{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:08:02Z","timestamp":1776690482642,"version":"3.51.2"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371864"],"award-info":[{"award-number":["81371864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572040"],"award-info":[{"award-number":["81572040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501791"],"award-info":[{"award-number":["81501791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2018JJ3819"],"award-info":[{"award-number":["2018JJ3819"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2019JJ40392"],"award-info":[{"award-number":["2019JJ40392"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s11274-021-03014-5","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T23:39:33Z","timestamp":1613691573000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chlamydia trachomatis induces autophagy by p62 in HeLa cell"],"prefix":"10.1007","volume":"37","author":[{"given":"Fuyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-7368","authenticated-orcid":false,"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"3014_CR1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/bph.14093","volume":"175","author":"F Alegre","year":"2018","unstructured":"Alegre F, Moragrega AB, Polo M, Marti-Rodrigo A, Esplugues JV, Blas-Garcia A, Apostolova N (2018) Role of p62\/SQSTM1 beyond autophagy: a lesson learned from drug-induced toxicity in vitro. Br J Pharmacol 175:440\u2013455. https:\/\/doi.org\/10.1111\/bph.14093","journal-title":"Br J Pharmacol"},{"key":"3014_CR2","doi-asserted-by":"publisher","first-page":"4751","DOI":"10.1128\/IAI.72.8.4751-4762.2004","volume":"72","author":"HM Al-Younes","year":"2004","unstructured":"Al-Younes HM, Brinkmann V, Meyer TF (2004) Interaction of Chlamydia trachomatis serovar L2 with the host autophagic pathway. Infect Immun 72:4751\u20134762. https:\/\/doi.org\/10.1128\/IAI.72.8.4751-4762.2004","journal-title":"Infect Immun"},{"key":"3014_CR3","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1111\/tra.12091","volume":"14","author":"J Bestebroer","year":"2013","unstructured":"Bestebroer J, V\u2019Kovski P, Mauthe M, Reggiori F (2013) Hidden behind autophagy: the unconventional roles of ATG proteins. Traffic 14:1029\u20131041. https:\/\/doi.org\/10.1111\/tra.12091","journal-title":"Traffic"},{"key":"3014_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101465","author":"F Cuomo","year":"2019","unstructured":"Cuomo F, Altucci L, Cobellis G (2019) Autophagy function and dysfunction: potential drugs as anti-cancer therapy. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers11101465","journal-title":"Cancers (Basel)"},{"key":"3014_CR5","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1042\/EBC20170035","volume":"61","author":"T Lamark","year":"2017","unstructured":"Lamark T, Svenning S, Johansen T (2017) Regulation of selective autophagy: the p62\/SQSTM1 paradigm. Essays Biochem 61:609\u2013624. https:\/\/doi.org\/10.1042\/EBC20170035","journal-title":"Essays Biochem"},{"key":"3014_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","volume":"132","author":"B Levine","year":"2008","unstructured":"Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27\u201342. https:\/\/doi.org\/10.1016\/j.cell.2007.12.018","journal-title":"Cell"},{"key":"3014_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.10.028","author":"P Lorincz","year":"2019","unstructured":"Lorincz P, Juhasz G (2019) Autophagosome-lysosome fusion. J Mol Biol. https:\/\/doi.org\/10.1016\/j.jmb.2019.10.028","journal-title":"J Mol Biol"},{"key":"3014_CR8","doi-asserted-by":"publisher","first-page":"R99","DOI":"10.1530\/REP-16-0561","volume":"154","author":"JP Mackern-Oberti","year":"2017","unstructured":"Mackern-Oberti JP et al (2017) Male genital tract immune response against Chlamydia trachomatis infection. Reproduction 154:R99\u2013R110. https:\/\/doi.org\/10.1530\/REP-16-0561","journal-title":"Reproduction"},{"key":"3014_CR9","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00640-17","author":"MJ McKuen","year":"2017","unstructured":"McKuen MJ, Mueller KE, Bae YS, Fields KA (2017) Fluorescence-reported allelic exchange mutagenesis reveals a role for Chlamydia trachomatis TmeA in invasion that is independent of host AHNAK. Infect Immun. https:\/\/doi.org\/10.1128\/IAI.00640-17","journal-title":"Infect Immun"},{"key":"3014_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1146\/annurev-cellbio-092910-154005","volume":"27","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Yoshimori T, Ohsumi Y (2011) The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol 27:107\u2013132. https:\/\/doi.org\/10.1146\/annurev-cellbio-092910-154005","journal-title":"Annu Rev Cell Dev Biol"},{"key":"3014_CR11","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1080\/15548627.2015.1071759","volume":"12","author":"RT Netea-Maier","year":"2016","unstructured":"Netea-Maier RT, Plantinga TS, van de Veerdonk FL, Smit JW, Netea MG (2016) Modulation of inflammation by autophagy: consequences for human disease. Autophagy 12:245\u2013260. https:\/\/doi.org\/10.1080\/15548627.2015.1071759","journal-title":"Autophagy"},{"key":"3014_CR12","doi-asserted-by":"publisher","first-page":"e0143304","DOI":"10.1371\/journal.pone.0143304","volume":"10","author":"L Newman","year":"2015","unstructured":"Newman L et al (2015) Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting. PLoS ONE 10:e0143304. https:\/\/doi.org\/10.1371\/journal.pone.0143304","journal-title":"PLoS ONE"},{"key":"3014_CR13","doi-asserted-by":"publisher","first-page":"390","DOI":"10.15698\/mic2016.09.525","volume":"3","author":"CM O'Connell","year":"2016","unstructured":"O\u2019Connell CM, Ferone ME (2016) Chlamydia trachomatis. Genital Infections. Microb Cell 3:390\u2013403. https:\/\/doi.org\/10.15698\/mic2016.09.525","journal-title":"Microb Cell"},{"key":"3014_CR14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3109\/07853890.2010.546365","volume":"44","author":"J Paavonen","year":"2012","unstructured":"Paavonen J (2012) Chlamydia trachomatis infections of the female genital tract: state of the art. Ann Med 44:18\u201328. https:\/\/doi.org\/10.3109\/07853890.2010.546365","journal-title":"Ann Med"},{"key":"3014_CR15","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1574-6968.2009.01494.x","volume":"292","author":"N Pachikara","year":"2009","unstructured":"Pachikara N, Zhang H, Pan Z, Jin S, Fan H (2009) Productive Chlamydia trachomatis lymphogranuloma venereum 434 infection in cells with augmented or inactivated autophagic activities. FEMS Microbiol Lett 292:240\u2013249. https:\/\/doi.org\/10.1111\/j.1574-6968.2009.01494.x","journal-title":"FEMS Microbiol Lett"},{"key":"3014_CR16","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1089\/ars.2013.5371","volume":"20","author":"KR Parzych","year":"2014","unstructured":"Parzych KR, Klionsky DJ (2014) An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal 20:460\u2013473. https:\/\/doi.org\/10.1089\/ars.2013.5371","journal-title":"Antioxid Redox Signal"},{"key":"3014_CR17","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1056\/NEJMcp030542","volume":"349","author":"JF Peipert","year":"2003","unstructured":"Peipert JF (2003) Clinical practice. Genital chlamydial infections. N Engl J Med 349:2424\u20132430. https:\/\/doi.org\/10.1056\/NEJMcp030542","journal-title":"N Engl J Med"},{"key":"3014_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.lfs.2017.08.029","volume":"188","author":"P Ravanan","year":"2017","unstructured":"Ravanan P, Srikumar IF, Talwar P (2017) Autophagy: the spotlight for cellular stress responses. Life Sci 188:53\u201367. https:\/\/doi.org\/10.1016\/j.lfs.2017.08.029","journal-title":"Life Sci"},{"key":"3014_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8070203","author":"V Ricci","year":"2016","unstructured":"Ricci V (2016) Relationship between VacA toxin and host cell autophagy in Helicobacter pylori infection of the human stomach: a few answers. Many Questions Toxins (Basel). https:\/\/doi.org\/10.3390\/toxins8070203","journal-title":"Many Questions Toxins (Basel)"},{"key":"3014_CR20","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.222836","author":"P Sanchez-Martin","year":"2018","unstructured":"Sanchez-Martin P, Komatsu M (2018) p62\/SQSTM1-steering the cell through health and disease. J Cell Sci. https:\/\/doi.org\/10.1242\/jcs.222836","journal-title":"J Cell Sci"},{"key":"3014_CR21","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3389\/fcell.2018.00147","volume":"6","author":"V Sharma","year":"2018","unstructured":"Sharma V, Verma S, Seranova E, Sarkar S, Kumar D (2018) Selective autophagy and xenophagy in infection and disease front cell. Dev Biol 6:147. https:\/\/doi.org\/10.3389\/fcell.2018.00147","journal-title":"Dev Biol"},{"key":"3014_CR22","doi-asserted-by":"publisher","first-page":"e1004846","DOI":"10.1371\/journal.ppat.1004846","volume":"11","author":"P Subbarayal","year":"2015","unstructured":"Subbarayal P, Karunakaran K, Winkler AC, Rother M, Gonzalez E, Meyer TF, Rudel T (2015) EphrinA2 receptor (EphA2) is an invasion and intracellular signaling receptor for Chlamydia trachomatis. PLoS Pathog 11:e1004846. https:\/\/doi.org\/10.1371\/journal.ppat.1004846","journal-title":"PLoS Pathog"},{"key":"3014_CR23","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1136\/sextrans-2019-053999","volume":"96","author":"W Tang","year":"2020","unstructured":"Tang W et al (2020) Pregnancy and fertility-related adverse outcomes associated with Chlamydia trachomatis infection: a global systematic review and meta-analysis. Sex Transm Infect 96:322\u2013329. https:\/\/doi.org\/10.1136\/sextrans-2019-053999","journal-title":"Sex Transm Infect"},{"key":"3014_CR24","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1051\/medsci\/20173303019","volume":"33","author":"I Vergne","year":"2017","unstructured":"Vergne I, Lafont F, Espert L, Esclatine A, Biard-Piechaczyk M (2017) Autophagy, ATG proteins and infectious diseases. Med Sci (Paris) 33:312\u2013318. https:\/\/doi.org\/10.1051\/medsci\/20173303019","journal-title":"Med Sci (Paris)"},{"key":"3014_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.09.132","author":"F Wang","year":"2019","unstructured":"Wang F et al (2019) Inflammatory mechanism of Chlamydia trachomatis-infected HeLa229cells regulated by Atg5. Biochem Biophys Res Commun. https:\/\/doi.org\/10.1016\/j.bbrc.2019.09.132","journal-title":"Biochem Biophys Res Commun"},{"key":"3014_CR26","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00203-17","author":"SS Witkin","year":"2017","unstructured":"Witkin SS, Minis E, Athanasiou A, Leizer J, Linhares IM (2017) Chlamydia trachomatis: the persistent pathogen. Clin Vaccine Immunol. https:\/\/doi.org\/10.1128\/CVI.00203-17","journal-title":"Clin Vaccine Immunol."},{"key":"3014_CR27","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.1038\/s41467-019-11671-2","volume":"10","author":"Y Yang","year":"2019","unstructured":"Yang Y et al (2019) Cytoplasmic DAXX drives SQSTM1\/p62 phase condensation to activate Nrf2-mediated stress response. Nat Commun 10:3759. https:\/\/doi.org\/10.1038\/s41467-019-11671-2","journal-title":"Nat Commun"},{"key":"3014_CR28","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.4049\/jimmunol.139.4.1297","volume":"139","author":"EC Yong","year":"1987","unstructured":"Yong EC, Chi EY, Kuo CC (1987) Differential antimicrobial activity of human mononuclear phagocytes against the human biovars of Chlamydia trachomatis. J Immunol 139:1297\u20131302","journal-title":"J Immunol"},{"key":"3014_CR29","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftw076","author":"P Yu","year":"2016","unstructured":"Yu P, Xiao L, Lin L, Tang L, Chen C, Wang F, Wang Y (2016) STAT3-mediated TLR2\/4 pathway upregulation in an IFN-gamma-induced Chlamydia trachomatis persistent infection model. Pathog Dis. https:\/\/doi.org\/10.1093\/femspd\/ftw076","journal-title":"Pathog Dis"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-021-03014-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11274-021-03014-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-021-03014-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T12:46:31Z","timestamp":1697892391000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11274-021-03014-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,16]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["3014"],"URL":"https:\/\/doi.org\/10.1007\/s11274-021-03014-5","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"value":"0959-3993","type":"print"},{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,16]]},"assertion":[{"value":"13 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the ethics committee of Xiangya School of medicine, Central South University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All the authors have agreed for authorship, read and approved the manuscript, and given consent for publication of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"50"}}