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This work aimed to formulate a modified release system that protects\n                    <jats:italic>S. boulardii<\/jats:italic>\n                    during the manufacturing process and under simulated acidic gastric conditions.\n                    <jats:italic>S. boulardii<\/jats:italic>\n                    was layered to sugar pellets, coated at 5% and 10% with the enteric polymer Eudragit\n                    <jats:sup>\u00ae<\/jats:sup>\n                    S12.5, and encapsulated in hard gelatin capsules. During manufacturing, the main determinant of viability was the incorporation of yeast onto the sugar pellets. The viability\n                    <jats:italic>S. boulardii<\/jats:italic>\n                    in the pellets unprotected was 87.7% \u00b1 1% after 80\u00a0min, whereas coating of unprotected pellets with 5% polymer required 54 additional min (total: 134\u00a0min) and the viability was 92.6% \u00b1 1%, while 10% coating took 55 additional min (total: 189\u00a0min) and viability was 88.7% \u00b1 1.8%. Notably,\n                    <jats:italic>S. boulardii<\/jats:italic>\n                    coated pellets were prepared before the recovery process. The weight variations of the pellets contained in the capsules were 0.53\u2009\u00b1\u20090.032\u00a0g and 0.55\u2009\u00b1\u20090.029\u00a0g for 5% and 10% coating, respectively. The disintegration time for each formulation was 18\u00a0min, which is below the limit of Mexican and European Pharmacopeias (30\u00a0min respectively). In the dissolution test, no release occurred under acid pH, regardless of the Eudragit percentage. In contrast, under alkaline pH conditions, polymer dissolution occurred, releasing\n                    <jats:italic>S. boulardii<\/jats:italic>\n                    65% \u00b1 0.46% and 68% \u00b1 0.23% for the 5% and 10% enteric coatings, respectively, after 20\u00a0min in alkaline condition the release was 81% \u00b1 0.48% and 87% \u00b1 0.33% respectively. In conclusion, this modified-release system may serve as an alternative for preserving the viability of\n                    <jats:italic>S. boulardii<\/jats:italic>\n                    during gastric passage, potentially increasing the number of viable yeast cells that reach the site of action, primarily the small intestine.\n                  <\/jats:p>","DOI":"10.1007\/s11274-025-04649-4","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T04:32:37Z","timestamp":1761798757000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Encapsulation of Saccharomyces boulardii into sugar pellets coated with an enteric polymer"],"prefix":"10.1007","volume":"41","author":[{"given":"Karla Lilian","family":"Bailon-Barceinas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-7574","authenticated-orcid":false,"given":"Zacnite","family":"S\u00e1nchez-Portilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-1061","authenticated-orcid":false,"given":"Alma Delia","family":"Rom\u00e1n-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5509-6415","authenticated-orcid":false,"given":"Luz Mar\u00eda","family":"Melgoza-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4400-7506","authenticated-orcid":false,"given":"Raquel","family":"Gonz\u00e1lez-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-7897","authenticated-orcid":false,"given":"Lino","family":"Mayorga-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6342-5549","authenticated-orcid":false,"given":"Mar\u00eda Ang\u00e9lica","family":"Guti\u00e9rrez-Nava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"4649_CR1","doi-asserted-by":"crossref","unstructured":"Agriopoulou S, Tarapoulouzi M, Varzakas T, Jafari SM (2023) Application of encapsulation strategies for probiotics: from individual loading to Co-Encapsulation. 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