{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:20:03Z","timestamp":1792783203442,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2021YFC2301004"],"award-info":[{"award-number":["2021YFC2301004"]}]},{"name":"National Key Inspection Specialty Construction projects"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s11274-024-04128-2","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T04:04:08Z","timestamp":1726459448000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adaptive physiological and metabolic alterations in Staphylococcus aureus evolution under vancomycin exposure"],"prefix":"10.1007","volume":"40","author":[{"given":"Xin","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuilong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"4128_CR1","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/infdis\/jiu007","volume":"209","author":"W Abdelhady","year":"2014","unstructured":"Abdelhady W, Bayer AS, Seidl K et al (2014) Impact of vancomycin on sarA-mediated biofilm formation: role in persistent endovascular infections due to methicillin-resistant Staphylococcus aureus. J Infect Dis 209:1231\u20131240. https:\/\/doi.org\/10.1093\/infdis\/jiu007","journal-title":"J Infect Dis"},{"key":"4128_CR2","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/nbt823","volume":"21","author":"J Allen","year":"2003","unstructured":"Allen J, Davey HM, Broadhurst D et al (2003) High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat Biotechnol 21:692\u2013696. https:\/\/doi.org\/10.1038\/nbt823","journal-title":"Nat Biotechnol"},{"key":"4128_CR3","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1099\/jmm.0.000988","volume":"68","author":"MDS Basco","year":"2019","unstructured":"Basco MDS, Kothari A, McKinzie PB et al (2019) Reduced vancomycin susceptibility and increased macrophage survival in Staphylococcus aureus strains sequentially isolated from a bacteraemic patient during a short course of antibiotic therapy. J Med Microbiol 68:848\u2013859. https:\/\/doi.org\/10.1099\/jmm.0.000988","journal-title":"J Med Microbiol"},{"key":"4128_CR4","doi-asserted-by":"publisher","first-page":"e00146","DOI":"10.1128\/IAI.00146-21","volume":"89","author":"WN Beavers","year":"2021","unstructured":"Beavers WN, DuMont AL, Monteith AJ et al (2021) Staphylococcus aureus peptide methionine sulfoxide reductases protect from human whole-blood killing. Infect Immun 89:e00146-e221. https:\/\/doi.org\/10.1128\/IAI.00146-21","journal-title":"Infect Immun"},{"issue":"5","key":"4128_CR5","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1128\/JCM.06307-11","volume":"50","author":"V Cafiso","year":"2012","unstructured":"Cafiso V, Bertuccio T, Spina D, Purrello S, Blandino G, Stefani S (2012) A novel \u03b4-hemolysis screening method for detecting heteroresistant vancomycin-intermediate Staphylococcus aureus and vancomycin-intermediate S. aureus. J Clin Microbiol 50(5):1742","journal-title":"J Clin Microbiol"},{"key":"4128_CR6","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.diagmicrobio.2014.12.006","volume":"81","author":"S-C Chang","year":"2015","unstructured":"Chang S-C, Liu T-P, Chen C-J et al (2015a) Detection of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates using a combination of \u03b4-hemolysis assay and Etest. Diagn Microbiol Infect Dis 81:246\u2013250. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2014.12.006","journal-title":"Diagn Microbiol Infect Dis"},{"key":"4128_CR7","doi-asserted-by":"publisher","first-page":"7906","DOI":"10.1128\/AAC.00568-15","volume":"59","author":"W Chang","year":"2015","unstructured":"Chang W, Ding D, Zhang S et al (2015b) Methicillin-resistant Staphylococcus aureus grown on vancomycin-supplemented screening agar displays enhanced biofilm formation. Antimicrob Agents Chemother 59:7906\u20137910. https:\/\/doi.org\/10.1128\/AAC.00568-15","journal-title":"Antimicrob Agents Chemother"},{"key":"4128_CR8","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1086\/381093","volume":"38","author":"PGP Charles","year":"2004","unstructured":"Charles PGP, Ward PB, Johnson PDR et al (2004) Clinical features associated with bacteremia due to heterogeneous vancomycin-intermediate Staphylococcus aureus. Clin Infect Dis 38:448\u2013451. https:\/\/doi.org\/10.1086\/381093","journal-title":"Clin Infect Dis"},{"key":"4128_CR9","doi-asserted-by":"publisher","first-page":"116180","DOI":"10.1016\/j.diagmicrobio.2024.116180","volume":"108","author":"X Cheng","year":"2024","unstructured":"Cheng X, Ma L, Wang Y et al (2024a) Prevalence and molecular characteristics of heterogeneous vancomycin intermediate Staphylococcus aureus in a tertiary care center of northern China. Diagn Microbiol Infect Dis 108:116180. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2024.116180","journal-title":"Diagn Microbiol Infect Dis"},{"key":"4128_CR10","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s42770-023-01192-y","volume":"55","author":"X Cheng","year":"2024","unstructured":"Cheng X, Wang Y, Ma J et al (2024b) Resistance phenotype and genetic features of a heterogeneous vancomycin intermediate\u2013resistant Staphylococcus aureus strain from an immunocompromised patient. Braz J Microbiol 55:323\u2013332. https:\/\/doi.org\/10.1007\/s42770-023-01192-y","journal-title":"Braz J Microbiol"},{"key":"4128_CR11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00797","author":"F Choueiry","year":"2023","unstructured":"Choueiry F, Xu R, Zhu J (2023) Adaptive metabolism of Staphylococcus aureus revealed by untargeted metabolomics. J Proteome Res. https:\/\/doi.org\/10.1021\/acs.jproteome.1c00797","journal-title":"J Proteome Res"},{"key":"4128_CR12","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3389\/fmicb.2019.01222","volume":"10","author":"Y Dai","year":"2019","unstructured":"Dai Y, Gao C, Chen L et al (2019) Heterogeneous vancomycin-intermediate Staphylococcus aureus uses the VraSR regulatory system to modulate autophagy for increased intracellular survival in macrophage-like cell line RAW264.7. Front Microbiol 10:1222. https:\/\/doi.org\/10.3389\/fmicb.2019.01222","journal-title":"Front Microbiol"},{"key":"4128_CR13","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.112-1241997","author":"K Dettmer","year":"2004","unstructured":"Dettmer K, Hammock BD (2004) Metabolomics\u2013a new exciting field within the \u201comics\u201d sciences. Environ Health Perspect. https:\/\/doi.org\/10.1289\/ehp.112-1241997","journal-title":"Environ Health Perspect"},{"key":"4128_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1089\/mdr.2016.0160","volume":"23","author":"S Di Gregorio","year":"2017","unstructured":"Di Gregorio S, Fernandez S, Cuirolo A et al (2017) Different vancomycin-intermediate Staphylococcus aureus phenotypes selected from the same ST100-hVISA parental strain. Microb Drug Resist 23:44\u201350. https:\/\/doi.org\/10.1089\/mdr.2016.0160","journal-title":"Microb Drug Resist"},{"key":"4128_CR15","doi-asserted-by":"publisher","first-page":"5404","DOI":"10.1128\/JB.00948-12","volume":"194","author":"AM Edwards","year":"2012","unstructured":"Edwards AM (2012) Phenotype switching is a natural consequence of Staphylococcus aureus replication. J Bacteriol 194:5404\u20135412. https:\/\/doi.org\/10.1128\/JB.00948-12","journal-title":"J Bacteriol"},{"key":"4128_CR16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/978-94-010-0448-0_11","volume-title":"Functional genomics","author":"O Fiehn","year":"2002","unstructured":"Fiehn O (2002) Metabolomics\u2014the link between genotypes and phenotypes. In: Town C (ed) Functional genomics. Springer, Dordrecht, pp 155\u2013171"},{"key":"4128_CR17","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s10096-009-0741-5","volume":"28","author":"RKC Fong","year":"2009","unstructured":"Fong RKC, Low J, Koh TH, Kurup A (2009) Clinical features and treatment outcomes of vancomycin-intermediate Staphylococcus aureus (VISA) and heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) in a tertiary care institution in Singapore. Eur J Clin Microbiol Infect Dis 28:983\u2013987. https:\/\/doi.org\/10.1007\/s10096-009-0741-5","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"4128_CR18","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.micinf.2019.04.003","volume":"21","author":"C Gao","year":"2019","unstructured":"Gao C, Dai Y, Chang W et al (2019) VraSR has an important role in immune evasion of Staphylococcus aureus with low level vancomycin resistance. Microbes Infect 21:361\u2013367. https:\/\/doi.org\/10.1016\/j.micinf.2019.04.003","journal-title":"Microbes Infect"},{"key":"4128_CR19","doi-asserted-by":"publisher","first-page":"e01608","DOI":"10.1128\/AAC.01608-17","volume":"62","author":"SG Gardner","year":"2018","unstructured":"Gardner SG, Marshall DD, Daum RS et al (2018) Metabolic mitigation of Staphylococcus aureus vancomycin intermediate-level susceptibility. Antimicrob Agents Chemother 62:e01608-e1617. https:\/\/doi.org\/10.1128\/AAC.01608-17","journal-title":"Antimicrob Agents Chemother"},{"key":"4128_CR20","doi-asserted-by":"publisher","first-page":"5668","DOI":"10.3390\/molecules28155668","volume":"28","author":"S Gu","year":"2023","unstructured":"Gu S, Fan B, Wan F et al (2023) Antibacterial activity and mechanism of canagliflozin against methicillin-resistant Staphylococcus aureus. Molecules 28:5668. https:\/\/doi.org\/10.3390\/molecules28155668","journal-title":"Molecules"},{"key":"4128_CR21","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1021\/acsinfecdis.2c00453","volume":"8","author":"MA Guevara","year":"2022","unstructured":"Guevara MA, Francis JD, Lu J et al (2022) Streptococcus agalactiae cadD is critical for pathogenesis in the invertebrate Galleria mellonella model. ACS Infect Dis 8:2405\u20132412. https:\/\/doi.org\/10.1021\/acsinfecdis.2c00453","journal-title":"ACS Infect Dis"},{"key":"4128_CR22","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3390\/ijms23031241","volume":"23","author":"H Guo","year":"2022","unstructured":"Guo H, Tong Y, Cheng J et al (2022) Biofilm and small colony variants\u2014an update on Staphylococcus aureus strategies toward drug resistance. IJMS 23:1241. https:\/\/doi.org\/10.3390\/ijms23031241","journal-title":"IJMS"},{"key":"4128_CR23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/jac\/42.2.199","volume":"42","author":"H Hanaki","year":"1998","unstructured":"Hanaki H (1998) Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50. J Antimicrob Chemother 42:199\u2013209. https:\/\/doi.org\/10.1093\/jac\/42.2.199","journal-title":"J Antimicrob Chemother"},{"key":"4128_CR24","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00364-10","author":"P Houston","year":"2011","unstructured":"Houston P, Rowe SE, Pozzi C et al (2011) Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype. Infect Immun. https:\/\/doi.org\/10.1128\/IAI.00364-10","journal-title":"Infect Immun"},{"key":"4128_CR25","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1128\/AAC.00422-06","volume":"50","author":"BP Howden","year":"2006","unstructured":"Howden BP, Johnson PDR, Ward PB et al (2006) Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 50:3039\u20133047. https:\/\/doi.org\/10.1128\/AAC.00422-06","journal-title":"Antimicrob Agents Chemother"},{"key":"4128_CR26","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.meegid.2013.03.047","volume":"21","author":"BP Howden","year":"2014","unstructured":"Howden BP, Peleg AY, Stinear TP (2014) The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA. Infect Genet Evol 21:575\u2013582. https:\/\/doi.org\/10.1016\/j.meegid.2013.03.047","journal-title":"Infect Genet Evol"},{"key":"4128_CR27","doi-asserted-by":"publisher","first-page":"e73300","DOI":"10.1371\/journal.pone.0073300","volume":"8","author":"J Hu","year":"2013","unstructured":"Hu J, Ma XX, Tian Y et al (2013) Reduced vancomycin susceptibility found in methicillin-resistant and methicillin-sensitive Staphylococcus aureus clinical isolates in Northeast China. PLoS ONE 8:e73300. https:\/\/doi.org\/10.1371\/journal.pone.0073300","journal-title":"PLoS ONE"},{"key":"4128_CR28","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.GPP3-0031-2018","author":"C Jenul","year":"2019","unstructured":"Jenul C, Horswill AR (2019) Regulation of Staphylococcus aureus virulence. Microbiol Spectr. https:\/\/doi.org\/10.1128\/microbiolspec.GPP3-0031-2018","journal-title":"Microbiol Spectr"},{"key":"4128_CR29","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.meegid.2013.05.016","volume":"21","author":"BC Kahl","year":"2014","unstructured":"Kahl BC (2014) Small colony variants (SCVs) of Staphylococcus aureus\u2014a bacterial survival strategy. Infect Genet Evol 21:515\u2013522. https:\/\/doi.org\/10.1016\/j.meegid.2013.05.016","journal-title":"Infect Genet Evol"},{"key":"4128_CR30","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/jac\/dkp394","volume":"65","author":"Y Kato","year":"2010","unstructured":"Kato Y, Suzuki T, Ida T, Maebashi K (2010) Genetic changes associated with glycopeptide resistance in Staphylococcus aureus: predominance of amino acid substitutions in YvqF\/VraSR. J Antimicrob Chemother 65:37\u201345. https:\/\/doi.org\/10.1093\/jac\/dkp394","journal-title":"J Antimicrob Chemother"},{"key":"4128_CR31","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/S0140-6736(97)07324-8","volume":"350","author":"H Keiichi","year":"1997","unstructured":"Keiichi H, Aritaka N, Hanaki H et al (1997) Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. The Lancet 350:1670\u20131673. https:\/\/doi.org\/10.1016\/S0140-6736(97)07324-8","journal-title":"The Lancet"},{"issue":"4","key":"4128_CR32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3389\/fcimb.2014.00141","volume":"21","author":"A Kriegeskorte","year":"2014","unstructured":"Kriegeskorte A, Grubm\u00fcller S, Huber C, Kahl BC, von Eiff C, Proctor RA, Peters G, Eisenreich W, Becker K (2014) Staphylococcus aureus small colony variants show common metabolic features in central metabolism irrespective of the underlying auxotrophism. Front Cell Infect Microbiol 21(4):141. https:\/\/doi.org\/10.3389\/fcimb.2014.00141","journal-title":"Front Cell Infect Microbiol"},{"key":"4128_CR33","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3390\/antibiotics10050583","volume":"10","author":"R Lamichhane-Khadka","year":"2021","unstructured":"Lamichhane-Khadka R, Dulal S, Cuaron J et al (2021) Apt (adenine phosphoribosyltransferase) mutation in laboratory-selected vancomycin-intermediate Staphylococcus aureus. Antibiotics 10:583. https:\/\/doi.org\/10.3390\/antibiotics10050583","journal-title":"Antibiotics"},{"key":"4128_CR34","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1039\/D2MO00229A","volume":"18","author":"J Liu","year":"2022","unstructured":"Liu J, Qi M, Yuan Z et al (2022) Nontargeted metabolomics reveals differences in the metabolite profiling among methicillin-resistant and methicillin-susceptible Staphylococcus aureus in response to antibiotics. Mol Omics 18:948\u2013956. https:\/\/doi.org\/10.1039\/D2MO00229A","journal-title":"Mol Omics"},{"key":"4128_CR35","doi-asserted-by":"publisher","first-page":"e01898","DOI":"10.1128\/spectrum.01898-22","volume":"11","author":"S Liu","year":"2023","unstructured":"Liu S, Chen H, Chen J et al (2023) Transcriptome and proteome of methicillin-resistant Staphylococcus aureus small-colony variants reveal changed metabolism and increased immune evasion. Microbiol Spectr 11:e01898-e1922. https:\/\/doi.org\/10.1128\/spectrum.01898-22","journal-title":"Microbiol Spectr"},{"key":"4128_CR36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808203390806","author":"FD Lowy","year":"1998","unstructured":"Lowy FD (1998) Staphylococcus aureus Infections. N Engl J Med. https:\/\/doi.org\/10.1056\/NEJM199808203390806","journal-title":"N Engl J Med"},{"key":"4128_CR37","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1086\/596629","volume":"199","author":"Y Maor","year":"2009","unstructured":"Maor Y, Hagin M, Belausov N et al (2009) Clinical features of heteroresistant vancomycin-intermediate Staphylococcus aureus bacteremia versus those of methicillin-resistant S. aureus bacteremia. J Infect Dis 199:619\u2013624. https:\/\/doi.org\/10.1086\/596629","journal-title":"J Infect Dis"},{"key":"4128_CR38","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1099\/jmm.0.029421-0","volume":"61","author":"L M\u00e9hes","year":"2012","unstructured":"M\u00e9hes L, Task\u00f3 S, Sz\u00e9kely A et al (2012) Phagocytosis and intracellular killing of heterogeneous vancomycin-intermediate Staphylococcus aureus strains. J Med Microbiol 61:198\u2013203. https:\/\/doi.org\/10.1099\/jmm.0.029421-0","journal-title":"J Med Microbiol"},{"key":"4128_CR39","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.VMBF-0027-2015","author":"KD Passalacqua","year":"2016","unstructured":"Passalacqua KD, Charbonneau M-E, O\u2019Riordan MXD (2016) Bacterial metabolism shapes the host-pathogen interface. Microbiol Spectr. https:\/\/doi.org\/10.1128\/microbiolspec.VMBF-0027-2015","journal-title":"Microbiol Spectr"},{"issue":"4","key":"4128_CR40","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1086\/596511","volume":"199","author":"AY Peleg","year":"2009","unstructured":"Peleg AY, Monga D, Pillai S, Mylonakis E, Moellering RC Jr, Eliopoulos GM (2009) Reduced susceptibility to vancomycin influences pathogenicity in Staphylococcus aureus infection. J Infect Dis 199(4):532","journal-title":"J Infect Dis"},{"key":"4128_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.620339","author":"GR Pidwill","year":"2021","unstructured":"Pidwill GR (2021) The role of macrophages in Staphylococcus aureus infection. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2020.620339","journal-title":"Front Immunol"},{"key":"4128_CR42","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41564-022-01080-5","volume":"7","author":"G Rosenberg","year":"2022","unstructured":"Rosenberg G, Riquelme S, Prince A, Avraham R (2022) Immunometabolic crosstalk during bacterial infection. Nat Microbiol 7:497\u2013507. https:\/\/doi.org\/10.1038\/s41564-022-01080-5","journal-title":"Nat Microbiol"},{"key":"4128_CR43","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1128\/AAC.46.5.1492-1502.2002","volume":"46","author":"G Sakoulas","year":"2002","unstructured":"Sakoulas G, Eliopoulos GM, Moellering RC et al (2002) Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin. Antimicrob Agents Chemother 46:1492\u20131502. https:\/\/doi.org\/10.1128\/AAC.46.5.1492-1502.2002","journal-title":"Antimicrob Agents Chemother"},{"key":"4128_CR44","doi-asserted-by":"publisher","first-page":"3540","DOI":"10.1128\/AAC.46.11.3540-3548.2002","volume":"46","author":"F Schaaff","year":"2002","unstructured":"Schaaff F, Reipert A, Bierbaum G (2002) An elevated mutation frequency favors development of vancomycin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 46:3540\u20133548. https:\/\/doi.org\/10.1128\/AAC.46.11.3540-3548.2002","journal-title":"Antimicrob Agents Chemother"},{"key":"4128_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00598","author":"C Shi","year":"2018","unstructured":"Shi C (2018) Genetic and virulent difference between pigmented and non-pigmented Staphylococcus aureus. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2018.00598","journal-title":"Front Microbiol"},{"key":"4128_CR46","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ijfoodmicro.2011.05.008","volume":"148","author":"AK Singh","year":"2011","unstructured":"Singh AK, Ulanov AV, Li Z et al (2011) Metabolomes of the psychrotolerant bacterium Listeria monocytogenes 10403S grown at 37\u00a0\u00b0C and 8\u00a0\u00b0C. Int J Food Microbiol 148:107\u2013114. https:\/\/doi.org\/10.1016\/j.ijfoodmicro.2011.05.008","journal-title":"Int J Food Microbiol"},{"key":"4128_CR47","doi-asserted-by":"publisher","first-page":"709841","DOI":"10.3389\/fmicb.2021.709841","volume":"12","author":"Y Sun","year":"2021","unstructured":"Sun Y, Liu M, Niu M, Zhao X (2021) Phenotypic switching of Staphylococcus aureus Mu50 into a large colony variant enhances heritable resistance against \u03b2-lactam antibiotics. Front Microbiol 12:709841. https:\/\/doi.org\/10.3389\/fmicb.2021.709841","journal-title":"Front Microbiol"},{"key":"4128_CR48","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nrmicro2508","volume":"9","author":"GE Thwaites","year":"2011","unstructured":"Thwaites GE, Gant V (2011) Are bloodstream leukocytes trojan horses for the metastasis of Staphylococcus aureus? Nat Rev Microbiol 9:215\u2013222. https:\/\/doi.org\/10.1038\/nrmicro2508","journal-title":"Nat Rev Microbiol"},{"key":"4128_CR49","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1086\/595740","volume":"199","author":"MP Trotonda","year":"2009","unstructured":"Trotonda MP, Xiong YQ, Memmi G et al (2009) Role of mgrA and sarA in methicillin-resistant Staphylococcus aureus autolysis and resistance to cell wall-active antibiotics. J Infect Dis 199:209\u2013218. https:\/\/doi.org\/10.1086\/595740","journal-title":"J Infect Dis"},{"key":"4128_CR50","doi-asserted-by":"publisher","first-page":"925746","DOI":"10.3389\/fcimb.2022.925746","volume":"12","author":"A Urso","year":"2022","unstructured":"Urso A, Prince A (2022) Anti-inflammatory metabolites in the pathogenesis of bacterial infection. Front Cell Infect Microbiol 12:925746. https:\/\/doi.org\/10.3389\/fcimb.2022.925746","journal-title":"Front Cell Infect Microbiol"},{"key":"4128_CR51","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/metabo13030320","volume":"13","author":"V Virtanen","year":"2023","unstructured":"Virtanen V, Puljula E, Walton G et al (2023) NMR metabolomics and DNA sequencing of Escherichia coli and Staphylococcus aureus cultures treated with hydrolyzable tannins. Metabolites 13:320. https:\/\/doi.org\/10.3390\/metabo13030320","journal-title":"Metabolites"},{"key":"4128_CR52","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1128\/JB.186.6.1838-1850.2004","volume":"186","author":"JM Yarwood","year":"2004","unstructured":"Yarwood JM, Bartels DJ, Volper EM, Greenberg EP (2004) Quorum sensing in Staphylococcus aureus biofilms. J Bacteriol 186:1838\u20131850. https:\/\/doi.org\/10.1128\/JB.186.6.1838-1850.2004","journal-title":"J Bacteriol"},{"key":"4128_CR53","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1128\/JCM.00265-08","volume":"46","author":"A Yusof","year":"2008","unstructured":"Yusof A, Engelhardt A, Karlsson \u00c5 et al (2008) Evaluation of a new etest vancomycin-teicoplanin strip for detection of glycopeptide-intermediate Staphylococcus aureus (GISA), in particular, heterogeneous GISA. J Clin Microbiol 46:3042\u20133047. https:\/\/doi.org\/10.1128\/JCM.00265-08","journal-title":"J Clin Microbiol"},{"key":"4128_CR54","doi-asserted-by":"publisher","first-page":"e02100","DOI":"10.1128\/AAC.02100-17","volume":"62","author":"X Zheng","year":"2018","unstructured":"Zheng X, Berti AD, McCrone S et al (2018) Combination antibiotic exposure selectively alters the development of vancomycin intermediate resistance in Staphylococcus aureus. Antimicrob Agents Chemother 62:e02100-e2117. https:\/\/doi.org\/10.1128\/AAC.02100-17","journal-title":"Antimicrob Agents Chemother"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-024-04128-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-024-04128-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-024-04128-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T04:30:09Z","timestamp":1729053009000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11274-024-04128-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["4128"],"URL":"https:\/\/doi.org\/10.1007\/s11274-024-04128-2","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"value":"0959-3993","type":"print"},{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"2 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was performed by the Declaration of Helsinki and approved by the Ethics Committee of Beijing Friendship Hospital, Capital Medical University (20210208).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"322"}}