{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:24:54Z","timestamp":1784431494900,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s11274-022-03442-x","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T03:02:26Z","timestamp":1667876546000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An inhibitory effect of schisandrone on \u03b1-hemolysin expression to combat methicillin-resistant staphylococcus aureus infections"],"prefix":"10.1007","volume":"39","author":[{"given":"Yingxin","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"3442_CR1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00113-17","author":"NM Abraham","year":"2017","unstructured":"Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Fikrig E (2017) A tick antivirulence protein potentiates antibiotics against Staphylococcus aureus. Antimicrob Agents Chemother. https:\/\/doi.org\/10.1128\/AAC.00113-17","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"3442_CR2","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3390\/pathogens9050362","volume":"9","author":"AM Algammal","year":"2020","unstructured":"Algammal AM, Enany ME, El-Tarabili RM, Ghobashy MOI, Helmy YA (2020) Prevalence, antimicrobial resistance profiles, virulence and enterotoxins-determinant genes of MRSA isolated from subclinical bovine mastitis in Egypt. Pathogens 9(5):362. https:\/\/doi.org\/10.3390\/pathogens9050362","journal-title":"Pathogens"},{"key":"3442_CR3","doi-asserted-by":"publisher","first-page":"104912","DOI":"10.1016\/j.micpath.2021.104912","volume":"155","author":"V Anju","year":"2021","unstructured":"Anju V, Busi S, Ranganathan S, Ampasala DR, Kumar S, Suchiang K, Dyavaiah M (2021) Sesamin and sesamolin rescues Caenorhabditis elegans from Pseudomonas aeruginosa infection through the attenuation of quorum sensing regulated virulence factors. Microb Pathog 155:104912","journal-title":"Microb Pathog"},{"issue":"1","key":"3442_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-42853-z","volume":"9","author":"IF Bezar","year":"2019","unstructured":"Bezar IF, Mashruwala AA, Boyd JM, Stock AM (2019) Drug-like fragments inhibit agr-mediated virulence expression in Staphylococcus aureus. Sci Rep 9(1):1\u201314","journal-title":"Sci Rep"},{"issue":"4","key":"3442_CR5","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1128\/mr.55.4.733-751.1991","volume":"55","author":"S Bhakdi","year":"1991","unstructured":"Bhakdi S, Tranum-Jensen J (1991) Alpha-toxin of Staphylococcus aureus. Microbiol Rev 55(4):733\u2013751. https:\/\/doi.org\/10.1128\/mr.55.4.733-751.1991","journal-title":"Microbiol Rev"},{"issue":"1","key":"3442_CR6","doi-asserted-by":"publisher","first-page":"16907","DOI":"10.1038\/s41598-020-73796-5","volume":"10","author":"T Boonsiri","year":"2020","unstructured":"Boonsiri T, Watanabe S, Tan XE, Thitiananpakorn K, Narimatsu R, Sasaki K, Cui L (2020) Identification and characterization of mutations responsible for the beta-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus. Sci Rep 10(1):16907. https:\/\/doi.org\/10.1038\/s41598-020-73796-5","journal-title":"Sci Rep"},{"issue":"1","key":"3442_CR7","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1080\/21505594.2021.1878688","volume":"12","author":"GY Cheung","year":"2021","unstructured":"Cheung GY, Bae JS, Otto M (2021) Pathogenicity and virulence of Staphylococcus aureus. Virulence 12(1):547\u2013569","journal-title":"Virulence"},{"issue":"9","key":"3442_CR8","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1016\/j.celrep.2018.02.027","volume":"22","author":"TS Cohen","year":"2018","unstructured":"Cohen TS, Boland ML, Boland BB, Takahashi V, Tovchigrechko A, Lee Y, Tkaczyk C (2018) S. aureus evades macrophage killing through NLRP3-dependent effects on mitochondrial trafficking. Cell Rep 22(9):2431\u20132441","journal-title":"Cell Rep"},{"issue":"4","key":"3442_CR9","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3390\/antibiotics4040521","volume":"4","author":"C Cuny","year":"2015","unstructured":"Cuny C, Wieler LH, Witte WJA (2015) Livestock-associated MRSA: the impact on humans. Antibiotics 4(4):521\u2013543","journal-title":"Antibiotics"},{"issue":"1","key":"3442_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.tim.2013.10.004","volume":"22","author":"AL DuMont","year":"2014","unstructured":"DuMont AL, Torres VJ (2014) Cell targeting by the Staphylococcus aureus pore-forming toxins: it\u2019s not just about lipids. Trends Microbiol 22(1):21\u201327. https:\/\/doi.org\/10.1016\/j.tim.2013.10.004","journal-title":"Trends Microbiol"},{"issue":"473","key":"3442_CR11","doi-asserted-by":"publisher","first-page":"eaau3174","DOI":"10.1126\/scitranslmed.aau3174","volume":"11","author":"JM Dziekan","year":"2019","unstructured":"Dziekan JM, Yu H, Chen D, Dai L, Wirjanata G, Larsson A, Nordlund P (2019) Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay. Sci Transl Med 11(473):eaau3174","journal-title":"Sci Transl Med"},{"key":"3442_CR37","doi-asserted-by":"publisher","unstructured":"Gao J, Inagaki Y, Li X, Kokudo N, Tang W (2013) Research progress on natural products from traditional Chinese medicine in treatment of Alzheimer's disease. Drug Discov Ther. https:\/\/doi.org\/10.5582\/ddt.2013.v7.2.46","DOI":"10.5582\/ddt.2013.v7.2.46"},{"issue":"6","key":"3442_CR12","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1111\/cmi.12550","volume":"18","author":"O Goldmann","year":"2016","unstructured":"Goldmann O, Tuchscherr L, Rohde M, Medina E (2016) \u03b1-hemolysin enhances Staphylococcus aureus internalization and survival within mast cells by modulating the expression of \u03b21 integrin. Cell Microbiol 18(6):807\u2013819","journal-title":"Cell Microbiol"},{"issue":"17","key":"3442_CR13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.clinmicnews.2005.08.005","volume":"27","author":"JT Gray","year":"2005","unstructured":"Gray JT, Shryock TR, J. (2005) Antibiotic susceptibility testing of bacteria isolated from animals. Clin Microbiol Newslett 27(17):131\u2013135","journal-title":"Clin Microbiol Newslett"},{"issue":"45","key":"3442_CR14","doi-asserted-by":"publisher","first-page":"14036","DOI":"10.1073\/pnas.1509251112","volume":"112","author":"RK Gupta","year":"2015","unstructured":"Gupta RK, Luong TT, Lee CY (2015) RNAIII of the Staphylococcus aureus agr system activates global regulator MgrA by stabilizing mRNA. Proc Natl Acad Sci USA 112(45):14036\u201314041. https:\/\/doi.org\/10.1073\/pnas.1509251112","journal-title":"Proc Natl Acad Sci USA"},{"key":"3442_CR15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jiph.2014.03.008","volume":"7","author":"E Huang","year":"2014","unstructured":"Huang E, Gurzau AE, Hanson BM, Kates AE, Smith TC, Pettigrew MM, Health P (2014) Detection of livestock-associated methicillin-resistant Staphylococcus aureus among swine workers in Romania. J Infect Public Health 7:323\u20133324","journal-title":"J Infect Public Health"},{"key":"3442_CR16","volume-title":"Influence of schisandrone on levels of IL-1? and iNOS mRNA in hippocampus of rats with Alzheimer-like disease","author":"L Jia","year":"1982","unstructured":"Jia L, Tuo X, Zhu J, Zhou J (1982) Influence of schisandrone on levels of IL-1? and iNOS mRNA in hippocampus of rats with Alzheimer-like disease. Academic Journal of Second Military Medical University, Shanghai"},{"issue":"2\u20133","key":"3442_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ejphar.2003.08.079","volume":"478","author":"CA Kassuya","year":"2003","unstructured":"Kassuya CA, Silvestre AA, Rehder VLG, Calixto JB (2003) Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. Eur J Pharmacol 478(2\u20133):145\u2013153","journal-title":"Eur J Pharmacol"},{"key":"3442_CR18","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.freeradbiomed.2021.05.019","volume":"171","author":"AM Kimura","year":"2021","unstructured":"Kimura AM, Tsuji M, Yasumoto T, Mori Y, Oguchi T, Tsuji Y, Nakamura S (2021) Myricetin prevents high molecular weight A\u03b21\u201342 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria. Free Radic Biol Med 171:232\u2013244","journal-title":"Free Radic Biol Med"},{"key":"3442_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8030072","author":"C Kong","year":"2016","unstructured":"Kong C, Neoh HM, Nathan S (2016) Targeting staphylococcus aureus toxins: a potential form of anti-virulence therapy. Toxins (Basel). https:\/\/doi.org\/10.3390\/toxins8030072","journal-title":"Toxins (Basel)"},{"issue":"03","key":"3442_CR20","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1055\/s-2007-969461","volume":"51","author":"L Lian-niang","year":"1985","unstructured":"Lian-niang L, Hung X (1985) Schisandrone, a new 4-aryltetralone lignan from Schisandra sphenanthera. Planta Med 51(03):217\u2013219","journal-title":"Planta Med"},{"issue":"4","key":"3442_CR21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TDJM (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 \u2013 \u2206\u2206 method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"key":"3442_CR22","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnw253","author":"S-H Mun","year":"2016","unstructured":"Mun S-H, Kong R, Seo Y-S, Zhou T, Kang O-H, Shin D-W, Kwon D-Y (2016) Subinhibitory concentrations of punicalagin reduces expression of virulence-related exoproteins by Staphylococcus aureus. FEMS Microbiol Lett. https:\/\/doi.org\/10.1093\/femsle\/fnw253","journal-title":"FEMS Microbiol Lett"},{"issue":"5","key":"3442_CR23","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1093\/jb\/mvh160","volume":"136","author":"VT Nguyen","year":"2004","unstructured":"Nguyen VT, Kamio Y (2004) Cooperative assembly of beta-barrel pore-forming toxins. J Biochem 136(5):563\u2013567. https:\/\/doi.org\/10.1093\/jb\/mvh160","journal-title":"J Biochem"},{"issue":"10","key":"3442_CR24","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1111\/j.1462-5822.2012.01832.x","volume":"14","author":"M Otto","year":"2012","unstructured":"Otto M (2012) MRSA virulence and spread. Cell Microbiol 14(10):1513\u20131521. https:\/\/doi.org\/10.1111\/j.1462-5822.2012.01832.x","journal-title":"Cell Microbiol"},{"key":"3442_CR25","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1007\/s10482-016-0690-9","volume":"109","author":"P Ouyang","year":"2016","unstructured":"Ouyang P, Chen J, Sun M, Yin Z, Lin J, Fu H, Deng XJA, v. L, (2016) Imperatorin inhibits the expression of alpha-hemolysin in Staphylococcus aureus strain BAA-1717 USA300. Antonie Van Leeuwenhoek 109:915\u2013922","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"6","key":"3442_CR26","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1159\/000319855","volume":"2","author":"YY Pang","year":"2010","unstructured":"Pang YY, Schwartz J, Thoendel M, Ackermann LW, Horswill AR, Nauseef WM (2010) agr-Dependent interactions of Staphylococcus aureus USA300 with human polymorphonuclear neutrophils. J Innate Immun 2(6):546\u2013559. https:\/\/doi.org\/10.1159\/000319855","journal-title":"J Innate Immun"},{"issue":"2","key":"3442_CR27","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.1574-6968.2010.02183.x","volume":"315","author":"J Qiu","year":"2011","unstructured":"Qiu J, Xiang H, Hu C, Wang Q, Dong J, Li H, Deng X (2011) Subinhibitory concentrations of farrerol reduce \u03b1-toxin expression in Staphylococcus aureus. FEMS Microbiol Lett 315(2):129\u2013133","journal-title":"FEMS Microbiol Lett"},{"issue":"2","key":"3442_CR28","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nrd3013","volume":"9","author":"DA Rasko","year":"2010","unstructured":"Rasko DA, Sperandio V (2010) Anti-virulence strategies to combat bacteria-mediated disease. Nat Rev Drug Discovery 9(2):117\u2013128","journal-title":"Nat Rev Drug Discovery"},{"issue":"7","key":"3442_CR29","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.bcp.2005.12.016","volume":"71","author":"SB Singh","year":"2006","unstructured":"Singh SB, Barrett JF (2006) Empirical antibacterial drug discovery\u2014foundation in natural products. Biochem Pharmacol 71(7):1006\u20131015","journal-title":"Biochem Pharmacol"},{"issue":"14","key":"3442_CR30","doi-asserted-by":"publisher","first-page":"4555","DOI":"10.1016\/j.bmcl.2012.05.112","volume":"22","author":"T-D Tran","year":"2012","unstructured":"Tran T-D, Do T-H, Tran N-C, Ngo T-D, Tran C-D, Thai K-MJB (2012) Synthesis and anti methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. Bioorganic Med Chem Lett 22(14):4555\u20134560","journal-title":"Bioorganic Med Chem Lett"},{"key":"3442_CR31","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1017\/S0950268809991567","volume":"138","author":"W Vanderhaeghen","year":"2010","unstructured":"Vanderhaeghen W, Hermans K, Haesebrouck F, Butaye PJE, Infection, (2010) Methicillin-resistant Staphylococcus aureus (MRSA) in food production animals. Epidemiol Infect 138:606\u20136255","journal-title":"Epidemiol Infect"},{"key":"3442_CR32","first-page":"135","volume":"112\u2013115","author":"P Wang","year":"2018","unstructured":"Wang P, Li W, Peng X, Zheng W, JIN YJJ o. P. P. (2018) Synthesis and anti-oxidation activity of schisandrone derivatives. J Pharm Pract 112\u2013115:135","journal-title":"J Pharm Pract"},{"key":"3442_CR33","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3389\/fcimb.2020.00330","volume":"10","author":"T Wang","year":"2020","unstructured":"Wang T, Zhang P, Lv H, Deng X, Wang J (2020) A natural dietary flavone myricetin as an alpha-hemolysin inhibitor for controlling Staphylococcus aureus infection. Front Cell Infect Microbiol 10:330. https:\/\/doi.org\/10.3389\/fcimb.2020.00330","journal-title":"Front Cell Infect Microbiol"},{"issue":"48","key":"3442_CR34","doi-asserted-by":"publisher","first-page":"13195","DOI":"10.1021\/acs.jafc.9b05595","volume":"67","author":"SC Wu","year":"2019","unstructured":"Wu SC, Liu F, Zhu K, Shen JZ (2019) Natural products that target virulence factors in antibiotic-resistant Staphylococcus aureus. J Agric Food Chem 67(48):13195\u201313211. https:\/\/doi.org\/10.1021\/acs.jafc.9b05595","journal-title":"J Agric Food Chem"},{"key":"3442_CR35","first-page":"1351","volume-title":"Schisandrone improves learning and memory abilities of Alzheimer-like rats and influences expression of NF-\u03baB, iNOS in rat hippocampus","author":"F YU","year":"2010","unstructured":"YU F (2010) Schisandrone improves learning and memory abilities of Alzheimer-like rats and influences expression of NF-\u03baB, iNOS in rat hippocampus. Academic Journal of Second Military Medical University, Shanghai, pp 1351\u20131355"},{"key":"3442_CR36","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.3389\/fmicb.2017.01715","volume":"8","author":"B Zhang","year":"2017","unstructured":"Zhang B, Teng Z, Li X, Lu G, Deng X, Niu X, Wang J (2017) Chalcone attenuates Staphylococcus aureus virulence by targeting sortase A and alpha-hemolysin. Front Microbiol 8:1715. https:\/\/doi.org\/10.3389\/fmicb.2017.01715","journal-title":"Front Microbiol"},{"issue":"8","key":"3442_CR38","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1007\/s11274-015-1879-1","volume":"31","author":"X Zhou","year":"2015","unstructured":"Zhou X, Liu S, Li W, Zhang B, Liu B, Liu Y, Peng L (2015) Phloretin derived from apple can reduce alpha-hemolysin expression in methicillin-resistant Staphylococcus aureus USA300. World J Microbiol Biotechnol 31(8):1259\u20131265. https:\/\/doi.org\/10.1007\/s11274-015-1879-1","journal-title":"World J Microbiol Biotechnol"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-022-03442-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-022-03442-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-022-03442-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T15:48:04Z","timestamp":1673365684000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11274-022-03442-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,8]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["3442"],"URL":"https:\/\/doi.org\/10.1007\/s11274-022-03442-x","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"value":"0959-3993","type":"print"},{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,8]]},"assertion":[{"value":"27 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"3"}}