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The study was conducted experimentally to determine the effect of dressing application containing <jats:italic>Bdellovibrio bacteriovorus<\/jats:italic> on superficial incisional surgical site infection caused by <jats:italic>Staphylococcus aureus<\/jats:italic> in mice. In the study, mice were divided into 6 different groups, BB: <jats:italic>B. bacteriovorus<\/jats:italic>; NC: Negative Control; PC: Positive Control Methicillin Resistant <jats:italic>S. aureus<\/jats:italic>; MRSA\u2009+\u2009BB: Methicillin Resistant <jats:italic>S. aureus<\/jats:italic>\u2009+\u2009<jats:italic>B. bacteriovorus<\/jats:italic> dressing; MRSA\u2009+\u2009V: Methicillin Resistant <jats:italic>S. aureus<\/jats:italic>\u2009+\u2009Vancomycin; MRSA\u2009+\u2009BB\u2009+\u2009V: Methicillin Resistant <jats:italic>S. aureus<\/jats:italic>\u2009+\u2009<jats:italic>B. bacteriovorus<\/jats:italic> dressing\u2009+\u2009Vancomycin group. The treatment procedures were applied over a period of 3 days. Infection symptoms were monitored and recorded at the 24th, 48th, and 72nd hours. In the <jats:italic>Staphylococcus aureus<\/jats:italic>\u2009+\u2009Vancomycin group, all mice developed edema, redness, and fever at 24\u00a0h. At 48\u00a0h, all mice exhibited edema and redness, with 50% showing fever. At 72\u00a0h, 70% of the mice showed edema and redness, and 10% showed fever. In the <jats:italic>Staphylococcus aureus\u2009+\u2009Bdellovibrio bacteriovorus<\/jats:italic>\u2009+\u2009Vancomycin combined treatment group, all mice exhibited edema, redness, and fever at 24\u00a0h. At 48\u00a0h, only 20% of the mice showed redness. At 72\u00a0h, no edema, redness, fever, purulent discharge, or suture dehiscence was observed. Sepsis developed in 2 of 10 mice in the <jats:italic>Staphylococcus aureus\u2009+\u2009Bdellovibrio bacteriovorus<\/jats:italic>\u2009+\u2009Vancomycin group. The most effective treatment was in the <jats:italic>Staphylococcus aureus<\/jats:italic>\u2009+\u2009<jats:italic>Bdellovibrio bacteriovorus<\/jats:italic>\u2009+\u2009Vancomycin group. It was determined that sepsis findings were the least in the <jats:italic>Staphylococcus aureus\u2009+\u2009Bdellovibrio bacteriovorus<\/jats:italic>\u2009+\u2009Vancomycin group. <jats:italic>B. bacteriovorus<\/jats:italic> holds the potential to be an effective control agent in preventing or slowing resistance development.<\/jats:p>","DOI":"10.1007\/s11274-025-04453-0","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T23:05:54Z","timestamp":1750806354000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Superficial incisional surgical site infections experimentally induced by Staphylococcus aureus in mice: the effect of Bdellovibrio bacteriovorus containing dressing*"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-5772","authenticated-orcid":false,"given":"G\u00fclseren","family":"Mara\u015f Baydo\u011fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-8713","authenticated-orcid":false,"given":"\u00d6zlem","family":"Ceyhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-0200","authenticated-orcid":false,"given":"P\u0131nar","family":"Sa\u011f\u0131ro\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2267-1238","authenticated-orcid":false,"given":"Mustafa","family":"Ermi\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"4453_CR1","doi-asserted-by":"crossref","unstructured":"Atterbury L, Hobley R, Till C et al (2016) Effects of orally administered Bdellovibrio Bacteriovorus on the Well-Being and Salmonella colonization of young chicks. 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