{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T23:09:49Z","timestamp":1789254589172,"version":"build-2803163510"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s11274-025-04427-2","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T22:19:31Z","timestamp":1750976371000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optimized solid lipid nanoparticles for co-delivery of gentamicin and doxycycline: a novel approach to combat intracellular brucella abortus infections"],"prefix":"10.1007","volume":"41","author":[{"given":"Bandar","family":"Almutairy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitah","family":"Alharthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Ebrahimi Shahmabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ebrahim","family":"Alavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"4427_CR1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.toxrep.2024.04.012","volume":"12","author":"M Ahangarzadeh","year":"2024","unstructured":"Ahangarzadeh M, Janghiyamachi R, Rahimi K, Babamiri B, Roohani M, Lotfy H, Goli R, Faraji N, Faramarzi MR, Mesri A (2024) Traditional cheese consumption leading to hemodialysis induced by rifampin treatment: a case report. Toxicol Rep 12:531\u2013533. https:\/\/doi.org\/10.1016\/j.toxrep.2024.04.012","journal-title":"Toxicol Rep"},{"issue":"12","key":"4427_CR2","doi-asserted-by":"publisher","first-page":"103809","DOI":"10.1016\/j.drudis.2023.103809","volume":"28","author":"M Alavi","year":"2023","unstructured":"Alavi M, Nokhodchi A (2023) Micro-and nanoformulations of antibiotics against Brucella. Drug Discov Today 28(12):103809. https:\/\/doi.org\/10.1016\/j.drudis.2023.103809","journal-title":"Drug Discov Today"},{"issue":"6","key":"4427_CR3","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1021\/acs.molpharmaceut.9b00308","volume":"16","author":"SE Alavi","year":"2019","unstructured":"Alavi SE, Cabot PJ, Moyle PM (2019) Glucagon-like peptide-1 receptor agonists and strategies to improve their efficiency. Mol Pharm 16(6):2278\u20132295. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.9b00308","journal-title":"Mol Pharm"},{"issue":"7","key":"4427_CR5","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1021\/acs.bioconjchem.0c00291","volume":"31","author":"SE Alavi","year":"2020","unstructured":"Alavi SE, Cabot PJ, Yap GY, Moyle PM (2020) Optimized methods for the production and bioconjugation of site-specific, alkyne-modified glucagon-like peptide-1 (GLP-1) analogs to azide-modified delivery platforms using copper-catalyzed alkyne\u2013azide cycloaddition. Bioconjug Chem 31(7):1820\u20131834. https:\/\/doi.org\/10.1021\/acs.bioconjchem.0c00291","journal-title":"Bioconjug Chem"},{"issue":"4","key":"4427_CR4","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1021\/acs.bioconjchem.1c00091","volume":"32","author":"SE Alavi","year":"2021","unstructured":"Alavi SE, Cabot PJ, Raza A, Moyle PM (2021) Developing GLP-1 conjugated self-assembling nanofibers using copper-catalyzed alkyne\u2013azide cycloaddition and evaluation of their biological activity. Bioconjug Chem 32(4):810\u2013820. https:\/\/doi.org\/10.1021\/acs.bioconjchem.1c00091","journal-title":"Bioconjug Chem"},{"issue":"11","key":"4427_CR6","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1016\/j.xphs.2022.06.002","volume":"111","author":"SE Alavi","year":"2022","unstructured":"Alavi SE, Raza A, Esfahani MKM, Akbarzadeh A, Abdollahi SH, Shahmabadi HE (2022) Carboplatin niosomal nanoplatform for potentiated chemotherapy. J Pharm Sci 111(11):3029\u20133037. https:\/\/doi.org\/10.1016\/j.xphs.2022.06.002","journal-title":"J Pharm Sci"},{"issue":"3","key":"4427_CR7","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3390\/vaccines11030694","volume":"11","author":"AM Almuzaini","year":"2023","unstructured":"Almuzaini AM (2023) An epidemiological study of brucellosis in different animal species from the Al-Qassim region, Saudi Arabia. Vaccines 11(3):694. https:\/\/doi.org\/10.3390\/vaccines11030694","journal-title":"Vaccines"},{"issue":"2","key":"4427_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12032-025-02603-w","volume":"42","author":"H Alyami","year":"2025","unstructured":"Alyami H, Alharthi S, Alqahtani AJ, Ebrahimi Shahmabadi H, Alavi SE (2025) Enhanced antitumor efficacy of nanostructured lipid carrier co-loaded with docetaxel and 5-fluorouracil for targeted gastric cancer therapy. Med Oncol 42(2):1\u201315. https:\/\/doi.org\/10.1007\/s12032-025-02603-w","journal-title":"Med Oncol"},{"issue":"2","key":"4427_CR9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.36468\/pharmaceutical-sciences.1293","volume":"86","author":"P Ayare","year":"2024","unstructured":"Ayare P, Bakre A, Hirlkear R (2024) Perspective on solid lipid nanoparticles as drug delivery system for infectious diseases. Ndian J Pharm Sci 86(2):433\u2013441. https:\/\/doi.org\/10.36468\/pharmaceutical-sciences.1293","journal-title":"Ndian J Pharm Sci"},{"issue":"20","key":"4427_CR10","doi-asserted-by":"publisher","first-page":"16968","DOI":"10.1021\/acsomega.1c07254","volume":"7","author":"S Beg","year":"2022","unstructured":"Beg S, Malik AK, Ansari MJ, Malik AA, Ali AMA, Theyab A, Algahtani M, Almalki WH, Alharbi KS, Alenezi SK (2022) Systematic development of solid lipid nanoparticles of abiraterone acetate with improved oral bioavailability and anticancer activity for prostate carcinoma treatment. ACS Omega 7(20):16968\u201316979. https:\/\/doi.org\/10.1021\/acsomega.1c07254","journal-title":"ACS Omega"},{"issue":"5","key":"4427_CR11","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s15010-021-01586-w","volume":"49","author":"M Bosilkovski","year":"2021","unstructured":"Bosilkovski M, Keramat F, Arapovi\u0107 J (2021) The current therapeutical strategies in human brucellosis. Infection 49(5):823\u2013832. https:\/\/doi.org\/10.1007\/s15010-021-01586-w","journal-title":"Infection"},{"key":"4427_CR12","doi-asserted-by":"publisher","first-page":"110744","DOI":"10.1016\/j.colsurfb.2019.110744","volume":"186","author":"Y Cheng","year":"2020","unstructured":"Cheng Y, Zhang Y, Deng W, Hu J (2020) Antibacterial and anticancer activities of asymmetric lollipop-like mesoporous silica nanoparticles loaded with curcumin and gentamicin sulfate. Colloids Surf B 186:110744. https:\/\/doi.org\/10.1016\/j.colsurfb.2019.110744","journal-title":"Colloids Surf B"},{"issue":"6","key":"4427_CR13","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.ajpath.2015.03.003","volume":"185","author":"P de Figueiredo","year":"2015","unstructured":"de Figueiredo P, Ficht TA, Rice-Ficht A, Rossetti CA, Adams LG (2015) Pathogenesis and immunobiology of brucellosis: review of Brucella\u2013host interactions. Am J Pathol 185(6):1505\u20131517. https:\/\/doi.org\/10.1016\/j.ajpath.2015.03.003","journal-title":"Am J Pathol"},{"issue":"1","key":"4427_CR14","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.amjms.2024.07.032","volume":"369","author":"L Deng","year":"2024","unstructured":"Deng L, Yu J, Li H, Zhang H (2024) Brucella as a cause of severe sepsis: case series and brief review. Am J Med Sci 369(1):116\u2013121. https:\/\/doi.org\/10.1016\/j.amjms.2024.07.032","journal-title":"Am J Med Sci"},{"issue":"02","key":"4427_CR15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3855\/jidc.16677","volume":"17","author":"K Eljaaly","year":"2023","unstructured":"Eljaaly K, Alghamdi H, Almehmadi H, Aljawi F, Hassan A, Thabit AK (2023) Long-term gastrointestinal adverse effects of doxycycline. J Infect Dev Ctries 17(02):281\u2013285. https:\/\/doi.org\/10.3855\/jidc.16677","journal-title":"J Infect Dev Ctries"},{"issue":"1","key":"4427_CR16","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1080\/21691401.2019.1593858","volume":"47","author":"J Ghaderkhani","year":"2019","unstructured":"Ghaderkhani J, Yousefimashouf R, Arabestani M, Roshanaei G, Asl SS, Abbasalipourkabir R (2019) Improved antibacterial function of rifampicin-loaded solid lipid nanoparticles on Brucella abortus. Artif Cells Nanomed Biotechnol 47(1):1181\u20131193. https:\/\/doi.org\/10.1080\/21691401.2019.1593858","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"1","key":"4427_CR17","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s13065-024-01200-8","volume":"18","author":"S Gohari","year":"2024","unstructured":"Gohari S, Hosseini SM, Nouri F, Yousefimashouf R, Arabestani MR, Taheri M (2024) Co-delivery of doxycycline and rifampicin using CdTe-labeled poly (lactic-co-glycolic) acid for treatment of Brucella melitensis infection. BMC Chem 18(1):100. https:\/\/doi.org\/10.1186\/s13065-024-01200-8","journal-title":"BMC Chem"},{"issue":"1","key":"4427_CR18","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s43094-024-00753-8","volume":"10","author":"K Himani","year":"2024","unstructured":"Himani K, Anbazhagan S, Prakasan L, Thomas P, Kumar A, Narayanan K, Singh P, Chaudhuri P (2024) Augmenting the safety and therapeutic efficacy of Doxycycline and rifampicin-loaded solid lipid nanoparticles against Brucella abortus using murine model. Futur J Pharm Sci 10(1):178. https:\/\/doi.org\/10.1186\/s43094-024-00753-8","journal-title":"Futur J Pharm Sci"},{"issue":"62","key":"4427_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13756-019-0504-8","volume":"8","author":"SM Hosseini","year":"2019","unstructured":"Hosseini SM, Abbasalipourkabir R, Jalilian FA, Asl SS, Farmany A, Roshanaei G, Arabestani MR (2019) Doxycycline-encapsulated solid lipid nanoparticles as promising tool against Brucella melitensis enclosed in macrophage: a pharmacodynamics study on J774A. 1 cell line. Antimicrob Resist Infect Control 8(62):1\u201312. https:\/\/doi.org\/10.1186\/s13756-019-0504-8","journal-title":"Antimicrob Resist Infect Control"},{"key":"4427_CR20","doi-asserted-by":"publisher","first-page":"890252","DOI":"10.3389\/fchem.2022.890252","volume":"10","author":"SM Hosseini","year":"2022","unstructured":"Hosseini SM, Farmany A, Alikhani MY, Taheri M, Asl SS, Alamian S, Arabestani MR (2022) Co-delivery of doxycycline and hydroxychloroquine using CdTe-labeled solid lipid nanoparticles for treatment of acute and chronic brucellosis. Front Chem 10:890252. https:\/\/doi.org\/10.3389\/fchem.2022.890252","journal-title":"Front Chem"},{"issue":"7","key":"4427_CR21","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1128\/aac.00378-13","volume":"57","author":"E Imbuluzqueta","year":"2013","unstructured":"Imbuluzqueta E, Gamazo C, Lana H, Campanero M\u00c1, Salas D, Gil AG, Elizondo E, Ventosa N, Veciana J, Blanco-Prieto MJ (2013) Hydrophobic gentamicin-loaded nanoparticles are effective against Brucella melitensis infection in mice. Antimicrob Agents Chemother 57(7):3326\u20133333. https:\/\/doi.org\/10.1128\/aac.00378-13","journal-title":"Antimicrob Agents Chemother"},{"key":"4427_CR22","doi-asserted-by":"publisher","first-page":"114116","DOI":"10.1016\/j.biopha.2022.114116","volume":"158","author":"Z Karimitabar","year":"2023","unstructured":"Karimitabar Z, Chegini Z, Shokoohizadeh L, Moez NM, Arabestani MR, Hosseini SM (2023) Use of the quantum dot-labeled solid lipid nanoparticles for delivery of streptomycin and hydroxychloroquine: a new therapeutic approach for treatment of intracellular Brucella abortus infection. Biomed Pharmacother 158:114116. https:\/\/doi.org\/10.1016\/j.biopha.2022.114116","journal-title":"Biomed Pharmacother"},{"key":"4427_CR23","first-page":"1","volume":"7","author":"D Kazemi","year":"2014","unstructured":"Kazemi D, Salouti M, Rostamizadeh K, Zabihian A (2014) Development of gentamicin-loaded solid lipid nanoparticles: evaluation of drug release kinetic and antibacterial activity against Staphylococcus aureus. Int J Pharmaceut Res Innov 7:1\u20136","journal-title":"Int J Pharmaceut Res Innov"},{"issue":"19","key":"4427_CR24","doi-asserted-by":"publisher","first-page":"e38283","DOI":"10.1016\/j.heliyon.2024.e38283","volume":"10","author":"H Li","year":"2024","unstructured":"Li H, Tan X, Qin L, Gatasheh MK, Zhang L, Lin W, Hu F, Yan R, Alshammri MK, Shen Y (2024) Preparation, process optimisation, stability and bacteriostatic assessment of composite nanoemulsion containing corosolic acid. Heliyon 10(19):e38283. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e38283","journal-title":"Heliyon"},{"issue":"16","key":"4427_CR25","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.3390\/ani14162416","volume":"14","author":"J Mart\u00ednez","year":"2024","unstructured":"Mart\u00ednez J, Escudero E, Badillo E, Yuste MT, Galecio JS, Marin P (2024) Pharmacokinetics of doxycycline in plasma and milk after intravenous and intramuscular administration in dairy goats. Animals 14(16):2416. https:\/\/doi.org\/10.3390\/ani14162416","journal-title":"Animals"},{"key":"4427_CR26","doi-asserted-by":"publisher","first-page":"509","DOI":"10.18433\/jpps31788","volume":"24","author":"N Mendoza-Mu\u00f1oz","year":"2021","unstructured":"Mendoza-Mu\u00f1oz N, Urb\u00e1n-Morl\u00e1n Z, Leyva-G\u00f3mez G, de la Luz Zambrano-Zaragoza M, Quintanar-Guerrero D (2021) Solid lipid nanoparticles: an approach to improve oral drug delivery. J Pharm Pharm Sci 24:509\u2013532. https:\/\/doi.org\/10.18433\/jpps31788","journal-title":"J Pharm Pharm Sci"},{"key":"4427_CR27","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.jconrel.2021.05.032","volume":"335","author":"Y Mirchandani","year":"2021","unstructured":"Mirchandani Y, Patravale VB, Brijesh S (2021) Solid lipid nanoparticles for hydrophilic drugs. J Control Release 335:457\u2013464. https:\/\/doi.org\/10.1016\/j.jconrel.2021.05.032","journal-title":"J Control Release"},{"issue":"1","key":"4427_CR28","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/s12872-021-02160-w","volume":"21","author":"A Oye-Somefun","year":"2021","unstructured":"Oye-Somefun A, Kuk JL, Ardern CI (2021) Associations between elevated kidney and liver biomarker ratios, metabolic syndrome and all-cause and coronary heart disease (CHD) mortality: analysis of the US National Health and Nutrition Examination Survey (NHANES). BMC Cardiovasc Disord 21(1):352. https:\/\/doi.org\/10.1186\/s12872-021-02160-w","journal-title":"BMC Cardiovasc Disord"},{"key":"4427_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2020.12.011","volume":"330","author":"YI Park","year":"2021","unstructured":"Park YI, Kwon S-H, Lee G, Motoyama K, Kim MW, Lin M, Niidome T, Choi JH, Lee R (2021) pH-sensitive multi-drug liposomes targeting folate receptor \u0392 for efficient treatment of non-small cell lung cancer. J Control Release 330:1\u201314. https:\/\/doi.org\/10.1016\/j.jconrel.2020.12.011","journal-title":"J Control Release"},{"key":"4427_CR30","doi-asserted-by":"publisher","first-page":"115875","DOI":"10.1016\/j.biopha.2023.115875","volume":"169","author":"A Razei","year":"2023","unstructured":"Razei A, Javanbakht M, Hajizade A, Heiat M, Zhao S, Aghamollaei H, Saadati M, Khafaei M, Asadi M, Cegolon L (2023) Nano and microparticle drug delivery systems for the treatment of Brucella infections. Biomed Pharmacother 169:115875. https:\/\/doi.org\/10.1016\/j.biopha.2023.115875","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"4427_CR31","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/0975-7406.124309","volume":"6","author":"MP Soni","year":"2014","unstructured":"Soni MP, Shelkar N, Gaikwad RV, Vanage GR, Samad A, Devarajan PV (2014) Buparvaquone loaded solid lipid nanoparticles for targeted delivery in theleriosis. J Pharm Bioallied Sci 6(1):22\u201330. https:\/\/doi.org\/10.4103\/0975-7406.124309","journal-title":"J Pharm Bioallied Sci"},{"issue":"12","key":"4427_CR32","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/j.jiph.2021.10.020","volume":"14","author":"TM Uddin","year":"2021","unstructured":"Uddin TM, Chakraborty AJ, Khusro A, Zidan BRM, Mitra S, Emran TB, Dhama K, Ripon MKH, Gajd\u00e1cs M, Sahibzada MUK (2021) Antibiotic resistance in microbes: history, mechanisms, therapeutic strategies and future prospects. J Infect Public Health 14(12):1750\u20131766. https:\/\/doi.org\/10.1016\/j.jiph.2021.10.020","journal-title":"J Infect Public Health"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-025-04427-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-025-04427-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-025-04427-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T16:02:14Z","timestamp":1753718534000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11274-025-04427-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["4427"],"URL":"https:\/\/doi.org\/10.1007\/s11274-025-04427-2","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"value":"0959-3993","type":"print"},{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]},"assertion":[{"value":"27 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"232"}}