{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:49:59Z","timestamp":1784346599996,"version":"3.55.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s11274-022-03410-5","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T08:14:44Z","timestamp":1663402484000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Thidiazuron, a phenyl-urea cytokinin, inhibits ergosterol synthesis and attenuates biofilm formation of Candida albicans"],"prefix":"10.1007","volume":"38","author":[{"given":"Pandurangan","family":"Harikrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balamani","family":"Arayambath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay Karthik","family":"Jayaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanimozhi","family":"Ekambaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad A.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palanisamy","family":"Senthilkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairul-Islam Mohamed","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjunan","family":"Sundaresan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-8806","authenticated-orcid":false,"given":"Krishnaraj","family":"Thirugnanasambantham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"key":"3410_CR1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1136\/pmj.78.922.455","volume":"78","author":"A Akpan","year":"2002","unstructured":"Akpan A (2002) Oral candidiasis. Postgrad Med J 78:455\u2013459. https:\/\/doi.org\/10.1136\/pmj.78.922.455","journal-title":"Postgrad Med J"},{"key":"3410_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1476-0711-9-7","volume":"9","author":"I Ali","year":"2010","unstructured":"Ali I, Khan FG, Suri KA et al (2010) In vitro antifungal activity of hydroxychavicol isolated from Piper betle L. Ann Clin Microbiol Antimicrob 9:7. https:\/\/doi.org\/10.1186\/1476-0711-9-7","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"3410_CR3","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/j.1472-765X.2004.01511.x","volume":"38","author":"S Bennis","year":"2004","unstructured":"Bennis S, Chami F, Chami N et al (2004) Surface alteration of Saccharomyces cerevisiae induced by thymol and eugenol. Lett Appl Microbiol 38:454\u2013458. https:\/\/doi.org\/10.1111\/j.1472-765X.2004.01511.x","journal-title":"Lett Appl Microbiol"},{"key":"3410_CR4","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.mib.2006.10.003","volume":"9","author":"JR Blankenship","year":"2006","unstructured":"Blankenship JR, Mitchell AP (2006) How to build a biofilm: a fungal perspective. Curr Opin Microbiol 9:588\u2013594. https:\/\/doi.org\/10.1016\/j.mib.2006.10.003","journal-title":"Curr Opin Microbiol"},{"key":"3410_CR5","first-page":"40","volume":"16","author":"Y Bonilla Rodr\u00edguez","year":"2012","unstructured":"Bonilla Rodr\u00edguez Y, Moreno Maldonado V, Mu\u00f1oz Hern\u00e1ndez B, Palma Cort\u00e9s G (2012) In vitro adhesion of Candida albicans in three different tissue conditioners used in prosthodontics. Rev Odontol Mex 16:40\u201345","journal-title":"Rev Odontol Mex"},{"key":"3410_CR6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/j.1439-0507.2008.01550.x","volume":"52","author":"S Boreck\u00e1-Melkusov\u00e1","year":"2009","unstructured":"Boreck\u00e1-Melkusov\u00e1 S, Moran GP, Sullivan DJ et al (2009) The expression of genes involved in the ergosterol biosynthesis pathway in Candida albicans and Candida dubliniensis biofilms exposed to fluconazole. Mycoses 52:118\u2013128. https:\/\/doi.org\/10.1111\/j.1439-0507.2008.01550.x","journal-title":"Mycoses"},{"key":"3410_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00028","author":"M Cavalheiro","year":"2018","unstructured":"Cavalheiro M, Teixeira MC (2018) Candida biofilms: threats, challenges, and promising strategies. Front Med. https:\/\/doi.org\/10.3389\/fmed.2018.00028","journal-title":"Front Med"},{"key":"3410_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2017.11.001","author":"M Chellappandian","year":"2018","unstructured":"Chellappandian M, Saravanan M, Pandikumar P et al (2018) Traditionally practiced medicinal plant extracts inhibit the ergosterol biosynthesis of clinically isolated dermatophytic pathogens. J Mycol Med. https:\/\/doi.org\/10.1016\/j.mycmed.2017.11.001","journal-title":"J Mycol Med"},{"key":"3410_CR9","volume-title":"Approved standard: document M38\u2013A2","author":"Clinical and Laboratory Standards Institute [CLSI]","year":"2008","unstructured":"Clinical and Laboratory Standards Institute [CLSI] (2008) Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard: document M38\u2013A2, 2nd edn. Clinical and Laboratory Standards Institute, Wayne","edition":"2"},{"key":"3410_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fov012","author":"RDA Cordeiro","year":"2015","unstructured":"Cordeiro RDA, Teixeira CEC, Brilhante RSN et al (2015) Exogenous tyrosol inhibits planktonic cells and biofilms of Candida species and enhances their susceptibility to antifungals. FEMS Yeast Res. https:\/\/doi.org\/10.1093\/femsyr\/fov012","journal-title":"FEMS Yeast Res"},{"key":"3410_CR11","doi-asserted-by":"publisher","first-page":"a019752","DOI":"10.1101\/cshperspect.a019752","volume":"5","author":"LE Cowen","year":"2014","unstructured":"Cowen LE, Sanglard D, Howard SJ et al (2014) Mechanisms of antifungal drug resistance. Cold Spring Harb Perspect Med 5:a019752. https:\/\/doi.org\/10.1101\/cshperspect.a019752","journal-title":"Cold Spring Harb Perspect Med"},{"key":"3410_CR12","doi-asserted-by":"publisher","DOI":"10.1590\/1519-6984.255080","author":"H Diniz-Neto","year":"2022","unstructured":"Diniz-Neto H, Silva SL, Cordeiro LV et al (2022) Antifungal activity of 2-chloro-N-phenylacetamide: a new molecule with fungicidal and antibiofilm activity against fluconazole-resistant Candida spp. Brazilian J Biol. https:\/\/doi.org\/10.1590\/1519-6984.255080","journal-title":"Brazilian J Biol"},{"key":"3410_CR13","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3201\/eid0702.010226","volume":"7","author":"RM Donlan","year":"2001","unstructured":"Donlan RM (2001) Biofilms and device-associated infections. Emerg Infect Dis 7:277\u2013281. https:\/\/doi.org\/10.3201\/eid0702.010226","journal-title":"Emerg Infect Dis"},{"key":"3410_CR14","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/s41396-020-00823-8","volume":"15","author":"Q Du","year":"2021","unstructured":"Du Q, Ren B, He J et al (2021) Candida albicans promotes tooth decay by inducing oral microbial dysbiosis. ISME J 15:894\u2013908. https:\/\/doi.org\/10.1038\/s41396-020-00823-8","journal-title":"ISME J"},{"key":"3410_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/app10228297","volume":"10","author":"PM Emeka","year":"2020","unstructured":"Emeka PM, Badger-Emeka LI, Ibrahim HIM et al (2020) Inhibitory potential of mangiferin on glucansucrase producing Streptococcus mutans biofilm in dental plaque. Appl Sci 10:1\u201317. https:\/\/doi.org\/10.3390\/app10228297","journal-title":"Appl Sci"},{"key":"3410_CR16","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.mib.2011.06.001","volume":"14","author":"S Ganguly","year":"2011","unstructured":"Ganguly S, Mitchell AP (2011) Mucosal biofilms of Candida albicans. Curr Opin Microbiol 14:380\u2013385. https:\/\/doi.org\/10.1016\/j.mib.2011.06.001","journal-title":"Curr Opin Microbiol"},{"key":"3410_CR17","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.micinf.2016.01.002","volume":"18","author":"M Gulati","year":"2016","unstructured":"Gulati M, Nobile CJ (2016) Candida albicans biofilms: development, regulation, and molecular mechanisms. Microbes Infect 18:310\u2013321. https:\/\/doi.org\/10.1016\/j.micinf.2016.01.002","journal-title":"Microbes Infect"},{"key":"3410_CR18","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03068-20","author":"R Gupta","year":"2021","unstructured":"Gupta R, Anand G, Pizarro L et al (2021) Cytokinin inhibits fungal development and virulence by targeting the cytoskeleton and cellular trafficking. Mbio. https:\/\/doi.org\/10.1128\/mBio.03068-20","journal-title":"Mbio"},{"key":"3410_CR19","doi-asserted-by":"publisher","first-page":"104129","DOI":"10.1016\/j.micpath.2020.104129","volume":"143","author":"MI Hairul Islam","year":"2020","unstructured":"Hairul Islam MI, Arokiyaraj S, Kuralarasan M et al (2020) Inhibitory potential of EGCG on Streptococcus mutans biofilm: a new approach to prevent cariogenesis. Microb Pathog 143:104129. https:\/\/doi.org\/10.1016\/j.micpath.2020.104129","journal-title":"Microb Pathog"},{"key":"3410_CR20","doi-asserted-by":"publisher","first-page":"6728","DOI":"10.1074\/jbc.M117.778308","volume":"292","author":"TY Hargrove","year":"2017","unstructured":"Hargrove TY, Friggeri L, Wawrzak Z et al (2017) Structural analyses of Candida albicans sterol 14\u03b1-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. J Biol Chem 292:6728\u20136743. https:\/\/doi.org\/10.1074\/jbc.M117.778308","journal-title":"J Biol Chem"},{"key":"3410_CR21","doi-asserted-by":"publisher","first-page":"108","DOI":"10.4236\/aim.2013.31017","volume":"03","author":"P Harikrishnan","year":"2013","unstructured":"Harikrishnan P, Subha TS, Kavitha V, Gnanamani A (2013) Microbial adhesion on orthodontic ligating materials: an <i>in vitro<\/i> assessment. Adv Microbiol 03:108\u2013114. https:\/\/doi.org\/10.4236\/aim.2013.31017","journal-title":"Adv Microbiol"},{"key":"3410_CR22","doi-asserted-by":"publisher","first-page":"8530","DOI":"10.1021\/acs.jafc.8b02117","volume":"66","author":"L-B Hu","year":"2018","unstructured":"Hu L-B, Ban F-F, Li H-B et al (2018) Thymol induces conidial apoptosis in Aspergillus flavus via stimulating k + eruption. J Agric Food Chem 66:8530\u20138536. https:\/\/doi.org\/10.1021\/acs.jafc.8b02117","journal-title":"J Agric Food Chem"},{"key":"3410_CR23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1266\/ggs.79.199","volume":"79","author":"M Iwase","year":"2004","unstructured":"Iwase M, Okada S, Oguchi T, Toh-e A (2004) Forchlorfenuron, a phenylurea cytokinin, disturbs septin organization in Saccharomyces cerevisiae. Genes Genet Syst 79:199\u2013206. https:\/\/doi.org\/10.1266\/ggs.79.199","journal-title":"Genes Genet Syst"},{"key":"3410_CR24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3201\/eid1001.030119","volume":"10","author":"MA Jabra-Rizk","year":"2004","unstructured":"Jabra-Rizk MA, Falkler WA, Meiller TF (2004) Fungal biofilms and drug resistance. Emerg Infect Dis 10:14\u201319. https:\/\/doi.org\/10.3201\/eid1001.030119","journal-title":"Emerg Infect Dis"},{"key":"3410_CR25","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1099\/jmm.0.000226","volume":"65","author":"KM James","year":"2016","unstructured":"James KM, MacDonald KW, Chanyi RM et al (2016) Inhibition of Candida albicans biofilm formation and modulation of gene expression by probiotic cells and supernatant. J Med Microbiol 65:328\u2013336. https:\/\/doi.org\/10.1099\/jmm.0.000226","journal-title":"J Med Microbiol"},{"key":"3410_CR26","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1093\/jac\/dkr512","volume":"67","author":"MSA Khan","year":"2012","unstructured":"Khan MSA, Ahmad I (2012) Antibiofilm activity of certain phytocompounds and their synergy with fluconazole against Candida albicans biofilms. J Antimicrob Chemother 67:618\u2013621. https:\/\/doi.org\/10.1093\/jac\/dkr512","journal-title":"J Antimicrob Chemother"},{"key":"3410_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02421","author":"I Khan","year":"2017","unstructured":"Khan I, Bahuguna A, Kumar P et al (2017) Antimicrobial potential of carvacrol against uropathogenic Escherichia coli via membrane disruption, depolarization, and reactive oxygen species generation. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2017.02421","journal-title":"Front Microbiol"},{"key":"3410_CR28","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.fbr.2017.06.001","volume":"31","author":"M Kieliszek","year":"2017","unstructured":"Kieliszek M, Kot AM, Bzducha-Wr\u00f3bel A et al (2017) Biotechnological use of Candida yeasts in the food industry: a review. Fungal Biol Rev 31:185\u2013198. https:\/\/doi.org\/10.1016\/j.fbr.2017.06.001","journal-title":"Fungal Biol Rev"},{"key":"3410_CR29","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1091\/mbc.e11-12-0994","volume":"23","author":"K Krumpe","year":"2012","unstructured":"Krumpe K, Frumkin I, Herzig Y et al (2012) Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell 23:3927\u20133935. https:\/\/doi.org\/10.1091\/mbc.e11-12-0994","journal-title":"Mol Biol Cell"},{"key":"3410_CR30","doi-asserted-by":"publisher","first-page":"17634","DOI":"10.1021\/acsomega.9b01482","volume":"4","author":"P Kumari","year":"2019","unstructured":"Kumari P, Arora N, Chatrath A et al (2019) Delineating the biofilm inhibition mechanisms of phenolic and aldehydic terpenes against Cryptococcus neoformans. ACS Omega 4:17634\u201317648. https:\/\/doi.org\/10.1021\/acsomega.9b01482","journal-title":"ACS Omega"},{"key":"3410_CR31","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1074\/jbc.M510317200","volume":"281","author":"GI Lepesheva","year":"2006","unstructured":"Lepesheva GI, Zaitseva NG, Nes WD et al (2006) CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B\u2019 helix defines substrate preferences of sterol 14\u03b1-demethylase. J Biol Chem 281:3577\u20133585. https:\/\/doi.org\/10.1074\/jbc.M510317200","journal-title":"J Biol Chem"},{"key":"3410_CR100","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"3410_CR32","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nrmicro.2017.107","volume":"16","author":"MB Lohse","year":"2018","unstructured":"Lohse MB, Gulati M, Johnson AD, Nobile CJ (2018) Development and regulation of single- and multi-species Candida albicans biofilms. Nat Rev Microbiol 16:19\u201331. https:\/\/doi.org\/10.1038\/nrmicro.2017.107","journal-title":"Nat Rev Microbiol"},{"key":"3410_CR33","doi-asserted-by":"publisher","first-page":"e0176755","DOI":"10.1371\/journal.pone.0176755","volume":"12","author":"F Madariaga-Venegas","year":"2017","unstructured":"Madariaga-Venegas F, Fern\u00e1ndez-Soto R, Duarte LF et al (2017) Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients. PLoS ONE 12:e0176755. https:\/\/doi.org\/10.1371\/journal.pone.0176755","journal-title":"PLoS ONE"},{"key":"3410_CR34","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4103\/0377-4929.94861","volume":"55","author":"T Menon","year":"2012","unstructured":"Menon T, Punithavathy P, Nalina K (2012) Antifungal susceptibility testing of Candida tropicalis biofilms against fluconazole using calorimetric indicator resazurin. Indian J Pathol Microbiol 55:72. https:\/\/doi.org\/10.4103\/0377-4929.94861","journal-title":"Indian J Pathol Microbiol"},{"key":"3410_CR35","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.diagmicrobio.2009.11.006","volume":"66","author":"F Morio","year":"2010","unstructured":"Morio F, Loge C, Besse B et al (2010) Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. Diagn Microbiol Infect Dis 66:373\u2013384. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2009.11.006","journal-title":"Diagn Microbiol Infect Dis"},{"key":"3410_CR36","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris GM, Huey R, Lindstrom W et al (2009) AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 30:2785\u20132791. https:\/\/doi.org\/10.1002\/jcc.21256","journal-title":"J Comput Chem"},{"key":"3410_CR37","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/S0925-4439(02)00087-X","volume":"1587","author":"J Morschh\u00e4user","year":"2002","unstructured":"Morschh\u00e4user J (2002) The genetic basis of fluconazole resistance development in Candida albicans. Biochim Biophys Acta 1587:240\u2013248. https:\/\/doi.org\/10.1016\/S0925-4439(02)00087-X","journal-title":"Biochim Biophys Acta"},{"key":"3410_CR38","doi-asserted-by":"publisher","first-page":"4333","DOI":"10.1128\/IAI.71.8.4333-4340.2003","volume":"71","author":"PK Mukherjee","year":"2003","unstructured":"Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA (2003) Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infect Immun 71:4333\u20134340. https:\/\/doi.org\/10.1128\/IAI.71.8.4333-4340.2003","journal-title":"Infect Immun"},{"key":"3410_CR39","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/pathogens5010033","volume":"5","author":"J Nett","year":"2016","unstructured":"Nett J (2016) The host\u2019s reply to Candida biofilm. Pathogens 5:33. https:\/\/doi.org\/10.3390\/pathogens5010033","journal-title":"Pathogens"},{"key":"3410_CR40","doi-asserted-by":"publisher","first-page":"e63","DOI":"10.1371\/journal.ppat.0020063","volume":"2","author":"CJ Nobile","year":"2006","unstructured":"Nobile CJ, Andes DR, Nett JE et al (2006) Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog 2:e63. https:\/\/doi.org\/10.1371\/journal.ppat.0020063","journal-title":"PLoS Pathog"},{"key":"3410_CR41","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nchembio709","volume":"1","author":"M Okada","year":"2005","unstructured":"Okada M, Sato I, Cho SJ et al (2005) Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX. Nat Chem Biol 1:23\u201324. https:\/\/doi.org\/10.1038\/nchembio709","journal-title":"Nat Chem Biol"},{"key":"3410_CR42","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1128\/AAC.47.3.956-964.2003","volume":"47","author":"C Onyewu","year":"2003","unstructured":"Onyewu C, Blankenship JR, Del Poeta M, Heitman J (2003) Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Antimicrob Agents Chemother 47:956\u2013964. https:\/\/doi.org\/10.1128\/AAC.47.3.956-964.2003","journal-title":"Antimicrob Agents Chemother"},{"key":"3410_CR43","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1574-6968.2002.tb11330.x","volume":"214","author":"G Ramage","year":"2002","unstructured":"Ramage G, VandeWalle K, Lopez-Ribot JL, Wickes BL (2002) The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans. FEMS Microbiol Lett 214:95\u2013100. https:\/\/doi.org\/10.1111\/j.1574-6968.2002.tb11330.x","journal-title":"FEMS Microbiol Lett"},{"key":"3410_CR44","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1080\/22311866.2013.817749","volume":"3","author":"JS Raut","year":"2013","unstructured":"Raut JS, Rajput SB, Shinde RB et al (2013) Vanillin inhibits growth, morphogenesis and biofilm formation by Candida albicans. J Biol Act Prod from Nat 3:130\u2013138. https:\/\/doi.org\/10.1080\/22311866.2013.817749","journal-title":"J Biol Act Prod from Nat"},{"key":"3410_CR45","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0022-1759(91)90114-U","volume":"142","author":"NW Roehm","year":"1991","unstructured":"Roehm NW, Rodgers GH, Hatfield SM, Glasebrook AL (1991) An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT. J Immunol Methods 142:257\u2013265. https:\/\/doi.org\/10.1016\/0022-1759(91)90114-U","journal-title":"J Immunol Methods"},{"key":"3410_CR46","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.plaphy.2017.09.016","volume":"120","author":"CS Schmidt","year":"2017","unstructured":"Schmidt CS, Mrnka L, Frant\u00edk T et al (2017) Combined effects of fungal inoculants and the cytokinin-like growth regulator thidiazuron on growth, phytohormone contents and endophytic root fungi in Miscanthus \u00d7 giganteus. Plant Physiol Biochem 120:120\u2013131. https:\/\/doi.org\/10.1016\/j.plaphy.2017.09.016","journal-title":"Plant Physiol Biochem"},{"key":"3410_CR47","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.3390\/molecules24112070","volume":"24","author":"G Simonetti","year":"2019","unstructured":"Simonetti G, Palocci C, Valletta A et al (2019) Anti-candida biofilm activity of pterostilbene or crude extract from non-fermented grape pomace entrapped in biopolymeric nanoparticles. Molecules 24:2070. https:\/\/doi.org\/10.3390\/molecules24112070","journal-title":"Molecules"},{"key":"3410_CR48","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.arcmed.2005.05.015","volume":"36","author":"CR Sims","year":"2005","unstructured":"Sims CR, Ostrosky-Zeichner L, Rex JH (2005) Invasive candidiasis in immunocompromised hospitalized patients. Arch Med Res 36:660\u2013671. https:\/\/doi.org\/10.1016\/j.arcmed.2005.05.015","journal-title":"Arch Med Res"},{"key":"3410_CR49","doi-asserted-by":"publisher","first-page":"13728","DOI":"10.1038\/s41598-020-70650-6","volume":"10","author":"RV Sionov","year":"2020","unstructured":"Sionov RV, Feldman M, Smoum R et al (2020) Anandamide prevents the adhesion of filamentous Candida albicans to cervical epithelial cells. Sci Rep 10:13728. https:\/\/doi.org\/10.1038\/s41598-020-70650-6","journal-title":"Sci Rep"},{"key":"3410_CR50","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1128\/IAI.70.2.921-927.2002","volume":"70","author":"P Staib","year":"2002","unstructured":"Staib P, Kretschmar M, Nichterlein T et al (2002) Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection. Infect Immun 70:921\u2013927. https:\/\/doi.org\/10.1128\/IAI.70.2.921-927.2002","journal-title":"Infect Immun"},{"key":"3410_CR51","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.micres.2017.11.002","volume":"207","author":"GA Subramenium","year":"2018","unstructured":"Subramenium GA, Swetha TK, Iyer PM et al (2018) 5-hydroxymethyl-2-furaldehyde from marine bacterium Bacillus subtilis inhibits biofilm and virulence of Candida albicans. Microbiol Res 207:19\u201332. https:\/\/doi.org\/10.1016\/j.micres.2017.11.002","journal-title":"Microbiol Res"},{"key":"3410_CR52","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/1471-2180-13-246","volume":"13","author":"S Theberge","year":"2013","unstructured":"Theberge S, Semlali A, Alamri A et al (2013) C. albicans growth, transition, biofilm formation, and gene expression modulation by antimicrobial decapeptide KSL-W. BMC Microbiol 13:246. https:\/\/doi.org\/10.1186\/1471-2180-13-246","journal-title":"BMC Microbiol"},{"key":"3410_CR53","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11240-009-9581-3","volume":"99","author":"G Thirukkumaran","year":"2009","unstructured":"Thirukkumaran G, Ntui VO, Khan RS, Mii M (2009) Thidiazuron: an efficient plant growth regulator for enhancing Agrobacterium-mediated transformation in Petunia hybrida. Plant Cell Tissue Organ Cult 99:109\u2013115. https:\/\/doi.org\/10.1007\/s11240-009-9581-3","journal-title":"Plant Cell Tissue Organ Cult"},{"key":"3410_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fmedt.2022.845322","author":"AK Verma","year":"2022","unstructured":"Verma AK, Majid A, Hossain MS et al (2022) Identification of 1,2,4-triazine and its derivatives against lanosterol 14-demethylase (CYP51) property of Candida albicans: influence on the development of new antifungal therapeutic strategies. Front Med Technol. https:\/\/doi.org\/10.3389\/fmedt.2022.845322","journal-title":"Front Med Technol"},{"key":"3410_CR55","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01333-14","author":"R Zarnowski","year":"2014","unstructured":"Zarnowski R, Westler WM, Lacmbouh GA et al (2014) Novel entries in a fungal biofilm matrix encyclopedia. Mbio. https:\/\/doi.org\/10.1128\/mBio.01333-14","journal-title":"Mbio"},{"key":"3410_CR56","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1186\/s12879-021-06295-1","volume":"21","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Cao Y, Li Y et al (2021) Risk factors and biofilm formation analyses of hospital-acquired infection of Candida pelliculosa in a neonatal intensive care unit. BMC Infect Dis 21:620. https:\/\/doi.org\/10.1186\/s12879-021-06295-1","journal-title":"BMC Infect Dis"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-022-03410-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-022-03410-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-022-03410-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T11:03:48Z","timestamp":1668423828000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11274-022-03410-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,17]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3410"],"URL":"https:\/\/doi.org\/10.1007\/s11274-022-03410-5","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"value":"0959-3993","type":"print"},{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,17]]},"assertion":[{"value":"22 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"224"}}