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Therefore, alternative biotechnological processes have been successfully developed and applied due to their reduced cost and lower aggressiveness in the environment. The remarkable adaptive versatility of\n                    <jats:italic>Chromobacterium violaceum<\/jats:italic>\n                    in metal-contaminated environments makes this bacterium a promising candidate for Pb bioremediation. Therefore, the reference strain\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    ATCC 12,472 and the environmental isolate\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    SCV1, the first strain of this species isolated from a Brazilian area with natural Pb occurrence, were evaluated for Pb resistance under different Pb concentrations and exposure times. Pb biosorption was assessed by scanning electron microscopy, while strain-specific protein profiles were characterized using tandem mass spectrometry-based proteomic analysis. The results obtained revealed the potential of\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    to perform lead bioremediation. Scanning electron microscopy analysis confirmed the biosorption of lead by\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    strains.\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    SCV1 was able to remove up to 40% more lead concentration when compared to ATCC 12,472 which suggested adaptation through natural selection process of\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    SCV1. Proteome analysis revealed 1531 proteins, of which several are candidates for lead bioremediation. This is the first study on the resistance proteomics of\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    against lead. The acclimatization of the bacteria linked to the identification of several proteins related to: biosorption; efflux and ionic uptake (bioaccumulation); biomolecule transport; and biomethylation, point out to this organism as a potential lead bioremediation agent.\n                  <\/jats:p>","DOI":"10.1007\/s11274-026-05190-8","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:26:45Z","timestamp":1788514005000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioprospecting Chromobacterium violaceum for bioremediation: an alternative to environmental lead pollution"],"prefix":"10.1007","volume":"42","author":[{"given":"Feliphe Lacerda Souza","family":"de Alencar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Alejandro","family":"Navoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Chaves","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Soares Caldeira","family":"Brant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane Souza","family":"do Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"issue":"2","key":"5190_CR1","first-page":"201","volume":"6","author":"LM Abdelatey","year":"2011","unstructured":"Abdelatey LM, Khalil WKB, Ali TH, Mahrous KF (2011) Heavy metal resistance and gene expression analysis of metal resistance genes in Gram-positive and Gram-negative bacteria present in Egyptian soils. 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