{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:53:37Z","timestamp":1762102417757,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Plan Propio Investigaci\u00f3n, University of C\u00f3rdoba","award":["XX","XXII"],"award-info":[{"award-number":["XX","XXII"]}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"crossref","award":["16-03398S"],"award-info":[{"award-number":["16-03398S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s11274-019-2698-6","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T06:02:27Z","timestamp":1564120947000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trk1, the sole potassium-specific transporter in Candida glabrata, contributes to the proper functioning of various cell processes"],"prefix":"10.1007","volume":"35","author":[{"given":"Gabriel","family":"Caro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Bieber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Ruiz-Castilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mich\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Sychrova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-1561","authenticated-orcid":false,"given":"Jos\u00e9","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"2698_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1128\/MMBR.00042-09","volume":"74","author":"J Ari\u00f1o","year":"2010","unstructured":"Ari\u00f1o J, Ramos J, Sychrov\u00e1 H (2010) Alkali metal cation transport and homeostasis in Yeasts. Microbiol Mol Biol Rev 74:95\u2013120","journal-title":"Microbiol Mol Biol Rev"},{"key":"2698_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.3355","author":"J Ari\u00f1o","year":"2018","unstructured":"Ari\u00f1o J, Ramos J, Sychrov\u00e1 H (2018) Monovalent cation transporters at the plasma membrane in yeasts. Yeast. https:\/\/doi.org\/10.1002\/yea.3355","journal-title":"Yeast"},{"key":"2698_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1128\/EC.3.2.359-368.2004","volume":"3","author":"B Benito","year":"2004","unstructured":"Benito B, Garciadebl\u00e1s B, Schreier P, Rodriguez-Navarro A (2004) Novel p-type ATPases mediate high-affinity potassium or sodium uptake in fungi. Eukaryot Cell 3:359\u2013368","journal-title":"Eukaryot Cell"},{"key":"2698_CR4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/yea.3019","volume":"31","author":"M Bolotin-Fukuhara","year":"2014","unstructured":"Bolotin-Fukuhara M, Fairhead C (2014) Candida glabrata: a deadly companion? Yeast 31:279\u2013288","journal-title":"Yeast"},{"key":"2698_CR5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nature02579","volume":"430","author":"B Dujon","year":"2004","unstructured":"Dujon B, Sherman D, Fischer G et al (2004) Genome evolution in yeasts. Nature 430:34\u201335","journal-title":"Nature"},{"key":"2698_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femsyr\/fow039","volume":"16","author":"H Elicharov\u00e1","year":"2016","unstructured":"Elicharov\u00e1 H, Hu\u0161ekov\u00e1 B, Sychrov\u00e1 H (2016) Three Candida albicans potassium uptake systems differ in their ability to provide Saccharomyces cerevisiae trk1trk2 mutants with necessary potassium. FEMS Yeast Res 16:1\u201310","journal-title":"FEMS Yeast Res"},{"key":"2698_CR7","doi-asserted-by":"publisher","first-page":"fox053","DOI":"10.1093\/femsyr\/fox053","volume":"17","author":"K Felcmanova","year":"2017","unstructured":"Felcmanova K, Neveceralova P, Sychrova H, O (2017) Yeast Kch1 and Kch2 membrane proteins play a pleiotropic role in membrane potential establishment and monovalent cation homeostasis regulation. FEMS Yeast Res 17:fox053","journal-title":"FEMS Yeast Res"},{"key":"2698_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/1471-2148-6-99","volume":"6","author":"DA Fitzpatrick","year":"2006","unstructured":"Fitzpatrick DA, Logue ME, Stajich JE, Butler G (2006) A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis. BMC Evol Biol 6:99","journal-title":"BMC Evol Biol"},{"key":"2698_CR9","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1186\/1471-2164-14-623","volume":"14","author":"T Gabald\u00f3n","year":"2013","unstructured":"Gabald\u00f3n T, Martin T, Marcet-Houben M et al (2013) Comparative genomics of emerging pathogens in the Candida glabrata clade. BMC Genomics 14:623","journal-title":"BMC Genomics"},{"key":"2698_CR10","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/(SICI)1097-0061(19980930)14:13<1189::AID-YEA320>3.0.CO;2-K","volume":"14","author":"D G\u00e1\u0161kov\u00e1","year":"1998","unstructured":"G\u00e1\u0161kov\u00e1 D, Brodsk\u00e1 B, He\u0159man P, Vecer J, Mal\u00ednsk\u00fd J, Sigler K, Benada O, Pl\u00e1sek J (1998) Fluorescent probing of membrane potential in walled cells: diS-C3(3) assay in Saccharomyces cerevisiae. Yeast 14:1189\u20131197","journal-title":"Yeast"},{"key":"2698_CR11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0378-1097(95)00441-6","volume":"135","author":"M G\u00f3mez","year":"1996","unstructured":"G\u00f3mez M, Luyten K, Ramos J (1996) The capacity to transport potassium influences sodium tolerance in Saccharomyces cerevisiae. FEMS Microbiol Lett 135:157\u2013160","journal-title":"FEMS Microbiol Lett"},{"key":"2698_CR12","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1128\/CMR.8.4.462","volume":"8","author":"KC Hazen","year":"1995","unstructured":"Hazen KC (1995) New and emerging yeast pathogens. Clin Microbiol Rev 8:462\u2013478","journal-title":"Clin Microbiol Rev"},{"key":"2698_CR13","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1139\/cjm-2015-0766","volume":"62","author":"B Hu\u0161ekov\u00e1","year":"2016","unstructured":"Hu\u0161ekov\u00e1 B, Elicharov\u00e1 H, Sychrov\u00e1 H (2016) Pathogenic Candida species differ in the ability to grow at limiting potassium concentrations. Can J Microbiol 62:394\u2013401","journal-title":"Can J Microbiol"},{"key":"2698_CR14","doi-asserted-by":"publisher","first-page":"e0139306","DOI":"10.1371\/journal.pone.0139306","volume":"10","author":"M Kodedov\u00e1","year":"2015","unstructured":"Kodedov\u00e1 M, Sychrov\u00e1 H (2015) Changes in the sterol composition of the plasma membrane affect membrane potential, salt tolerance and the activity of multidrug resistance pumps in Saccharomyces cerevisiae. PLoS ONE 10:e0139306","journal-title":"PLoS ONE"},{"key":"2698_CR15","doi-asserted-by":"publisher","first-page":"e0153374","DOI":"10.1371\/journal.pone.0153374","volume":"11","author":"V Llopis-Torregrosa","year":"2016","unstructured":"Llopis-Torregrosa V, Hu\u0161ekov\u00e1 B, Sychrov\u00e1 H (2016) Potassium uptake mediated by Trk1 is crucial for Candida glabrata growth and fitness. PLoS ONE 11:e0153374","journal-title":"PLoS ONE"},{"key":"2698_CR16","doi-asserted-by":"publisher","first-page":"14838","DOI":"10.1074\/jbc.273.24.14838","volume":"273","author":"R Madrid","year":"1998","unstructured":"Madrid R, G\u00f3mez MJ, Ramos J, Rodr\u00edguez-Navarro A (1998) Ectopic potassium uptake in trk1 trk2 mutants of Saccharomyces cerevisiae correlates with a highly hyperpolarized membrane potential. J Biol Chem 273:14838\u201314844","journal-title":"J Biol Chem"},{"key":"2698_CR17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/yea.1755","volume":"27","author":"L Mare\u0161ov\u00e1","year":"2010","unstructured":"Mare\u0161ov\u00e1 L, Ho\u0161kov\u00e1 BJ, Urb\u00e1nkov\u00e1 E, Chaloupka R, Sychrov\u00e1 H (2010) New applications of pHluorin\u2014measuring intracellular pH of prototrophic yeasts and determining changes in the buffering capacity of strains with affected potassium homeostasis. Yeast 27:317\u2013325","journal-title":"Yeast"},{"key":"2698_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.fgb.2010.06.013","volume":"48","author":"J Mart\u00ednez","year":"2011","unstructured":"Mart\u00ednez J, Sychrova H, Ramos J (2011) Monovalent cations regulate expression and activity of the Hak1 potassium transporter in Debaryomyces hansenii. Fungal Genet Biol 48:177\u2013184","journal-title":"Fungal Genet Biol"},{"key":"2698_CR19","first-page":"508","volume":"10","author":"C Navarrete","year":"2010","unstructured":"Navarrete C, Petrezs\u00e9lyov\u00e1 S, Barreto L, Mart\u00ednez JL, Zahr\u00e1dka J, Ari\u00f1o J, Sychrov\u00e1 H, Ramos J (2010) Lack of main K+ uptake systems in Saccharomyces cerevisiae cells affects yeast performance in both potassium-sufficient and potassium-limiting conditions. FEMS Yeast Res 10:508","journal-title":"FEMS Yeast Res"},{"key":"2698_CR20","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1080\/13693780701218689","volume":"45","author":"J Perlroth","year":"2007","unstructured":"Perlroth J, Choi B, Spellberg B (2007) Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol 45:321\u2013346","journal-title":"Med Mycol"},{"key":"2698_CR21","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1128\/AEM.63.10.4005-4009.1997","volume":"63","author":"C Prista","year":"1997","unstructured":"Prista C, Almagro A, Loureiro-Dias MC, Ramos J (1997) Physiological basis for the high salt tolerance of Debaryomyces hansenii. Appl Environm Microbiol 63:4005\u20134009","journal-title":"Appl Environm Microbiol"},{"key":"2698_CR22","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0076-6879(02)47044-9","volume":"347","author":"C Pueyo","year":"2002","unstructured":"Pueyo C, Jurado J, Prieto-Alamo MJ, Monje-Casas F, L\u00f3pez-Barea J (2002) Multiplex reverse transcription-polymerase chain reaction for determining transcriptional regulation of thioredoxin and glutaredoxin pathways. Methods Enzymol 347:441\u2013451","journal-title":"Methods Enzymol"},{"key":"2698_CR23","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1432-1033.1986.tb09398.x","volume":"154","author":"J Ramos","year":"1986","unstructured":"Ramos J, Rodr\u00edguez-Navarro A (1986) Regulation and interconversion of the potassium transport systems of Saccharomyces cerevisiae as revealed by rubidium transport. Eur J Biochem 154:307\u2013311","journal-title":"Eur J Biochem"},{"key":"2698_CR24","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0005-2736(90)90156-I","volume":"1029","author":"J Ramos","year":"1990","unstructured":"Ramos J, Haro R, Rodr\u00edguez-Navarro A (1990) Regulation of potassium fluxes in Saccharomyces cerevisiae. BBA Biomembranes 1029:211\u2013217","journal-title":"BBA Biomembranes"},{"key":"2698_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1128\/jb.176.1.249-252.1994","volume":"176","author":"J Ramos","year":"1994","unstructured":"Ramos J, Alijo R, Haro R, Rodr\u00edguez-Navarro A (1994) TRK2 is not a low-affinity potassium transporter in Saccharomyces cerevisiae. J Bacteriol 176:249\u2013252","journal-title":"J Bacteriol"},{"key":"2698_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1574-6968.2011.02214.x","volume":"317","author":"J Ramos","year":"2011","unstructured":"Ramos J, Ari\u00f1o J, Sychrov\u00e1 H (2011) Alkali\u2013metal\u2013cation influx and efflux systems in nonconventional yeast species. FEMS Microbiol Lett 317:1\u20138","journal-title":"FEMS Microbiol Lett"},{"key":"2698_CR27","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.mycmed.2018.07.006","volume":"28","author":"R Ribeiro de Carvalho","year":"2018","unstructured":"Ribeiro de Carvalho R, Chaves Silva N, Cusinato M, Tranches Dias KS, Dos Santos MH, Viegas Junior C, Gon\u00e7alves Silva \u00c9, Tranches Dias AL (2018) Promising synergistic activity of fluconazole with bioactive Guttiferone-A and derivatives against non-albicans Candida species. J Mycol M\u00e9d 28:645\u2013650","journal-title":"J Mycol M\u00e9d"},{"key":"2698_CR28","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1128\/JB.159.3.940-945.1984","volume":"159","author":"A Rodriguez-Navarro","year":"1984","unstructured":"Rodriguez-Navarro A, Ramos J (1984) Dual system for potassium transport in Saccharomyces cerevisiae. J Bacteriol 159:940\u2013945","journal-title":"J Bacteriol"},{"key":"2698_CR29","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1085\/jgp.201411176","volume":"143","author":"MJ Shipston","year":"2014","unstructured":"Shipston MJ (2014) Ion channel regulation by protein S-acylation. J Gen Physiol 143:659\u2013678","journal-title":"J Gen Physiol"},{"key":"2698_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/mmy\/myy122","volume":"1","author":"H Xin","year":"2018","unstructured":"Xin H (2018) Effects of immune suppression in murine models of disseminated Candida glabrata and Candida tropicalis infection and utility of a synthetic peptide vaccine. Med Mycol 1:1. https:\/\/doi.org\/10.1093\/mmy\/myy122","journal-title":"Med Mycol"},{"key":"2698_CR31","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.bbamem.2015.02.007","volume":"1848","author":"V Zayats","year":"2015","unstructured":"Zayats V, Stockner T, Pandey SK, W\u00f6rz K, Ettrich R, Ludwig J (2015) A refined atomic scale model of the Saccharomyces cerevisiae K+-translocation protein Trk1p combined with experimental evidence confirms the role of selectivity filter glycines and other key residues. BBA Biomembranes 1848:1183\u20131195","journal-title":"BBA Biomembranes"},{"key":"2698_CR32","doi-asserted-by":"publisher","first-page":"fov029","DOI":"10.1093\/femsyr\/fov029","volume":"15","author":"O Zimmermannova","year":"2015","unstructured":"Zimmermannova O, Salzar A, Sychrova H, Ramos J (2015) The Zygosaccharomyces rouxii Trk1 is an efficient potassium transporter providing yeast cells with high lithium tolerance. FEMS Yeast Res 15:fov029","journal-title":"FEMS Yeast Res"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-019-2698-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11274-019-2698-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-019-2698-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T10:53:40Z","timestamp":1721559220000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11274-019-2698-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,26]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["2698"],"URL":"https:\/\/doi.org\/10.1007\/s11274-019-2698-6","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"type":"print","value":"0959-3993"},{"type":"electronic","value":"1573-0972"}],"subject":[],"published":{"date-parts":[[2019,7,26]]},"assertion":[{"value":"30 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict interest"}}],"article-number":"124"}}