{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:09:30Z","timestamp":1778598570285,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning","award":["2022R1A2C1013108"],"award-info":[{"award-number":["2022R1A2C1013108"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"DOI":"10.1007\/s11274-026-04906-0","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:31:08Z","timestamp":1775788268000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tissue- and time-dependent modulation of JAK\/STAT pathway genes in Tenebrio molitor\u00a0during Listeria monocytogenes\u00a0infection"],"prefix":"10.1007","volume":"42","author":[{"given":"Shahidul Ahmed","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Beom","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon Soo","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"4906_CR1","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S1534-5807(03)00244-2","volume":"5","author":"H Agaisse","year":"2003","unstructured":"Agaisse H, Petersen U-M, Boutros M, Mathey-Prevot B, Perrimon N (2003) Signaling role of hemocytes in Drosophila JAK\/STAT-dependent response to septic injury. Dev Cell 5:441\u2013450","journal-title":"Dev Cell"},{"key":"4906_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076751","volume":"24","author":"M Ali Mohammadie Kojour","year":"2023","unstructured":"Ali Mohammadie Kojour M, Jang HA, Lee YS, Jo YH, Han YS (2023) Innate immune response of TmToll-3 following systemic microbial infection in Tenebrio molitor. Int J Mol Sci 24:6751","journal-title":"Int J Mol Sci"},{"key":"4906_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.991678","volume":"13","author":"M Arch","year":"2022","unstructured":"Arch M, Vidal M, Koiffman R, Melkie ST, Cardona P-J (2022) Drosophila melanogaster as a model to study innate immune memory. Front Microbiol 13:991678","journal-title":"Front Microbiol"},{"key":"4906_CR4","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad011","volume":"47","author":"M Asai","year":"2023","unstructured":"Asai M, Li Y, Newton SM, Robertson BD, Langford PR (2023) Galleria mellonella\u2013intracellular bacteria pathogen infection models: the ins and outs. FEMS Microbiol Rev 47:fuad011","journal-title":"FEMS Microbiol Rev"},{"key":"4906_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001317","volume":"5","author":"AC Bahia","year":"2011","unstructured":"Bahia AC, Kubota MS, Tempone AJ, Ara\u00fajo HR, Guedes BA, Orfan\u00f3 AS, Tadei WP, R\u00edos-Vel\u00e1squez CM, Han YS, Secundino NF (2011) The JAK-STAT pathway controls Plasmodium vivax load in early stages of Anopheles aquasalis infection. PLoS Negl Trop Dis 5:e1317","journal-title":"PLoS Negl Trop Dis"},{"key":"4906_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.745160","volume":"12","author":"D Bruno","year":"2021","unstructured":"Bruno D, Montali A, Mastore M, Brivio MF, Mohamed A, Tian L, Grimaldi A, Casartelli M, Tettamanti G (2021) Insights into the immune response of the black soldier fly larvae to bacteria. Front Immunol 12:745160","journal-title":"Front Immunol"},{"key":"4906_CR7","doi-asserted-by":"publisher","first-page":"22578","DOI":"10.1038\/s41598-021-01842-x","volume":"11","author":"AL Carr","year":"2021","unstructured":"Carr AL, Rinker DC, Dong Y, Dimopoulos G, Zwiebel LJ (2021) Transcriptome profiles of Anopheles gambiae harboring natural low-level Plasmodium infection reveal adaptive advantages for the mosquito. Sci Rep 11:22578","journal-title":"Sci Rep"},{"key":"4906_CR8","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.dci.2011.09.010","volume":"36","author":"J-H Chae","year":"2012","unstructured":"Chae J-H, Kurokawa K, So Y-I, Hwang HO, Kim M-S, Park J-W, Jo Y-H, Lee YS, Lee BL (2012) Purification and characterization of tenecin 4, a new anti-Gram-negative bacterial peptide, from the beetle Tenebrio molitor. Dev Comp Immunol 36:540\u2013546","journal-title":"Dev Comp Immunol"},{"key":"4906_CR9","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.dci.2008.03.003","volume":"32","author":"WY Chen","year":"2008","unstructured":"Chen WY, Ho KC, Leu JH, Liu KF, Wang HC, Kou GH, Lo CF (2008) WSSV infection activates STAT in shrimp. Dev Comp Immunol 32:1142\u20131150","journal-title":"Dev Comp Immunol"},{"key":"4906_CR10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/bs.ai.2018.08.002","volume":"140","author":"J Chow","year":"2018","unstructured":"Chow J, Kagan JC (2018) The fly way of antiviral resistance and disease tolerance. Adv Immunol 140:59\u201393","journal-title":"Adv Immunol"},{"key":"4906_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.106168","volume":"205","author":"B Ding","year":"2024","unstructured":"Ding B, Zhang C, He L, Zeng Q, Zhang S, Yang H, Yang H (2024) JAK\/STAT signaling pathway is involved in antibacterial immunity in the green peach aphid Myzus persicae (Sulzer). Pestic Biochem Physiol 205:106168","journal-title":"Pestic Biochem Physiol"},{"key":"4906_CR12","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.chom.2018.03.004","volume":"23","author":"R Drolia","year":"2018","unstructured":"Drolia R, Tenguria S, Durkes AC, Turner JR, Bhunia AK (2018) Listeria adhesion protein induces intestinal epithelial barrier dysfunction for bacterial translocation. Cell Host Microbe 23:470\u2013484e7","journal-title":"Cell Host Microbe"},{"key":"4906_CR13","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3390\/ijms21041232","volume":"21","author":"TT Edosa","year":"2020","unstructured":"Edosa TT, Jo YH, Keshavarz M, Park KB, Cho JH, Bae YM, Kim B, Lee YS, Han YS (2020) Tm Atg6 plays an important role in anti-microbial defense against Listeria monocytogenes in the mealworm, Tenebrio molitor. Int J Mol Sci 21:1232","journal-title":"Int J Mol Sci"},{"key":"4906_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jip.2020.107473","volume":"179","author":"T Geng","year":"2021","unstructured":"Geng T, Lu F, Wu H, Wang Y, Lou D, Tu N, Zhu F, Wang S (2021) C-type lectin 5, a novel pattern recognition receptor for the JAK\/STAT signaling pathway in Bombyx mori. J Invertebr Pathol 179:107473","journal-title":"J Invertebr Pathol"},{"key":"4906_CR15","doi-asserted-by":"publisher","first-page":"15731","DOI":"10.1074\/jbc.M109.082115","volume":"285","author":"A Goto","year":"2010","unstructured":"Goto A, Yano T, Terashima J, Iwashita S, Oshima Y, Kurata S (2010) Cooperative regulation of the induction of the novel antibacterial Listericin by peptidoglycan recognition protein LE and the JAK-STAT pathway. J Biol Chem 285:15731\u201315738","journal-title":"J Biol Chem"},{"key":"4906_CR16","doi-asserted-by":"publisher","first-page":"17333","DOI":"10.1073\/pnas.1007765107","volume":"107","author":"E Gouin","year":"2010","unstructured":"Gouin E, Adib-Conquy M, Balestrino D, Nahori M-A, Villiers V, Colland F, Dramsi S, Dussurget O, Cossart P (2010) The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I\u03baB kinase subunit IKK\u03b1. Proc Natl Acad Sci 107:17333\u201317338","journal-title":"Proc Natl Acad Sci"},{"key":"4906_CR17","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01469-24","volume":"15","author":"D Guo","year":"2024","unstructured":"Guo D, Xu W, Cui T, Rong Q, Wu Q (2024) Protein-coding circular RNA enhances antiviral immunity via JAK\/STAT pathway in Drosophila. MBio 15:e01469-24","journal-title":"MBio"},{"key":"4906_CR18","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.chom.2009.04.003","volume":"5","author":"L Gupta","year":"2009","unstructured":"Gupta L, Molina-Cruz A, Kumar S, Rodrigues J, Dixit R, Zamora RE, Barillas-Mury C (2009) The STAT pathway mediates late-phase immunity against Plasmodium in the mosquito Anopheles gambiae. Cell Host Microbe 5:498\u2013507","journal-title":"Cell Host Microbe"},{"key":"4906_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-45978-4","volume":"13","author":"SH Hwang","year":"2023","unstructured":"Hwang SH, Jang HA, Kojour MAM, Yun K, Lee YS, Han YS, Jo YH (2023) Effects of TmTak1 silencing on AMP production as an Imd pathway component in Tenebrio molitor. Sci Rep 13:18914","journal-title":"Sci Rep"},{"key":"4906_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.906192","volume":"13","author":"HA Jang","year":"2022","unstructured":"Jang HA, Kojour MAM, Patnaik BB, Han YS, Jo YH (2022) Current status of immune deficiency pathway in Tenebrio molitor innate immunity. Front Immunol 13:906192","journal-title":"Front Immunol"},{"key":"4906_CR21","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.cell.2009.05.014","volume":"137","author":"H Jiang","year":"2009","unstructured":"Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, Edgar BA (2009) Cytokine\/Jak\/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137:1343\u20131355","journal-title":"Cell"},{"key":"4906_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/srep46459","volume":"7","author":"YH Jo","year":"2017","unstructured":"Jo YH, Kim YJ, Park KB, Seong JH, Kim SG, Park S, Noh MY, Lee YS, Han YS (2017) TmCactin plays an important role in Gram-negative and-positive bacterial infection by regulating expression of 7 AMP genes in Tenebrio molitor. Sci Rep 7:46459","journal-title":"Sci Rep"},{"key":"4906_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.667664","volume":"12","author":"YH Jo","year":"2021","unstructured":"Jo YH, Lee JH, Patnaik BB, Keshavarz M, Lee YS, Han YS (2021) Autophagy in Tenebrio molitor immunity: Conserved antimicrobial functions in insect defenses. Front Immunol 12:667664","journal-title":"Front Immunol"},{"key":"4906_CR24","doi-asserted-by":"publisher","first-page":"10389","DOI":"10.3390\/ijms231810389","volume":"23","author":"S Kausar","year":"2022","unstructured":"Kausar S, Gul I, Liu R, Ke X-X, Dong Z, Abbas MN, Cui H (2022) Antheraea pernyi suppressor of cytokine signaling 2 negatively modulates the JAK\/STAT pathway to attenuate microbial infection. Int J Mol Sci 23:10389","journal-title":"Int J Mol Sci"},{"key":"4906_CR26","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3390\/insects11030188","volume":"11","author":"M Keshavarz","year":"2020","unstructured":"Keshavarz M, Jo YH, Edosa TT, Han YS (2020) Two roles for the Tenebrio molitor relish in the regulation of antimicrobial peptides and autophagy-related genes in response to Listeria monocytogenes. Insects 11:188","journal-title":"Insects"},{"key":"4906_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53497-4","volume":"9","author":"M Keshavarz","year":"2019","unstructured":"Keshavarz M, Jo YH, Park KB, Ko HJ, Edosa TT, Lee YS, Han YS (2019) Tm DorX2 positively regulates antimicrobial peptides in Tenebrio molitor gut, fat body, and hemocytes in response to bacterial and fungal infection. Sci Rep 9:16878","journal-title":"Sci Rep"},{"key":"4906_CR27","doi-asserted-by":"crossref","unstructured":"Kim H, Kwon Y, Kim Y, Lee I, Jin B, Han Y, Cheon H, Kang Y, Seo S (2011) Molecular cloning and characterization of the STAT gene in Hyphantria cunea haemocytes.\u00a0Insect Mol Biol 20:723\u2013732","DOI":"10.1111\/j.1365-2583.2011.01102.x"},{"key":"4906_CR28","doi-asserted-by":"publisher","first-page":"14490","DOI":"10.3390\/ijms232214490","volume":"23","author":"MAM Kojour","year":"2022","unstructured":"Kojour MAM, Jang HA, Lee YS, Jo YH, Han YS (2022) Immunological roles of TmToll-2 in response to Escherichia coli systemic infection in Tenebrio molitor. Int J Mol Sci 23:14490","journal-title":"Int J Mol Sci"},{"key":"4906_CR29","doi-asserted-by":"publisher","first-page":"11427","DOI":"10.1073\/pnas.97.21.11427","volume":"97","author":"M Lagueux","year":"2000","unstructured":"Lagueux M, Perrodou E, Levashina EA, Capovilla M, Hoffmann JA (2000) Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Proc Natl Acad Sci USA 97:11427\u201311432","journal-title":"Proc Natl Acad Sci USA"},{"key":"4906_CR30","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s13071-017-2302-6","volume":"10","author":"GP League","year":"2017","unstructured":"League GP, Est\u00e9vez-Lao TY, Yan Y, Garcia-Lopez VA, Hillyer JF (2017) Anopheles gambiae larvae mount stronger immune responses against bacterial infection than adults: evidence of adaptive decoupling in mosquitoes. Parasit Vectors 10:367","journal-title":"Parasit Vectors"},{"key":"4906_CR31","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","volume":"25","author":"B Lemaitre","year":"2007","unstructured":"Lemaitre B, Hoffmann J (2007) The host defense of Drosophila melanogaster. Annu Rev Immunol 25:697\u2013743","journal-title":"Annu Rev Immunol"},{"key":"4906_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1485951","volume":"15","author":"W Liang","year":"2024","unstructured":"Liang W, Zhou L, Dang Z, Wang S, Zhao P, Xia Q, Lu Z (2024) Downregulation of BmSTAT transcription factor promoted nucleopolyhedrovirus replication in Bombyx mori. Front Microbiol 15:1485951","journal-title":"Front Microbiol"},{"key":"4906_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032777","volume":"7","author":"C Liongue","year":"2012","unstructured":"Liongue C, O\u2019Sullivan LA, Trengove MC, Ward AC (2012) Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One 7:e32777","journal-title":"PLoS One"},{"key":"4906_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.905467","volume":"14","author":"S Li","year":"2023","unstructured":"Li S, Wang J, Tian X, Toufeeq S, Huang W (2023) Immunometabolic regulation during the presence of microorganisms and parasitoids in insects. Front Immunol 14:905467","journal-title":"Front Immunol"},{"key":"4906_CR35","first-page":"1414382","volume-title":"Reviews in insect immune responses: 2022","author":"Q Liu","year":"2024","unstructured":"Liu Q (2024) Reviews in insect immune responses: 2022. Frontiers Media SA, p 1414382"},{"key":"4906_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01240-y","volume":"21","author":"M Mahjoor","year":"2023","unstructured":"Mahjoor M, Mahmoudvand G, Farokhi S, Shadab A, Kashfi M, Afkhami H (2023) Double-edged sword of JAK\/STAT signaling pathway in viral infections: novel insights into virotherapy. Cell Commun Signal 21:272","journal-title":"Cell Commun Signal"},{"key":"4906_CR37","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1186\/s12864-021-07729-5","volume":"22","author":"M Medina Munoz","year":"2021","unstructured":"Medina Munoz M, Brenner C, Richmond D, Spencer N, Rio RV (2021) The holobiont transcriptome of teneral tsetse fly species of varying vector competence. BMC Genomics 22:400","journal-title":"BMC Genomics"},{"key":"4906_CR38","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s40168-022-01378-w","volume":"10","author":"S Narasimhan","year":"2022","unstructured":"Narasimhan S, Rajeevan N, Graham M, Wu M-J, DePonte K, Marion S, Masson O, O\u2019Neal AJ, Pedra JH, Sonenshine DE (2022) Tick transmission of Borrelia burgdorferi to the murine host is not influenced by environmentally acquired midgut microbiota. Microbiome 10:173","journal-title":"Microbiome"},{"key":"4906_CR39","doi-asserted-by":"publisher","first-page":"484","DOI":"10.4049\/jimmunol.176.1.484","volume":"176","author":"B Opitz","year":"2006","unstructured":"Opitz B, Puschel A, Beermann W, Hocke AC, Fo\u0308rster S, Schmeck B, van Laak V, Chakraborty T, Suttorp N, Hippenstiel S (2006) Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J Immunol 176:484\u2013490","journal-title":"J Immunol"},{"key":"4906_CR40","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3389\/fimmu.2019.00310","volume":"10","author":"S Park","year":"2019","unstructured":"Park S, Jo YH, Park KB, Ko HJ, Kim CE, Bae YM, Kim B, Jun SA, Bang IS, Lee YS (2019) TmToll-7 plays a crucial role in innate immune responses against Gram-negative bacteria by regulating 5 AMP genes in Tenebrio molitor. Front Immunol 10:310","journal-title":"Front Immunol"},{"key":"4906_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10101983","volume":"10","author":"G Petronio","year":"2022","unstructured":"Petronio G, Pietrangelo L, Cutuli MA, Magnifico I, Venditti N, Guarnieri A, Abate GA, Yewhalaw D, Davinelli S, Di Marco R (2022) Emerging evidence on tenebrio molitor immunity: a focus on gene expression involved in microbial infection for host-pathogen interaction studies. Microorganisms 10:1983","journal-title":"Microorganisms"},{"key":"4906_CR42","unstructured":"Philippot L (2009) Molecular ecology of denitrifiers, Society for General Microbiology (SGM) Conference, pp np"},{"key":"4906_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10121545","volume":"10","author":"M Piatek","year":"2021","unstructured":"Piatek M, Sheehan G, Kavanagh K (2021) Galleria mellonella: the versatile host for drug discovery, in vivo toxicity testing and characterising host-pathogen interactions. Antibiotics 10:1545","journal-title":"Antibiotics"},{"key":"4906_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2023.104756","volume":"147","author":"A Prakash","year":"2023","unstructured":"Prakash A, Monteith KM, Bonnet M, Vale PF (2023) Duox and Jak\/Stat signalling influence disease tolerance in Drosophila during Pseudomonas entomophila infection. Dev Comp Immunol 147:104756","journal-title":"Dev Comp Immunol"},{"key":"4906_CR45","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61409","volume":"10","author":"D Rodrigues","year":"2021","unstructured":"Rodrigues D, Renaud Y, VijayRaghavan K, Waltzer L, Inamdar MS (2021) Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors. Elife 10:e61409","journal-title":"Elife"},{"key":"4906_CR46","unstructured":"Sadashiva Rao S, Nelson PA, Lunde HS, Haugland GT (2023) Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly (I: C) exposure"},{"key":"4906_CR47","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-023-00151-1","volume":"4","author":"A Sarapultsev","year":"2023","unstructured":"Sarapultsev A, Gusev E, Komelkova M, Utepova I, Luo S, Hu D (2023) JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions. Mol Biomed 4:40","journal-title":"Mol Biomed"},{"key":"4906_CR48","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative CT method. Nat Protoc 3:1101\u20131108","journal-title":"Nat Protoc"},{"key":"4906_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.718840","volume":"11","author":"D Shi","year":"2021","unstructured":"Shi D, Anwar TM, Pan H, Chai W, Xu S, Yue M (2021) Genomic determinants of pathogenicity and antimicrobial resistance for 60 global Listeria monocytogenes isolates responsible for invasive infections. Frontiers in Cellular and Infection Microbiology 11:718840","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"4906_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04498-0","volume":"14","author":"MA Sloan","year":"2021","unstructured":"Sloan MA, Sadlova J, Lestinova T, Sanders MJ, Cotton JA, Volf P, Ligoxygakis P (2021) The Phlebotomus papatasi systemic transcriptional response to trypanosomatid-contaminated blood does not differ from the non-infected blood meal. Parasit Vectors 14:15","journal-title":"Parasit Vectors"},{"key":"4906_CR51","doi-asserted-by":"publisher","first-page":"17841","DOI":"10.1073\/pnas.0905006106","volume":"106","author":"JA Souza-Neto","year":"2009","unstructured":"Souza-Neto JA, Sim S, Dimopoulos G (2009) An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense. Proc Natl Acad Sci U S A 106:17841\u201317846","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4906_CR52","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1186\/s12864-017-4058-y","volume":"18","author":"A Tsurumi","year":"2017","unstructured":"Tsurumi A, Zhao C, Li WX (2017) Canonical and non-canonical JAK\/STAT transcriptional targets may be involved in distinct and overlapping cellular processes. BMC Genomics 18:718","journal-title":"BMC Genomics"},{"key":"4906_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-387680-5.00001-X","volume":"42","author":"N Vodovar","year":"2012","unstructured":"Vodovar N, Saleh M-C (2012) Of insects and viruses: the role of small RNAs in insect defence. Adv Insect Physiol 42:1\u201336","journal-title":"Adv Insect Physiol"},{"key":"4906_CR54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007020","volume":"14","author":"C West","year":"2018","unstructured":"West C, Silverman N (2018) p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila. PLoS Pathog 14:e1007020","journal-title":"PLoS Pathog"},{"key":"4906_CR55","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15940-2","volume":"7","author":"H Yang","year":"2017","unstructured":"Yang H, Hultmark D (2017) Drosophila muscles regulate the immune response against wasp infection via carbohydrate metabolism. Sci Rep 7:15713","journal-title":"Sci Rep"},{"key":"4906_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-6351-4","volume":"20","author":"M Yu","year":"2019","unstructured":"Yu M, Zheng L, Wang X, Wu M, Qi M, Fu W, Zhang Y (2019) Comparative transcriptomic analysis of surf clams (Paphia undulate) infected with two strains of Vibrio spp. reveals the identity of key immune genes involved in host defense. BMC Genomics 20:988","journal-title":"BMC Genomics"},{"key":"4906_CR57","unstructured":"Zaalberg RM, Andersen LB, Hansen LS, Gebreyesus G, Henryon M, Jensen K, Nielsen HM (2025) Strong potential for selection for larger larval size in the black soldier fly (Hermetia illucens)"},{"key":"4906_CR58","doi-asserted-by":"publisher","first-page":"15132","DOI":"10.3390\/ijms232315132","volume":"23","author":"T Zeng","year":"2022","unstructured":"Zeng T, Jaffar S, Xu Y, Qi Y (2022) The intestinal immune defense system in insects. Int J Mol Sci 23:15132","journal-title":"Int J Mol Sci"},{"key":"4906_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/insects16010082","volume":"16","author":"S Zhang","year":"2025","unstructured":"Zhang S, Wang Z, Luo Q, Zhou L, Du X, Ren Y (2025) Effects of microbes on insect host physiology and behavior mediated by the host immune system. Insects 16:82","journal-title":"Insects"},{"key":"4906_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.105915","volume":"202","author":"Y-J Zhao","year":"2024","unstructured":"Zhao Y-J, Li Y-M, Yang T, Lu Z (2024) The Janus kinase\/signal transducers and activators of transcription (JAK\/STAT) pathway contributes to the defense against bacterial infection in the pea aphid. Pestic Biochem Physiol 202:105915","journal-title":"Pestic Biochem Physiol"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-026-04906-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-026-04906-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-026-04906-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:31:00Z","timestamp":1778596260000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11274-026-04906-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["4906"],"URL":"https:\/\/doi.org\/10.1007\/s11274-026-04906-0","relation":{},"ISSN":["1573-0972"],"issn-type":[{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"187"}}