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We integrated spectroscopic analysis, computational genomic, and molecular docking to explore isocoumarin biosynthesis of this mushroom. Using plate-based overlay bioassays we showed that\n                    <jats:italic>G. trabeum<\/jats:italic>\n                    is antagonistic against three microbes:\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    , and\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    , with most effect against\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    . The culture filtrates of\n                    <jats:italic>G. trabeum<\/jats:italic>\n                    were analysed by LCMS, with four products being further characterised by 2-D NMR, leading to the characterization of four rare coumarin-based polyketides: compound 1(tentatively, hydroxylated naphthoquinone derivative), compound 2 (oospoglycol), compound 3 (oosponol), and compound 4 (Naphthazarin-6,7-dihydrodiol (FD48)). Notably, both oospoglycol and oosponol exhibited antimicrobial activity against\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    . Genome mining and annotation of\n                    <jats:italic>G. trabeum<\/jats:italic>\n                    predicted several biosynthetic gene clusters (BGCs), including clusters associated with isocoumarin-derived compounds, which likely corresponds to the newly identified metabolites. The docking analysis in its turn identified oosponol as the most promising lead compound, exhibiting exceptional affinity for UspA1 of\n                    <jats:italic>Moraxella catarrhalis<\/jats:italic>\n                    , while oospoglycol showed broader antimicrobial potential through interactions with multiple targets, highlighting UspA1 as a key candidate for further future validation. Given that oosponol derivatives are commercially unavailable, due to the high costs associated with their production and purification, therefore characterising these compounds in\n                    <jats:italic>G. trabeum<\/jats:italic>\n                    considered an important scientific progress, as\n                    <jats:italic>G. trabeum<\/jats:italic>\n                    represents the only species from the Gloeophyllales order with available whole-genome sequences. Characterizing these unique compounds and their putative BGCs in\n                    <jats:italic>G. trabeum<\/jats:italic>\n                    boost the potential for high-yield, rapid cost effect production and development of novel antibiotics through synthetic biology and pharmacophore modelling.\n                  <\/jats:p>","DOI":"10.1007\/s11274-026-05181-9","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:31:51Z","timestamp":1786703511000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring rare coumarins biosynthesis by Gloeophyllum trabeum: an integrated computational genomics, molecular docking and spectroscopic approach"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-7904","authenticated-orcid":false,"given":"Suhad A. 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