{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:05:35Z","timestamp":1767805535171,"version":"3.49.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K27787"],"award-info":[{"award-number":["23K27787"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oral Radiol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Mold therapy using gold-198 grains (Au-mold therapy) is a radical treatment for early stage oral cancer owing to its localized delivery of radiation. Understanding the efficacy and limitations of Au-mold therapy is crucial for optimizing treatment protocols and enhancing outcomes. Thus, this study evaluated the treatment outcomes of Au-mold therapy in patients with hard palate and gingival cancer and assessed its feasibility as a therapeutic modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed data from 37 cases with hard palate and gingival cancer who received Au-mold therapy alone. Treatment outcomes and complications were evaluated, and the dose distribution of Au-mold therapy was simulated using clinically available calculation systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A notable 5-year local control rate of approximately 80% was noted in primary cases, whereas recurrent cases exhibited lower local control rates. Severe oral mucositis was not observed, and late complications, such as osteoradionecrosis and oral ulceration, were infrequent following Au-mold therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides insights into the use of Au-mold therapy for oral cancer. Promising outcomes in primary cases suggest its potential as a treatment option. Future research should focus on innovative strategies to enhance the efficacy of Au-mold therapy in oral cancer management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11282-025-00853-y","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T08:50:59Z","timestamp":1756111859000},"page":"197-203","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of low-dose rate brachytherapy utilizing a mold with gold-198 grains for hard palate and gingival cancer"],"prefix":"10.1007","volume":"42","author":[{"given":"Hitomi","family":"Nojima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5891-4348","authenticated-orcid":false,"given":"Atsushi","family":"Kaida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Haraguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Murase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Tomioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"853_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0167-8140(91)90338-h","volume":"21","author":"J Horiuchi","year":"1991","unstructured":"Horiuchi J, Takeda M, Shibuya H, Matsumoto S, Hoshina M, Suzuki S. 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J Clin Periodontol. 2020;47:479\u201388. https:\/\/doi.org\/10.1111\/jcpe.13254.","journal-title":"J Clin Periodontol"}],"container-title":["Oral Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11282-025-00853-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11282-025-00853-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11282-025-00853-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T15:44:39Z","timestamp":1767800679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11282-025-00853-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["853"],"URL":"https:\/\/doi.org\/10.1007\/s11282-025-00853-y","relation":{},"ISSN":["0911-6028","1613-9674"],"issn-type":[{"value":"0911-6028","type":"print"},{"value":"1613-9674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,25]]},"assertion":[{"value":"16 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The present study was approved by the Ethics Review Committee and Committee on Conflicts of Interest in Clinical Research at Institute of Science Tokyo (Approval No. D2022-057).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from the Ethics Review Committee in the form of an opt-out.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}