{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:32:32Z","timestamp":1793287952599,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003489","name":"Henan University of Technology","doi-asserted-by":"publisher","award":["2025TXTD12"],"award-info":[{"award-number":["2025TXTD12"]}],"id":[{"id":"10.13039\/501100003489","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Youth Found of the Natural Science Foundation of Henan Province","award":["252300423562"],"award-info":[{"award-number":["252300423562"]}]},{"name":"The National Key R&D Project","award":["2022YFD2101400"],"award-info":[{"award-number":["2022YFD2101400"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"DOI":"10.1007\/s11274-026-05267-4","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:17:25Z","timestamp":1790407045000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HOM2 and TPK1 are associated with Kluyveromyces marxianus growth under high-temperature and reduced-aeration conditions"],"prefix":"10.1007","volume":"42","author":[{"given":"Huan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9784-9769","authenticated-orcid":false,"given":"Zhongke","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifu","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yini","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"5267_CR1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b03400","author":"M Avbelj","year":"2015","unstructured":"Avbelj M, Zupan J, Kranjc L, Raspor P (2015) Quorum-sensing kinetics in Saccharomyces cerevisiae: a symphony of ARO genes and aromatic alcohols. J Agric Food Chem. https:\/\/doi.org\/10.1021\/acs.jafc.5b03400","journal-title":"J Agric Food Chem"},{"key":"5267_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2022.108027","volume":"60","author":"M Baptista","year":"2022","unstructured":"Baptista M, Domingues L (2022) Kluyveromyces marxianus as a microbial cell factory for lignocellulosic biomass valorisation. Biotechnol Adv 60:108027. https:\/\/doi.org\/10.1016\/j.biotechadv.2022.108027","journal-title":"Biotechnol Adv"},{"key":"5267_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108121","volume":"64","author":"PD Brabander","year":"2023","unstructured":"Brabander PD, Uitterhaegen E, Delmulle T, Winter KD, Soetaert W (2023) Challenges and progress towards industrial recombinant protein production in yeasts: a review. Biotechnol Adv 64:108121. https:\/\/doi.org\/10.1016\/j.biotechadv.2023.108121","journal-title":"Biotechnol Adv"},{"issue":"4","key":"5267_CR4","doi-asserted-by":"publisher","first-page":"119209","DOI":"10.1016\/j.bbamcr.2021.119209","volume":"1869","author":"L Ca\u00f1onero","year":"2021","unstructured":"Ca\u00f1onero L, Pautasso C, Galello F, Sigaut L, Pietrasanta L, Javier A, Moretti MBerm\u00fadez, Portela P, Rossi S (2021) Heat stress regulates the expression of TPK1 gene at transcriptional and post-transcriptional levels in Saccharomyces cerevisiae. Biochim et Biophys Acta-Molecular Cell Res 1869(4):119209. https:\/\/doi.org\/10.1016\/j.bbamcr.2021.119209","journal-title":"Biochim et Biophys Acta-Molecular Cell Res"},{"issue":"17","key":"5267_CR5","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1016\/j.molcel.2023.07.018","volume":"83","author":"M Cao","year":"2023","unstructured":"Cao M, Day AM, Galler M, Latimer HR, Byrne DP, Foy TW, Dwyer E, Bennett E, Palmer J, Morgan BA, Eyers PA, Veal EA (2023) A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms. Mol Cell 83(17):3140\u20133154. https:\/\/doi.org\/10.1016\/j.molcel.2023.07.018","journal-title":"Mol Cell"},{"issue":"8","key":"5267_CR6","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.bbamcr.2007.05.003","volume":"1773","author":"RE Chen","year":"2007","unstructured":"Chen RE, Thorner J (2007) Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1773(8):1311\u20131340. https:\/\/doi.org\/10.1016\/j.bbamcr.2007.05.003","journal-title":"Biochim Biophys Acta"},{"key":"5267_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114360","author":"DR Creamer","year":"2024","unstructured":"Creamer DR, Beynon RJ, Hubbard SJ, Ashe MP, Grant CM (2024) Isoform-specific sequestration of protein kinase A fine-tunes intracellular signaling during heat stress. Cell Rep. https:\/\/doi.org\/10.1016\/j.celrep.2024.114360","journal-title":"Cell Rep"},{"issue":"2","key":"5267_CR8","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/pbi.70343","volume":"24","author":"B Deng","year":"2026","unstructured":"Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q (2026) Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. Plant Biotechnol J 24(2):363\u2013380. https:\/\/doi.org\/10.1111\/pbi.70343","journal-title":"Plant Biotechnol J"},{"issue":"2","key":"5267_CR9","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/j.1365-2958.2012.08193.x","volume":"86","author":"S Fanning","year":"2012","unstructured":"Fanning S, Xu W, Beaurepaire C, Suhan JP, Nantel A, Mitchell AP (2012) Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1. Mol Microbiol 86(2):284\u2013302. https:\/\/doi.org\/10.1111\/j.1365-2958.2012.08193.x","journal-title":"Mol Microbiol"},{"issue":"3","key":"5267_CR10","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1534\/genetics.104.034256","volume":"169","author":"SB Ferguson","year":"2005","unstructured":"Ferguson SB, Anderson ES, Harshaw RB, Thate T, Craig NL, Nelson HCM (2005) Protein kinase A regulates constitutive expression of small heat-shock genes in an Msn2\/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae. Genetics 169(3):1203\u20131214. https:\/\/doi.org\/10.1534\/genetics.104.034256","journal-title":"Genetics"},{"key":"5267_CR11","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.jprot.2015.06.006","volume":"127","author":"A Gil-Bona","year":"2015","unstructured":"Gil-Bona A, Parra-Giraldo CM, Hern\u00e1ez ML, Reales-Calderon JA, Solis NV, Filler SG, Monteoliva L, Gil C (2015) Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host-pathogen interaction. J Proteomics 127:340\u2013351. https:\/\/doi.org\/10.1016\/j.jprot.2015.06.006","journal-title":"J Proteomics"},{"key":"5267_CR12","doi-asserted-by":"publisher","unstructured":"Gombert AK, Gonz\u00e1lez-Siso JJos\u00e9V (2016) Mar\u00eda-Isabel. Kluyveromyces marxianus as a host for heterologous protein synthesis. Applied Microbiology and Biotechnology. 100 (14), 6193\u20136208. https:\/\/doi.org\/10.1007\/s00253-016-7645-y","DOI":"10.1007\/s00253-016-7645-y"},{"issue":"18","key":"5267_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/cells13181543","volume":"13","author":"P Gudmann","year":"2024","unstructured":"Gudmann P, Gombos I, Peter M, Balogh G, Torok Z, Vigh L, Glatz A (2024) Mild heat stress alters the physical state and structure of membranes in triacylglycerol-deficient fission yeast, Schizosaccharomyces pombe. Cells 13(18):1543. https:\/\/doi.org\/10.3390\/cells13181543","journal-title":"Cells"},{"issue":"8","key":"5267_CR14","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1111\/1462-2920.12866","volume":"17","author":"S Guyot","year":"2015","unstructured":"Guyot S, Gervais P, Young M, Winckler P, Dumont J, Davey HM (2015) Surviving the heat: heterogeneity of response in Saccharomyces cerevisiae provides insight into thermal damage to the membrane. Environ Microbiol 17(8):2982\u20132992. https:\/\/doi.org\/10.1111\/1462-2920.12866","journal-title":"Environ Microbiol"},{"issue":"28","key":"5267_CR15","doi-asserted-by":"publisher","first-page":"11700","DOI":"10.1073\/pnas.0705212104","volume":"104","author":"JL Hartman","year":"2007","unstructured":"Hartman JL (2007) Buffering of deoxyribonucleotide pool homeostasis by threonine metabolism. Proceedings of the National Academy of Sciences (PNAS) 104(28):11700\u201311705. https:\/\/doi.org\/10.1073\/pnas.0705212104","journal-title":"Proceedings of the National Academy of Sciences (PNAS)"},{"issue":"1","key":"5267_CR16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0168-6445(03)00017-2","volume":"27","author":"JK Hiltunen","year":"2003","unstructured":"Hiltunen JK, Mursula AM, Rottensteiner H, Wierenga RK, Kastaniotis AJ, Gurvitz A (2003) The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 27(1):35\u201364. https:\/\/doi.org\/10.1016\/S0168-6445(03)00017-2","journal-title":"FEMS Microbiol Rev"},{"issue":"1\u20132","key":"5267_CR17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.mrfmmm.2004.09.006","volume":"569","author":"A Ikner","year":"2005","unstructured":"Ikner A, Shiozaki K (2005) Yeast signaling pathways in the oxidative stress response. Mutat Res 569(1\u20132):13\u201327. https:\/\/doi.org\/10.1016\/j.mrfmmm.2004.09.006","journal-title":"Mutat Res"},{"key":"5267_CR18","doi-asserted-by":"publisher","unstructured":"Jeong H, Lee D-H, Kim SH, Kim H-J, Lee K, Song JY Byung Kwon Kim., Sung, Bong Hyun. 2012. Genome sequence of the thermotolerant yeast Kluyveromyces marxianus var. marxianus KCTC 17555. Eukaryot Cell 11 (12), 1584\u20131585. https:\/\/doi.org\/10.1128\/EC.00260-12","DOI":"10.1128\/EC.00260-12"},{"issue":"14","key":"5267_CR19","doi-asserted-by":"publisher","first-page":"8145","DOI":"10.1093\/nar\/gkab585","volume":"49","author":"M Jessulat","year":"2021","unstructured":"Jessulat M, Amin S, Hooshyar M, Malty R, Moutaoufik MT, Zilocchi M, Istace Z, Phanse S (2021) The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF. Nucleic Acids Res 49(14):8145\u20138160. https:\/\/doi.org\/10.1093\/nar\/gkab585","journal-title":"Nucleic Acids Res"},{"key":"5267_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2020.108818","volume":"333","author":"A Karim","year":"2020","unstructured":"Karim A, Gerliani N, A\u00efder M (2020) Kluyveromyces marxianus: an emerging yeast cell factory for applications in food and biotechnology. Int J Food Microbiol 333:108818. https:\/\/doi.org\/10.1016\/j.ijfoodmicro.2020.108818","journal-title":"Int J Food Microbiol"},{"issue":"8","key":"5267_CR21","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/foy092","volume":"18","author":"B Knoblach","year":"2018","unstructured":"Knoblach B, Rachubinski RA (2018) Reconstitution of human peroxisomal \u03b2-oxidation in yeast. FEMS Yeast Res 18(8):foy092. https:\/\/doi.org\/10.1093\/femsyr\/foy092","journal-title":"FEMS Yeast Res"},{"issue":"5","key":"5267_CR22","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/j.1567-1364.2006.00197.x","volume":"7","author":"M-A Lachance","year":"2007","unstructured":"Lachance M-A (2007) Current status of Kluyveromyces systematics. FEMS Yeast Res 7(5):642\u2013645. https:\/\/doi.org\/10.1111\/j.1567-1364.2006.00197.x","journal-title":"FEMS Yeast Res"},{"key":"5267_CR23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13068-015-0227-x","volume":"8","author":"N Lertwattanasakul","year":"2015","unstructured":"Lertwattanasakul N, Kosaka T, Hosoyama A, Suzuki Y, Rodrussamee N, Matsutani M, Murata M, Fujimoto N (2015) Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses. Biotechnol Biofuels 8:47. https:\/\/doi.org\/10.1186\/s13068-015-0227-x","journal-title":"Biotechnol Biofuels"},{"issue":"4","key":"5267_CR24","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1534\/genetics.111.128264","volume":"189","author":"D Levin","year":"2011","unstructured":"Levin D (2011) Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway. Genetics 189(4):1145\u20131175. https:\/\/doi.org\/10.1534\/genetics.111.128264","journal-title":"Genetics"},{"issue":"1","key":"5267_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100850","volume":"297","author":"Y Liu","year":"2021","unstructured":"Liu Y, Chen J, Xia P, Stratakis CA, Cheng Z (2021) Loss of PKA regulatory subunit 1\u03b1 aggravates cardiomyocyte necrosis and myocardial ischemia\/reperfusion injury. J Biol Chem 297(1):100850. https:\/\/doi.org\/10.1016\/j.jbc.2021.100850","journal-title":"J Biol Chem"},{"issue":"2","key":"5267_CR26","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.tcb.2018.10.004","volume":"29","author":"TM Luengo","year":"2018","unstructured":"Luengo TM, Mayer MP, R\u00fcdiger SGD (2018) The Hsp70-Hsp90 chaperone cascade in protein folding. Trends Cell Biol 29(2):164\u2013177. https:\/\/doi.org\/10.1016\/j.tcb.2018.10.004","journal-title":"Trends Cell Biol"},{"issue":"1","key":"5267_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-019-3134-5","volume":"20","author":"S Marci\u0161auskas","year":"2019","unstructured":"Marci\u0161auskas S, Ji B, Nielsen J (2019) Reconstruction and analysis of a Kluyveromyces marxianus genome-scale metabolic model. BMC Bioinformatics 20(1):551. https:\/\/doi.org\/10.1186\/s12859-019-3134-5","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"5267_CR28","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","volume":"62","author":"MP Mayer","year":"2005","unstructured":"Mayer MP, Bukau B (2005) Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci 62(6):670\u2013684. https:\/\/doi.org\/10.1007\/s00018-004-4464-6","journal-title":"Cell Mol Life Sci"},{"key":"5267_CR29","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.bej.2016.01.014","volume":"109","author":"K Meier","year":"2016","unstructured":"Meier K, Kl\u00f6ckner W, Bonhage B, Antonov E, Regestein L, B\u00fcchs J (2016) Correlation for the maximum oxygen transfer capacity in shake flasks for a wide range of operating conditions and for different culture media. Biochem Eng J 109:228\u2013235. https:\/\/doi.org\/10.1016\/j.bej.2016.01.014","journal-title":"Biochem Eng J"},{"issue":"1","key":"5267_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48733-w","volume":"9","author":"AD Moreno","year":"2019","unstructured":"Moreno AD, Gonz\u00e1lez-Fern\u00e1ndez C, Ballesteros M, Tom\u00e1s-Pej\u00f3 E (2019) Insoluble solids at high concentrations repress yeast\u2019s response against stress and increase intracellular ROS levels. Sci Rep 9(1):12236. https:\/\/doi.org\/10.1038\/s41598-019-48733-w","journal-title":"Sci Rep"},{"issue":"1","key":"5267_CR31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1021\/acssynbio.4c00436","volume":"14","author":"A Nguyen","year":"2025","unstructured":"Nguyen A, Tunn I, Penttil\u00e4 M, Frey AD (2025) Enhancing chitin production as a fermentation byproduct through a genetic toolbox that activates the cell wall integrity response. ACS Synth Biol 14(1):113\u2013128. https:\/\/doi.org\/10.1021\/acssynbio.4c00436","journal-title":"ACS Synth Biol"},{"issue":"2","key":"5267_CR32","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00253-019-10224-3","volume":"104","author":"M Nurcholis","year":"2020","unstructured":"Nurcholis M, Lertwattanasakul N, Rodrussamee N, Kosaka T, Murata M, Yamada M (2020) Integration of comprehensive data and biotechnological tools for industrial applications of Kluyveromyces marxianus. Appl Microbiol Biotechnol 104(2):475\u2013488. https:\/\/doi.org\/10.1007\/s00253-019-10224-3","journal-title":"Appl Microbiol Biotechnol"},{"issue":"11","key":"5267_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9110266","volume":"9","author":"D Pan","year":"2019","unstructured":"Pan D, Wiedemann N, Kammerer B (2019) Heat stress-induced metabolic remodeling in Saccharomyces cerevisiae. Metabolites 9(11):266. https:\/\/doi.org\/10.3390\/metabo9110266","journal-title":"Metabolites"},{"key":"5267_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-12-6","volume":"12","author":"F Pillet","year":"2014","unstructured":"Pillet F, Lemonier S, Schiavone M, Formosa C, Martin-Yken H, Francois JM, Dague E (2014) Uncovering by atomic force microscopy of an original circular structure at the yeast cell surface in response to heat shock. BMC Biol 12:6. https:\/\/doi.org\/10.1186\/1741-7007-12-6","journal-title":"BMC Biol"},{"key":"5267_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108125","volume":"64","author":"Y Qiu","year":"2023","unstructured":"Qiu Y, Lei P, Wang R, Sun L, Luo Z, Li S, Xu H (2023) Kluyveromyces as promising yeast cell factories for industrial bioproduction: from bio-functional design to applications. Biotechnol Adv 64:108125. https:\/\/doi.org\/10.1016\/j.biotechadv.2023.108125","journal-title":"Biotechnol Adv"},{"issue":"1","key":"5267_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1074\/jbc.M114.590984","volume":"290","author":"E Raspelli","year":"2015","unstructured":"Raspelli E, Cassani C, Chiroli E, Fraschini R (2015) Budding yeast Swe1 is involved in the control of mitotic spindle elongation and is regulated by Cdc14 phosphatase during mitosis. J Biol Chem 290(1):1\u201312. https:\/\/doi.org\/10.1074\/jbc.M114.590984","journal-title":"J Biol Chem"},{"issue":"9","key":"5267_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2020.194599","volume":"1863","author":"S Reca","year":"2020","unstructured":"Reca S, Galello F, Ojeda L, Pautasso C, Ca\u00f1onero L, Moreno S, Portela P, Rossi S (2020) Chromatin remodeling and transcription of the TPK1 subunit of PKA during stress in Saccharomyces cerevisiae. Biochim Biophys Acta Gene Regul Mech 1863(9):194599. https:\/\/doi.org\/10.1016\/j.bbagrm.2020.194599","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"issue":"4","key":"5267_CR38","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s00253-022-12354-7","volume":"107","author":"D Sandoval-Nu\u00f1ez","year":"2023","unstructured":"Sandoval-Nu\u00f1ez D, Romero-Guti\u00e9rrez T, G\u00f3mez-M\u00e1rquez C, Gshaedler A, Arellano-Plaza M, Amaya-Delgado L (2023) Physiological and transcriptome analyses of Kluyveromyces marxianus reveal adaptive traits in stress response. Appl Microbiol Biotechnol 107(4):1421\u20131438. https:\/\/doi.org\/10.1007\/s00253-022-12354-7","journal-title":"Appl Microbiol Biotechnol"},{"issue":"4","key":"5267_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/biot.70013","volume":"20","author":"A Schulte","year":"2025","unstructured":"Schulte A, Jordan A, Kl\u00f6ckner W, Schumacher M, Corves B, B\u00fcchs J (2025) Effect of high-speed shaking on oxygen transfer in shake flasks. Biotechnol J 20(4):e70013. https:\/\/doi.org\/10.1002\/biot.70013","journal-title":"Biotechnol J"},{"issue":"10","key":"5267_CR40","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s10295-003-0090-9","volume":"30","author":"C St\u00f6ckmann","year":"2003","unstructured":"St\u00f6ckmann C, Maier U, Anderlei T, Knocke C, Gellissen G, B\u00fcchs J (2003) The oxygen transfer rate as key parameter for the characterization of Hansenula polymorpha screening cultures. J Ind Microbiol Biotechnol 30(10):613\u2013622. https:\/\/doi.org\/10.1007\/s10295-003-0090-9","journal-title":"J Ind Microbiol Biotechnol"},{"issue":"1","key":"5267_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-019-1651-z","volume":"19","author":"J Terol","year":"2019","unstructured":"Terol J, Nueda MJ, Ventimilla D, Tadeo F, Talon M (2019) Transcriptomic analysis of Citrus clementina mandarin fruits maturation reveals a MADS-box transcription factor that might be involved in the regulation of earliness. BMC Plant Biol 19(1):47. https:\/\/doi.org\/10.1186\/s12870-019-1651-z","journal-title":"BMC Plant Biol"},{"issue":"1","key":"5267_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/BF00330954","volume":"217","author":"D Thomas","year":"1989","unstructured":"Thomas D, Surdin-Kerjan Y (1989) Structure of the HOM2 gene of Saccharomyces cerevisiae and regulation of its expression. Molecular & general genetics\u202f: MGG 217(1):149\u2013154. https:\/\/doi.org\/10.1007\/BF00330954","journal-title":"Molecular & general genetics : MGG"},{"key":"5267_CR43","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1534\/genetics.120.303369","volume":"1","author":"MD Vandermeulen","year":"2020","unstructured":"Vandermeulen MD, Cullen PJ (2020) New Aspects of Invasive Growth Regulation Identified by Functional Profiling of MAPK Pathway Targets in Saccharomyces cerevisiae. Genetics 1:95\u2013116. https:\/\/doi.org\/10.1534\/genetics.120.303369","journal-title":"Genetics"},{"issue":"26","key":"5267_CR44","doi-asserted-by":"publisher","first-page":"14177","DOI":"10.1039\/c8ra00335a","volume":"8","author":"D Wang","year":"2018","unstructured":"Wang D, Wu D, Yang X, Hong J (2018) Transcriptomic analysis of thermotolerant yeast Kluyveromyces marxianus in multiple inhibitors tolerance. RSC Anvances 8(26):14177\u201314192. https:\/\/doi.org\/10.1039\/c8ra00335a","journal-title":"RSC Anvances"},{"key":"5267_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2025.101221","volume":"11","author":"H Wang","year":"2025","unstructured":"Wang H, Sun Z, Ni Z, Qi Y, Feng X, Xiao H, Wang L, Hong J, Liang Y, Li C (2025) From genetic constraints to process hurdles: a review of Kluyveromyces marxianus for efficient bio-manufacturing and bio-processing in food industry. Curr Res Food Sci 11:101221. https:\/\/doi.org\/10.1016\/j.crfs.2025.101221","journal-title":"Curr Res Food Sci"},{"issue":"18","key":"5267_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810645","volume":"23","author":"T Wangsanut","year":"2022","unstructured":"Wangsanut T, Pongpom M (2022) The role of the glutathione system in stress adaptation, morphogenesis and virulence of pathogenic fungi. Int J Mol Sci 23(18):10645. https:\/\/doi.org\/10.3390\/ijms231810645","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5267_CR47","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00253-024-13097-3","volume":"108","author":"D-W Zeng","year":"2024","unstructured":"Zeng D-W, Yang Y-Q, Wang Q, Zhang F-L, Zhang M-D, Liao S, Liu Z-Q, Fan Y-C, Liu C-G, Zhang L, Zhao X-Q (2024) Transcriptome analysis of Kluyveromyces marxianus under succinic acid stress and development of robust strains. Appl Microbiol Biotechnol 108(1):293. https:\/\/doi.org\/10.1007\/s00253-024-13097-3","journal-title":"Appl Microbiol Biotechnol"},{"key":"5267_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochms.2022.100095","volume":"4","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Lan Q, Yu Y, Zhou J, Lu H (2022) Comparative metabolome and transcriptome analyses of the properties of Kluyveromyces marxianus and Saccharomyces yeasts in apple cider fermentation. Food Chemistry: Molecular Sciences 4:100095. https:\/\/doi.org\/10.1016\/j.fochms.2022.100095","journal-title":"Food Chemistry: Molecular Sciences"},{"issue":"4","key":"5267_CR49","doi-asserted-by":"publisher","DOI":"10.71150\/jm.2411008","volume":"63","author":"X Zhao","year":"2025","unstructured":"Zhao X, Wang Y, Zhang Q, Huang Y, Wei X, Wu D (2025) Antifungal effects of Metformin against Candida albicans by autophagy regulation. J Microbiol 63(4):e2411008. https:\/\/doi.org\/10.71150\/jm.2411008","journal-title":"J Microbiol"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-026-05267-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-026-05267-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-026-05267-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:44:11Z","timestamp":1793285051000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-026-05267-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":49,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["5267"],"URL":"https:\/\/doi.org\/10.1007\/s11274-026-05267-4","relation":{},"ISSN":["1573-0972"],"issn-type":[{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]},"assertion":[{"value":"24 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors read and agree to the content of this paper and its publication.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"551"}}