{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:20Z","timestamp":1792783280993,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Hiroshima University","id":[{"id":"https:\/\/ror.org\/03t78wx29","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oral Radiol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study evaluated the safety and efficacy of an iodinated contrast agent for videofluoroscopic swallowing studies (VFSS) in patients with swallowing disorders, compared with barium sulfate contrast agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 20 patients who underwent VFSS at Hiroshima University Hospital in 2025 for dysphagia evaluation. Iodixanol (Visipaque 270\u00ae; GE Healthcare Pharma Co., Ltd., Chicago, Illinois) was used as the iodinated contrast agent. For comparison, VFSS images obtained with Barytester\u00ae (FUSHIMI Pharmaceutical Co., Ltd., Kagawa, Japan) in the same patients served as barium sulfate controls. The frequency of adverse events associated with oral Visipaque 270\u00ae administration was assessed. VFSS images obtained with Barytester\u00ae and Visipaque 270\u00ae in the same patients were compared to evaluate imaging performance. To determine whether image evaluation outcomes were equivalent between Visipaque 270\u00ae and Barytester\u00ae, an equivalence test was performed using the two one-sided tests procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Visipaque 270\u00ae was associated with no adverse events, including gastrointestinal or other adverse events. Image evaluations using Visipaque 270\u00ae and Barytester\u00ae were statistically equivalent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VFSS was performed using the iodinated contrast agent Visipaque 270\u00ae. No adverse events related to oral Visipaque 270\u00ae administration were observed, and contrast enhancement on VFSS images was comparable to that achieved with Barytester\u00ae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Japan Registry of Clinical Trials, jRCTs061240040; registered 26 July, 2024.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11282-026-00959-x","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:07:22Z","timestamp":1785582442000},"page":"1163-1171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and efficacy of a nonionic water-soluble iodinated contrast medium for videofluoroscopic swallowing studies"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5247-2195","authenticated-orcid":false,"given":"Masaru","family":"Konishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Nagasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Shimabukuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineka","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Kakimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"959_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1034\/j.1600-0404.106.s178.2.x","volume":"106","author":"GC Rom\u00e1n","year":"2002","unstructured":"Rom\u00e1n GC. Defining dementia: clinical criteria for the diagnosis of vascular dementia. Acta Neurol Scand. 2002;106:6\u20139. https:\/\/doi.org\/10.1034\/j.1600-0404.106.s178.2.x.","journal-title":"Acta Neurol Scand"},{"key":"959_CR2","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00455-017-9828-9","volume":"32","author":"R Dziewas","year":"2017","unstructured":"Dziewas R, Baijens L, Schindler A, Verin E, Michou E, Clave P. European society for swallowing disorders FEES accreditation program for neurogenic and geriatric oropharyngeal dysphagia. Dysphagia. 2017;32:725\u201333. https:\/\/doi.org\/10.1007\/s00455-017-9828-9.","journal-title":"Dysphagia"},{"key":"959_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3342\/ceo.2013.6.3.117","volume":"6","author":"N Denaro","year":"2013","unstructured":"Denaro N, Merlano MC, Russi EG. Dysphagia in head and neck cancer patients: pretreatment evaluation, predictive factors, and assessment during radio-chemotherapy, recommendations. Clin Exp Otorhinolaryngol. 2013;6:117. https:\/\/doi.org\/10.3342\/ceo.2013.6.3.117.","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"959_CR4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1447-0594.2010.00688.x","volume":"11","author":"M Yoshida","year":"2011","unstructured":"Yoshida M, Kikutani T, Yoshikawa M, Tsuga K, Kimura M, Akagawa Y. Correlation between dental and nutritional status in community-dwelling elderly Japanese. Geriatr Gerontol Int. 2011;11:315\u20139. https:\/\/doi.org\/10.1111\/j.1447-0594.2010.00688.x.","journal-title":"Geriatr Gerontol Int"},{"key":"959_CR5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/ger.12512","volume":"38","author":"M Konishi","year":"2021","unstructured":"Konishi M, Kakimoto N. 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This study was approved by the Hiroshima University Ethics Committee (approval number CRB2024-0002). The study was also registered with the Japan Registry of Clinical Trials (jRCTs061240040).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}