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Its high adaptability and antibiotic resistance are largely mediated by quorum sensing (QS), a cell-to-cell communication system that coordinates the expression of virulence factors and biofilm formation. Targeting QS\u2014rather than bacterial viability\u2014has emerged as a promising antivirulence strategy known as quorum quenching (QQ). This review analyses current QQ approaches against\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , emphasizing their mechanisms, efficacy, and translational potential. Five main strategies are discussed: (i) inhibition of autoinducer synthesis through enzyme blockers targeting LasI, RhlI, and Pqs biosynthetic enzymes; (ii) enzymatic degradation or inactivation of QS signals by lactonases, acylases, and oxidoreductases; (iii) interference with signal release, particularly via disruption of outer membrane vesicle formation; (iv) inhibition of QS receptors (LasR, RhlR, and PqsR) using natural and synthetic antagonists; and (v) suppression of downstream signalling cascades. Although significant advances have been achieved, the clinical translation of QS inhibitors remains limited by issues of molecular stability, strain variability, and bioavailability. Nevertheless, structure-guided inhibitor design, synergistic combinations with antibiotics, and biofilm-targeted delivery systems are expanding the therapeutic landscape. Overall, QQ represents a sustainable strategy to attenuate bacterial virulence while minimizing selective pressure for resistance, offering a paradigm shift in the treatment of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    infections and other multidrug-resistant pathogens.\n                  <\/jats:p>","DOI":"10.1007\/s11274-026-05014-9","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:38:10Z","timestamp":1781084290000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quorum sensing inhibition strategies for the control of Pseudomonas aeruginosa infections"],"prefix":"10.1007","volume":"42","author":[{"given":"Juan","family":"S\u00e1nchez-Mateos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 David","family":"Flores-F\u00e9lix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"5014_CR1","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00253-010-2498-2","volume":"86","author":"AM Abdel-Mawgoud","year":"2010","unstructured":"Abdel-Mawgoud AM, L\u00e9pine F, D\u00e9ziel E (2010) Rhamnolipids: diversity of structures, microbial origins and roles. 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