{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T06:34:49Z","timestamp":1763793289137,"version":"3.45.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Research Program of State Key Laboratory of Food Science and Resources, Jiangnan University","award":["No. SKLF-ZZB-202508"],"award-info":[{"award-number":["No. SKLF-ZZB-202508"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s11274-025-04648-5","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:22:54Z","timestamp":1761196974000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulatory mechanism of ferrous ion in enhancing the biosynthesis of L-homoserine, L-threonine, and L-isoleucine in Corynebacterium glutamicum"],"prefix":"10.1007","volume":"41","author":[{"given":"Guihong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dezhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"4648_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.nbt.2022.06.004","volume":"71","author":"A Baez","year":"2022","unstructured":"Baez A, Sharma AK, Bryukhanov A, Anderson ED, Rudack L, Olivares-Hern\u00e1ndez R, Quan D, Shiloach J (2022) Iron availability enhances the cellular energetics of aerobic Escherichia coli cultures while upregulating anaerobic respiratory chains. New Biotechnol 71:11\u201320. https:\/\/doi.org\/10.1016\/j.nbt.2022.06.004","journal-title":"New Biotechnol"},{"issue":"1","key":"4648_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0168-1656(03)00144-5","volume":"104","author":"M Bott","year":"2003","unstructured":"Bott M, Niebisch A (2003) The respiratory chain of Corynebacterium glutamicum. J Biotechnol 104(1):129\u2013153. https:\/\/doi.org\/10.1016\/S0168-1656(03)00144-5","journal-title":"J Biotechnol"},{"issue":"3","key":"4648_CR3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/S0968-0004(99)01359-6","volume":"24","author":"V Braun","year":"1999","unstructured":"Braun V, Killmann H (1999) Bacterial solutions to the iron-supply problem. Trends Biochem Sci 24(3):104\u2013109. https:\/\/doi.org\/10.1016\/S0968-0004(99)01359-6","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"4648_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-21","volume":"7","author":"I Brune","year":"2006","unstructured":"Brune I, Werner H, H\u00fcser AT, Kalinowski J, P\u00fchler A, Tauch A (2006) The DtxR protein acting as dual transcriptional regulator directs a global regulatory network involved in iron metabolism of Corynebacterium glutamicum. BMC Genomics 7(1):21. https:\/\/doi.org\/10.1186\/1471-2164-7-21","journal-title":"BMC Genomics"},{"issue":"38","key":"4648_CR5","doi-asserted-by":"publisher","first-page":"29305","DOI":"10.1074\/jbc.M110.156372","volume":"285","author":"M Bussmann","year":"2010","unstructured":"Bussmann M, Baumgart M, Bott M (2010) RosR (Cg1324), a hydrogen peroxide-sensitive MarR-type transcriptional regulator of Corynebacterium glutamicum. J Biol Chem 285(38):29305\u201329318. https:\/\/doi.org\/10.1074\/jbc.M110.156372","journal-title":"J Biol Chem"},{"issue":"10","key":"4648_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-023-03705-1","volume":"39","author":"R Chen","year":"2023","unstructured":"Chen R, Shi F, Xiang Y, Lai W, Ji G (2023) Establishment of CRISPR-Cpf1-assisted gene editing tool and engineering of 4-hydroxyisoleucine biosynthesis in Corynebacterium glutamicum. World J Microbiol Biotechnol 39(10):266. https:\/\/doi.org\/10.1007\/s11274-023-03705-1","journal-title":"World J Microbiol Biotechnol"},{"issue":"9","key":"4648_CR7","doi-asserted-by":"publisher","first-page":"e03026","DOI":"10.1128\/AEM.03026-18","volume":"85","author":"J Choi","year":"2019","unstructured":"Choi J, Ryu S (2019) Regulation of iron uptake by fine-tuning the iron responsiveness of the iron sensor fur. Appl Environ Microbiol 85(9):e03026\u2013e03018. https:\/\/doi.org\/10.1128\/AEM.03026-18","journal-title":"Appl Environ Microbiol"},{"issue":"6","key":"4648_CR8","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s10295-016-1763-5","volume":"43","author":"X Dong","year":"2016","unstructured":"Dong X, Zhao Y, Zhao J, Wang X (2016) Characterization of aspartate kinase and homoserine dehydrogenase from Corynebacterium glutamicum IWJ001 and systematic investigation of L-isoleucine biosynthesis. J Ind Microbiol Biotechnol 43(6):873\u2013885. https:\/\/doi.org\/10.1007\/s10295-016-1763-5","journal-title":"J Ind Microbiol Biotechnol"},{"issue":"1","key":"4648_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-621","volume":"10","author":"M Follmann","year":"2009","unstructured":"Follmann M, Ochrombel I, Kr\u00e4mer R, Tr\u00f6tschel C, Poetsch A, R\u00fcckert C, H\u00fcser A, Persicke M, Seiferling D, Kalinowski J, Marin K (2009) Functional genomics of pH homeostasis in Corynebacterium glutamicum revealed novel links between pH response, oxidative stress, iron homeostasis and methionine synthesis. BMC Genomics 10(1):621. https:\/\/doi.org\/10.1186\/1471-2164-10-621","journal-title":"BMC Genomics"},{"issue":"6","key":"4648_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104748","volume":"299","author":"CR Fontenot","year":"2023","unstructured":"Fontenot CR, Ding H (2023) Ferric uptake regulator (Fur) binds a [2Fe-2S] cluster to regulate intracellular iron homeostasis in Escherichia coli. J Biol Chem 299(6):104748. https:\/\/doi.org\/10.1016\/j.jbc.2023.104748","journal-title":"J Biol Chem"},{"issue":"5","key":"4648_CR11","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1038\/s44318-025-00379-3","volume":"44","author":"TS Fung","year":"2025","unstructured":"Fung TS, Ryu KW, Thompson CB (2025) Arginine: at the crossroads of nitrogen metabolism. EMBO J 44(5):1275\u20131293. https:\/\/doi.org\/10.1038\/s44318-025-00379-3","journal-title":"EMBO J"},{"key":"4648_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2023.740361","volume":"580","author":"J Gong","year":"2024","unstructured":"Gong J, Wang Y, Jiang Y, Zhang D, Cai Y, Shan X, Gong H, Dong H (2024) Ferric uptake regulator (Fur) affects the pathogenicity of Aeromonas veronii TH0426 by regulating flagellar assembly and biofilm formation. Aquaculture 580:740361. https:\/\/doi.org\/10.1016\/j.aquaculture.2023.740361","journal-title":"Aquaculture"},{"issue":"1","key":"4648_CR13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.resmic.2015.09.005","volume":"167","author":"E Hong","year":"2016","unstructured":"Hong E, Kim P, Kim E, Kim Y, Lee H (2016) Involvement of the osrR gene in the hydrogen peroxide-mediated stress response of Corynebacterium glutamicum. Res Microbiol 167(1):20\u201328. https:\/\/doi.org\/10.1016\/j.resmic.2015.09.005","journal-title":"Res Microbiol"},{"issue":"10","key":"4648_CR14","doi-asserted-by":"publisher","first-page":"e00065","DOI":"10.1128\/AEM.00065-20","volume":"86","author":"A K\u00fcberl","year":"2020","unstructured":"K\u00fcberl A, Mengus-Kaya A, Polen T, Bott M (2020) The iron deficiency response of Corynebacterium glutamicum and a link to thiamine biosynthesis. Appl Environ Microbiol 86(10):e00065\u2013e00020. https:\/\/doi.org\/10.1128\/AEM.00065-20","journal-title":"Appl Environ Microbiol"},{"issue":"13","key":"4648_CR15","doi-asserted-by":"publisher","first-page":"5105","DOI":"10.1007\/s00253-022-12034-6","volume":"106","author":"W Lai","year":"2022","unstructured":"Lai W, Shi F, Tan S, Liu H, Li Y, Xiang Y (2022) Dynamic control of 4-hydroxyisoleucine biosynthesis by multi-biosensor in Corynebacterium glutamicum. Appl Microbiol Biotechnol 106(13):5105\u20135121. https:\/\/doi.org\/10.1007\/s00253-022-12034-6","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"4648_CR16","doi-asserted-by":"publisher","first-page":"e01938","DOI":"10.1128\/AEM.01938-18","volume":"85","author":"C Li","year":"2018","unstructured":"Li C, Zhu L, Pan D, Li S, Xiao H, Zhang Z, Shen X, Wang Y, Long M (2018) Siderophore-mediated iron acquisition enhances resistance to oxidative and aromatic compound stress in Cupriavidus necator JMP134. Appl Environ Microbiol 85(1):e01938\u2013e01918. https:\/\/doi.org\/10.1128\/AEM.01938-18","journal-title":"Appl Environ Microbiol"},{"key":"4648_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2021.108255","volume":"177","author":"H Li","year":"2022","unstructured":"Li H, Xu D, Liu Y, Tan X, Qiao J, Li Z, Qi B, Hu X, Wang X (2022) Preventing mycolic acid reduction in Corynebacterium glutamicum can efficiently increase L-glutamate production. Biochem Eng J 177:108255. https:\/\/doi.org\/10.1016\/j.bej.2021.108255","journal-title":"Biochem Eng J"},{"key":"4648_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2022.127260","volume":"267","author":"H Li","year":"2023","unstructured":"Li H, Xu D, Tan X, Huang D, Huang Y, Zhao G, Hu X, Wang X (2023a) The role of trehalose biosynthesis on mycolate composition and L-glutamate production in Corynebacterium glutamicum. Microbiol Res 267:127260. https:\/\/doi.org\/10.1016\/j.micres.2022.127260","journal-title":"Microbiol Res"},{"key":"4648_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2023.127390","volume":"272","author":"H Li","year":"2023","unstructured":"Li H, Xu D, Zhang D, Tan X, Huang D, Ma W, Zhao G, Li Y, Liu Z, Wang Y, Hu X, Wang X (2023b) Improve L-isoleucine production in Corynebacterium glutamicum WM001 by destructing the biosynthesis of trehalose dicorynomycolate. Microbiol Res 272:127390. https:\/\/doi.org\/10.1016\/j.micres.2023.127390","journal-title":"Microbiol Res"},{"key":"4648_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2022.128473","volume":"369","author":"N Li","year":"2023","unstructured":"Li N, Li L, Yu S, Zhou J (2023c) Dual-channel glycolysis balances cofactor supply for L-homoserine biosynthesis in Corynebacterium glutamicum. Bioresour Technol 369:128473. https:\/\/doi.org\/10.1016\/j.biortech.2022.128473","journal-title":"Bioresour Technol"},{"issue":"9","key":"4648_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-024-04066-z","volume":"40","author":"Y Li","year":"2024","unstructured":"Li Y, Guo Y, Niu F, Gao H, Wang Q, Xu M (2024) Regulation of oxidative stress response and antioxidant modification in Corynebacterium glutamicum. World J Microbiol Biotechnol 40(9):267. https:\/\/doi.org\/10.1007\/s11274-024-04066-z","journal-title":"World J Microbiol Biotechnol"},{"issue":"6","key":"4648_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.524","volume":"6","author":"Y Liu","year":"2017","unstructured":"Liu Y, Li Y, Wang X (2017) Molecular evolution of acetohydroxyacid synthase in bacteria. Microbiol Open 6(6):e00524. https:\/\/doi.org\/10.1002\/mbo3.524","journal-title":"Microbiol Open"},{"issue":"3","key":"4648_CR23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00253-005-0308-z","volume":"70","author":"C-D Lu","year":"2006","unstructured":"Lu C-D (2006) Pathways and regulation of bacterial arginine metabolism and perspectives for obtaining arginine overproducing strains. Appl Microbiol Biotechnol 70(3):261\u2013272. https:\/\/doi.org\/10.1007\/s00253-005-0308-z","journal-title":"Appl Microbiol Biotechnol"},{"issue":"7","key":"4648_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-023-03633-0","volume":"39","author":"F Ma","year":"2023","unstructured":"Ma F, Liu H, Shi F, Xiang Y, Fan Z (2023) Quorum sensing-mediated dynamic regulation of 4-hydroxyisoleucine biosynthesis in Corynebacterium glutamicum. World J Microbiol Biotechnol 39(7):181. https:\/\/doi.org\/10.1007\/s11274-023-03633-0","journal-title":"World J Microbiol Biotechnol"},{"issue":"1","key":"4648_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/bab.1698","volume":"66","author":"W Ma","year":"2019","unstructured":"Ma W, Wang J, Li Y, Wang X (2019) Cysteine synthase A overexpression in Corynebacterium glutamicum enhances L-isoleucine production. Biotechnol Appl Biochem 66(1):74\u201381. https:\/\/doi.org\/10.1002\/bab.1698","journal-title":"Biotechnol Appl Biochem"},{"issue":"11","key":"4648_CR26","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41579-022-00745-6","volume":"20","author":"CC Murdoch","year":"2022","unstructured":"Murdoch CC, Skaar EP (2022) Nutritional immunity: the battle for nutrient metals at the host\u2013pathogen interface. Nat Rev Microbiol 20(11):657\u2013670. https:\/\/doi.org\/10.1038\/s41579-022-00745-6","journal-title":"Nat Rev Microbiol"},{"key":"4648_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1493811","volume":"15","author":"E Ng Kwan Lim","year":"2024","unstructured":"Ng Kwan Lim E, Gr\u00fcll M, Larabi N, Lalaouna D, Mass\u00e9 E (2024) Coordination of cell division and chromosome segregation by iron and a sRNA in Escherichia coli. Front Microbiol 15:1493811. https:\/\/doi.org\/10.3389\/fmicb.2024.1493811","journal-title":"Front Microbiol"},{"doi-asserted-by":"publisher","unstructured":"Paterson JR, Wadsworth JM, Hu P, Sharples GJ (2023) A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of Escherichia coli to metal restriction. Microb Genomics 9(12). https:\/\/doi.org\/10.1099\/mgen.0.001153","key":"4648_CR28","DOI":"10.1099\/mgen.0.001153"},{"issue":"1","key":"4648_CR29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41579-024-01090-6","volume":"23","author":"IJ Schalk","year":"2025","unstructured":"Schalk IJ (2025) Bacterial siderophores: diversity, uptake pathways and applications. Nat Rev Microbiol 23(1):24\u201340. https:\/\/doi.org\/10.1038\/s41579-024-01090-6","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"4648_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5910","volume":"5","author":"SW Seo","year":"2014","unstructured":"Seo SW, Kim D, Latif H, O\u2019Brien EJ, Szubin R, Palsson BO (2014) Deciphering fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli. Nat Commun 5(1):4910. https:\/\/doi.org\/10.1038\/ncomms5910","journal-title":"Nat Commun"},{"issue":"11","key":"4648_CR31","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1007\/s00253-022-11995-y","volume":"106","author":"EV Soares","year":"2022","unstructured":"Soares EV (2022) Perspective on the biotechnological production of bacterial siderophores and their use. Appl Microbiol Biotechnol 106(11):3985\u20134004. https:\/\/doi.org\/10.1007\/s00253-022-11995-y","journal-title":"Appl Microbiol Biotechnol"},{"issue":"9","key":"4648_CR32","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1021\/acssynbio.0c00127","volume":"9","author":"S Tan","year":"2020","unstructured":"Tan S, Shi F, Liu H, Yu X, Wei S, Fan Z, Li Y (2020) Dynamic control of 4-hydroxyisoleucine biosynthesis by modified L-isoleucine biosensor in recombinant Corynebacterium glutamicum. ACS Synth Biol 9(9):2378\u20132389. https:\/\/doi.org\/10.1021\/acssynbio.0c00127","journal-title":"ACS Synth Biol"},{"issue":"5","key":"4648_CR33","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1111\/1751-7915.14244","volume":"16","author":"F Thoma","year":"2023","unstructured":"Thoma F, Appel C, Russ D, Huber J, Werner F, Blombach B (2023) Improving growth properties of Corynebacterium glutamicum by implementing an iron-responsive protocatechuate biosynthesis. Microb Biotechnol 16(5):1041\u20131053. https:\/\/doi.org\/10.1111\/1751-7915.14244","journal-title":"Microb Biotechnol"},{"issue":"14","key":"4648_CR34","doi-asserted-by":"publisher","first-page":"8039","DOI":"10.1021\/acs.jafc.4c00914","volume":"72","author":"S Tian","year":"2024","unstructured":"Tian S, Zhao G, Lv G, Wu C, Su R, Wang F, Wang Z, Liu Y, Chen N, Li Y (2024) Efficient fermentative production of D-alanine and other D-amino acids by metabolically engineered Corynebacterium glutamicum. J Agric Food Chem 72(14):8039\u20138051. https:\/\/doi.org\/10.1021\/acs.jafc.4c00914","journal-title":"J Agric Food Chem"},{"issue":"2","key":"4648_CR35","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/bit.25103","volume":"111","author":"S Unthan","year":"2014","unstructured":"Unthan S, Gr\u00fcnberger A, van Ooyen J, G\u00e4tgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S (2014) Beyond growth rate 0.6: what drives Corynebacterium glutamicum to higher growth rates in defined medium. Biotechnol Bioeng 111(2):359\u2013371. https:\/\/doi.org\/10.1002\/bit.25103","journal-title":"Biotechnol Bioeng"},{"issue":"9","key":"4648_CR36","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1021\/acssynbio.4c00278","volume":"13","author":"F Wang","year":"2024","unstructured":"Wang F, Cai N, Leng Y, Wu C, Wang Y, Tian S, Zhang C, Xu Q, Peng H, Chen N, Li Y (2024) Metabolic engineering of Corynebacterium glutamicum for the high-level production of L-valine under aerobic conditions. ACS Synth Biol 13(9):2861\u20132872. https:\/\/doi.org\/10.1021\/acssynbio.4c00278","journal-title":"ACS Synth Biol"},{"issue":"17","key":"4648_CR37","doi-asserted-by":"publisher","first-page":"5603","DOI":"10.1007\/s00253-022-12109-4","volume":"106","author":"H Wang","year":"2022","unstructured":"Wang H, Xu J, Zhang W (2022) Metabolic engineering of Escherichia coli for efficient production of L-arginine. Appl Microbiol Biotechnol 106(17):5603\u20135613. https:\/\/doi.org\/10.1007\/s00253-022-12109-4","journal-title":"Appl Microbiol Biotechnol"},{"issue":"49","key":"4648_CR38","doi-asserted-by":"publisher","first-page":"40500","DOI":"10.1074\/jbc.M508693200","volume":"280","author":"J Wennerhold","year":"2005","unstructured":"Wennerhold J, Krug A, Bott M (2005) The AraC-type regulator RipA represses aconitase and other iron proteins from Corynebacterium under iron limitation and is itself repressed by DtxR. J Biol Chem 280(49):40500\u201340508. https:\/\/doi.org\/10.1074\/jbc.M508693200","journal-title":"J Biol Chem"},{"issue":"7","key":"4648_CR39","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1007\/s00253-023-12460-0","volume":"107","author":"H Yang","year":"2023","unstructured":"Yang H, Song H, Zhang J, Li W, Han Q, Zhang W (2023) Proteomic analysis reveals the adaptation of Vibrio Splendidus to an iron deprivation condition. Appl Microbiol Biotechnol 107(7):2533\u20132546. https:\/\/doi.org\/10.1007\/s00253-023-12460-0","journal-title":"Appl Microbiol Biotechnol"},{"key":"4648_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2025.132617","volume":"431","author":"G Zhao","year":"2025","unstructured":"Zhao G, Tang Y, Li Z, Liu G, Zhang D, Hu X, Wang X (2025a) Engineering Corynebacterium glutamicum for efficient L-homoserine production. Bioresour Technol 431:132617. https:\/\/doi.org\/10.1016\/j.biortech.2025.132617","journal-title":"Bioresour Technol"},{"key":"4648_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ymben.2025.02.012","volume":"90","author":"G Zhao","year":"2025","unstructured":"Zhao G, Zhang D, Tang Y, Hu X, Wang X (2025b) Recent advances on engineering Escherichia coli and Corynebacterium glutamicum for efficient production of L-threonine and its derivatives. Metab Eng 90:1\u201315. https:\/\/doi.org\/10.1016\/j.ymben.2025.02.012","journal-title":"Metab Eng"},{"issue":"10","key":"4648_CR42","doi-asserted-by":"publisher","first-page":"3446","DOI":"10.1021\/acssynbio.4c00518","volume":"13","author":"G Zhao","year":"2024","unstructured":"Zhao G, Zhang D, Zhou B, Li Z, Liu G, Li H, Hu X, Wang X (2024) Fine-regulating the carbon flux of L-isoleucine producing Corynebacterium glutamicum WM001 for efficient L-threonine production. ACS Synth Biol 13(10):3446\u20133460. https:\/\/doi.org\/10.1021\/acssynbio.4c00518","journal-title":"ACS Synth Biol"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-025-04648-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-025-04648-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-025-04648-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T06:32:16Z","timestamp":1763793136000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11274-025-04648-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["4648"],"URL":"https:\/\/doi.org\/10.1007\/s11274-025-04648-5","relation":{},"ISSN":["0959-3993","1573-0972"],"issn-type":[{"type":"print","value":"0959-3993"},{"type":"electronic","value":"1573-0972"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"30 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"407"}}