{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T08:15:50Z","timestamp":1774512950091,"version":"3.50.1"},"reference-count":137,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s11274-022-03263-y","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T02:02:17Z","timestamp":1648260137000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Biotechnological production of specialty aromatic and aromatic-derivative compounds"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-0726","authenticated-orcid":false,"given":"A.","family":"Braga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-8178","authenticated-orcid":false,"given":"N.","family":"Faria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"3263_CR1","first-page":"205","volume":"205","author":"E Ahmed","year":"2017","unstructured":"Ahmed E, Arshad M, Zakriyya Khan M et al (2017) Secondary metabolites and their multidimensional prospective in plant life. J Pharmacogn Phytochem 205:205\u2013214","journal-title":"J Pharmacogn Phytochem"},{"key":"3263_CR2","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","volume":"33","author":"AG Atanasov","year":"2015","unstructured":"Atanasov AG, Waltenberger B, Eva-Maria Pferschy-Wenzig TL et al (2015) Discovery and resupply of pharmacologically active plant- derived natural products: a review. Biotechnol Adv 33:1582\u20131614. https:\/\/doi.org\/10.1016\/j.biotechadv.2015.08.001","journal-title":"Biotechnol Adv"},{"key":"3263_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00032","author":"NJH Averesch","year":"2018","unstructured":"Averesch NJH, Kr\u00f6mer JO (2018) Metabolic engineering of the shikimate pathway for production of aromatics and derived compounds\u2014present and future strain construction strategies. Front Bioeng Biotechnol. https:\/\/doi.org\/10.3389\/fbioe.2018.00032","journal-title":"Front Bioeng Biotechnol"},{"key":"3263_CR4","unstructured":"Baerends R, Simon E, Meyer J, Vazquez C (2014) A method for producing modified resveratrol. Evolva SA; US Patent No. 20160215306A1."},{"key":"3263_CR5","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1007\/s12257-020-0313-1","volume":"26","author":"HB Bang","year":"2021","unstructured":"Bang HB, Choi IH, Jang JH, Jeong KJ (2021) Engineering of Escherichia coli for the economic production L-phenylalanine in Large-Scale Bioreactor. Biotechnol Bioprocess Eng 26:468\u2013475. https:\/\/doi.org\/10.1007\/s12257-020-0313-1","journal-title":"Biotechnol Bioprocess Eng"},{"key":"3263_CR6","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s00253-018-9568-2","volume":"103","author":"\u017b Beata","year":"2019","unstructured":"Beata \u017b, Niemczyk E, Lipok J (2019) Metabolic relation of cyanobacteria to aromatic compounds. Appl Microbiol Biotechnol 103:1167\u20131178","journal-title":"Appl Microbiol Biotechnol"},{"key":"3263_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S1567-1356(03)00157-0","volume":"4","author":"JVW Becker","year":"2003","unstructured":"Becker JVW, Armstrong GO, Van Der Merwe MJ et al (2003) Metabolic engineering of Saccharomyces cerevisiae for the synthesis of the wine-related antioxidant resveratrol. FEMS Yeast Res 4:79\u201385. https:\/\/doi.org\/10.1016\/S1567-1356(03)00157-0","journal-title":"FEMS Yeast Res"},{"key":"3263_CR8","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.1128\/AEM.00609-06","volume":"72","author":"J Beekwilder","year":"2006","unstructured":"Beekwilder J, Wolswinkel R, Jonker H et al (2006) Production of resveratrol in recombinant microorganisms. Appl Environ Microbiol 72:5670\u20135672. https:\/\/doi.org\/10.1128\/AEM.00609-06","journal-title":"Appl Environ Microbiol"},{"key":"3263_CR9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ces.2012.10.009","volume":"103","author":"N Bhan","year":"2013","unstructured":"Bhan N, Xu P, Khalidi O, Koffas MAG (2013) Redirecting carbon flux into malonyl-CoA to improve resveratrol titers: proof of concept for genetic interventions predicted by OptForce computational framework. Chem Eng Sci 103:109\u2013114. https:\/\/doi.org\/10.1016\/j.ces.2012.10.009","journal-title":"Chem Eng Sci"},{"key":"3263_CR10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1006\/mben.2001.0196","volume":"3","author":"J Bongaerts","year":"2001","unstructured":"Bongaerts J, Kr\u00e4mer M, M\u00fcller U et al (2001) Metabolic engineering for microbial production of aromatic amino acids and derived compounds. Metab Eng 3:289\u2013300. https:\/\/doi.org\/10.1006\/mben.2001.0196","journal-title":"Metab Eng"},{"key":"3263_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00096","author":"A Braga","year":"2020","unstructured":"Braga A, Faria N (2020) Bioprocess optimization for the production of aromatic compounds with metabolically engineered hosts: recent developments and future challenges. Front Bioeng Biotechnol. https:\/\/doi.org\/10.3389\/fbioe.2020.00096","journal-title":"Front Bioeng Biotechnol"},{"key":"3263_CR12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s11274-018-2506-8","volume":"34","author":"A Braga","year":"2018","unstructured":"Braga A, Ferreira P, Oliveira J et al (2018a) Heterologous production of resveratrol in bacterial hosts: current status and perspectives. World J Microbiol Biotechnol 34:122. https:\/\/doi.org\/10.1007\/s11274-018-2506-8","journal-title":"World J Microbiol Biotechnol"},{"key":"3263_CR13","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jbiotec.2017.11.006","volume":"265","author":"A Braga","year":"2018","unstructured":"Braga A, Oliveira J, Silva R et al (2018b) Impact of the cultivation strategy on resveratrol production from glucose in engineered Corynebacterium glutamicum. J Biotechnol 265:70\u201375. https:\/\/doi.org\/10.1016\/j.jbiotec.2017.11.006","journal-title":"J Biotechnol"},{"key":"3263_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/jctb.5538","author":"A Braga","year":"2018","unstructured":"Braga A, Silva M, Oliveira J et al (2018c) An adsorptive bioprocess for production and recovery of resveratrol with Corynebacterium glutamicum. J Chem Technol Biotechnol. https:\/\/doi.org\/10.1002\/jctb.5538","journal-title":"J Chem Technol Biotechnol"},{"key":"3263_CR15","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1021\/acs.biochem.7b01018","volume":"57","author":"D Burschowsky","year":"2018","unstructured":"Burschowsky D, Thorbj\u00f8rnsrud HV, Heim JB et al (2018) Inter-enzyme allosteric regulation of chorismate mutase in Corynebacterium glutamicum: structural basis of feedback activation by Trp. Biochemistry 57:557\u2013573. https:\/\/doi.org\/10.1021\/acs.biochem.7b01018","journal-title":"Biochemistry"},{"key":"3263_CR16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s12934-016-0562-z","volume":"15","author":"JM Camacho-Zaragoza","year":"2016","unstructured":"Camacho-Zaragoza JM, Hern\u00e1ndez-Ch\u00e1vez G, Moreno-Avitia F et al (2016) Engineering of a microbial coculture of Escherichia coli strains for the biosynthesis of resveratrol. Microb Cell Fact 15:163. https:\/\/doi.org\/10.1186\/s12934-016-0562-z","journal-title":"Microb Cell Fact"},{"key":"3263_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2019.08.008","author":"M Cao","year":"2019","unstructured":"Cao M, Gao M, Suastegui M et al (2019) Building microbial factories for the production of aromatic amino acid pathway derivatives: From commodity chemicals to plant-sourced natural products. Metab Eng. https:\/\/doi.org\/10.1016\/j.ymben.2019.08.008","journal-title":"Metab Eng"},{"key":"3263_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep32640","volume":"6","author":"W Cao","year":"2016","unstructured":"Cao W, Ma W, Wang X et al (2016) Enhanced pinocembrin production in Escherichia coli by regulating cinnamic acid metabolism. Sci Rep 6:1\u20139. https:\/\/doi.org\/10.1038\/srep32640","journal-title":"Sci Rep"},{"key":"3263_CR19","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.ymben.2018.05.001","volume":"47","author":"L Chen","year":"2018","unstructured":"Chen L, Chen M, Ma C, Zeng AP (2018) Discovery of feed-forward regulation in L-tryptophan biosynthesis and its use in metabolic engineering of E. coli for efficient tryptophan bioproduction. Metab Eng 47:434\u2013444. https:\/\/doi.org\/10.1016\/j.ymben.2018.05.001","journal-title":"Metab Eng"},{"key":"3263_CR20","doi-asserted-by":"publisher","first-page":"e00094","DOI":"10.1016\/j.mec.2019.e00094","volume":"9","author":"M Chen","year":"2019","unstructured":"Chen M, Chen L, Zeng AP (2019) CRISPR\/Cas9-facilitated engineering with growth-coupled and sensor-guided in vivo screening of enzyme variants for a more efficient chorismate pathway in E coli.. Metab Eng Commun 9:e00094. https:\/\/doi.org\/10.1016\/j.mec.2019.e00094","journal-title":"Metab Eng Commun"},{"key":"3263_CR21","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1007\/s10295-011-0954-3","volume":"38","author":"O Choi","year":"2011","unstructured":"Choi O, Wu C-Z, Kang SY et al (2011) Biosynthesis of plant-specific phenylpropanoids by construction of an artificial biosynthetic pathway in Escherichia coli. J Ind Microbiol Biotechnol 38:1657\u20131665. https:\/\/doi.org\/10.1007\/s10295-011-0954-3","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3263_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00241","author":"SS Choi","year":"2019","unstructured":"Choi SS, Seo SY, Park SO et al (2019) Cell factory design and culture process optimization for dehydroshikimate biosynthesis in Escherichia coli. Front Bioeng Biotechnol. https:\/\/doi.org\/10.3389\/fbioe.2019.00241","journal-title":"Front Bioeng Biotechnol"},{"key":"3263_CR23","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nchembio.1816","volume":"11","author":"WC Deloache","year":"2015","unstructured":"Deloache WC, Russ ZN, Narcross L et al (2015) An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose. Nat Chem Biol 11:465\u2013471. https:\/\/doi.org\/10.1038\/nchembio.1816","journal-title":"Nat Chem Biol"},{"key":"3263_CR24","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nmeth.1297.Probing","volume":"8","author":"FMS Dias","year":"2017","unstructured":"Dias FMS, Gomez JGC, Silva LF (2017) Exploring the microbial production of aromatic fine chemicals to overcome the barriers of traditional methods. Adv Appl Sci Res 8:94\u2013109. https:\/\/doi.org\/10.1038\/nmeth.1297.Probing","journal-title":"Adv Appl Sci Res"},{"key":"3263_CR25","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.tibtech.2009.09.005","volume":"27","author":"D Donnez","year":"2009","unstructured":"Donnez D, Jeandet P, Cl\u00e9ment C, Courot E (2009) Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms. Trends Biotechnol 27:706\u2013713. https:\/\/doi.org\/10.1016\/j.tibtech.2009.09.005","journal-title":"Trends Biotechnol"},{"key":"3263_CR26","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s11101-017-9532-2","volume":"17","author":"A Dudnik","year":"2018","unstructured":"Dudnik A, Almeida AF, Andrade R et al (2018) BacHBerry: BACterial Hosts for production of bioactive phenolics from bERRY fruits. Phytochem Rev 17:291\u2013326. https:\/\/doi.org\/10.1007\/s11101-017-9532-2","journal-title":"Phytochem Rev"},{"key":"3263_CR27","doi-asserted-by":"publisher","unstructured":"Dyk TKV, Templeton LJ, Cantera KA, et al (2004) Characterization of the Escherichia coli AaeAB efflux pump\u202f: a metabolic relief valve\u202f? 186: 7196\u20137204. https:\/\/doi.org\/10.1128\/JB.186.21.7196","DOI":"10.1128\/JB.186.21.7196"},{"key":"3263_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2859-12-62","volume":"12","author":"A Eudes","year":"2013","unstructured":"Eudes A, Juminaga D, Baidoo EEK et al (2013) Production of hydroxycinnamoyl anthranilates from glucose in Escherichia coli. Microb Cell Fact 12:1\u201310. https:\/\/doi.org\/10.1186\/1475-2859-12-62","journal-title":"Microb Cell Fact"},{"key":"3263_CR29","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.pbi.2005.09.008","volume":"8","author":"PJ Facchini","year":"2005","unstructured":"Facchini PJ, St-pierre B (2005) Synthesis and trafficking of alkaloid biosynthetic enzymes. Curr Opin Plant Biol 8:657\u2013666. https:\/\/doi.org\/10.1016\/j.pbi.2005.09.008","journal-title":"Curr Opin Plant Biol"},{"key":"3263_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms4283","volume":"5","author":"E Fossati","year":"2014","unstructured":"Fossati E, Ekins A, Narcross L et al (2014) Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae. Nat Commun 5:1\u201311. https:\/\/doi.org\/10.1038\/ncomms4283","journal-title":"Nat Commun"},{"key":"3263_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0124459","volume":"10","author":"E Fossati","year":"2015","unstructured":"Fossati E, Narcross L, Ekins A et al (2015) Synthesis of morphinan alkaloids in Saccharomyces cerevisiae. PLoS ONE 10:1\u201315. https:\/\/doi.org\/10.1371\/journal.pone.0124459","journal-title":"PLoS ONE"},{"key":"3263_CR32","doi-asserted-by":"crossref","unstructured":"Galanie S, Thodey K, Trenchard IJ, et al (2015) Complete biosynthesis of opioids in yeast. Science 349:1095\u20131100","DOI":"10.1126\/science.aac9373"},{"key":"3263_CR33","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.molp.2014.11.008","volume":"8","author":"NJ Gallage","year":"2015","unstructured":"Gallage NJ, M\u00f8ller BL (2015) Vanillin-bioconversion and bioengineering of the most popular plant flavor and its de novo biosynthesis in the vanilla orchid. Mol Plant 8:40\u201357","journal-title":"Mol Plant"},{"key":"3263_CR34","unstructured":"Gaspar P, Dudnik A, Neves AR, F\u00f6ster J (2016) Engineering Lactococcus lactis for stilbene production. In: Abstract from 28th international conference on polyphenols 2016. Vienna, Austria"},{"key":"3263_CR35","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.copbio.2009.09.012","volume":"20","author":"G Gosset","year":"2009","unstructured":"Gosset G (2009) Production of aromatic compounds in bacteria. Curr Opin Biotechnol 20:651\u2013658. https:\/\/doi.org\/10.1016\/j.copbio.2009.09.012","journal-title":"Curr Opin Biotechnol"},{"key":"3263_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/bit.27924","author":"D Guo","year":"2021","unstructured":"Guo D, Kong S, Sun Y et al (2021) Development of an artificial biosynthetic pathway for biosynthesis of (S)-reticuline based on HpaBC in engineered Escherichia coli. Biotechnol Bioeng. https:\/\/doi.org\/10.1002\/bit.27924","journal-title":"Biotechnol Bioeng"},{"key":"3263_CR37","doi-asserted-by":"publisher","unstructured":"Han J, Wu Y, Zhou Y, Li S (2021) Engineering Saccharomyces cerevisiae to produce plant benzylisoquinoline alkaloids. aBIOTECH 2:264\u2013275. https:\/\/doi.org\/10.1007\/s42994-021-00055-0","DOI":"10.1007\/s42994-021-00055-0"},{"key":"3263_CR38","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1128\/AEM.02681-08","volume":"75","author":"EH Hansen","year":"2009","unstructured":"Hansen EH, M\u00f8ller BL, Kock GR et al (2009) De novo biosynthesis of Vanillin in fission yeast (Schizosaccharomyces pombe) and baker\u2019s yeast (Saccharomyces cerevisiae). Appl Environ Microbiol 75:2765\u20132774. https:\/\/doi.org\/10.1128\/AEM.02681-08","journal-title":"Appl Environ Microbiol"},{"key":"3263_CR39","unstructured":"Hawkins K (2009) Metabolic engineering of Saccharomyces cerevisiae for the production of benzylisoquinoline alkaloids. PhD Thesis, California Institute of Technology."},{"key":"3263_CR40","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nchembio.105","volume":"4","author":"KM Hawkins","year":"2008","unstructured":"Hawkins KM, Smolke CD (2008) Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat Chem Biol 4:564\u2013573. https:\/\/doi.org\/10.1038\/nchembio.105","journal-title":"Nat Chem Biol"},{"key":"3263_CR41","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1128\/AEM.02625-07","volume":"74","author":"LA Hazelwood","year":"2008","unstructured":"Hazelwood LA, Daran J, Van MAJA et al (2008) The ehrlich pathway for fusel alcohol production: a century of research on Saccharomyces cerevisiae metabolism. Appl Env Microbiol 74:2259\u20132266. https:\/\/doi.org\/10.1128\/AEM.02625-07","journal-title":"Appl Env Microbiol"},{"key":"3263_CR42","doi-asserted-by":"publisher","first-page":"907","DOI":"10.2307\/3870046","volume":"7","author":"KM Herrmann","year":"1995","unstructured":"Herrmann KM (1995) The shikimate pathway: early steps in the biosynthesis of aromatic compounds. Plant Cell 7:907. https:\/\/doi.org\/10.2307\/3870046","journal-title":"Plant Cell"},{"key":"3263_CR43","doi-asserted-by":"publisher","first-page":"3466","DOI":"10.1021\/acs.jafc.9b07628","volume":"68","author":"J Hong","year":"2020","unstructured":"Hong J, Im D, Oh M-K (2020) Investigating E. coli coculture for resveratrol production with 13C metabolic flux analysis. J Agric Food Chem 68:3466\u20133473. https:\/\/doi.org\/10.1021\/acs.jafc.9b07628","journal-title":"J Agric Food Chem"},{"key":"3263_CR46","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1128\/aem.59.7.2244-2250.1993","volume":"59","author":"Z Huang","year":"1993","unstructured":"Huang Z, Dostal L, Rosazza JPN (1993) Microbial transformations of ferulic acid by Saccharomyces cerevisiae and Pseudomonas fluorescens. Appl Environ Microbiol 59:2244\u20132250","journal-title":"Appl Environ Microbiol"},{"key":"3263_CR44","unstructured":"Huang LL, Xue Z, Zhu QQ (2006) Method for the production of resveratrol in a recombinant oleaginous microorganism. U.S. Patent No 7,772,444."},{"key":"3263_CR45","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.1002\/bit.24988","volume":"110","author":"Q Huang","year":"2013","unstructured":"Huang Q, Lin Y, Yan Y (2013) Caffeic acid production enhancement by engineering a phenylalanine over-producing Escherichia coli strain. Biotechnol Bioeng 110:3188\u20133196. https:\/\/doi.org\/10.1002\/bit.24988","journal-title":"Biotechnol Bioeng"},{"key":"3263_CR47","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12934-019-1090-4","volume":"18","author":"D Huccetogullari","year":"2019","unstructured":"Huccetogullari D, Luo ZW, Lee SY (2019) Metabolic engineering of microorganisms for production of aromatic compounds. Microb Cell Fact 18:41. https:\/\/doi.org\/10.1186\/s12934-019-1090-4","journal-title":"Microb Cell Fact"},{"key":"3263_CR48","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1074\/jbc.M803738200","volume":"284","author":"A Ilari","year":"2009","unstructured":"Ilari A, Franceschini S, Bonamore A et al (2009) Structural basis of enzymatic ( S )-norcoclaurine biosynthesis. J Biol Chem 284:897\u2013904. https:\/\/doi.org\/10.1074\/jbc.M803738200","journal-title":"J Biol Chem"},{"key":"3263_CR49","doi-asserted-by":"publisher","first-page":"123093","DOI":"10.1016\/j.biortech.2020.123093","volume":"307","author":"SM Ioannidou","year":"2020","unstructured":"Ioannidou SM, Pateraki C, Ladakis D et al (2020) Sustainable production of bio-based chemicals and polymers via integrated biomass refining and bioprocessing in a circular bioeconomy context. Bioresour Technol 307:123093. https:\/\/doi.org\/10.1016\/j.biortech.2020.123093","journal-title":"Bioresour Technol"},{"key":"3263_CR50","doi-asserted-by":"publisher","unstructured":"Jako\u010di\u016bnas T, Klitgaard AK, Romero-Suarez D, et al (2019) Versatile polyketide biosynthesis platform for production of aromatic compounds in yeast. J bioRxiv. https:\/\/doi.org\/10.1101\/618751","DOI":"10.1101\/618751"},{"key":"3263_CR52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ymben.2016.06.003","volume":"38","author":"N Kallscheuer","year":"2016","unstructured":"Kallscheuer N, Vogt M, Stenzel A et al (2016) Construction of a Corynebacterium glutamicum platform strain for the production of stilbenes and (2S)-flavanones. Metab Eng 38:47\u201355. https:\/\/doi.org\/10.1016\/j.ymben.2016.06.003","journal-title":"Metab Eng"},{"key":"3263_CR51","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1021\/acssynbio.6b00291","volume":"6","author":"N Kallscheuer","year":"2017","unstructured":"Kallscheuer N, Vogt M, Marienhagen J (2017) A novel synthetic pathway enables microbial production of polyphenols independent from the endogenous aromatic amino acid metabolism. ACS Synth Biol 6:410\u2013415. https:\/\/doi.org\/10.1021\/acssynbio.6b00291","journal-title":"ACS Synth Biol"},{"key":"3263_CR53","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1002\/biot.200700098","volume":"2","author":"Y Katsuyama","year":"2007","unstructured":"Katsuyama Y, Funa N, Horinouchi S (2007) Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli. Biotechnol J 2:1286\u20131293. https:\/\/doi.org\/10.1002\/biot.200700098","journal-title":"Biotechnol J"},{"key":"3263_CR54","unstructured":"Katz M, Durhuus T, Smits HP, F\u00d6rster J (2011) Production of metabolites. WO2011147818 (A2)"},{"key":"3263_CR55","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s12010-012-0066-1","volume":"169","author":"B Kaur","year":"2013","unstructured":"Kaur B, Chakraborty D (2013) Biotechnological and molecular approaches for vanillin production: a review. Appl Biochem Biotechnol 169:1353\u20131372","journal-title":"Appl Biochem Biotechnol"},{"key":"3263_CR57","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1271\/bbb.130552","volume":"77","author":"J Kim","year":"2014","unstructured":"Kim J, Nakagawa A, Yamazaki Y et al (2014) Improvement of Reticuline Productivity from Dopamine by Using Engineered Escherichia coli. Biosci Biotechnol Biochem 77:2166\u20132168. https:\/\/doi.org\/10.1271\/bbb.130552","journal-title":"Biosci Biotechnol Biochem"},{"key":"3263_CR56","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1002\/bit.26797","volume":"115","author":"B Kim","year":"2018","unstructured":"Kim B, Binkley R, Kim HU, Lee SY (2018) Metabolic engineering of Escherichia coli for the enhanced production of l-tyrosine. Biotechnol Bioeng 115:2554\u20132564. https:\/\/doi.org\/10.1002\/bit.26797","journal-title":"Biotechnol Bioeng"},{"key":"3263_CR58","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s00253-011-3184-8","volume":"90","author":"KV Kiselev","year":"2011","unstructured":"Kiselev KV (2011) Perspectives for production and application of resveratrol. Appl Microbiol Biotechnol 90:417\u2013425. https:\/\/doi.org\/10.1007\/s00253-011-3184-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"3263_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fbioe.2020.00403","volume":"8","author":"JO Kr\u00f6mer","year":"2020","unstructured":"Kr\u00f6mer JO, Ferreira RG, Petrides D, Kohlheb N (2020) Economic process evaluation and environmental life-cycle assessment of bio-aromatics production. Front Bioeng Biotechnol 8:1\u20139. https:\/\/doi.org\/10.3389\/fbioe.2020.00403","journal-title":"Front Bioeng Biotechnol"},{"key":"3263_CR60","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.jbiotec.2016.11.016","volume":"257","author":"J Lee","year":"2017","unstructured":"Lee J, Wendisch V (2017) Biotechnological production of aromatic compounds of the extended shikimate pathway from renewable biomass. J Biotechnol 257:211\u2013221. https:\/\/doi.org\/10.1016\/j.jbiotec.2016.11.016","journal-title":"J Biotechnol"},{"key":"3263_CR61","doi-asserted-by":"publisher","first-page":"10545","DOI":"10.1021\/ja9817747","volume":"120","author":"K Li","year":"1998","unstructured":"Li K, Frost JW (1998) Synthesis of vanillin from glucose. J Am Chem Soc 120:10545\u201310546. https:\/\/doi.org\/10.1021\/ja9817747","journal-title":"J Am Chem Soc"},{"key":"3263_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ymben.2015.08.007","volume":"32","author":"M Li","year":"2015","unstructured":"Li M, Kildegaard KR, Chen Y et al (2015) De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae. Metab Eng 32:1\u201311. https:\/\/doi.org\/10.1016\/j.ymben.2015.08.007","journal-title":"Metab Eng"},{"key":"3263_CR65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721469115","author":"Y Li","year":"2018","unstructured":"Li Y, Li S, Thodey K et al (2018) Complete biosynthesis of noscapine and halogenated alkaloids in yeast. PNAS. https:\/\/doi.org\/10.1073\/pnas.1721469115","journal-title":"PNAS"},{"key":"3263_CR62","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1039\/c9np00016j","volume":"37","author":"M Li","year":"2020","unstructured":"Li M, Hou F, Wu T et al (2020a) Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories. Nat Prod Rep 37:80\u201399. https:\/\/doi.org\/10.1039\/c9np00016j","journal-title":"Nat Prod Rep"},{"key":"3263_CR64","doi-asserted-by":"publisher","first-page":"107548","DOI":"10.1016\/j.biotechadv.2020.107548","volume":"41","author":"M Li","year":"2020","unstructured":"Li M, Liu C, Yang J et al (2020b) Common problems associated with the microbial productions of aromatic compounds and corresponding metabolic engineering strategies. Biotechnol Adv 41:107548. https:\/\/doi.org\/10.1016\/j.biotechadv.2020.107548","journal-title":"Biotechnol Adv"},{"key":"3263_CR66","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1128\/AEM.02186-10","volume":"77","author":"CG Lim","year":"2011","unstructured":"Lim CG, Fowler ZL, Hueller T et al (2011) High-yield resveratrol production in engineered Escherichia coli. Appl Environ Microbiol 77:3451\u20133460. https:\/\/doi.org\/10.1128\/AEM.02186-10","journal-title":"Appl Environ Microbiol"},{"key":"3263_CR68","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.procbio.2014.01.001","volume":"49","author":"SP Liu","year":"2014","unstructured":"Liu SP, Liu RX, Xiao MR et al (2014a) A systems level engineered E. coli capable of efficiently producing L-phenylalanine. Process Biochem 49:751\u2013757. https:\/\/doi.org\/10.1016\/j.procbio.2014.01.001","journal-title":"Process Biochem"},{"key":"3263_CR69","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1007\/s11274-014-1679-z","volume":"30","author":"X Liu","year":"2014","unstructured":"Liu X, Lin J, Hu H (2014b) Metabolic engineering of Escherichia coli to enhance shikimic acid production from sorbitol. World J Microbiol Biotechnol 30:2543\u20132550. https:\/\/doi.org\/10.1007\/s11274-014-1679-z","journal-title":"World J Microbiol Biotechnol"},{"key":"3263_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12896-018-0418-1","volume":"18","author":"Y Liu","year":"2018","unstructured":"Liu Y, Xu Y, Ding D et al (2018) Genetic engineering of Escherichia coli to improve L-phenylalanine production. BMC Biotechnol 18:1\u201312. https:\/\/doi.org\/10.1186\/s12896-018-0418-1","journal-title":"BMC Biotechnol"},{"key":"3263_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/pr7040213","author":"L Liu","year":"2019","unstructured":"Liu L, Bilal M, Luo H et al (2019) Metabolic engineering and fermentation process strategies for L-tryptophan production by Escherichia coli. Processes. https:\/\/doi.org\/10.3390\/pr7040213","journal-title":"Processes"},{"key":"3263_CR71","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.foodchem.2006.10.068","volume":"104","author":"C Lucas-Abell\u00e1n","year":"2007","unstructured":"Lucas-Abell\u00e1n C, Fortea I, L\u00f3pez-Nicol\u00e1s JM, N\u00fa\u00f1ez-Delicado E (2007) Cyclodextrins as resveratrol carrier system. Food Chem 104:39\u201344. https:\/\/doi.org\/10.1016\/j.foodchem.2006.10.068","journal-title":"Food Chem"},{"key":"3263_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00279","author":"F Luziatelli","year":"2019","unstructured":"Luziatelli F, Brunetti L, Ficca AG, Ruzzi M (2019) Maximizing the efficiency of vanillin production by biocatalyst enhancement and process optimization. Front Bioeng Biotechnol. https:\/\/doi.org\/10.3389\/fbioe.2019.00279","journal-title":"Front Bioeng Biotechnol"},{"key":"3263_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09168451.2016.1243985","volume":"8451","author":"E Matsumura","year":"2017","unstructured":"Matsumura E, Nakagawa A, Tomabechi Y et al (2017) Laboratory-scale production of (S)-reticuline, an important intermediate of benzylisoquinoline alkaloids, using a bacterial-based method. Biosci Biotechnol Biochem 8451:1\u20137. https:\/\/doi.org\/10.1080\/09168451.2016.1243985","journal-title":"Biosci Biotechnol Biochem"},{"key":"3263_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-26306-7","volume":"8","author":"E Matsumura","year":"2018","unstructured":"Matsumura E, Nakagawa A, Tomabechi Y et al (2018) Microbial production of novel sulphated alkaloids for drug discovery. Sci Rep 8:1\u201310. https:\/\/doi.org\/10.1038\/s41598-018-26306-7","journal-title":"Sci Rep"},{"key":"3263_CR75","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-8747-5","author":"L Milke","year":"2018","unstructured":"Milke L, Aschenbrenner J, Marienhagen J, Kallscheuer N (2018) Production of plant-derived polyphenols in microorganisms: current state and perspectives. Appl Microbiol Biotechnol. https:\/\/doi.org\/10.1007\/s00253-018-8747-5","journal-title":"Appl Microbiol Biotechnol"},{"key":"3263_CR76","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1002\/bit.26939","volume":"116","author":"L Milke","year":"2019","unstructured":"Milke L, Ferreira P, Kallscheuer N et al (2019) Modulation of the central carbon metabolism of Corynebacterium glutamicum improves malonyl-CoA availability and increases plant polyphenol synthesis. Biotechnol Bioeng 116:1380\u20131391. https:\/\/doi.org\/10.1002\/bit.26939","journal-title":"Biotechnol Bioeng"},{"key":"3263_CR77","doi-asserted-by":"publisher","first-page":"7393","DOI":"10.1007\/BF00261660","volume":"105","author":"H Minami","year":"2008","unstructured":"Minami H, Kim JS, Ikezawa N et al (2008) Microbial production of plant benzylisoquinoline alkaloid. Proc Natl Acad Sci 105:7393\u20137398. https:\/\/doi.org\/10.1007\/BF00261660","journal-title":"Proc Natl Acad Sci"},{"key":"3263_CR78","unstructured":"Muheim A, M\u00fcller B, M\u00fcnch T, Wetli M (2001) Microbiological process for producing vanillin. U.S. Patent No 6,235,507"},{"key":"3263_CR80","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/ncomms1327","volume":"2","author":"A Nakagawa","year":"2011","unstructured":"Nakagawa A, Minami H, Kim J-S et al (2011) A bacterial platform for fermentative production of plant alkaloids Akira. Nat Commun 2:326\u2013328. https:\/\/doi.org\/10.1038\/ncomms1327","journal-title":"Nat Commun"},{"key":"3263_CR81","doi-asserted-by":"publisher","first-page":"49","DOI":"10.4161\/bbug.3.1.18446","volume":"3","author":"A Nakagawa","year":"2012","unstructured":"Nakagawa A, Minami H, Kim JS et al (2012) Bench-top fermentative production of plant benzylisoquinoline alkaloids using a bacterial platform. Bioeng Bugs 3:49\u201353. https:\/\/doi.org\/10.4161\/bbug.3.1.18446","journal-title":"Bioeng Bugs"},{"key":"3263_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms10390","volume":"6","author":"A Nakagawa","year":"2016","unstructured":"Nakagawa A, Matsumura E, Koyanagi T et al (2016) Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli. Nat Commun 6:1\u20138. https:\/\/doi.org\/10.1038\/ncomms10390","journal-title":"Nat Commun"},{"key":"3263_CR82","doi-asserted-by":"publisher","first-page":"5433","DOI":"10.1007\/s00253-021-11401-z","volume":"105","author":"A Nakagawa","year":"2021","unstructured":"Nakagawa A, Nakamura S, Matsumura E et al (2021) Selection of the optimal tyrosine hydroxylation enzyme for (S)-reticuline production in Escherichia coli. Appl Microbiol Biotechnol 105:5433\u20135447. https:\/\/doi.org\/10.1007\/s00253-021-11401-z","journal-title":"Appl Microbiol Biotechnol"},{"key":"3263_CR83","doi-asserted-by":"publisher","first-page":"13670","DOI":"10.1038\/srep13670","volume":"5","author":"J Ni","year":"2015","unstructured":"Ni J, Tao F, Du H, Xu P (2015) Mimicking a natural pathway for de novo biosynthesis: natural vanillin production from accessible carbon sources. Sci Rep 5:13670. https:\/\/doi.org\/10.1038\/srep13670","journal-title":"Sci Rep"},{"key":"3263_CR84","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/anie.201207081","volume":"52","author":"KC Nicolaou","year":"2013","unstructured":"Nicolaou KC (2013) The emergence of the structure of the molecule and the art of its synthesis. Angew Chemie Int Ed 52:131\u2013146. https:\/\/doi.org\/10.1002\/anie.201207081","journal-title":"Angew Chemie Int Ed"},{"key":"3263_CR86","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.cell.2016.02.004","volume":"164","author":"J Nielsen","year":"2016","unstructured":"Nielsen J, Keasling JD (2016) Engineering cellular metabolism. Cell 164:1185\u20131197. https:\/\/doi.org\/10.1016\/j.cell.2016.02.004","journal-title":"Cell"},{"key":"3263_CR85","doi-asserted-by":"publisher","first-page":"4837","DOI":"10.1007\/s00253-017-8310-9","volume":"101","author":"J Nielsen","year":"2017","unstructured":"Nielsen J, Archer J, Essack M et al (2017) Building a bio-based industry in the middle east through harnessing the potential of the Red Sea biodiversity. Appl Microbiol Biotechnol 101:4837\u20134851. https:\/\/doi.org\/10.1007\/s00253-017-8310-9","journal-title":"Appl Microbiol Biotechnol"},{"key":"3263_CR87","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.tibtech.2017.05.006","volume":"35","author":"S Noda","year":"2017","unstructured":"Noda S, Kondo A (2017) Recent advances in microbial production of aromatic chemicals and derivatives. Trends Biotechnol 35:785\u2013796. https:\/\/doi.org\/10.1016\/j.tibtech.2017.05.006","journal-title":"Trends Biotechnol"},{"key":"3263_CR88","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ymben.2015.11.007","volume":"33","author":"S Noda","year":"2016","unstructured":"Noda S, Shirai T, Oyama S, Kondo A (2016) Metabolic design of a platform Escherichia coli strain producing various chorismate derivatives. Metab Eng 33:119\u2013129. https:\/\/doi.org\/10.1016\/j.ymben.2015.11.007","journal-title":"Metab Eng"},{"key":"3263_CR89","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/nature12051","volume":"496","author":"CJ Paddon","year":"2013","unstructured":"Paddon CJ, Westfall PJ, Pitera DJ et al (2013) High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 496:528. https:\/\/doi.org\/10.1038\/nature12051","journal-title":"Nature"},{"key":"3263_CR90","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.biotechadv.2016.02.012","volume":"34","author":"RP Pandey","year":"2016","unstructured":"Pandey RP, Parajuli P, Koffas MAG, Sohng JK (2016) Microbial production of natural and non-natural flavonoids: pathway engineering, directed evolution and systems\/synthetic biology. Biotechnol Adv 34:634\u2013662. https:\/\/doi.org\/10.1016\/j.biotechadv.2016.02.012","journal-title":"Biotechnol Adv"},{"key":"3263_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2859-11-50","volume":"11","author":"M Papagianni","year":"2012","unstructured":"Papagianni M (2012) Recent advances in engineering the central carbon metabolism of industrially important bacteria. Microb Cell Fact 11:1\u201313. https:\/\/doi.org\/10.1186\/1475-2859-11-50","journal-title":"Microb Cell Fact"},{"key":"3263_CR93","doi-asserted-by":"publisher","first-page":"1700190","DOI":"10.1002\/adbi.201700190","volume":"1700190","author":"SY Park","year":"2017","unstructured":"Park SY, Yang D, Ha SH, Lee SY (2017) Metabolic engineering of microorganisms for the production of natural compounds. Adv Biosyst 1700190:1700190. https:\/\/doi.org\/10.1002\/adbi.201700190","journal-title":"Adv Biosyst"},{"key":"3263_CR92","doi-asserted-by":"publisher","DOI":"10.1186\/s13765-021-00595-5","author":"JY Park","year":"2021","unstructured":"Park JY, Lim JH, Ahn JH, Kim BG (2021) Biosynthesis of resveratrol using metabolically engineered Escherichia coli. Appl Biol Chem. https:\/\/doi.org\/10.1186\/s13765-021-00595-5","journal-title":"Appl Biol Chem"},{"key":"3263_CR94","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/bit.21765","volume":"99","author":"R Patnaik","year":"2008","unstructured":"Patnaik R, Zolandz RR, Green DA, Kraynie DF (2008) L-tyrosine production by recombinant Escherichia coli: Fermentation optimization and recovery. Biotechnol Bioeng 99:741\u2013752. https:\/\/doi.org\/10.1002\/bit.21765","journal-title":"Biotechnol Bioeng"},{"key":"3263_CR95","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1007\/s002530100687","volume":"56","author":"H Priefert","year":"2001","unstructured":"Priefert H, Rabenhorst J, Steinb\u00fcchel A (2001) Biotechnological production of vanillin. Appl Microbiol Biotechnol 56:296\u2013314","journal-title":"Appl Microbiol Biotechnol"},{"key":"3263_CR137","doi-asserted-by":"publisher","unstructured":"Priya VK, Sarkar S, Sinha S (2014) Evolution of tryptophan biosynthetic pathway in microbial genomes: a comparative genetic study. Syst Synth Biol 8:59\u201372. https:\/\/doi.org\/10.1007\/s11693-013-9127-1","DOI":"10.1007\/s11693-013-9127-1"},{"key":"3263_CR96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-17172-x","volume":"11","author":"ME Pyne","year":"2020","unstructured":"Pyne ME, Kevvai K, Grewal PS et al (2020) A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids. Nat Commun 11:1\u201310. https:\/\/doi.org\/10.1038\/s41467-020-17172-x","journal-title":"Nat Commun"},{"key":"3263_CR97","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1002\/anie.201000044","volume":"50","author":"S Quideau","year":"2011","unstructured":"Quideau S, Deffieux D, Douat-Casassus C, Pouys\u00e9gu L (2011) Plant polyphenols: Chemical properties, biological activities, and synthesis. Angew Chemie - Int Ed 50:586\u2013621. https:\/\/doi.org\/10.1002\/anie.201000044","journal-title":"Angew Chemie - Int Ed"},{"key":"3263_CR98","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/340520","author":"M Reinisalo","year":"2015","unstructured":"Reinisalo M, K\u00e5rlund A, Koskela A et al (2015) Polyphenol stilbenes: molecular mechanisms of defence against oxidative stress and aging-related diseases. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2015\/340520","journal-title":"Oxid Med Cell Longev"},{"key":"3263_CR99","doi-asserted-by":"publisher","first-page":"4665","DOI":"10.1039\/d1gc00931a","volume":"23","author":"JC Sadler","year":"2021","unstructured":"Sadler JC, Wallace S (2021) Microbial synthesis of vanillin from waste poly(ethylene terephthalate). Green Chem 23:4665\u20134672. https:\/\/doi.org\/10.1039\/d1gc00931a","journal-title":"Green Chem"},{"key":"3263_CR100","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ymben.2020.08.009","volume":"62","author":"J S\u00e1ez-S\u00e1ez","year":"2020","unstructured":"S\u00e1ez-S\u00e1ez J, Wang G, Marella ER et al (2020) Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production. Metab Eng 62:51\u201361. https:\/\/doi.org\/10.1016\/j.ymben.2020.08.009","journal-title":"Metab Eng"},{"key":"3263_CR101","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev.micro.61.080706.093248","volume":"61","author":"FS Sariaslani","year":"2007","unstructured":"Sariaslani FS (2007) Development of a combined biological and chemical process for production of industrial aromatics from renewable resources. Annu Rev Microbiol 61:51\u201369. https:\/\/doi.org\/10.1146\/annurev.micro.61.080706.093248","journal-title":"Annu Rev Microbiol"},{"key":"3263_CR102","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00407","author":"YP Shen","year":"2020","unstructured":"Shen YP, Niu FX, Yan ZB et al (2020) Recent advances in metabolically engineered microorganisms for the production of aromatic chemicals derived from aromatic amino acids. Front Bioeng Biotechnol. https:\/\/doi.org\/10.3389\/fbioe.2020.00407","journal-title":"Front Bioeng Biotechnol"},{"key":"3263_CR103","doi-asserted-by":"publisher","first-page":"9691","DOI":"10.1007\/s00253-018-9323-8","volume":"102","author":"A Shrestha","year":"2018","unstructured":"Shrestha A, Pandey RP, Pokhrel AR et al (2018) Modular pathway engineering for resveratrol and piceatannol production in engineered Escherichia coli. Appl Microbiol Biotechnol 102:9691\u20139706. https:\/\/doi.org\/10.1007\/s00253-018-9323-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"3263_CR104","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1007\/s10295-016-1824-9","volume":"43","author":"M Su\u00e1stegui","year":"2016","unstructured":"Su\u00e1stegui M, Shao Z (2016) Yeast factories for the production of aromatic compounds: from building blocks to plant secondary metabolites. J Ind Microbiol Biotechnol 43:1611\u20131624. https:\/\/doi.org\/10.1007\/s10295-016-1824-9","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3263_CR105","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1128\/AEM.02796-09","volume":"76","author":"T Sydor","year":"2010","unstructured":"Sydor T, Schaffer S, Boles E (2010) Considerable increase in resveratrol production by recombinant industrial yeast strains with use of rich medium. Appl Environ Microbiol 76:3361\u20133363. https:\/\/doi.org\/10.1128\/AEM.02796-09","journal-title":"Appl Environ Microbiol"},{"key":"3263_CR106","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.5897\/JMPR11.1695","volume":"6","author":"S Oksana","year":"2012","unstructured":"Oksana S, Marian B, Mahendra R, Bo SH (2012) Plant phenolic compounds for food, pharmaceutical and cosmetics production. J Med Plants Res 6:2526\u20132539. https:\/\/doi.org\/10.5897\/JMPR11.1695","journal-title":"J Med Plants Res"},{"key":"3263_CR107","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1371\/journal.pbio.0020031","volume":"2","author":"Y Tang","year":"2004","unstructured":"Tang Y, Lee TS, Khosla C (2004) Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. PLoS Biol 2:227\u2013238. https:\/\/doi.org\/10.1371\/journal.pbio.0020031","journal-title":"PLoS Biol"},{"key":"3263_CR108","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/nchembio.1613.A","volume":"10","author":"K Thodey","year":"2014","unstructured":"Thodey K, Galanie S, Smolke CD (2014) A microbial biomanufacturing platform for natural and semi- synthetic opiates. Nat Chem Biol 10:837\u2013844. https:\/\/doi.org\/10.1038\/nchembio.1613.A","journal-title":"Nat Chem Biol"},{"key":"3263_CR109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.copbio.2015.07.004","volume":"36","author":"B Thompson","year":"2015","unstructured":"Thompson B, Machas M, Nielsen DR (2015) Creating pathways towards aromatic building blocks and fine chemicals. Curr Opin Biotechnol 36:1\u20137. https:\/\/doi.org\/10.1016\/j.copbio.2015.07.004","journal-title":"Curr Opin Biotechnol"},{"key":"3263_CR110","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ymben.2009.07.004","volume":"11","author":"E Trantas","year":"2009","unstructured":"Trantas E, Panopoulos N, Ververidis F (2009) Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae. Metab Eng 11:355\u2013366. https:\/\/doi.org\/10.1016\/j.ymben.2009.07.004","journal-title":"Metab Eng"},{"key":"3263_CR112","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ymben.2015.05.001","volume":"30","author":"IJ Trenchard","year":"2015","unstructured":"Trenchard IJ, Smolke CD (2015) Engineering strategies for the fermentative production of plant alkaloids in yeast. Metab Eng 30:96\u2013104. https:\/\/doi.org\/10.1016\/j.ymben.2015.05.001","journal-title":"Metab Eng"},{"key":"3263_CR111","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ymben.2015.06.010","volume":"31","author":"IJ Trenchard","year":"2015","unstructured":"Trenchard IJ, Siddiqui MS, Thodey K, Smolke CD (2015) De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast. Metab Eng 31:74\u201383. https:\/\/doi.org\/10.1016\/j.ymben.2015.06.010","journal-title":"Metab Eng"},{"key":"3263_CR113","first-page":"494","volume":"56","author":"K Tro\u0161t","year":"2009","unstructured":"Tro\u0161t K, Golc-Wondra A, Pro\u0161ek M (2009) Degradation of polyphenolic antioxidants in blueberry nectar aseptically filled in PET. Acta Chim Slov 56:494\u2013502","journal-title":"Acta Chim Slov"},{"key":"3263_CR136","doi-asserted-by":"publisher","unstructured":"Tzin V, Galili G, Aharoni A (2012) Shikimate Pathway and Aromatic Amino Acid Biosynthesis. In: eLS. John Wiley & Sons, Ltd, Chichester. https:\/\/doi.org\/10.1002\/9780470015902.a0001315.pub2","DOI":"10.1002\/9780470015902.a0001315.pub2"},{"key":"3263_CR114","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1128\/AEM.02966-14","volume":"81","author":"PV van Summeren-Wesenhagen","year":"2015","unstructured":"van Summeren-Wesenhagen PV, Marienhagen J (2015) Metabolic engineering of Escherichia coli for the synthesis of the plant polyphenol pinosylvin. Appl Environ Microbiol 81:840\u2013849. https:\/\/doi.org\/10.1128\/AEM.02966-14","journal-title":"Appl Environ Microbiol"},{"key":"3263_CR115","unstructured":"Vanilla (2014) A sustainable production route. In: Evolva A\/S. www.evolva\/products\/vanilla"},{"key":"3263_CR116","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.devcel.2005.09.017","volume":"9","author":"M Viswanathan","year":"2005","unstructured":"Viswanathan M, Kim SK, Berdichevsky A, Guarente L (2005) A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell 9:605\u2013615. https:\/\/doi.org\/10.1016\/j.devcel.2005.09.017","journal-title":"Dev Cell"},{"key":"3263_CR119","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jbiotec.2011.11.003","volume":"157","author":"Y Wang","year":"2012","unstructured":"Wang Y, Yu O (2012) Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells. J Biotechnol 157:258\u2013260. https:\/\/doi.org\/10.1016\/j.jbiotec.2011.11.003","journal-title":"J Biotechnol"},{"key":"3263_CR118","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.ymben.2011.04.005","volume":"13","author":"Y Wang","year":"2011","unstructured":"Wang Y, Halls C, Zhang J et al (2011) Stepwise increase of resveratrol biosynthesis in yeast Saccharomyces cerevisiae by metabolic engineering. Metab Eng 13:455\u2013463. https:\/\/doi.org\/10.1016\/j.ymben.2011.04.005","journal-title":"Metab Eng"},{"key":"3263_CR117","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00253-017-8599-4","volume":"102","author":"J Wang","year":"2018","unstructured":"Wang J, Shen X, Rey J et al (2018) Recent advances in microbial production of aromatic natural products and their derivatives. Appl Microbiol Biotechnol 102:47\u201361. https:\/\/doi.org\/10.1007\/s00253-017-8599-4","journal-title":"Appl Microbiol Biotechnol"},{"key":"3263_CR120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6750-6-22","volume":"6","author":"KT Watts","year":"2006","unstructured":"Watts KT, Lee PC, Schmidt-Dannert C (2006) Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli. BMC Biotechnol 6:1\u201312. https:\/\/doi.org\/10.1186\/1472-6750-6-22","journal-title":"BMC Biotechnol"},{"key":"3263_CR121","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ymben.2019.03.008","volume":"58","author":"VF Wendisch","year":"2020","unstructured":"Wendisch VF (2020) Metabolic engineering advances and prospects for amino acid production. Metab Eng 58:17\u201334. https:\/\/doi.org\/10.1016\/j.ymben.2019.03.008","journal-title":"Metab Eng"},{"key":"3263_CR123","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.jbiotec.2013.07.030","volume":"167","author":"J Wu","year":"2013","unstructured":"Wu J, Liu P, Fan Y et al (2013) Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l-tyrosine. J Biotechnol 167:404\u2013411. https:\/\/doi.org\/10.1016\/j.jbiotec.2013.07.030","journal-title":"J Biotechnol"},{"key":"3263_CR124","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1007\/s10295-017-1937-9","volume":"44","author":"J Wu","year":"2017","unstructured":"Wu J, Zhou P, Zhang X, Dong M (2017) Efficient de novo synthesis of resveratrol by metabolically engineered Escherichia coli. J Ind Microbiol Biotechnol 44:1083\u20131095. https:\/\/doi.org\/10.1007\/s10295-017-1937-9","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3263_CR122","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1002\/bab.1605","volume":"65","author":"WB Wu","year":"2018","unstructured":"Wu WB, Guo XL, Zhang ML et al (2018a) Enhancement of l-phenylalanine production in Escherichia coli by heterologous expression of Vitreoscilla hemoglobin. Biotechnol Appl Biochem 65:476\u2013483. https:\/\/doi.org\/10.1002\/bab.1605","journal-title":"Biotechnol Appl Biochem"},{"key":"3263_CR125","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b01018","author":"K Wu","year":"2018","unstructured":"Wu K, Kast P, Krengel U (2018b) Inter-enzyme allosteric regulation of chorismate mutase in Corynebacterium glutamicum: structural basis of feedback activation by Trp. Biochemistry. https:\/\/doi.org\/10.1021\/acs.biochem.7b01018","journal-title":"Biochemistry"},{"key":"3263_CR126","doi-asserted-by":"publisher","first-page":"e00184","DOI":"10.1016\/j.mec.2021.e00184","volume":"13","author":"Y Yamada","year":"2021","unstructured":"Yamada Y, Urui M, Oki H et al (2021) Transport engineering for improving the production and secretion of valuable alkaloids in Escherichia coli. Metab Eng Commun 13:e00184. https:\/\/doi.org\/10.1016\/j.mec.2021.e00184","journal-title":"Metab Eng Commun"},{"key":"3263_CR127","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ymben.2015.03.018","volume":"29","author":"Y Yang","year":"2015","unstructured":"Yang Y, Lin Y, Li L et al (2015) Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products. Metab Eng 29:217\u2013226. https:\/\/doi.org\/10.1016\/j.ymben.2015.03.018","journal-title":"Metab Eng"},{"key":"3263_CR128","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12934-020-01401-5","volume":"19","author":"SF Yuan","year":"2020","unstructured":"Yuan SF, Yi X, Johnston TG, Alper HS (2020) De novo resveratrol production through modular engineering of an Escherichia coli-Saccharomyces cerevisiae co-culture. Microb Cell Fact 19:1\u201312. https:\/\/doi.org\/10.1186\/s12934-020-01401-5","journal-title":"Microb Cell Fact"},{"key":"3263_CR129","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.ymben.2009.01.005","volume":"11","author":"W Zha","year":"2009","unstructured":"Zha W, Rubin-Pitel SB, Shao Z, Zhao H (2009) Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering. Metab Eng 11:192\u2013198. https:\/\/doi.org\/10.1016\/j.ymben.2009.01.005","journal-title":"Metab Eng"},{"key":"3263_CR131","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1007\/s00253-012-4544-8","volume":"97","author":"H Zhang","year":"2013","unstructured":"Zhang H, Stephanopoulos G (2013) Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Appl Microbiol Biotechnol 97:3333\u20133341. https:\/\/doi.org\/10.1007\/s00253-012-4544-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"3263_CR133","doi-asserted-by":"publisher","first-page":"13030","DOI":"10.1021\/ja0622094","volume":"128","author":"Y Zhang","year":"2006","unstructured":"Zhang Y, Li SZ, Li J et al (2006) Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and mammalian cells. J Am Chem Soc 128:13030\u201313031. https:\/\/doi.org\/10.1021\/ja0622094","journal-title":"J Am Chem Soc"},{"key":"3263_CR130","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1007\/s11274-015-1889-z","volume":"31","author":"E Zhang","year":"2015","unstructured":"Zhang E, Guo X, Meng Z et al (2015) Construction, expression, and characterization of Arabidopsis thaliana 4CL and Arachis hypogaea RS fusion gene 4CL::RS in Escherichia coli. World J Microbiol Biotechnol 31:1379\u20131385. https:\/\/doi.org\/10.1007\/s11274-015-1889-z","journal-title":"World J Microbiol Biotechnol"},{"key":"3263_CR132","doi-asserted-by":"publisher","first-page":"111833","DOI":"10.1016\/j.biopha.2021.111833","volume":"141","author":"HW Zhang","year":"2021","unstructured":"Zhang HW, Lv C, Zhang LJ et al (2021) Application of omics- and multi-omics-based techniques for natural product target discovery. Biomed Pharmacother 141:111833. https:\/\/doi.org\/10.1016\/j.biopha.2021.111833","journal-title":"Biomed Pharmacother"},{"key":"3263_CR134","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1007\/s10529-005-1466-x","volume":"27","author":"L-Q Zhao","year":"2005","unstructured":"Zhao L-Q, Sun Z-H, Zheng P, Zhu L-L (2005) Biotransformation of Isoeugenol to vanillin by a novel strain of Bacillus fusiformis. Biotechnol Lett 27:1505\u20131509. https:\/\/doi.org\/10.1007\/s10529-005-1466-x","journal-title":"Biotechnol Lett"},{"key":"3263_CR135","doi-asserted-by":"publisher","first-page":"10443","DOI":"10.1007\/s00253-016-7672-8","volume":"100","author":"S Zhou","year":"2016","unstructured":"Zhou S, Liu P, Chen J et al (2016) Characterization of mutants of a tyrosine ammonia-lyase from Rhodotorula glutinis. Appl Microbiol Biotechnol 100:10443\u201310452. https:\/\/doi.org\/10.1007\/s00253-016-7672-8","journal-title":"Appl Microbiol Biotechnol"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-022-03263-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-022-03263-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-022-03263-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T10:13:31Z","timestamp":1652264011000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11274-022-03263-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,26]]},"references-count":137,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["3263"],"URL":"https:\/\/doi.org\/10.1007\/s11274-022-03263-y","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"value":"0959-3993","type":"print"},{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,26]]},"assertion":[{"value":"9 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"80"}}