year":"2009","unstructured":"Jacoby GA (2009) AmpC beta-lactamases. Clin Microbiol Rev 22:161\u2013182","journal-title":"Clin Microbiol Rev"},{"key":"2689_CR18","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1111\/j.1462-2920.2012.02881.x","volume":"14","author":"YS Kang","year":"2012","unstructured":"Kang YS, Heinemann J, Bothner B, Rensing C, McDermott TR (2012) Integrated co-regulation of bacterial arsenic and phosphorus metabolisms. Environ Microbiol 14:3097\u20133109","journal-title":"Environ Microbiol"},{"key":"2689_CR19","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1111\/1462-2920.12468","volume":"17","author":"Y-S Kang","year":"2015","unstructured":"Kang Y-S, Shi Z, Bothner B, Wang G, McDermott TR (2015) Involvement of the Acr3 and DctA anti-porters in arsenite oxidation in Agrobacterium tumefaciens 5A. Environ Microbiol 17:1950\u20131962","journal-title":"Environ Microbiol"},{"key":"2689_CR20","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1128\/JB.188.3.1081-1088.2006","volume":"188","author":"DR Kashyap","year":"2006","unstructured":"Kashyap DR, Botero LM, Franck WL, Hassett DJ, McDermott TR (2006) Complex regulation of arsenite oxidation in Agrobacterium tumefaciens. J Bacteriol 188:1081\u20131088","journal-title":"J Bacteriol"},{"key":"2689_CR52","doi-asserted-by":"publisher","first-page":"5639","DOI":"10.1128\/JB.183.19.5639-5644.2001","volume":"183","author":"N Kobayashi","year":"2001","unstructured":"Kobayashi N, Nishino K, Yamaguchi A (2001) Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J Bacteriol 183:5639\u20135644","journal-title":"J Bacteriol"},{"key":"2689_CR21","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.1007\/s00253-013-4838-5","volume":"97","author":"MC Kruger","year":"2013","unstructured":"Kruger MC, Bertin PN, Heipieper HJ, Arsene-Ploetze F (2013) Bacterial metabolism of environmental arsenic: mechanisms and biotechnological applications. Appl Microbiol Biotechnol 97:3827\u20133841","journal-title":"Appl Microbiol Biotechnol"},{"key":"2689_CR22","first-page":"347","volume":"4","author":"H Li","year":"2013","unstructured":"Li H, Li M, Huang Y, Rensing C, Wang G (2013) In silico analysis of bacterial arsenic islands reveals remarkable synteny and functional relatedness between arsenate and phosphate. Front Microbiol 4:347","journal-title":"Front Microbiol"},{"key":"2689_CR23","doi-asserted-by":"publisher","first-page":"e92236","DOI":"10.1371\/journal.pone.0092236","volume":"9","author":"X Li","year":"2014","unstructured":"Li X, Zhang L, Wang G (2014) Genomic evidence reveals the extreme diversity and wide distribution of the arsenic-related genes in Burkholderiales. PLoS One 9:e92236","journal-title":"PLoS One"},{"key":"2689_CR51","doi-asserted-by":"publisher","first-page":"e0132843","DOI":"10.1371\/journal.pone.0132843","volume":"10","author":"MF Lin","year":"2015","unstructured":"Lin MF, Lin YY, Lan CY (2015) The role of the two-component system BaeSR in disposing chemicals through regulating transporter systems in Acinetobacter baumannii. PLoS One 10:e0132843","journal-title":"PLoS One"},{"key":"2689_CR24","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.1128\/jb.179.20.6228-6237.1997","volume":"179","author":"AJ Link","year":"1997","unstructured":"Link AJ, Phillips D, Church GM (1997) Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization. J Bacteriol 179:6228\u20136237","journal-title":"J Bacteriol"},{"key":"2689_CR25","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1111\/j.1462-2920.2011.02672.x","volume":"14","author":"G Liu","year":"2012","unstructured":"Liu G et al (2012) A periplasmic arsenite-binding protein involved in regulating arsenite oxidation. Environ Microbiol 14:1624\u20131634","journal-title":"Environ Microbiol"},{"key":"2689_CR26","doi-asserted-by":"publisher","first-page":"4865","DOI":"10.1128\/JB.00756-13","volume":"195","author":"S Lu","year":"2013","unstructured":"Lu S, Zgurskaya HI (2013) MacA, a periplasmic membrane fusion protein of the macrolide transporter MacAB-TolC, binds lipopolysaccharide core specifically and with high affinity. J Bacteriol 195:4865\u20134872","journal-title":"J Bacteriol"},{"key":"2689_CR27","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1021\/es034455a","volume":"38","author":"RE Macur","year":"2004","unstructured":"Macur RE, Jackson CR, Botero LM, McDermott TR, Inskeep WP (2004) Bacterial populations associated with the oxidation and reduction of arsenic in an unsaturated soil. Environ Sci Technol 38:104\u2013111","journal-title":"Environ Sci Technol"},{"key":"2689_CR28","doi-asserted-by":"publisher","first-page":"18334","DOI":"10.1074\/jbc.M400037200","volume":"279","author":"YL Meng","year":"2004","unstructured":"Meng YL, Liu Z, Rosen BP (2004) As(III) and Sb(III) uptake by GlpF and efflux by ArsB in Escherichia coli. J Biol Chem 279:18334\u201318341","journal-title":"J Biol Chem"},{"key":"2689_CR29","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.bbapap.2008.10.004","volume":"1794","author":"H Nikaido","year":"2009","unstructured":"Nikaido H, Takatsuka Y (2009) Mechanisms of RND multidrug efflux pumps. Biochim Biophys Acta 1794:769\u2013781","journal-title":"Biochim Biophys Acta"},{"key":"2689_CR30","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/bs.ampbs.2017.02.001","volume":"70","author":"C Pal","year":"2017","unstructured":"Pal C, Asiani K, Arya S, Rensing C, Stekel DJ, Larsson DGJ, Hobman JL (2017) Metal resistance and its association with antibiotic resistance. Adv Microb Physiol 70:261\u2013313","journal-title":"Adv Microb Physiol"},{"key":"2689_CR31","doi-asserted-by":"publisher","first-page":"8761","DOI":"10.1074\/jbc.M312080200","volume":"279","author":"K Perron","year":"2004","unstructured":"Perron K, Caille O, Rossier C, Van Delden C, Dumas JL, Kohler T (2004) CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa. J Biol Chem 279:8761\u20138768","journal-title":"J Biol Chem"},{"key":"2689_CR32","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1128\/JB.00067-10","volume":"192","author":"Y Ren","year":"2010","unstructured":"Ren Y, Ren Y, Zhou Z, Guo X, Li Y, Feng L, Wang L (2010) Complete genome sequence of Enterobacter cloacae subsp. cloacae type strain ATCC 13047. J Bacteriol 192:2463\u20132464","journal-title":"J Bacteriol"},{"key":"2689_CR33","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/bies.201100012","volume":"33","author":"BP Rosen","year":"2011","unstructured":"Rosen BP, Ajees AA, McDermott TR (2011) Life and death with arsenic. Arsenic life: an analysis of the recent report \"A bacterium that can grow by using arsenic instead of phosphorus\". BioEssays 33:350\u2013357","journal-title":"BioEssays"},{"key":"2689_CR34","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.envint.2008.04.009","volume":"34","author":"A Sapkota","year":"2008","unstructured":"Sapkota A, Sapkota AR, Kucharski M, Burke J, McKenzie S, Walker P, Lawrence R (2008) Aquaculture practices and potential human health risks: current knowledge and future priorities. Environ Int 34:1215\u20131226","journal-title":"Environ Int"},{"key":"2689_CR35","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s11274-018-2526-4","volume":"34","author":"N Serrato-Gami\u00f1o","year":"2018","unstructured":"Serrato-Gami\u00f1o N, Salgado-Lora MG, Ch\u00e1vez-Moctezuma MP, Campos-Garc\u00eda J, Cervantes C (2018) Analysis of the ars gene cluster from highly arsenic-resistant Burkholderia xenovorans LB400. World J Microbiol Biotechnol 34:142","journal-title":"World J Microbiol Biotechnol"},{"key":"2689_CR36","doi-asserted-by":"publisher","first-page":"43252","DOI":"10.1038\/srep43252","volume":"7","author":"K Shi","year":"2017","unstructured":"Shi K, Fan X, Qiao Z, Han Y, McDermott TR, Wang Q, Wang G (2017) Arsenite oxidation regulator AioR regulates bacterial chemotaxis towards arsenite in Agrobacterium tumefaciens GW4. Sci Rep 7:43252","journal-title":"Sci Rep"},{"key":"2689_CR37","doi-asserted-by":"publisher","first-page":"e01842","DOI":"10.1128\/AEM.01842-18","volume":"84","author":"K Shi","year":"2018","unstructured":"Shi K, Li C, Rensing C, Dai X, Fan X, Wang G (2018a) Efflux transporter ArsK is responsible for bacterial resistance to arsenite, antimonite, trivalent roxarsone, and methylarsenite. Appl Environ Microbiol 84:e01842","journal-title":"Appl Environ Microbiol"},{"key":"2689_CR38","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.envpol.2018.01.006","volume":"235","author":"K Shi","year":"2018","unstructured":"Shi K, Wang Q, Fan X, Wang G (2018b) Proteomics and genetic analyses reveal the effects of arsenite oxidation on metabolic pathways and the roles of AioR in Agrobacterium tumefaciens GW4. Environ Pollut 235:700\u2013709","journal-title":"Environ Pollut"},{"key":"2689_CR39","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.biortech.2017.03.025","volume":"234","author":"W Sun","year":"2017","unstructured":"Sun W, Qian X, Gu J, Wang X, Zhang L, Guo A (2017) Mechanisms and effects of arsanilic acid on antibiotic resistance genes and microbial communities during pig manure digestion. Bioresour Technol 234:217\u2013223","journal-title":"Bioresour Technol"},{"key":"2689_CR40","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/j.1365-2958.2006.05549.x","volume":"63","author":"EB Tikhonova","year":"2007","unstructured":"Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI (2007) Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB. Mol Microbiol 63:895\u2013910","journal-title":"Mol Microbiol"},{"key":"2689_CR41","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1002\/mbo3.203","volume":"3","author":"E Turlin","year":"2014","unstructured":"Turlin E, Heuck G, Simoes Brandao MI, Szili N, Mellin JR, Lange N, Wandersman C (2014) Protoporphyrin (PPIX) efflux by the MacAB-TolC pump in Escherichia coli. Microbiologyopen 3:849\u2013859","journal-title":"Microbiologyopen"},{"key":"2689_CR42","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s002840010277","volume":"43","author":"JS Virdi","year":"2001","unstructured":"Virdi JS, Sinha I, Rajendran P, Singh I (2001) Arsenite-induced multiple antibiotic resistance phenotype in environmental isolates of Yersinia enterocolitica. Curr Microbiol 43:144\u2013146","journal-title":"Curr Microbiol"},{"key":"2689_CR43","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1111\/1462-2920.12465","volume":"17","author":"Q Wang","year":"2015","unstructured":"Wang Q et al (2015a) Fate of arsenate following arsenite oxidation in Agrobacterium tumefaciens GW4. Environ Microbiol 17:1926\u20131940","journal-title":"Environ Microbiol"},{"key":"2689_CR44","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1128\/AEM.02981-14","volume":"81","author":"Q Wang","year":"2015","unstructured":"Wang Q et al (2015b) Arsenite oxidase also functions as an antimonite oxidase. Appl Environ Microbiol 81:1959\u20131965","journal-title":"Appl Environ Microbiol"},{"key":"2689_CR45","first-page":"e00515","volume":"9","author":"S Wu","year":"2018","unstructured":"Wu S et al (2018) Signature arsenic detoxification pathways in Halomonas sp. strain GFAJ-1. MBio 9:e00515","journal-title":"MBio"},{"key":"2689_CR46","doi-asserted-by":"publisher","first-page":"30061","DOI":"10.1074\/jbc.272.48.30061","volume":"272","author":"R Wysocki","year":"1997","unstructured":"Wysocki R, Bobrowicz P, Ulaszewski S (1997) The\u00a0Saccharomyces cerevisiae ACR46 gene encodes a putative membrane protein involved in arsenite transport. J Biol Chem 272:30061\u201330066","journal-title":"J Biol Chem"},{"key":"2689_CR47","doi-asserted-by":"publisher","first-page":"7693","DOI":"10.1128\/JB.00853-08","volume":"190","author":"H Yamanaka","year":"2008","unstructured":"Yamanaka H, Kobayashi H, Takahashi E, Okamoto K (2008) MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II. J Bacteriol 190:7693\u20137698","journal-title":"J Bacteriol"},{"key":"2689_CR48","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.envpol.2016.10.075","volume":"220","author":"Z Zhao","year":"2017","unstructured":"Zhao Z et al (2017) Nutrients, heavy metals and microbial communities co-driven distribution of antibiotic resistance genes in adjacent environment of mariculture. Environ pollut 220:909\u2013918","journal-title":"Environ pollut"},{"key":"2689_CR49","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev-earth-060313-054942","volume":"42","author":"YG Zhu","year":"2014","unstructured":"Zhu YG, Yoshinaga M, Zhao FJ, Rosen BP (2014) Earth abides arsenic biotransformations. Annu Rev Earth Planet Sci 42:443\u2013467","journal-title":"Annu Rev Earth Planet Sci"},{"key":"2689_CR50","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.3389\/fmicb.2017.02573","volume":"8","author":"W Zhuang","year":"2017","unstructured":"Zhuang W, Liu H, Li J, Chen L, Wang G (2017) Regulation of class A beta-lactamase CzoA by CzoR and IscR in Comamonas testosteroni S44. Front Microbiol 8:2573","journal-title":"Front Microbiol"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-019-2689-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11274-019-2689-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-019-2689-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T23:11:01Z","timestamp":1595286661000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11274-019-2689-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["2689"],"URL":"https:\/\/doi.org\/10.1007\/s11274-019-2689-7","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"value":"0959-3993","type":"print"},{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]},"assertion":[{"value":"7 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"115"}}