{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:08:39Z","timestamp":1773745719528,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,8,17]],"date-time":"2014-08-17T00:00:00Z","timestamp":1408233600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s11302-014-9421-8","type":"journal-article","created":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T20:47:09Z","timestamp":1408222029000},"page":"603-609","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of ecto-5\u2032-nucleotidase (eN) in astrocytes on adenosine and inosine formation"],"prefix":"10.1007","volume":"10","author":[{"given":"Stephanie","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona E.","family":"Parkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,17]]},"reference":[{"key":"9421_CR1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.2174\/156802611795347582","volume":"11","author":"FE Parkinson","year":"2011","unstructured":"Parkinson FE, Damaraju VL, Graham K, Yao SYM, Baldwin SA, Cass CE, Young JD (2011) Molecular biology of nucleoside transporters and their distributions and functions in the brain. Curr Top Med Chem 11:948\u2013972","journal-title":"Curr Top Med Chem"},{"key":"9421_CR2","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1073\/pnas.1120997109","volume":"109","author":"D Lovatt","year":"2012","unstructured":"Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M (2012) Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proc Natl Acad Sci U S A 109:6265\u201370","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9421_CR3","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1046\/j.1471-4159.2003.02266.x","volume":"88","author":"FE Parkinson","year":"2004","unstructured":"Parkinson FE, Xiong W (2004) Stimulus- and cell-type-specific release of purines in cultured rat forebrain astrocytes and neurons. J Neurochem 88:1305\u201312","journal-title":"J Neurochem"},{"key":"9421_CR4","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/bph.12445","volume":"170","author":"SP Alexander","year":"2013","unstructured":"Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, Harmar AJ (2013) The Concise Guide to PHARMACOLOGY 2013\/14: G protein-coupled receptors. Br J Pharmacol 170:1459\u2013581","journal-title":"Br J Pharmacol"},{"key":"9421_CR5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.1116916","volume":"310","author":"O Pascual","year":"2005","unstructured":"Pascual O, Casper KB, Kubera C, Zhang J, Revilla-Sanchez R, Sul JY, Takano H, Moss SJ, McCarthy K, Haydon PG (2005) Astrocytic purinergic signaling coordinates synaptic networks. Science 310:113\u20136","journal-title":"Science"},{"key":"9421_CR6","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/bph.12446","volume":"170","author":"SP Alexander","year":"2013","unstructured":"Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, Harmar AJ (2013) The Concise Guide to PHARMACOLOGY 2013\/14: ligand-gated ion channels. Br J Pharmacol 170:1582\u2013606","journal-title":"Br J Pharmacol"},{"key":"9421_CR7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11302-012-9309-4","volume":"8","author":"H Zimmermann","year":"2012","unstructured":"Zimmermann H, Zebisch M, Strater N (2012) Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal 8:437\u2013502","journal-title":"Purinergic Signal"},{"key":"9421_CR8","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jnr.20988","volume":"84","author":"FE Parkinson","year":"2006","unstructured":"Parkinson FE, Ferguson J, Zamzow CR, Xiong W (2006) Gene expression for enzymes and transporters involved in regulating adenosine and inosine levels in rat forebrain neurons, astrocytes and C6 glioma cells. J Neurosci Res 84:801\u20138","journal-title":"J Neurosci Res"},{"key":"9421_CR9","doi-asserted-by":"crossref","first-page":"11390","DOI":"10.1523\/JNEUROSCI.5817-12.2013","volume":"33","author":"E Augusto","year":"2013","unstructured":"Augusto E, Matos M, Sevigny J, El-Tayeb A, Bynoe MS, Muller CE, Cunha RA, Chen JF (2013) Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. J Neurosci 33:11390\u20139","journal-title":"J Neurosci"},{"key":"9421_CR10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0028-3908(02)00083-7","volume":"43","author":"FE Parkinson","year":"2002","unstructured":"Parkinson FE, Sinclair CJ, Othman T, Haughey NJ, Geiger JD (2002) Differences between rat primary cortical neurons and astrocytes in purine release evoked by ischemic conditions. Neuropharmacology 43:836\u201346","journal-title":"Neuropharmacology"},{"key":"9421_CR11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1471-4159.2011.07242.x","volume":"118","author":"D Zhang","year":"2011","unstructured":"Zhang D, Xiong W, Albensi BC, Parkinson FE (2011) Expression of human equilibrative nucleoside transporter 1 in mouse neurons regulates adenosine levels in physiological and hypoxic-ischemic conditions. J Neurochem 118:4\u201311","journal-title":"J Neurochem"},{"key":"9421_CR12","doi-asserted-by":"crossref","first-page":"e39772","DOI":"10.1371\/journal.pone.0039772","volume":"7","author":"D Zhang","year":"2012","unstructured":"Zhang D, Xiong W, Chu S, Sun C, Albensi BC, Parkinson FE (2012) Inhibition of hippocampal synaptic activity by ATP, hypoxia or oxygen-glucose deprivation does not require CD73. PLoS One 7:e39772","journal-title":"PLoS One"},{"key":"9421_CR13","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.20040915","volume":"200","author":"LF Thompson","year":"2004","unstructured":"Thompson LF, Eltzschig HK, Ibla JC, Van De Wiele CJ, Resta R, Morote-Garcia JC, Colgan SP (2004) Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med 200:1395\u2013405","journal-title":"J Exp Med"},{"key":"9421_CR14","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/j.1471-4159.2006.04425.x","volume":"101","author":"BG Frenguelli","year":"2007","unstructured":"Frenguelli BG, Wigmore G, Llaudet E, Dale N (2007) Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus. J Neurochem 101:1400\u201313","journal-title":"J Neurochem"},{"key":"9421_CR15","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1046\/j.1471-4159.2003.01957.x","volume":"86","author":"BG Frenguelli","year":"2003","unstructured":"Frenguelli BG, Llaudet E, Dale N (2003) High-resolution real-time recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat hippocampal slices. J Neurochem 86:1506\u201315","journal-title":"J Neurochem"},{"key":"9421_CR16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11302-012-9343-2","volume":"9","author":"ML Pajski","year":"2013","unstructured":"Pajski ML, Venton BJ (2013) The mechanism of electrically stimulated adenosine release varies by brain region. Purinergic Signal 9:167\u201374","journal-title":"Purinergic Signal"},{"key":"9421_CR17","doi-asserted-by":"crossref","unstructured":"Ross AE, Nguyen MD, Privman E, Venton BJ (2014) Mechanical stimulation evokes rapid increases in extracellular adenosine concentration in the prefrontal cortex. J Neurochem, in press.","DOI":"10.1111\/jnc.12711"},{"key":"9421_CR18","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1002\/jnr.21789","volume":"86","author":"CR Zamzow","year":"2008","unstructured":"Zamzow CR, Xiong W, Parkinson FE (2008) Adenosine produced by neurons is metabolized to hypoxanthine by astrocytes. J Neurosci Res 86:3447\u201355","journal-title":"J Neurosci Res"},{"key":"9421_CR19","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1007\/s11064-010-0325-x","volume":"35","author":"Y Zhou","year":"2010","unstructured":"Zhou Y, Li HL, Zhao R, Yang LT, Dong Y, Yue X, Ma YY, Wang Z, Chen J, Cui CL, Yu AC (2010) Astrocytes express N-methyl-D-aspartate receptor subunits in development, ischemia and post-ischemia. Neurochem Res 35:2124\u201334","journal-title":"Neurochem Res"},{"key":"9421_CR20","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1002\/jnr.21718","volume":"86","author":"CR Zamzow","year":"2008","unstructured":"Zamzow CR, Xiong W, Parkinson FE (2008) Astrocytes affect the profile of purines released from cultured cortical neurons. J Neurosci Res 86:2641\u20139","journal-title":"J Neurosci Res"},{"key":"9421_CR21","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/nn2004","volume":"10","author":"DJ Rossi","year":"2007","unstructured":"Rossi DJ, Brady JD, Mohr C (2007) Astrocyte metabolism and signaling during brain ischemia. Nat Neurosci 10:1377\u201386","journal-title":"Nat Neurosci"},{"key":"9421_CR22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuropharm.2008.05.023","volume":"55","author":"L Hertz","year":"2008","unstructured":"Hertz L (2008) Bioenergetics of cerebral ischemia: a cellular perspective. Neuropharmacology 55:289\u2013309","journal-title":"Neuropharmacology"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-014-9421-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11302-014-9421-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-014-9421-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T23:15:19Z","timestamp":1553642119000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11302-014-9421-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,17]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["9421"],"URL":"https:\/\/doi.org\/10.1007\/s11302-014-9421-8","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,17]]}}}