{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:32:39Z","timestamp":1793287959656,"version":"4.5.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Microbiol Biotechnol"],"DOI":"10.1007\/s11274-026-05298-x","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:19:50Z","timestamp":1790857190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbial valorization of pomegranate peel pectin into pectic oligosaccharides with selective anticancer activities: in vitro and in silico evaluation"],"prefix":"10.1007","volume":"42","author":[{"given":"Zahra","family":"Ghobadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrouzossadat","family":"Hosseini-Abari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Amini-Rourani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad J.","family":"Taherzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"5298_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","volume":"1","author":"MJ Abraham","year":"2015","unstructured":"Abraham MJ, Murtola T, Schulz R, P\u00e1ll S, Smith JC, Hess B, Lindahl E (2015) GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX 1:19\u201325. https:\/\/doi.org\/10.1016\/j.softx.2015.06.001","journal-title":"SoftwareX"},{"key":"5298_CR2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/B978-8-12-819001-2.00014-0","volume-title":"Microorganisms for sustainable environment and health","author":"G Anand","year":"2020","unstructured":"Anand G, Yadav S, Gupta R, Yadav D (2020) Pectinases: from microbes to industries. In: Chowdhary P, Raj A, Verma D, Akhter Y (eds) Microorganisms for sustainable environment and health. Elsevier, Cambridge, pp 287\u2013313. https:\/\/doi.org\/10.1016\/B978-8-12-819001-2.00014-0"},{"key":"5298_CR3","doi-asserted-by":"publisher","first-page":"15830","DOI":"10.1038\/s41598-022-20011-2","volume":"12","author":"B Ashrafian","year":"2022","unstructured":"Ashrafian B, Hosseini-Abari A (2022) Investigation of bioactivity of unsaturated oligo\u2013galacturonic acids produced from apple waste by Alcaligenes faecalis AGS3 and Paenibacillus polymyxa S4 Pectinases. Sci Rep 12:15830. https:\/\/doi.org\/10.1038\/s41598-022-20011-2","journal-title":"Sci Rep"},{"key":"5298_CR4","doi-asserted-by":"publisher","DOI":"10.4137\/CMO.S285","author":"M Az\u00e9mar","year":"2007","unstructured":"Az\u00e9mar M, Hildenbrand B, Haering B, Heim ME, Unger C (2007) Clinical benefit in patients with advanced solid tumors treated with modified citrus pectin: a prospective pilot study. Clin Med Oncol. https:\/\/doi.org\/10.4137\/CMO.S285. 1:CMO S285","journal-title":"Clin Med Oncol"},{"key":"5298_CR5","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1063\/1.448118","volume":"81","author":"HJ Berendsen","year":"1984","unstructured":"Berendsen HJ, Van Postma Jv WF, DiNola A, Haak JR (1984) Molecular dynamics with coupling to an external bath. J Chem Phys 81:3684\u20133690. https:\/\/doi.org\/10.1063\/1.448118","journal-title":"J Chem Phys"},{"key":"5298_CR6","doi-asserted-by":"publisher","first-page":"e25007","DOI":"10.1371\/journal.pone.0025007","volume":"6","author":"C-F Bian","year":"2011","unstructured":"Bian C-F, Zhang Y, Sun H, Li D-F, Wang D-C (2011) Structural basis for distinct binding properties of the human galectins to Thomsen-Friedenreich antigen. PLoS ONE 6:e25007. https:\/\/doi.org\/10.1371\/journal.pone.0025007","journal-title":"PLoS ONE"},{"key":"5298_CR7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1590\/S1516-89132005000200013","volume":"48","author":"MH Canteri-Schemin","year":"2005","unstructured":"Canteri-Schemin MH, Fertonani HCR, Waszczynskyj N, Wosiacki G (2005) Extraction of pectin from apple pomace. Braz Arch Biol Technol 48:259\u2013266. https:\/\/doi.org\/10.1590\/S1516-89132005000200013","journal-title":"Braz Arch Biol Technol"},{"key":"5298_CR8","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.3390\/foods11172683","volume":"11","author":"V Chandel","year":"2022","unstructured":"Chandel V, Biswas D, Roy S, Vaidya D, Verma A, Gupta A (2022) Current advancements in pectin: Extraction, properties and multifunctional applications. Foods 11:2683. https:\/\/doi.org\/10.3390\/foods11172683","journal-title":"Foods"},{"key":"5298_CR9","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1139\/m79-014","volume":"25","author":"AK Chatterjee","year":"1979","unstructured":"Chatterjee AK, Buchanan GE, Behrens MK, Starr MP (1979) Synthesis and excretion of polygalacturonic acid trans-eliminase in Erwinia, Yersinia, and Klebsiella species. Can J Microbiol 25:94\u2013102. https:\/\/doi.org\/10.1139\/m79-014","journal-title":"Can J Microbiol"},{"key":"5298_CR10","doi-asserted-by":"publisher","first-page":"126438","DOI":"10.1016\/j.jclepro.2021.126438","volume":"295","author":"C Chauhan","year":"2021","unstructured":"Chauhan C, Dhir A, Akram MU, Salo J (2021) Food loss and waste in food supply chains. A systematic literature review and framework development approach. J Clean Prod 295:126438. https:\/\/doi.org\/10.1016\/j.jclepro.2021.126438","journal-title":"J Clean Prod"},{"key":"5298_CR11","doi-asserted-by":"publisher","first-page":"e1501240","DOI":"10.1126\/sciadv.1501240","volume":"2","author":"D Chen","year":"2016","unstructured":"Chen D, Oezguen N, Urvil P, Ferguson C, Dann SM, Savidge TC (2016) Regulation of protein-ligand binding affinity by hydrogen bond pairing. Sci Sdv 2:e1501240. https:\/\/doi.org\/10.1126\/sciadv.1501240","journal-title":"Sci Sdv"},{"key":"5298_CR12","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.3390\/microorganisms11061384","volume":"11","author":"VM Corbu","year":"2023","unstructured":"Corbu VM, Gheorghe-Barbu I, Dumbrav\u0103 A\u0218, Vr\u00e2ncianu CO, \u0218esan TE (2023) Current insights in fungal importance\u2014a comprehensive review. Microorganisms 11:1384. https:\/\/doi.org\/10.3390\/microorganisms11061384","journal-title":"Microorganisms"},{"key":"5298_CR13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.phanu.2012.12.001","volume":"1","author":"FL Courts","year":"2013","unstructured":"Courts FL (2013) Profiling of modified citrus pectin oligosaccharide transport across Caco-2 cell monolayers. Pharma Nutr 1:22\u201331. https:\/\/doi.org\/10.1016\/j.phanu.2012.12.001","journal-title":"Pharma Nutr"},{"key":"5298_CR14","doi-asserted-by":"publisher","first-page":"10089","DOI":"10.1063\/1.464397","volume":"98","author":"T Darden","year":"1993","unstructured":"Darden T, York D, Pedersen L (1993) Particle mesh Ewald: An N log (N) method for Ewald sums in large systems. J Chem Phys 98:10089. https:\/\/doi.org\/10.1063\/1.464397","journal-title":"J Chem Phys"},{"key":"5298_CR15","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.7314\/APJCP.2015.16.13.5265","volume":"16","author":"L Delphi","year":"2015","unstructured":"Delphi L, Sepehri H, Khorramizadeh MR, Mansoori F (2015) Pectic-oligoshaccharides from apples induce apoptosis and cell cycle arrest in MDA-MB-231 cells, a model of human breast cancer. Asian Pac J Cancer Pre 16:5265\u20135271. https:\/\/doi.org\/10.7314\/APJCP.2015.16.13.5265","journal-title":"Asian Pac J Cancer Pre"},{"key":"5298_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21767\/2573-4466.100005","volume":"1","author":"S Devi","year":"2017","unstructured":"Devi S, Kanwar S (2017) Cholesterol oxidase: source, properties and applications. Insight Enzyme Res 1:1\u20135. https:\/\/doi.org\/10.21767\/2573-4466.100005","journal-title":"Insight Enzyme Res"},{"key":"5298_CR17","doi-asserted-by":"publisher","first-page":"5131","DOI":"10.1021\/jf0701483","volume":"55","author":"JV Diaz","year":"2007","unstructured":"Diaz JV, Anthon GE, Barrett DM (2007) Nonenzymatic degradation of citrus pectin and pectate during prolonged heating: effects of pH, temperature, and degree of methyl esterification. J Agric Food Chem 55:5131\u20135136. https:\/\/doi.org\/10.1021\/jf0701483","journal-title":"J Agric Food Chem"},{"issue":"7","key":"5298_CR18","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1007\/s13197-018-3190-2","volume":"55","author":"LCR Dos Reis","year":"2018","unstructured":"Dos Reis LCR, Facco EMP, Salvador M, Fl\u00f4res SH, de Oliveira Rios A (2018) Antioxidant potential and physicochemical characterization of yellow, purple and orange passion fruit. J Food Sci Technol 55(7):2679\u20132691. https:\/\/doi.org\/10.1007\/s13197-018-3190-2","journal-title":"J Food Sci Technol"},{"key":"5298_CR19","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3923\/ijp.2014.182.199","volume":"10","author":"NE-A El-Naggar","year":"2014","unstructured":"El-Naggar NE-A, El-Ewasy SM, El-Shweihy NM (2014) Microbial L-asparaginase as a potential therapeutic agent for the treatment of acute lymphoblastic leukemia: the pros and cons. Int J Pharmacol 10:182\u2013199. https:\/\/doi.org\/10.3923\/ijp.2014.182.199","journal-title":"Int J Pharmacol"},{"key":"5298_CR20","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1111\/ijfs.13726","volume":"53","author":"J Esteban","year":"2018","unstructured":"Esteban J, Ladero M (2018) Food waste as a source of value-added chemicals and materials: a biorefinery perspective. Int J Food Sci Technol 53:1095\u20131108. https:\/\/doi.org\/10.1111\/ijfs.13726","journal-title":"Int J Food Sci Technol"},{"key":"5298_CR21","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3390\/coatings11080922","volume":"11","author":"CMP Freitas","year":"2021","unstructured":"Freitas CMP, Coimbra JSR, Souza VGL, Sousa RCS (2021) Structure and applications of pectin in food, biomedical, and pharmaceutical industry: A review. Coatings 11:922. https:\/\/doi.org\/10.3390\/coatings11080922","journal-title":"Coatings"},{"key":"5298_CR22","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1021\/acs.jcim.8b00312","volume":"58","author":"T Gaillard","year":"2018","unstructured":"Gaillard T (2018) Evaluation of AutoDock and AutoDock Vina on the CASF-2013 benchmark. J Chem Inf Model 58:1697\u20131706. https:\/\/doi.org\/10.1021\/acs.jcim.8b00312","journal-title":"J Chem Inf Model"},{"key":"5298_CR23","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3390\/foods10020203","volume":"10","author":"P Garc\u00eda","year":"2021","unstructured":"Garc\u00eda P, Fredes C, Cea I, Lozano-S\u00e1nchez J, Leyva-Jim\u00e9nez FJ, Robert P, Vergara C, Jimenez P (2021) Recovery of bioactive compounds from pomegranate (Punica granatum L.) peel using pressurized liquid extraction. Foods 10:203. https:\/\/doi.org\/10.3390\/foods10020203","journal-title":"Foods"},{"key":"5298_CR27","doi-asserted-by":"publisher","first-page":"7561","DOI":"10.7314\/APJCP.2013.14.12.7561","volume":"14","author":"H Ghamartaj","year":"2013","unstructured":"Ghamartaj H, Keshavarz M, Ahmadi S, Naderi N (2013) Synergistic effects of PectaSol-C modified citrus pectin an inhibitor of Galectin-3 and paclitaxel on apoptosis of human SKOV-3 ovarian cancer cells. Asian Pac J Cancer Prev 14:7561\u20137568. https:\/\/doi.org\/10.7314\/APJCP.2013.14.12.7561","journal-title":"Asian Pac J Cancer Prev"},{"key":"5298_CR24","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1002\/jcc.10379","volume":"25","author":"H Gohlke","year":"2004","unstructured":"Gohlke H, Case DA (2004) Converging free energy estimates: MM-PB (GB) SA studies on the protein\u2013protein complex Ras\u2013Raf. J Comput Chem 25:238\u2013250. https:\/\/doi.org\/10.1002\/jcc.10379","journal-title":"J Comput Chem"},{"key":"5298_CR25","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/jctb.4569","volume":"91","author":"B G\u00f3mez","year":"2016","unstructured":"G\u00f3mez B, Y\u00e1\u00f1ez R, Paraj\u00f3 JC, Alonso JL (2016) Production of pectin-derived oligosaccharides from lemon peels by extraction, enzymatic hydrolysis and membrane filtration. J Chem Technol Biotechnol 91:234\u2013247. https:\/\/doi.org\/10.1002\/jctb.4569","journal-title":"J Chem Technol Biotechnol"},{"key":"5298_CR26","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X","volume":"18","author":"B Hess","year":"1997","unstructured":"Hess B, Bekker H, Berendsen HJ, Fraaije JG (1997) LINCS: A linear constraint solver for molecular simulations. J Comput Chem 18:1463\u20131472. https:\/\/doi.org\/10.1002\/(SICI)1096-987X(199709)18:12,1463::AID-JCC4.3.0.CO;2-H","journal-title":"J Comput Chem"},{"key":"5298_CR29","doi-asserted-by":"publisher","first-page":"8491","DOI":"10.1038\/s41598-021-87804-9","volume":"11","author":"A Hosseini Abari","year":"2021","unstructured":"Hosseini Abari A, Amini Rourani H, Ghasemi SM, Kim H, Kim Y-G (2021) Investigation of antioxidant and anticancer activities of unsaturated oligo-galacturonic acids produced by pectinase of Streptomyces hydrogenans YAM1. Sci Rep 11:8491. https:\/\/doi.org\/10.1038\/s41598-021-87804-9","journal-title":"Sci Rep"},{"key":"5298_CR28","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/jobm.201800332","volume":"59","author":"A Hosseini-Abari","year":"2019","unstructured":"Hosseini-Abari A, Emtiazi G, Jazini M, Kim J, Kim BG (2019) LC\/MS detection of oligogalacturonic acids obtained from tragacanth degradation by pectinase producing bacteria. J Basic Microbiol 59:249\u2013255. https:\/\/doi.org\/10.1002\/jobm.201800332","journal-title":"J Basic Microbiol"},{"key":"5298_CR30","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1093\/glycob\/cwm054","volume":"17","author":"CL Jackson","year":"2007","unstructured":"Jackson CL, Dreaden TM, Theobald LK, Tran NM, Beal TL, Eid M, Gao MY, Shirley RB, Stoffel MT, Kumar MV (2007) Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Glycobiol 17:805\u2013819. https:\/\/doi.org\/10.1093\/glycob\/cwm054","journal-title":"Glycobiol"},{"key":"5298_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9861-6","volume-title":"Basic Techniques in Biochemistry, Microbiology and Molecular Biology: Principles and Techniques","author":"A Jain","year":"2020","unstructured":"Jain A, Jain R, Jain S (2020) Basic Techniques in Biochemistry, Microbiology and Molecular Biology: Principles and Techniques. Springer, New York, NY. https:\/\/doi.org\/10.1007\/978-1-4939-9861-6"},{"key":"5298_CR32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ijbiomac.2019.07.134","volume":"139","author":"B Jiang","year":"2019","unstructured":"Jiang B, Zhang Y, Zhao H, Guo T, Wu W, Jin Y (2019) Structure-antioxidant activity relationship of active oxygen catalytic lignin and lignin-carbohydrate complex. Int J Biol Macromol 139:21\u201329. https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.07.134","journal-title":"Int J Biol Macromol"},{"key":"5298_CR33","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"WL Jorgensen","year":"1983","unstructured":"Jorgensen WL, Chandrasekhar J, Madura JD, Impey RW, Klein ML (1983) Comparison of simple potential functions for simulating liquid water. J Chem Phys 79:926\u2013935. https:\/\/doi.org\/10.1063\/1.445869","journal-title":"J Chem Phys"},{"key":"5298_CR34","doi-asserted-by":"publisher","first-page":"3396","DOI":"10.1080\/07391102.2019.1657499","volume":"38","author":"N Kumar","year":"2020","unstructured":"Kumar N, Srivastava R, Prakash A, Lynn AM (2020) Structure-based virtual screening, molecular dynamics simulation and MM-PBSA toward identifying the inhibitors for two-component regulatory system protein NarL of Mycobacterium Tuberculosis. J Biomol Struct Dyn 38:3396\u20133410. https:\/\/doi.org\/10.1080\/07391102.2019.1657499","journal-title":"J Biomol Struct Dyn"},{"key":"5298_CR35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00394-011-0194-3","volume":"51","author":"Y Li","year":"2012","unstructured":"Li Y, Liu L, Niu Y, Feng J, Sun Y, Kong X, Chen Y, Chen X, Gan H, Cao S (2012a) Modified apple polysaccharide prevents against tumorigenesis in a mouse model of colitis-associated colon cancer: role of galectin-3 and apoptosis in cancer prevention. Eur J Nutr 51:107\u2013117. https:\/\/doi.org\/10.1007\/s00394-011-0194-3","journal-title":"Eur J Nutr"},{"key":"5298_CR36","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1080\/01635581.2012.658951","volume":"64","author":"Y Li","year":"2012","unstructured":"Li Y, Mei L, Niu Y, Sun Y, Huang H, Li Q, Kong X, Liu L, Li Z, Mei Q (2012b) Low molecular weight apple polysaccharides induced cell cycle arrest in colorectal tumor. Nutr Cancer 64:439\u2013463. https:\/\/doi.org\/10.1080\/01635581.2012.658951","journal-title":"Nutr Cancer"},{"key":"5298_CR37","doi-asserted-by":"publisher","unstructured":"Liu J, Li D, Liu X (2016) A simple and accurate algorithm for path integral molecular dynamics with the Langevin thermostat. J Chem Phys 145. https:\/\/doi.org\/10.1063\/1.4954990","DOI":"10.1063\/1.4954990"},{"key":"5298_CR38","doi-asserted-by":"publisher","first-page":"153402","DOI":"10.1016\/j.phymed.2020.153402","volume":"80","author":"Y-Q Liu","year":"2021","unstructured":"Liu Y-Q, Wang X-L, He D-H, Cheng Y-X (2021) Protection against chemotherapy-and radiotherapy-induced side effects: A review based on the mechanisms and therapeutic opportunities of phytochemicals. Phytomedicine 80:153402. https:\/\/doi.org\/10.1016\/j.phymed.2020.153402","journal-title":"Phytomedicine"},{"key":"5298_CR39","doi-asserted-by":"publisher","first-page":"5555","DOI":"10.3390\/molecules27175555","volume":"27","author":"F Marra","year":"2022","unstructured":"Marra F, Petrovicova B, Canino F, Maffia A, Mallamaci C, Muscolo A (2022) Pomegranate wastes are rich in bioactive compounds with potential benefit on human health. Molecules 27:5555. https:\/\/doi.org\/10.3390\/molecules27175555","journal-title":"Molecules"},{"key":"5298_CR40","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1007\/s11696-020-01161-x","volume":"74","author":"F Martinez-Morales","year":"2020","unstructured":"Martinez-Morales F, Alonso-Castro AJ, Zapata-Morales JR, Carranza-\u00c1lvarez C, Aragon-Martinez OH (2020) Use of standardized units for a correct interpretation of IC50 values obtained from the inhibition of the DPPH radical by natural antioxidants. Chem Pap 74:3325\u20133334. https:\/\/doi.org\/10.1007\/s11696-020-01161-x","journal-title":"Chem Pap"},{"key":"5298_CR41","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.carbpol.2015.09.063","volume":"136","author":"EG Maxwell","year":"2016","unstructured":"Maxwell EG, Colquhoun IJ, Chau HK, Hotchkiss AT, Waldron KW, Morris VJ, Belshaw NJ (2016) Modified sugar beet pectin induces apoptosis of colon cancer cells via an interaction with the neutral sugar side-chains. Carbohydr Polym 136:923\u2013929. https:\/\/doi.org\/10.1016\/j.carbpol.2015.09.063","journal-title":"Carbohydr Polym"},{"key":"5298_CR42","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1093\/yiel\/yvab061","volume":"31","author":"MA Mekouar","year":"2020","unstructured":"Mekouar MA (2020) Food and Agriculture Organization of the United Nations (FAO). Yearb Int Environ Law 31:326\u2013340. https:\/\/doi.org\/10.1093\/yiel\/yvab061","journal-title":"Yearb Int Environ Law"},{"key":"5298_CR43","doi-asserted-by":"publisher","first-page":"887113","DOI":"10.3389\/fnut.2022.887113","volume":"9","author":"Y Mo","year":"2022","unstructured":"Mo Y, Ma J, Gao W, Zhang L, Li J, Li J, Zang J (2022) Pomegranate peel as a source of bioactive compounds: A mini review on their physiological functions. Front Nutr 9:887113. https:\/\/doi.org\/10.3389\/fnut.2022.887113","journal-title":"Front Nutr"},{"key":"5298_CR44","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.3390\/ijms22073380","volume":"22","author":"IG Munteanu","year":"2021","unstructured":"Munteanu IG, Apetrei C (2021) Analytical methods used in determining antioxidant activity: A review. Int J Mol Sci 22:3380. https:\/\/doi.org\/10.3390\/ijms22073380","journal-title":"Int J Mol Sci"},{"key":"5298_CR45","doi-asserted-by":"publisher","first-page":"8367","DOI":"10.3390\/molecules27238367","volume":"27","author":"A Naeem","year":"2022","unstructured":"Naeem A, Hu P, Yang M, Zhang J, Liu Y, Zhu W, Zheng Q (2022) Natural products as anticancer agents: current status and future perspectives. Molecules 27:8367. https:\/\/doi.org\/10.3390\/molecules27238367","journal-title":"Molecules"},{"key":"5298_CR46","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.3390\/molecules2581971","volume":"25","author":"G Poli","year":"2020","unstructured":"Poli G, Granchi C, Rizzolio F, Tuccinardi T (2020) Application of MM-PBSA methods in virtual screening. Molecules 25:1971. https:\/\/doi.org\/10.3390\/molecules2581971","journal-title":"Molecules"},{"key":"5298_CR47","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1038\/s41598-018-19930-w","volume":"8","author":"Y Rai","year":"2018","unstructured":"Rai Y, Pathak R, Kumari N, Sah DK, Pandey S, Kalra N, Soni R, Dwarakanath B, Bhatt AN (2018) Mitochondrial biogenesis and metabolic hyperactivation limits the application of MTT assay in the estimation of radiation induced growth inhibition. Sci Rep 8:1531. https:\/\/doi.org\/10.1038\/s41598-018-19930-w","journal-title":"Sci Rep"},{"key":"5298_CR48","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1007\/s12257-022-0065-1","volume":"27","author":"HH Ranjbar","year":"2022","unstructured":"Ranjbar HH, Abari AH, Ghasemi SM, Ghorbani N (2022) Antioxidant and anticancer effects of epsilon-poly-L-lysine produced by two novel strains of Paenibacillus polymyxa HS6 and Stenotrophomonas maltophilia YS8. Biotechnol Bioprocess Eng 27:586\u2013595. https:\/\/doi.org\/10.1007\/s12257-022-0065-1","journal-title":"Biotechnol Bioprocess Eng"},{"key":"5298_CR49","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3390\/bioengineering5040093","volume":"5","author":"R Ravindran","year":"2018","unstructured":"Ravindran R, Hassan SS, Williams GA, Jaiswal AK (2018) A review on bioconversion of agro-industrial wastes to industrially important enzymes. Bioeng 5:93. https:\/\/doi.org\/10.3390\/bioengineering5040093","journal-title":"Bioeng"},{"key":"5298_CR50","doi-asserted-by":"publisher","first-page":"248","DOI":"10.15414\/jmbfs.2019.9.2.248-266","volume":"9","author":"S Samanta","year":"2019","unstructured":"Samanta S (2019) Microbial pectinases: a review on molecular and biotechnological perspectives. J Microbiol Biotechnol Food Sci 9:248. https:\/\/doi.org\/10.15414\/jmbfs.2019.9.2.248-266","journal-title":"J Microbiol Biotechnol Food Sci"},{"key":"5298_CR51","doi-asserted-by":"publisher","first-page":"2000376","DOI":"10.1002\/clen.202000376","volume":"49","author":"M S\u00e1nchez","year":"2021","unstructured":"S\u00e1nchez M, Laca A, Laca A, D\u00edaz M (2021) Value-added products from fruit and vegetable wastes: a review. CLEAN\u2013Soil Air Water 49:2000376. https:\/\/doi.org\/10.1002\/clen.202000376","journal-title":"CLEAN\u2013Soil Air Water"},{"key":"5298_CR52","doi-asserted-by":"publisher","first-page":"889034","DOI":"10.3389\/fonc.2022.889034","volume":"12","author":"Y Shi","year":"2022","unstructured":"Shi Y, Tang D, Li X, Xie X, Ye Y, Wang L (2022) Galectin family members: emerging novel targets for lymphoma therapy? Front Oncol 12:889034. https:\/\/doi.org\/10.3389\/fonc.2022.889034","journal-title":"Front Oncol"},{"key":"5298_CR54","doi-asserted-by":"publisher","first-page":"101910","DOI":"10.1016\/j.bcab.2021.101910","volume":"31","author":"RP Singh","year":"2021","unstructured":"Singh RP, Tingirikari JMR (2021) Agro waste derived pectin poly and oligosaccharides: Synthesis and functional characterization. Biocatal Agric Biotechnol 31:101910. https:\/\/doi.org\/10.1016\/j.bcab.2021.101910","journal-title":"Biocatal Agric Biotechnol"},{"key":"5298_CR53","doi-asserted-by":"publisher","first-page":"105988","DOI":"10.1016\/j.foodhyd.2020.105988","volume":"108","author":"RP Singh","year":"2020","unstructured":"Singh RP, Prakash S, Bhatia R, Negi M, Singh J, Bishnoi M, Kondepudi KK (2020) Generation of structurally diverse pectin oligosaccharides having prebiotic attributes. Food Hydrocoll 108:105988. https:\/\/doi.org\/10.1016\/j.foodhyd.2020.105988","journal-title":"Food Hydrocoll"},{"key":"5298_CR55","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.ijbiomac.2018.09.142","volume":"120","author":"Y Sun","year":"2018","unstructured":"Sun Y, Fan L, Mian W, Zhang F, Liu X, Tang Y, Zeng X, Mei Q, Li Y (2018) Modified apple polysaccharide influences MUC-1 expression to prevent ICR mice from colitis-associated carcinogenesis. Int J Biol Macromol 120:1387\u20131395. https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.09.142","journal-title":"Int J Biol Macromol"},{"key":"5298_CR56","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s43393-020-00015-7","volume":"1","author":"LP Vandenberghe","year":"2021","unstructured":"Vandenberghe LP, Pandey A, Carvalho JC, Letti LA, Woiciechowski AL, Karp SG, Thomaz-Soccol V, Mart\u00ednez-Burgos WJ, Penha RO, Herrmann LW (2021) Solid-state fermentation technology and innovation for the production of agricultural and animal feed bioproducts. Syst Microbiol Biomanuf 1:142\u2013165. https:\/\/doi.org\/10.1007\/s43393-020-00015-7","journal-title":"Syst Microbiol Biomanuf"},{"key":"5298_CR57","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.3390\/foods10071564","volume":"10","author":"AA Vilas-Boas","year":"2021","unstructured":"Vilas-Boas AA, Pintado M, Oliveira AL (2021) Natural bioactive compounds from food waste: Toxicity and safety concerns. Foods 10:1564. https:\/\/doi.org\/10.3390\/foods10071564","journal-title":"Foods"},{"key":"5298_CR58","doi-asserted-by":"publisher","first-page":"106779","DOI":"10.1016\/j.foodhyd.2021.106779","volume":"118","author":"YK Yeung","year":"2021","unstructured":"Yeung YK, Kang Y-R, So BR, Jung SK, Chang YH (2021) Structural, antioxidant, prebiotic and anti-inflammatory properties of pectic oligosaccharides hydrolyzed from okra pectin by Fenton reaction. Food Hydrocoll 118:106779. https:\/\/doi.org\/10.1016\/j.foodhyd.2021.106779","journal-title":"Food Hydrocoll"},{"key":"5298_CR59","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1111\/1541-4337.12689","volume":"20","author":"A Zdunek","year":"2021","unstructured":"Zdunek A, Pieczywek PM, Cybulska J (2021) The primary, secondary, and structures of higher levels of pectin polysaccharides. Compr Rev Food Sci Food Saf 20:1101\u20131117. https:\/\/doi.org\/10.1111\/1541-4337.12689","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"5298_CR61","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.tifs.2015.04.001","volume":"44","author":"W Zhang","year":"2015","unstructured":"Zhang W, Xu P, Zhang H (2015) Pectin in cancer therapy: A review. Trends Food Sci Technol 44:258\u2013271. https:\/\/doi.org\/10.1016\/j.tifs.2015.04.001","journal-title":"Trends Food Sci Technol"},{"key":"5298_CR60","doi-asserted-by":"publisher","first-page":"109531","DOI":"10.1016\/j.enzmictec.2020.109531","volume":"136","author":"J Zhang","year":"2020","unstructured":"Zhang J, Xu C, Chen X, Ruan X, Zhang Y, Xu H, Guo Y, Xu J, Lv P, Wang Z (2020) Engineered Bacillus subtilis harbouring gene of D-tagatose 3-epimerase for the bioconversion of D-fructose into D-psicose through fermentation. Enzyme Microb Technol 136:109531. https:\/\/doi.org\/10.1016\/j.enzmictec.2020.109531","journal-title":"Enzyme Microb Technol"},{"key":"5298_CR62","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0048-4059(72)90048-3","volume":"2","author":"M Zucker","year":"1972","unstructured":"Zucker M, Hankin L, Sands D (1972) Factors governing pectate lyase synthesis in soft rot and non-soft rot bacteria. Physiol Plant Pathol 2:59\u201367. https:\/\/doi.org\/10.1016\/0048-4059(72)90048-3","journal-title":"Physiol Plant Pathol"}],"container-title":["World Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-026-05298-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-026-05298-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11274-026-05298-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:44:22Z","timestamp":1793285062000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11274-026-05298-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":62,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["5298"],"URL":"https:\/\/doi.org\/10.1007\/s11274-026-05298-x","relation":{},"ISSN":["1573-0972"],"issn-type":[{"value":"1573-0972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"3 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Correspondence and requests for materials should be addressed to A.H.A.","order":2,"name":"Ethics","label":"Additional information","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"571"}}