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These bactericidal antibiotics were used as first-line treatments for several decades but were largely replaced by \u00df-lactams and fluoroquinolones in the 1980s, although widespread emergence of antibiotic-resistance has led to renewed interest in aminoglycosides. The primary site of action for aminoglycosides is the 30\u00a0S ribosomal subunit where they disrupt protein translation, which contributes to widespread cellular damage through a number of secondary effects including rapid uptake of aminoglycosides via elevated proton-motive force (PMF), membrane damage and breakdown, oxidative stress, and hyperpolarisation of the membrane. Several factors associated with aminoglycoside entry have been shown to impact upon bacterial killing, and more recent work has revealed a complex relationship between metabolic states and the efficacy of different aminoglycosides. Hence, it is imperative to consider the environmental conditions and bacterial physiology and how this can impact upon aminoglycoside entry and potency. This mini-review seeks to discuss recent advances in this area and how this might affect the future use of aminoglycosides.\n                  <\/jats:p>","DOI":"10.1007\/s11274-022-03445-8","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:03:30Z","timestamp":1667952210000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy"],"prefix":"10.1007","volume":"39","author":[{"given":"Calum M.","family":"Webster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"3445_CR1","doi-asserted-by":"publisher","first-page":"4636","DOI":"10.1128\/AAC.00572-10","volume":"54","author":"JB Aggen","year":"2010","unstructured":"Aggen JB, Armstrong ES, Goldblum AA et al (2010) Synthesis and spectrum of the neoglycoside ACHN-490. 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