{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:59:22Z","timestamp":1789268362906,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2019YFE0196900"],"award-info":[{"award-number":["2019YFE0196900"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["19ZR1463600"],"award-info":[{"award-number":["19ZR1463600"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014628","name":"Royal Asiatic Society of Great Britain and Ireland","doi-asserted-by":"publisher","award":["NAF\\R2\\180721"],"award-info":[{"award-number":["NAF\\R2\\180721"]}],"id":[{"id":"10.13039\/100014628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s11274-022-03266-9","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T12:05:49Z","timestamp":1648555549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Blocking the 2,3-butanediol synthesis pathway of Klebsiella pneumoniae resulted in l-valine production"],"prefix":"10.1007","volume":"38","author":[{"given":"Qinghui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjie","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Mojovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorica","family":"Knezevic-Jugovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Baganz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Lye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4403-8188","authenticated-orcid":false,"given":"Jian","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"3266_CR1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1128\/jb.136.1.168-174.1978","volume":"136","author":"JJ Anderson","year":"1978","unstructured":"Anderson JJ, Oxender DL (1978) Genetic separation of high- and low-affinity transport systems for branched-chain amino acids in Escherichia coli K-12. J Bacteriol 136:168\u2013174. https:\/\/doi.org\/10.1128\/jb.136.1.168-174.1978","journal-title":"J Bacteriol"},{"key":"3266_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/nature06450","volume":"451","author":"S Atsumi","year":"2008","unstructured":"Atsumi S, Hanai T, Liao JC (2008) Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels. Nature 451:86\u201389. https:\/\/doi.org\/10.1038\/nature06450","journal-title":"Nature"},{"key":"3266_CR3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s10295-009-0669-x","volume":"37","author":"T Bartek","year":"2010","unstructured":"Bartek T, Z\u00f6nnchen E, Klein B, Gerstmeir R, Makus P, Lang S, Oldiges M (2010) Analysing overexpression of L-valine biosynthesis genes in pyruvate-dehydrogenase-deficient Corynebacterium glutamicum. J Ind Microbiol Biotechnol 37:263\u2013270. https:\/\/doi.org\/10.1007\/s10295-009-0669-x","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3266_CR4","doi-asserted-by":"publisher","first-page":"5566","DOI":"10.1128\/AEM.01741-13","volume":"79","author":"J Buchholz","year":"2013","unstructured":"Buchholz J, Schwentner A, Brunnenkan B, Gabris C, Grimm S, Gerstmeir R, Takors R, Eikmanns BJ, Blombach B (2013) Platform engineering of Corynebacterium glutamicum with reduced pyruvate dehydrogenase complex activity for improved production of L-lysine, L-valine, and 2-ketoisovalerate. Appl Environ Microbiol 79:5566\u20135575. https:\/\/doi.org\/10.1128\/AEM.01741-13","journal-title":"Appl Environ Microbiol"},{"key":"3266_CR5","doi-asserted-by":"publisher","first-page":"4603","DOI":"10.1007\/s00253-014-5526-9","volume":"98","author":"C Chen","year":"2014","unstructured":"Chen C, Wei D, Shi J, Wang M, Hao J (2014) Mechanism of 2,3-butanediol stereoisomer formation in Klebsiella pneumoniae. Appl Microbiol Biotechnol 98:4603\u20134613. https:\/\/doi.org\/10.1007\/s00253-014-5526-9","journal-title":"Appl Microbiol Biotechnol"},{"key":"3266_CR6","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1073\/pnas.48.10.1804","volume":"48","author":"M Freundlich","year":"1962","unstructured":"Freundlich M, Burns RO, Umbarger HE (1962) Control of isoleucine, valine, and leucine biosynthesis. I. Multivalent repression. PNAS 48:1804\u20131808. https:\/\/doi.org\/10.1073\/pnas.48.10.1804","journal-title":"PNAS"},{"key":"3266_CR7","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13068-016-0502-5","volume":"9","author":"J Fu","year":"2016","unstructured":"Fu J, Huo GX, Feng LL, Mao YF, Wang ZW, Ma HW, Chen T, Xm Z (2016) Metabolic engineering of Bacillus subtilis for chiral pure meso-2,3-butanediol production. Biotechnol Biofuels 9:90. https:\/\/doi.org\/10.1186\/s13068-016-0502-5","journal-title":"Biotechnol Biofuels"},{"key":"3266_CR9","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1007\/s10295-014-1476-6","volume":"41","author":"P Gu","year":"2014","unstructured":"Gu P, Yang F, Su TY, Li FF, Li YK, Qi QS (2014) Construction of an L-serine producing Escherichia coli via metabolic engineering. J Ind Microbiol Biotechnol 41:1443\u20131450. https:\/\/doi.org\/10.1007\/s10295-014-1476-6","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3266_CR8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ymben.2017.07.003","volume":"43","author":"J Gu","year":"2017","unstructured":"Gu J, Zhou J, Zhang Z, Kim CH, Jiang B, Shi JP, Hao J (2017) Isobutanol and 2-ketoisovalerate production by Klebsiella pneumoniae via a native pathway. Metab Eng 43:71\u201384. https:\/\/doi.org\/10.1016\/j.ymben.2017.07.003","journal-title":"Metab Eng"},{"key":"3266_CR10","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1754-6834-7-44","volume":"7","author":"X Guo","year":"2014","unstructured":"Guo X, Cao CH, Wang YZ, Li CQ, Wu MY, Chen YF, Zhang CY, Pei HD, Xiao DG (2014) Effect of the inactivation of lactate dehydrogenase, ethanol dehydrogenase, and phosphotransacetylase on 2,3-butanediol production in Klebsiella pneumoniae strain. Biotechnol Biofuels 7:44. https:\/\/doi.org\/10.1186\/1754-6834-7-44","journal-title":"Biotechnol Biofuels"},{"key":"3266_CR11","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1073\/pnas.0337542100","volume":"100","author":"B Gust","year":"2003","unstructured":"Gust B, Challis GL, Fowler K, Kieser T, Chater KF (2003) PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. PNAS 100:1541\u20131546. https:\/\/doi.org\/10.1073\/pnas.0337542100","journal-title":"PNAS"},{"key":"3266_CR12","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1007\/s11274-008-9665-y","volume":"24","author":"J Hao","year":"2008","unstructured":"Hao J, Lin RH, Zheng ZM, Liu HJ, Liu DH (2008) Isolation and characterization of microorganisms able to produce 1,3-propanediol under aerobic conditions. World J Microbiol Biotechnol 24:1731\u20131740. https:\/\/doi.org\/10.1007\/s11274-008-9665-y","journal-title":"World J Microbiol Biotechnol"},{"key":"3266_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ymben.2020.01.004","volume":"59","author":"S Hasegawa","year":"2020","unstructured":"Hasegawa S, Jojima T, Suda M, Inui M (2020) Isobutanol production in Corynebacterium glutamicum: suppressed succinate by-production by pckA inactivation and enhanced productivity via the Entner-Doudoroff pathway. Metab Eng 59:24\u201335. https:\/\/doi.org\/10.1016\/j.ymben.2020.01.004","journal-title":"Metab Eng"},{"key":"3266_CR14","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1007\/s00726-012-1308-9","volume":"43","author":"XH Hou","year":"2012","unstructured":"Hou XH, Chen XD, Zhang Y, Qiang H, Zhang WG (2012a) L-valine production with minimization of by-products\u2019 synthesis in Corynebacterium glutamicum and Brevibacterium flavum. Amino Acids 43:2301\u20132311. https:\/\/doi.org\/10.1007\/s00726-012-1308-9","journal-title":"Amino Acids"},{"key":"3266_CR15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10295-011-1000-1","volume":"39","author":"XH Hou","year":"2012","unstructured":"Hou XH, Ge XY, Wu D, Qian H, Zhang WG (2012b) Improvement of L-valine production at high temperature in Brevibacterium flavum by overexpressing ilvEBNrC genes. J Ind Microbiol Biotechnol 39:63\u201372. https:\/\/doi.org\/10.1007\/s10295-011-1000-1","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3266_CR16","doi-asserted-by":"publisher","first-page":"6195","DOI":"10.1128\/AEM.02069-14","volume":"80","author":"MY Jung","year":"2014","unstructured":"Jung MY, Mazumdar S, Shin SH, Yang KS, Lee J, Oh MK (2014) Improvement of 2,3-butanediol yield in Klebsiella pneumoniae by deletion of the pyruvate formate-lyase gene. Appl Environ Microbiol 80:6195\u20136203. https:\/\/doi.org\/10.1128\/AEM.02069-14","journal-title":"Appl Environ Microbiol"},{"key":"3266_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0065-2164(08)70480-5","volume":"1","author":"S Kinoshita","year":"1959","unstructured":"Kinoshita S (1959) The production of amino acids by fermentation processes. Adv Appl Microbiol 1:201\u2013214. https:\/\/doi.org\/10.1016\/S0065-2164(08)70480-5","journal-title":"Adv Appl Microbiol"},{"key":"3266_CR18","doi-asserted-by":"publisher","first-page":"8053","DOI":"10.1128\/AEM.01710-10","volume":"76","author":"FS Krause","year":"2010","unstructured":"Krause FS, Blombach B, Eikmanns BJ (2010) Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production. Appl Environ Microbiol 76:8053\u20138061. https:\/\/doi.org\/10.1128\/AEM.01710-10","journal-title":"Appl Environ Microbiol"},{"key":"3266_CR19","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1073\/pnas.78.2.922","volume":"78","author":"RP Lawther","year":"1981","unstructured":"Lawther RP, Calhoun DH, Adams CW, Hauser CA, Gray J, Hatfield GW (1981) Molecular basis of valine resistance in Escherichia coli K-12. PNAS 78:922\u2013925. https:\/\/doi.org\/10.1073\/pnas.78.2.922","journal-title":"PNAS"},{"key":"3266_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00253-005-0155-y","volume":"69","author":"W Leuchtenberger","year":"2005","unstructured":"Leuchtenberger W, Huthmacher K, Drauz K (2005) Biotechnological production of amino acids and derivatives: current status and prospects. Appl Microbiol Biotechnol 69:1\u20138. https:\/\/doi.org\/10.1007\/s00253-005-0155-y","journal-title":"Appl Microbiol Biotechnol"},{"key":"3266_CR21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00253-008-1732-7","volume":"82","author":"CQ Ma","year":"2009","unstructured":"Ma CQ, Wang A, Qin JY, Li LX, Ai XL, Jiang TY, Tang HZ, Xu P (2009) Enhanced 2,3-butanediol production by Klebsiella pneumoniae SDM. Appl Microbiol Biotechnol 82:49\u201357. https:\/\/doi.org\/10.1007\/s00253-008-1732-7","journal-title":"Appl Microbiol Biotechnol"},{"key":"3266_CR22","doi-asserted-by":"publisher","first-page":"5859","DOI":"10.1007\/s00253-014-5782-8","volume":"98","author":"M Oldiges","year":"2014","unstructured":"Oldiges M, Eikmanns BJ, Blombach B (2014) Application of metabolic engineering for the biotechnological production of L-valine. Appl Microbiol Biotechnol 98:5859\u20135870. https:\/\/doi.org\/10.1007\/s00253-014-5782-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"3266_CR25","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00253-009-2307-y","volume":"85","author":"JH Park","year":"2010","unstructured":"Park JH, Lee SY (2010) Fermentative production of branched chain amino acids: a focus on metabolic engineering. Appl Microbiol Biotechnol 85:491\u2013506. https:\/\/doi.org\/10.1007\/s00253-009-2307-y","journal-title":"Appl Microbiol Biotechnol"},{"key":"3266_CR23","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1002\/bit.23044","volume":"108","author":"JH Park","year":"2011","unstructured":"Park JH, Jang YS, Lee JW, Lee SY (2011a) Escherichia coli was a new platform strain for the enhanced production of L-valine by systems metabolic engineering. Biotechnol Bioeng 108:1140\u20131147. https:\/\/doi.org\/10.1002\/bit.23044","journal-title":"Biotechnol Bioeng"},{"key":"3266_CR24","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1002\/bit.22995","volume":"108","author":"JH Park","year":"2011","unstructured":"Park JH, Kim TY, Lee KH, Lee SY (2011b) Fed-batch culture of Escherichia coli for L-valine production based on in silico flux response analysis. Biotechnol Bioeng 108:934\u2013946. https:\/\/doi.org\/10.1002\/bit.22995","journal-title":"Biotechnol Bioeng"},{"key":"3266_CR26","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bej.2015.09.016","volume":"105","author":"A Priya","year":"2016","unstructured":"Priya A, Dureja P, Talukdar P, Rathi R, Lal B, Sarma PM (2016) Microbial production of 2,3-butanediol through a two-stage pH and agitation strategy in 150l bioreactor. Biochem Eng J 105:159\u2013167. https:\/\/doi.org\/10.1016\/j.bej.2015.09.016","journal-title":"Biochem Eng J"},{"key":"3266_CR27","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1128\/AEM.68.5.2246-2250.2002","volume":"68","author":"E Radmacher","year":"2002","unstructured":"Radmacher E, Vaitsikova A, Burger U, Krumbach K, Sahm H, Eggeling L (2002) Linking central metabolism with increased pathway flux: L-valine accumulation by Corynebacterium glutamicum. Appl Environ Microbiol 68:2246\u20132250. https:\/\/doi.org\/10.1128\/AEM.68.5.2246-2250.2002","journal-title":"Appl Environ Microbiol"},{"key":"3266_CR28","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s10529-016-2062-y","volume":"38","author":"C Rathnasingh","year":"2016","unstructured":"Rathnasingh C, Park JM, Kim DK, Song H, Chang YK (2016) Metabolic engineering of Klebsiella pneumoniae and in silico investigation for enhanced 2,3-butanediol production. Biotechnol Lett 38:975\u2013982. https:\/\/doi.org\/10.1007\/s10529-016-2062-y","journal-title":"Biotechnol Lett"},{"key":"3266_CR29","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1007\/BF00418038","volume":"249","author":"K Stucky","year":"1995","unstructured":"Stucky K, Hagting A, Klein JR, Matern H, Henrich B, Konings WN, Plapp R (1995) Cloning and characterization of brnQ, a gene encoding a low-affinity, branched-chain amino acid carrier in Lactobacillus delbrlickii subsp, lactis DSM7290. Mol Gen Genet 249:682\u2013690. https:\/\/doi.org\/10.1007\/BF00418038","journal-title":"Mol Gen Genet"},{"key":"3266_CR30","doi-asserted-by":"publisher","first-page":"781","DOI":"10.4014\/jmb.1401.01038","volume":"24","author":"Y Sun","year":"2014","unstructured":"Sun Y, Wei D, Shi JP, Mojovic L, Han ZS, Hao J (2014) Two-stage fermentation for 2-ketogluconic acid production by Klebsiella pneumoniae. J Microbiol Biotechnol 24:781\u2013787. https:\/\/doi.org\/10.4014\/jmb.1401.01038","journal-title":"J Microbiol Biotechnol"},{"key":"3266_CR31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s002030050576","volume":"169","author":"A Tauch","year":"1998","unstructured":"Tauch A, Hermann T, Burkovski A, Kr\u00e4mer R, P\u00fchler A, Kalinowski J (1998) Isoleucine uptake in Corynebacterium glutamicum ATCC 13032 is directed by the brnQ gene product. Arch Microbiol 169:303\u2013312. https:\/\/doi.org\/10.1007\/s002030050576","journal-title":"Arch Microbiol"},{"key":"3266_CR33","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s10295-015-1638-1","volume":"42","author":"D Wang","year":"2015","unstructured":"Wang D, Zhou J, Chen C, Wei D, Shi JP, Jiang B, Liu PF, Hao J (2015) R-acetoin accumulation and dissimilation in Klebsiella pneumoniae. J Ind Microbiol Biotechnol 42:1105\u20131115. https:\/\/doi.org\/10.1007\/s10295-015-1638-1","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3266_CR32","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s11274-016-2080-x","volume":"32","author":"D Wang","year":"2016","unstructured":"Wang D, Wang C, Wei D, Shi JP, Kim CH, Jiang B, Han ZS, Hao J (2016) Gluconic acid production by gad mutant of Klebsiella pneumoniae. World J Microbiol Biotechnol 32:132. https:\/\/doi.org\/10.1007\/s11274-016-2080-x","journal-title":"World J Microbiol Biotechnol"},{"key":"3266_CR34","doi-asserted-by":"publisher","first-page":"6601","DOI":"10.1007\/s00253-020-10711-y","volume":"104","author":"YK Wang","year":"2020","unstructured":"Wang YK, Gu JJ, Lu XY, Zhang ZX, Yang Y, Sun SQ, Kostas ET, Shi JP, Gao MT, Baganz F, Lye JG, Hao J (2020) 2,3-Dihydroxyisovalerate production by Klebsiella pneumoniae. Appl Microbiol Biotechnol 104:6601\u20136613. https:\/\/doi.org\/10.1007\/s00253-020-10711-y","journal-title":"Appl Microbiol Biotechnol"},{"key":"3266_CR35","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s10295-012-1117-x","volume":"39","author":"D Wei","year":"2012","unstructured":"Wei D, Wang M, Shi JP, Hao J (2012) Red recombinase assisted gene replacement in Klebsiella pneumoniae. J Ind Microbiol Biotechnol 39:1219\u20131226. https:\/\/doi.org\/10.1007\/s10295-012-1117-x","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3266_CR36","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s10295-013-1261-y","volume":"40","author":"D Wei","year":"2013","unstructured":"Wei D, Xu JQ, Sun JS, Shi JP, Hao J (2013) 2-Ketogluconic acid production by Klebsiella pneumoniae CGMCC 1.6366. J Ind Microbiol Biotechnol 40:561\u2013570. https:\/\/doi.org\/10.1007\/s10295-013-1261-y","journal-title":"J Ind Microbiol Biotechnol"},{"key":"3266_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2020.109650","volume":"140","author":"Y Yang","year":"2020","unstructured":"Yang Y, Zhang ZX, Lu XY, Gu JJ, Wang YK, Yao Y, Liao XY, Shi JP, Lye G, Baganz F, Hao J (2020) Production of 2,3-dihydroxyisovalerate by Enterobacter cloacae. Enzyme Microb Technol 140:109650. https:\/\/doi.org\/10.1016\/j.enzmictec.2020.109650","journal-title":"Enzyme Microb Technol"},{"key":"3266_CR38","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/BF00172538","volume":"33","author":"AP Zeng","year":"1990","unstructured":"Zeng AP, Biebl H, Deckwer WD (1990) Effect of pH and acetic acid on growth and 2, 3-butanediol production of Enterobacter aerogenesin in continuous culture. Appl Microbiol Biotechnol 33:485\u2013489. https:\/\/doi.org\/10.1007\/BF00172538","journal-title":"Appl Microbiol Biotechnol"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-022-03266-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-022-03266-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-022-03266-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T10:15:43Z","timestamp":1652264143000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11274-022-03266-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["3266"],"URL":"https:\/\/doi.org\/10.1007\/s11274-022-03266-9","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"value":"0959-3993","type":"print"},{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,29]]},"assertion":[{"value":"1 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"81"}}