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Gerbils inoculated with <jats:italic>H. pylori<\/jats:italic> exhibited the presence of this bacterium, as revealed by the expression of some virulence factors, as CagA and OMPs in stomach and pancreas, and confirmed by urease activity, bacterial culture, PCR and immunofluorescence assays. Non-apparent morphological changes were observed in pancreatic tissue of infected animals; however, delocalization of intercellular junction proteins (claudin-1, claudin-4, occludin, ZO-1, E-cadherin, \u03b2-catenin, desmoglein-2 and desmoplakin I\/II) and rearrangement of the actin-cytoskeleton were exhibited. This structural damage was consistent with alterations in the distribution of insulin and glucagon, and a systemic inflammation, event demonstrated by elevated IL-8 levels. Overall, these findings indicate that <jats:italic>H. pylori<\/jats:italic> can reach the pancreas, possibly affecting its function and contributing to the development of pancreatic diseases.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s11274-024-04081-0","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T02:01:30Z","timestamp":1721440890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Helicobacter pylori infection alters the intercellular junctions on the pancreas of gerbils (Meriones unguiculatus)"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4055-3678","authenticated-orcid":false,"given":"Edgar G.","family":"Hurtado-Monz\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5979-6652","authenticated-orcid":false,"given":"Pedro","family":"Valencia-Mayoral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica","family":"Silva-Olivares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8168-4488","authenticated-orcid":false,"given":"Cecilia","family":"Ba\u00f1uelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-7260","authenticated-orcid":false,"given":"Norma","family":"Vel\u00e1zquez-Guadarrama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-0481","authenticated-orcid":false,"given":"Abigail","family":"Betanzos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"4081_CR1","first-page":"81","volume":"12","author":"N Ahmed","year":"2013","unstructured":"Ahmed N, Ali Khan MS, Mat Jais AM et al (2013) Anti-ulcer activity of sandalwood (Santalum album L.) stem hydro-alcoholic extract in three gastric-ulceration models of wistar rats. 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