{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:32:32Z","timestamp":1793287952697,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"DOI":"10.1007\/s11274-026-05274-5","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:33:34Z","timestamp":1789994014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rosa damascena-derived exosome-like nanovesicles inhibit Salmonella enterica via membrane disruption, oxidative stress, and virulence suppression"],"prefix":"10.1007","volume":"42","author":[{"given":"Subhashini","family":"Brahadeeswaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-7649","authenticated-orcid":false,"given":"Ramasamy","family":"Tamizhselvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"5274_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13050839","author":"FA Alzahrani","year":"2023","unstructured":"Alzahrani FA, Khan MI, Kameli N, Alsahafi E, Riza YM (2023) Plant-derived extracellular vesicles and their exciting potential as the future of next-generation drug delivery. Biomolecules. https:\/\/doi.org\/10.3390\/biom13050839","journal-title":"Biomolecules"},{"issue":"1","key":"5274_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-025-92435-5","volume":"15","author":"S Bie","year":"2025","unstructured":"Bie S, Yuan H, Shi C, Li C, Lu M, Yao Z et al (2025) Antibiofilm activity of Plumbagin against Staphylococcus aureus. Sci Rep 15(1):1\u201311. https:\/\/doi.org\/10.1038\/s41598-025-92435-5","journal-title":"Sci Rep"},{"issue":"4","key":"5274_CR3","first-page":"295","volume":"14","author":"MH Boskabady","year":"2011","unstructured":"Boskabady MH, Shafei MN, Saberi Z, Amini S (2011) Pharmacological effects of rosa damascena. Iran J Basic Med Sci 14(4):295\u2013307","journal-title":"Iran J Basic Med Sci"},{"issue":"1","key":"5274_CR4","doi-asserted-by":"publisher","DOI":"10.1080\/15592324.2026.2641285","volume":"21","author":"S Brahadeeswaran","year":"2026","unstructured":"Brahadeeswaran S, Tamizhselvi R (2026) Proteomic mapping of Rosa damascena nanovesicles reveals plastid mitochondrial metabolic convergence and antimicrobial peptides. Plant Signal Behav 21(1):2641285. https:\/\/doi.org\/10.1080\/15592324.2026.2641285","journal-title":"Plant Signal Behav"},{"issue":"6","key":"5274_CR5","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1021\/acs.molpharmaceut.9b00246","volume":"16","author":"X Chen","year":"2019","unstructured":"Chen X, Zhou Y, Yu J (2019) Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation. Mol Pharm 16(6):2690\u20132699. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.9b00246","journal-title":"Mol Pharm"},{"key":"5274_CR6","doi-asserted-by":"publisher","DOI":"10.4103\/apjtb.apjtb_823_23","author":"T Dasgupta","year":"2024","unstructured":"Dasgupta T, Manickam V (2024) Benzydamine hydrochloride ameliorates ethanol-induced inflammation in RAW 264.7 macrophages by stabilizing redox homeostasis. Asian Pac J Trop Biomed 14(2):73\u201381. https:\/\/doi.org\/10.4103\/apjtb.apjtb_823_23","journal-title":"Asian Pac J Trop Biomed"},{"issue":"27","key":"5274_CR7","doi-asserted-by":"publisher","first-page":"21369","DOI":"10.1039\/d5ra01831e","volume":"15","author":"MK Gaballah","year":"2025","unstructured":"Gaballah MK, Khalid SA, Seleem MA, Bass AKA, El-Sherbiny IM, Mayhoub AS (2025) Development and evaluation of new nanoformulated thiolactone derivatives for enhanced disruption of pseudomonal biofilms. RSC Adv 15(27):21369\u201321380. https:\/\/doi.org\/10.1039\/d5ra01831e","journal-title":"RSC Adv"},{"key":"5274_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1478488","author":"JF Gonz\u00e1lez","year":"2024","unstructured":"Gonz\u00e1lez JF, Laipply B, Sadowski VA, Price M, Gunn JS (2024) Functional role of the biofilm regulator CsgD in Salmonella enterica sv. Typhi. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2024.1478488","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"5274_CR9","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1128\/JB.01826-08","volume":"192","author":"N Grantcharova","year":"2010","unstructured":"Grantcharova N, Peters V, Monteiro C, Zakikhany K, R\u00f6mling U (2010) Bistable expression of CsgD in biofilm development of Salmonella enterica serovar typhimurium. J Bacteriol 192(2):456\u2013466. https:\/\/doi.org\/10.1128\/JB.01826-08","journal-title":"J Bacteriol"},{"key":"5274_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-025-01955-0","author":"S Isik","year":"2025","unstructured":"Isik S, Alhelwani S, Sahsahi A, Balcilar H, Yeman-Kiyak B (2025) Plant-derived exosome-like nanovesicles: mechanisms and molecular understanding in neurological disorders with potential therapeutic applications. Drug Deliv Transl Res. https:\/\/doi.org\/10.1007\/s13346-025-01955-0","journal-title":"Drug Deliv Transl Res"},{"issue":"1","key":"5274_CR11","first-page":"40","volume":"4","author":"A Jafari-Sales","year":"2020","unstructured":"Jafari-Sales A, Jafari B, Khaneshpour H, Pashazadeh M (2020) Antibacterial Effect of Methanolic Extract of Rosa damascena on Standard Bacteria Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa in Vitro. Int J Nat Life Sci (IJNLS) 4(1):40\u201346","journal-title":"Int J Nat Life Sci (IJNLS)"},{"issue":"1","key":"5274_CR12","doi-asserted-by":"publisher","first-page":"eesp","DOI":"10.1128\/ecosalplus.esp-0001-2023","volume":"12","author":"H Jing","year":"2024","unstructured":"Jing H, Nesreen A, Shaohua Z, Hailin T, Heather H, Maria H et al (2024) Infection biology of Salmonella enterica. EcoSal Plus 12(1):eesp\u20130001. https:\/\/doi.org\/10.1128\/ecosalplus.esp-0001-2023","journal-title":"EcoSal Plus"},{"issue":"30","key":"5274_CR13","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1080\/17435889.2024.2354159","volume":"19","author":"P Kathait","year":"2024","unstructured":"Kathait P, Patel PK, Sahu AN (2024) Harnessing exosomes and plant-derived exosomes as nanocarriers for the efficient delivery of plant bioactives. Nanomedicine 19(30):2679\u20132697. https:\/\/doi.org\/10.1080\/17435889.2024.2354159","journal-title":"Nanomedicine"},{"key":"5274_CR14","doi-asserted-by":"publisher","DOI":"10.1590\/0103-8478cr20230146","author":"V Laviniki","year":"2024","unstructured":"Laviniki V, Simoni C, Carloto AF, Lopes GV (2024) The biofilm-forming ability of Salmonella enterica subsp. enterica isolated from swine-feed mills. Cienc Rural. https:\/\/doi.org\/10.1590\/0103-8478cr20230146","journal-title":"Cienc Rural"},{"issue":"July","key":"5274_CR15","doi-asserted-by":"publisher","first-page":"4891","DOI":"10.2147\/IJN.S315040","volume":"16","author":"C Leiva-Sabadini","year":"2021","unstructured":"Leiva-Sabadini C, Alvarez S, Barrera NP, Schuh CMAP, Aguayo S (2021) Antibacterial effect of honey-derived exosomes containing antimicrobial peptides against oral streptococci. Int J Nanomed 16(July):4891\u20134900. https:\/\/doi.org\/10.2147\/IJN.S315040","journal-title":"Int J Nanomed"},{"key":"5274_CR16","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8743096","author":"Q Li","year":"2022","unstructured":"Li Q, Huang KX, Pan S, Su C, Bi J, Lu X (2022) Thymol disrupts cell homeostasis and inhibits the growth of Staphylococcus aureus. Contrast Media Mol Imaging. https:\/\/doi.org\/10.1155\/2022\/8743096","journal-title":"Contrast Media Mol Imaging"},{"key":"5274_CR17","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jgar.2023.09.016","volume":"35","author":"M Liu","year":"2023","unstructured":"Liu M, Zhu K, Li X, Han Y, Yang C, Liu H et al (2023) Genetic characterization of a Salmonella enterica serovar Typhimurium isolated from an infant with concurrent resistance to ceftriaxone, ciprofloxacin and azithromycin. J Global Antimicrob Resist 35:252\u2013256. https:\/\/doi.org\/10.1016\/j.jgar.2023.09.016","journal-title":"J Global Antimicrob Resist"},{"issue":"4","key":"5274_CR18","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.tem.2022.01.002","volume":"33","author":"J Martel","year":"2022","unstructured":"Martel J, Chang SH, Ko YF, Hwang TL, Young JD, Ojcius DM (2022) Gut barrier disruption and chronic disease. Trends Endocrinol Metab 33(4):247\u2013265. https:\/\/doi.org\/10.1016\/j.tem.2022.01.002","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"5274_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-06657-y","volume":"12","author":"CR Mendes","year":"2022","unstructured":"Mendes CR, Dilarri G, Forsan CF, Sapata V, de MR, Lopes PRM, de Moraes PB et al (2022) Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens. Sci Rep 12(1):1\u201310. https:\/\/doi.org\/10.1038\/s41598-022-06657-y","journal-title":"Sci Rep"},{"key":"5274_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18362-x","author":"A Mirzaei","year":"2022","unstructured":"Mirzaei A, Nasr Esfahani B, Ghanadian M, Moghim S (2022) Alhagi maurorum extract modulates quorum sensing genes and biofilm formation in Proteus mirabilis. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-022-18362-x","journal-title":"Sci Rep"},{"issue":"9","key":"5274_CR21","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1089\/fpd.2022.0080","volume":"20","author":"N Nuanmuang","year":"2023","unstructured":"Nuanmuang N, Leekitcharoenphon P, Njage PMK, Gmeiner A, Aarestrup FM (2023) An overview of antimicrobial resistance profiles of publicly available Salmonella genomes with sufficient quality and metadata. Foodborne Pathog Dis 20(9):405\u2013413. https:\/\/doi.org\/10.1089\/fpd.2022.0080","journal-title":"Foodborne Pathog Dis"},{"key":"5274_CR22","doi-asserted-by":"crossref","unstructured":"Passmore IJ, Letertre MPM, Preston MD, Bianconi I, Harrison A, Nasher F et al (2018) Para -cresol production by clostridium difficile affects microbial diversity and membrane integrity of gram-negative bacteria","DOI":"10.1371\/journal.ppat.1007191"},{"issue":"1","key":"5274_CR23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.pcl.2021.09.007","volume":"69","author":"FN Qamar","year":"2022","unstructured":"Qamar FN, Hussain W, Qureshi S (2022) Salmonellosis Including Enteric Fever. Pediatr Clin North Am 69(1):65\u201377. https:\/\/doi.org\/10.1016\/j.pcl.2021.09.007","journal-title":"Pediatr Clin North Am"},{"key":"5274_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1133569","author":"S Saha","year":"2023","unstructured":"Saha S, Aggarwal S, Singh DV (2023) Attenuation of quorum sensing system and virulence in Vibrio cholerae by phytomolecules. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2023.1133569","journal-title":"Front Microbiol"},{"issue":"1","key":"5274_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5829\/idosi.gjp.2014.8.1.81275","volume":"8","author":"M Shohayeb","year":"2014","unstructured":"Shohayeb M, Abdel-Hameed ESS, Bazaid SA, Maghrabi I (2014) Antibacterial and antifungal activity of Rosa damascena MILL. essential oil, different extracts of rose petals. Global J Pharmacol 8(1):1\u20137. https:\/\/doi.org\/10.5829\/idosi.gjp.2014.8.1.81275","journal-title":"Global J Pharmacol"},{"issue":"October 2022","key":"5274_CR26","doi-asserted-by":"publisher","first-page":"100084","DOI":"10.1016\/j.medmic.2023.100084","volume":"16","author":"P Shree","year":"2023","unstructured":"Shree P, Kant C, Kaur K, Niranjane J, Kumar D (2023) Medicine in Microecology Bio fi lms: Understanding the structure and contribution towards bacterial resistance in antibiotics. Med Microecology 16(October 2022):100084. https:\/\/doi.org\/10.1016\/j.medmic.2023.100084","journal-title":"Med Microecology"},{"issue":"7","key":"5274_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/microorganisms8070964","volume":"8","author":"AS Sokaribo","year":"2020","unstructured":"Sokaribo AS, Hansen EG, McCarthy M, Desin TS, Waldner LL, Mackenzie KD et al (2020) Metabolic activation of csgd in the regulation of salmonella biofilms. Microorganisms 8(7):1\u201325. https:\/\/doi.org\/10.3390\/microorganisms8070964","journal-title":"Microorganisms"},{"key":"5274_CR28","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5080843","author":"LJ Su","year":"2019","unstructured":"Su LJ, Zhang JH, Gomez H, Murugan R, Hong X, Xu D et al (2019) Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2019\/5080843","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"5274_CR29","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s44197-023-00160-x","volume":"13","author":"H Talukder","year":"2023","unstructured":"Talukder H, Roky SA, Debnath K, Sharma B, Ahmed J, Roy S (2023) Prevalence and antimicrobial resistance profile of Salmonella isolated from human, animal and environment samples in South Asia: a 10-year meta-analysis. J Epidemiol Glob Health 13(4):637\u2013652. https:\/\/doi.org\/10.1007\/s44197-023-00160-x","journal-title":"J Epidemiol Glob Health"},{"issue":"March","key":"5274_CR30","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jconrel.2024.02.045","volume":"368","author":"S Tan","year":"2024","unstructured":"Tan S, Liu Z, Cong M, Zhong X, Mao Y, Fan M et al (2024) Dandelion-derived vesicles-laden hydrogel dressings capable of neutralizing Staphylococcus aureus exotoxins for the care of invasive wounds. J Controlled Release 368(March):355\u2013371. https:\/\/doi.org\/10.1016\/j.jconrel.2024.02.045","journal-title":"J Controlled Release"},{"key":"5274_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/foods12091756","author":"AD Teklemariam","year":"2023","unstructured":"Teklemariam AD, Al-Hindi RR, Albiheyri RS, Alharbi MG, Alghamdi MA, Filimban AAR et al (2023) Human salmonellosis: a continuous global threat in the farm-to-fork food safety continuum. Foods. https:\/\/doi.org\/10.3390\/foods12091756","journal-title":"Foods"},{"issue":"October","key":"5274_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2022.1025768","volume":"13","author":"Y Teng","year":"2022","unstructured":"Teng Y, He J, Zhong Q, Zhang Y, Lu Z, Guan T et al (2022) Grape exosome-like nanoparticles: A potential therapeutic strategy for vascular calcification. Front Pharmacol 13(October):1\u20139. https:\/\/doi.org\/10.3389\/fphar.2022.1025768","journal-title":"Front Pharmacol"},{"issue":"2","key":"5274_CR33","first-page":"33","volume":"8","author":"N Thallaj","year":"2020","unstructured":"Thallaj N, Labban L (2020) The Medicinal and Pharmacological Properties of Damascene Rose (Rosa damascena). Int J Herb Med 8(2):33\u201337","journal-title":"Int J Herb Med"},{"issue":"1","key":"5274_CR34","first-page":"225","volume":"14","author":"Z Tofighi","year":"2015","unstructured":"Tofighi Z, Molazem M, Doostdar B, Taban P, Shahverdi AR, Samadi N et al (2015) Antimicrobial Activities of Three Medicinal Plants and Investigation of Flavonoids of Tripleurospermum disciforme. Iran J Pharm research: IJPR 14(1):225\u2013231","journal-title":"Iran J Pharm research: IJPR"},{"key":"5274_CR35","doi-asserted-by":"crossref","unstructured":"Wei Y, Cai X, Wu Q, Liao H, Liang S, et al (2023) Extraction, isolation, and component analysis of turmeric-derived exosome-like nanoparticles. Published online 2023.","DOI":"10.3390\/bioengineering10101199"},{"issue":"7","key":"5274_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms22073719","volume":"22","author":"E Woith","year":"2021","unstructured":"Woith E, Guerriero G, Hausman JF, Renaut J, Leclercq CC, Weise C et al (2021) Plant extracellular vesicles and nanovesicles: focus on secondary metabolites, proteins and lipids with perspectives on their potential and sources. Int J Mol Sci 22(7):1\u201320. https:\/\/doi.org\/10.3390\/ijms22073719","journal-title":"Int J Mol Sci"},{"issue":"October","key":"5274_CR37","doi-asserted-by":"publisher","first-page":"11941","DOI":"10.2147\/IJN.S483091","volume":"19","author":"Q Xie","year":"2024","unstructured":"Xie Q, Gu J, Sun Y, Hong J, Wang J, Li N et al (2024) Therapeutic Potential of Ginger Exosome-Like Nanoparticles for Alleviating Periodontitis-Induced Tissue Damage. Int J Nanomed 19(October):11941\u201311956. https:\/\/doi.org\/10.2147\/IJN.S483091","journal-title":"Int J Nanomed"},{"issue":"1","key":"5274_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-023-01858-7","volume":"21","author":"Z Xu","year":"2023","unstructured":"Xu Z, Xu Y, Zhang K, Liu Y, Liang Q, Thakur A et al (2023) Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities. J Nanobiotechnol 21(1):1\u201313. https:\/\/doi.org\/10.1186\/s12951-023-01858-7","journal-title":"J Nanobiotechnol"},{"key":"5274_CR39","doi-asserted-by":"publisher","unstructured":"Zhu C, Gao B, Li J (2024) Zingiber officinale-derived exosome-like nanoparticles as antimicrobial agents via lipid-mediated inhibition. Nano Ex 5:045009. https:\/\/doi.org\/10.1088\/2632-959X\/ad9299","DOI":"10.1088\/2632-959X\/ad9299"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-026-05274-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-026-05274-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-026-05274-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:44:23Z","timestamp":1793285063000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-026-05274-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["5274"],"URL":"https:\/\/doi.org\/10.1007\/s11274-026-05274-5","relation":{},"ISSN":["1573-0972"],"issn-type":[{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"20 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"544"}}