{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:14:43Z","timestamp":1759616083954,"version":"3.37.3"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Kementerian Pengajian Tinggi Malaysia","award":["203.PPSP.6171238"],"award-info":[{"award-number":["203.PPSP.6171238"]}]},{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","award":["304\/PPSP\/6315333"],"award-info":[{"award-number":["304\/PPSP\/6315333"]}],"id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s11302-021-09764-z","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T02:34:53Z","timestamp":1613702093000},"page":"201-213","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Contribution of P2X4 receptor in pain associated with rheumatoid arthritis: a review"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8150-6999","authenticated-orcid":false,"given":"Nurul Ajilah Mohamed","family":"Khir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-9290","authenticated-orcid":false,"given":"Ain\u2019 Sabreena Mohd","family":"Noh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8524-1852","authenticated-orcid":false,"given":"Nazlahshaniza","family":"Shafin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-3575","authenticated-orcid":false,"given":"Che Aishah Nazariah","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"9764_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13075-019-2042-4","volume":"21","author":"P Ten Klooster","year":"2019","unstructured":"Ten Klooster P, De Graaf N, Vonkeman H (2019) Association between pain phenotype and disease activity in rheumatoid arthritis patients: a non-interventional, longitudinal cohort study. Arthritis Res Ther 21:257","journal-title":"Arthritis Res Ther"},{"key":"9764_CR2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nrrheum.2014.64","volume":"10","author":"DA Walsh","year":"2014","unstructured":"Walsh DA, McWilliams DF (2014) Mechanisms, impact and management of pain in rheumatoid arthritis. Nat Rev Rheumatol 10:581\u2013592. https:\/\/doi.org\/10.1038\/nrrheum.2014.64","journal-title":"Nat Rev Rheumatol"},{"key":"9764_CR3","doi-asserted-by":"publisher","first-page":"R83","DOI":"10.1186\/ar3353","volume":"13","author":"YC Lee","year":"2011","unstructured":"Lee YC, Cui J, Lu B, Frits ML, Iannacone CK, Shadick NA, Weinblatt ME, Solomon DH (2011) Pain persists in DAS28 rheumatoid arthritis remission but not in ACR\/EULAR remission: a longitudinal observational study. Arhritis Res Ther 13:R83","journal-title":"Arhritis Res Ther"},{"issue":"1","key":"9764_CR4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/rheumatology\/keq455","volume":"51","author":"ST Hewlett","year":"2012","unstructured":"Hewlett ST, Sanderson T, May J, Alten R, Bingham CO III, Cross M, March L, Pohl C, Woodworth T, Bartlett SJ (2012) I\u2019m hurting, I want to kill myself\u2019: rheumatoid arthritis flare is more than a high joint count\u2014an international patient perspective on flare where medical help is sought. Rheumatology 51(1):69\u201376. https:\/\/doi.org\/10.1093\/rheumatology\/keq455","journal-title":"Rheumatology"},{"key":"9764_CR5","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/ar2498","volume":"10","author":"N Courvoisier","year":"2008","unstructured":"Courvoisier N, Dougados M, Cantagrel A, Goupille P, Meyer O, Sibilia J, Daures JP, Combe B (2008) Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study. Arthritis Res Ther 10:R106. https:\/\/doi.org\/10.1186\/ar2498","journal-title":"Arthritis Res Ther"},{"key":"9764_CR6","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1002\/acr.21723","volume":"64","author":"DF McWilliams","year":"2012","unstructured":"McWilliams DF, Zhang W, Mansell JS, Kiely PD, Young A, Walsh DA (2012) Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study. Arthritis Care Res 64:1505\u20131513. https:\/\/doi.org\/10.1002\/acr.21723","journal-title":"Arthritis Care Res"},{"key":"9764_CR7","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2177\/jsci.40.391","volume":"40","author":"N Umeda","year":"2017","unstructured":"Umeda N, Matsumoto I, Sumida T (2017) The pathogenic role of ACPA in rheumatoid arthritis. Nihon Rinsho Meneki Gakkai Kaishi 40:391\u2013395. https:\/\/doi.org\/10.2177\/jsci.40.391","journal-title":"Nihon Rinsho Meneki Gakkai Kaishi"},{"key":"9764_CR8","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1136\/annrheumdis-2015-208094","volume":"75","author":"G Wigerbald","year":"2016","unstructured":"Wigerbald G, Bas DU, Fernandes-Cerqueira C, Krishanmurthy A, Nandakumar KS, Rogoz S, Kato J, Sandor K, Su J, Lundlberg K, Holmdahl R, Jakobsson P-J, Malmstr\u00f6m V, Catrina AI, Klareskorg L, Svensson CI (2016) Autoantibodies to citrullinated proteins may induce joint pain independent of inflammation. Ann Rheum Dis 75:730\u2013865. https:\/\/doi.org\/10.1136\/annrheumdis-2015-208094","journal-title":"Ann Rheum Dis"},{"key":"9764_CR9","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3109\/03009742.2016.1139174","volume":"45","author":"AW Christensen","year":"2016","unstructured":"Christensen AW, Rifbjerg-Madsen S, Christensen R, Dreyer L, Tillings\u00f8e H, Seven S, Boesen M, Ellegard K, Bliddal H, Danneskiold-Sams\u00f8e B (2016) Non-nociceptive pain in rheumatoid arthritis is frequent and affects disease activity estimation: cross-sectional data from the FRAME study. Scand J Rheumatol 45:461\u2013469. https:\/\/doi.org\/10.3109\/03009742.2016.1139174","journal-title":"Scand J Rheumatol"},{"key":"9764_CR10","doi-asserted-by":"publisher","first-page":"104875","DOI":"10.1016\/j.phrs.2020.104875","volume":"158","author":"W-J Zhang","year":"2020","unstructured":"Zhang W-J, Zhu Z-M, Liu Z-X (2020a) The role of P2X4 receptor in neuropathic pain and its pharmacological properties. Pharmacol Res 158:104875. https:\/\/doi.org\/10.1016\/j.phrs.2020.104875","journal-title":"Pharmacol Res"},{"key":"9764_CR11","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nature04886","volume":"442","author":"BS Khakh","year":"2006","unstructured":"Khakh BS, North RA (2006) P2X receptors as cell-surface ATP sensors in health and disease. Nature 442:527\u2013532. https:\/\/doi.org\/10.1038\/nature04886","journal-title":"Nature"},{"key":"9764_CR12","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1080\/09687680802050385","volume":"25","author":"RD Murrel-Lagnado","year":"2008","unstructured":"Murrel-Lagnado RD, Qureshi OS (2008) Assembly and trafficking of P2X purinergic receptors. Mol Membr Biol 25:321\u2013331. https:\/\/doi.org\/10.1080\/09687680802050385","journal-title":"Mol Membr Biol"},{"key":"9764_CR13","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1523\/JNEUROSCI.16-08-02495.1996","volume":"16","author":"G Collo","year":"1996","unstructured":"Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Suprenant A, Buell G (1996) Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16:2495\u20132507. https:\/\/doi.org\/10.1523\/JNEUROSCI.16-08-02495.1996","journal-title":"J Neurosci"},{"key":"9764_CR14","doi-asserted-by":"publisher","first-page":"110447","DOI":"10.1016\/j.biopha.2020.110447","volume":"129","author":"W-J Zhang","year":"2020","unstructured":"Zhang W-J, Luo H-L, Zhu Z-M (2020b) The role of P2X4 receptors in chronic pain: a potential pharmacological target. Biomed Pharmacother 129:110447. https:\/\/doi.org\/10.1016\/j.biopha.2020.110447","journal-title":"Biomed Pharmacother"},{"key":"9764_CR15","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","volume":"82","author":"RA North","year":"2002","unstructured":"North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013\u20131067. https:\/\/doi.org\/10.1152\/physrev.00015.2002","journal-title":"Physiol Rev"},{"key":"9764_CR16","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s11926-016-0581-0","volume":"18","author":"SD Boyden","year":"2016","unstructured":"Boyden SD, Hossain IN, Wohlfahrt A, Lee YC (2016) Non-inflammatory causes of pain in patients with rheumatoid arthritis. Curr Rheumatol Rep 18:30. https:\/\/doi.org\/10.1007\/s11926-016-0581-0","journal-title":"Curr Rheumatol Rep"},{"key":"9764_CR17","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.ejmech.2014.10.071","volume":"89","author":"D Dal Ben","year":"2015","unstructured":"Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Thomas A, Volpini R (2015) Purinergic P2X receptors: structural models and analysis of ligand-target interaction. Eur J Med Chem 89:561\u2013580. https:\/\/doi.org\/10.1016\/j.ejmech.2014.10.071","journal-title":"Eur J Med Chem"},{"key":"9764_CR18","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s11302-019-09675-0","volume":"15","author":"A Asif","year":"2019","unstructured":"Asif A, Khalid M, Ahmad H, Rehman AU (2019) Role of purinergic receptors in hepatobiliary carcinoma in Pakistani population: an approach towards proinflammatory role of P2X4 and P2X7 receptors. Purinergic Signal 15:367\u2013374. https:\/\/doi.org\/10.1007\/s11302-019-09675-0","journal-title":"Purinergic Signal"},{"key":"9764_CR19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/13880209.2018.1561730","volume":"57","author":"Y Wang","year":"2019","unstructured":"Wang Y, Chen Z, Liu C, Lu X, Yang C, Qiu S (2019) Distributive differences of P2Xs between the forelimb and hind limb of adjuvant arthritis rats and intervention by Notopterygh rhizoma et radix. Pharm Biol 57:81\u201388. https:\/\/doi.org\/10.1080\/13880209.2018.1561730","journal-title":"Pharm Biol"},{"key":"9764_CR20","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/nature01786","volume":"424","author":"M Tsuda","year":"2003","unstructured":"Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K (2003) P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424:778\u2013783. https:\/\/doi.org\/10.1038\/nature01786","journal-title":"Nature"},{"key":"9764_CR21","volume-title":"Etude mol\u00e9culaire de la dilatation des r\u00e9cepteurs P2X","author":"M Harkat","year":"2017","unstructured":"Harkat M (2017) Etude mol\u00e9culaire de la dilatation des r\u00e9cepteurs P2X. Doctoral dissertation, Universit\u00e9 de Strasbourg"},{"key":"9764_CR22","doi-asserted-by":"publisher","first-page":"32461","DOI":"10.1038\/srep32461","volume":"6","author":"Y Matsumura","year":"2016","unstructured":"Matsumura Y, Yamashita T, Sasaki A, Nakata A, Kohno K, Masuda T, Tozaki-Saitoh H, Imai T, Kuraishi Y, Tsuda M (2016) A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain. Sci Rep 6:32461. https:\/\/doi.org\/10.1038\/srep32461","journal-title":"Sci Rep"},{"key":"9764_CR23","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/WNR.0000000000001170","volume":"30","author":"W Zhang","year":"2019","unstructured":"Zhang W, Liu Y, Yang B, Liu Z, Yu Q (2019) Microencapsulated olfactory ensheathing-cell transplantation reduces pain in rats by inhibiting P2X4 receptor overexpression in the dorsal root ganglion. Neuro Report 30:120\u2013126. https:\/\/doi.org\/10.1097\/WNR.0000000000001170","journal-title":"Neuro Report"},{"key":"9764_CR24","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.neuropharm.2015.11.001","volume":"104","author":"T Engel","year":"2016","unstructured":"Engel T, Alves M, Sheedy C, Henshall DC (2016) ATPergic signalling during seizures and epilepsy. Neuropharmacology 104:140\u2013153. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.11.001","journal-title":"Neuropharmacology"},{"key":"9764_CR25","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/glia.22516","volume":"61","author":"L Ulmann","year":"2013","unstructured":"Ulmann L, Levavasseur F, Avignone E, Peyroutou R, Hirbec H, Audinat E, Rassendren F (2013) Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus. Glia 61:1306\u20131319. https:\/\/doi.org\/10.1002\/glia.22516","journal-title":"Glia"},{"key":"9764_CR26","doi-asserted-by":"publisher","unstructured":"Bertin E, Deluc T, Pilch KS, Martinez A, Pougnet J-T, Doudnikoff E, Allain A-E, Bergmann P, Rousseau M, Toulm\u00e9 E (2020) Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-019-0641-8","DOI":"10.1038\/s41380-019-0641-8"},{"key":"9764_CR27","doi-asserted-by":"publisher","first-page":"113308","DOI":"10.1016\/j.expneurol.2020.113308","volume":"329","author":"P Srivastava","year":"2020","unstructured":"Srivastava P, Cronin CG, Scranton VL, Jacobson KA, Liang BT, Verma R (2020) Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke. Exp Neurol 329:113308. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113308","journal-title":"Exp Neurol"},{"key":"9764_CR28","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1007\/s11064-019-02798-1","volume":"44","author":"A T\u00f3th","year":"2019","unstructured":"T\u00f3th A, Antal Z, Bereczeki D, Sperl\u00e1gh B (2019) Purinergic signalling in Parkinson\u2019s disease: a multi-target system to combat neurodegeneration. Neurochem Res 44:2413\u20132422. https:\/\/doi.org\/10.1007\/s11064-019-02798-1","journal-title":"Neurochem Res"},{"key":"9764_CR29","doi-asserted-by":"publisher","first-page":"L58","DOI":"10.1152\/ajplung.00157.2018","volume":"316","author":"VE Wilkermann","year":"2019","unstructured":"Wilkermann VE, Thompson KE, Neuland K, Jaramillo AM, Fois G, Schmidt H, Wittekindt OH, Han W, Tuvim MJ, Dickey BF (2019) Inflammation-induced upregulation of P2X4 expression augments mucin secretion in airway epithelia. Am J Physiol-Lung C 316:L58\u2013L70. https:\/\/doi.org\/10.1152\/ajplung.00157.2018","journal-title":"Am J Physiol-Lung C"},{"key":"9764_CR30","doi-asserted-by":"publisher","unstructured":"Zabala A, Vazquez-Villoldo N, Rissiek B, Gejo J, Martin A, Palomino A, Perez-Samart\u00edn A, Pulagam KR, Lukowiak M, Capetillo-Zarate E (2018) P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis. EMBO Mol Med 10:e8743. https:\/\/doi.org\/10.15252\/emmm.201708743","DOI":"10.15252\/emmm.201708743"},{"key":"9764_CR31","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.bbi.2017.07.155","volume":"66","author":"R Verma","year":"2017","unstructured":"Verma R, Cronin CG, Hudobenko J, Venna VR, McCullough LD, Liang BT (2017) Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke. Brain Behav Immun 66:302\u2013312. https:\/\/doi.org\/10.1016\/j.bbi.2017.07.155","journal-title":"Brain Behav Immun"},{"key":"9764_CR32","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/jne.12161","volume":"26","author":"I Rana","year":"2014","unstructured":"Rana I, Badoer E, Alahmadi E, Leo C, Woodman O, Stebbing M (2014) Microglia are selectively activated in endocrine and cardiovascular control centres in streptozotocin-induced diabetic rats. J Neuroendocrinol 26:413\u2013425. https:\/\/doi.org\/10.1111\/jne.12161","journal-title":"J Neuroendocrinol"},{"key":"9764_CR33","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1080\/030097499442540","volume":"28","author":"TWL Dhont","year":"1999","unstructured":"Dhont TWL, Verbruggen A, Oostendorp RAB, Duquet W (1999) Pain threshold in patients with rheumatoid arthritis and effect of manual oscillations. Scand J Rheumatol 28:88\u201393. https:\/\/doi.org\/10.1080\/030097499442540","journal-title":"Scand J Rheumatol"},{"key":"9764_CR34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/art.37733","volume":"65","author":"YC Lee","year":"2013","unstructured":"Lee YC, Lu B, Edwards RR, Wasan AD, Nassikas NJ, Clauw DJ, Solomon DH, Karlson EW (2013) The role of sleep problems in central pain processing in rheumatoid arthritis. Arthritis Rheum 65:59\u201368. https:\/\/doi.org\/10.1002\/art.37733","journal-title":"Arthritis Rheum"},{"key":"9764_CR35","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1054\/jocn.1999.0775","volume":"8","author":"J Wendler","year":"2001","unstructured":"Wendler J, Hummel T, Reissinger M, Manger B, Pauli E, Kalden JR, Kobal G (2001) Patients with rheumatoid arthritis adapt differently to repetitive painful stimuli compared to healthy controls. J Clin Neurosci 8:272\u2013277. https:\/\/doi.org\/10.1054\/jocn.1999.0775","journal-title":"J Clin Neurosci"},{"key":"9764_CR36","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/BF02032098","volume":"8","author":"EM Gerecz-Simon","year":"1989","unstructured":"Gerecz-Simon EM, Tunks ER, Heale JA, Kean WF, Buchanan WW (1989) Measurement of pain threshold in patients with rheumatoid arthritis, ankylosing spondylitis, and healthy controls. Clin Rheumatol 8:467\u2013474. https:\/\/doi.org\/10.1007\/BF02032098","journal-title":"Clin Rheumatol"},{"key":"9764_CR37","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1749-6632.2002.tb04234.x","volume":"966","author":"H-G Schaible","year":"2002","unstructured":"Schaible H-G, Ebersberger A, Von Banchet GS (2002) Mechanisms of pain in arthritis. Ann N Y Acad Sci 966:343\u2013354. https:\/\/doi.org\/10.1111\/j.1749-6632.2002.tb04234.x","journal-title":"Ann N Y Acad Sci"},{"key":"9764_CR38","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1053\/eujp.2001.0313","volume":"6","author":"A-S Leffler","year":"2002","unstructured":"Leffler A-S, Kosek E, Lerndal T, Nordmark B, Hansson P (2002) Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis. Eur J Pain 6:161\u2013176. https:\/\/doi.org\/10.1053\/eujp.2001.0313","journal-title":"Eur J Pain"},{"key":"9764_CR39","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1006\/clin.1994.1164","volume":"73","author":"FH Duris","year":"1994","unstructured":"Duris FH, Fava RA, Noelle RJ (1994) Collagen-induced arthritis as a model of rheumatoid arthritis. J Clin Immunol 73:11\u201318. https:\/\/doi.org\/10.1006\/clin.1994.1164","journal-title":"J Clin Immunol"},{"key":"9764_CR40","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1189\/jlb.70.6.849","volume":"70","author":"A Billiau","year":"2001","unstructured":"Billiau A, Matthys P (2001) Modes of action of Freund\u2019s adjuvants in experimental models of autoimmune diseases. J Leukoc Biol 70:849\u2013860. https:\/\/doi.org\/10.1189\/jlb.70.6.849","journal-title":"J Leukoc Biol"},{"issue":"1744-8069","key":"9764_CR41","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1744-8069-5-28","volume":"5","author":"M Tsuda","year":"2009","unstructured":"Tsuda M, Kuboyama K, Inoue T, Nagata K, Tozaki-Saitoh H, Inoue K (2009) Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays. Mol Pain 5(1744-8069):5\u201328. https:\/\/doi.org\/10.1186\/1744-8069-5-28","journal-title":"Mol Pain"},{"key":"9764_CR42","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1093\/bja\/aeu199","volume":"114","author":"X-M Chen","year":"2015","unstructured":"Chen X-M, Xu J, Song J-G, Zheng B-J, Wang X-R (2015) Electroacupuncture inhibits excessive interferon-\u03b3 evoked up-regulation of P2X4 receptor in spinal microglia in a CCI rat model for neuropathic pain. Br J Anaesth 114:150\u2013157. https:\/\/doi.org\/10.1093\/bja\/aeu199","journal-title":"Br J Anaesth"},{"key":"9764_CR43","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1016\/0024-3205(89)90062-3","volume":"45","author":"WH Lyness","year":"1989","unstructured":"Lyness WH, Smith FL, Heavner JE, Iacono CU, Garvin RD (1989) Morphine self-administration in the rat during adjuvant-induced arthritis. Life Sci 45:2217\u20132224. https:\/\/doi.org\/10.1016\/0024-3205(89)90062-3","journal-title":"Life Sci"},{"key":"9764_CR44","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1007\/BF02975325","volume":"22","author":"EH Park","year":"1999","unstructured":"Park EH, Kahng JH (1999) Suppressive effects of propolis in rat adjuvant arthritis. Arch Pharm Res 22:554\u2013558. https:\/\/doi.org\/10.1007\/BF02975325","journal-title":"Arch Pharm Res"},{"key":"9764_CR45","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/aps.2008.20","volume":"30","author":"Y-L Liu","year":"2009","unstructured":"Liu Y-L, Lin H-M, Rong Z, Wu J-C, Han R, Raymond LN, Reid RF, Qin Z-H (2009) Suppression of complete Freund\u2019s adjuvant-induced adjuvant arthritis by cobratoxin. Acta Pharmacol Sin 30:219\u2013227. https:\/\/doi.org\/10.1038\/aps.2008.20","journal-title":"Acta Pharmacol Sin"},{"key":"9764_CR46","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.imr.2017.11.002","volume":"7","author":"HJ Mahdi","year":"2018","unstructured":"Mahdi HJ, Khan NAK, Asmawi MZ, Mahmud R, Vikneswaran A, Murugaiyah L (2018) In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund\u2019s adjuvant (CFA)-induced arthritis in rats. Integr Med Res 7:85\u201394. https:\/\/doi.org\/10.1016\/j.imr.2017.11.002","journal-title":"Integr Med Res"},{"key":"9764_CR47","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1523\/JNEUROSCI.4595-08.2009","volume":"29","author":"RJ Horvath","year":"2009","unstructured":"Horvath RJ, De Leo JA (2009) Morphine enhances microglial migration through modulation of P2X4 receptor signaling. J Neurosci 29:998\u20131005. https:\/\/doi.org\/10.1523\/JNEUROSCI.4595-08.2009","journal-title":"J Neurosci"},{"key":"9764_CR48","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jddst.2017.07.022","volume":"41","author":"AK Dewangan","year":"2017","unstructured":"Dewangan AK, Perumal Y, Pavurala N, Chopra K, Mazumder S (2017) Preparation, characterization and anti-inflammatory effects of curcumin loaded carboxymethyl cellulose acetate butyrate nanoparticles on adjuvant induced arthritis in rats. J Drug Deliv Sci Technol 41:269\u2013279. https:\/\/doi.org\/10.1016\/j.jddst.2017.07.022","journal-title":"J Drug Deliv Sci Technol"},{"key":"9764_CR49","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.physbeh.2005.12.005","volume":"87","author":"CD Cook","year":"2006","unstructured":"Cook CD, Moore KI (2006) Effects of sex, hindpaw injection site and stimulus modality on nociceptive sensitivity in arthritic rats. Physiol Behav 87:552\u2013562. https:\/\/doi.org\/10.1016\/j.physbeh.2005.12.005","journal-title":"Physiol Behav"},{"key":"9764_CR50","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0091-3057(97)00583-2","volume":"60","author":"FL Smith","year":"1998","unstructured":"Smith FL, Ken F, Lowe J, Welch SP (1998) Characterization of \u03949-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats. Pharmacol Biochem Behav 60:183\u2013191. https:\/\/doi.org\/10.1016\/S0091-3057(97)00583-2","journal-title":"Pharmacol Biochem Behav"},{"key":"9764_CR51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jneuroim.2005.03.007","volume":"163","author":"L-H Guo","year":"2005","unstructured":"Guo L-H, Trautmann K, Schluesener HJ (2005) Expression of P2X4 receptor by lesional activated microglia during formalin-induced inflammatory pain. J Neuroimmunol 163:120\u2013127. https:\/\/doi.org\/10.1016\/j.jneuroim.2005.03.007","journal-title":"J Neuroimmunol"},{"key":"9764_CR52","doi-asserted-by":"publisher","first-page":"44","DOI":"10.33899\/mmed.2012.64587","volume":"38","author":"HM Majdal","year":"2012","unstructured":"Majdal HM, Sulaiman SM, Sulaiman ME (2012) Nerve conduction and electromyography in rheumatoid arthritis patients: a case-control study. Ann Coll Med Mosul 38:44\u201351","journal-title":"Ann Coll Med Mosul"},{"key":"9764_CR53","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00441-003-0758-5","volume":"313","author":"X Bo","year":"2003","unstructured":"Bo X, Kim M, Nori SL, Schoepfer R, Burnstock G, North RA (2003) Tissue distribution of P2X 4 receptors studied with an ectodomain antibody. Cell Tissue Res 313:159\u2013165. https:\/\/doi.org\/10.1007\/s00441-003-0758-5","journal-title":"Cell Tissue Res"},{"key":"9764_CR54","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1038\/emboj.2010.126","volume":"29","author":"L Ulmann","year":"2010","unstructured":"Ulmann L, Hirbec H, Rassendren F (2010) P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain. EMBO J 29:2290\u20132300. https:\/\/doi.org\/10.1038\/emboj.2010.126","journal-title":"EMBO J"},{"key":"9764_CR55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neuint.2017.02.004","volume":"108","author":"M Ying","year":"2017","unstructured":"Ying M, Liu H, Zhang T, Jiang C, Gong Y, Wu B, Zou L, Yi Z, Rao S, Li G (2017) Effect of artemisinin on neuropathic pain mediated by P2X4 receptor in dorsal root ganglia. Neurochem Int 108:27\u201333. https:\/\/doi.org\/10.1016\/j.neuint.2017.02.004","journal-title":"Neurochem Int"},{"key":"9764_CR56","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1097\/j.pain.0000000000001587","volume":"160","author":"WA Williams","year":"2019","unstructured":"Williams WA, Linley JE, Jones CA, Shibata Y, Snijder A, Button J, Hatcher JP, Huang L, Taddese B, Thornton P (2019) Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain. Pain 160:1989\u20132003. https:\/\/doi.org\/10.1097\/j.pain.0000000000001587","journal-title":"Pain"},{"key":"9764_CR57","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.neuroscience.2018.12.003","volume":"398","author":"JM Teixeira","year":"2019","unstructured":"Teixeira JM, Dos Santos GG, Neves AF, Athie MCP, Bonet IJM, Nishijima CM, Farias FH, Figueiredo JG, Hernandez-Olmos V, Alshaibani S (2019) Diabetes-induced neuropathic mechanical hyperalgesia depends on P2X4 receptor activation in dorsal root ganglia. Neuroscience 398:158\u2013170. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.12.003","journal-title":"Neuroscience"},{"key":"9764_CR58","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/ner.12648","volume":"21","author":"B Pan","year":"2018","unstructured":"Pan B, Zhang Z, Chao D, Hogan QH (2018) Dorsal root ganglion field stimulation prevents inflammation and joint damage in a rat model of rheumatoid arthritis. Neuromodulation. 21:247\u2013253. https:\/\/doi.org\/10.1111\/ner.12648","journal-title":"Neuromodulation."},{"key":"9764_CR59","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1084\/jem.189.5.865","volume":"189","author":"M Kerschensteiner","year":"1999","unstructured":"Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld (1999) Activated human T cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lessions: a neuroprotective rol of inflammation? J Exp Med 189:865\u2013870. https:\/\/doi.org\/10.1084\/jem.189.5.865","journal-title":"J Exp Med"},{"key":"9764_CR60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036693","volume":"7","author":"K Klein","year":"2012","unstructured":"Klein K, Aeschlimann A, Jordan S, Gay R, Gay S, Sprott H (2012) ATP induced brain-derived neurotrophic factor expression and release from osteoarthritis synovial fibroblasts is mediated by purinergic receptor P2X4. PLoS One 7:e36693. https:\/\/doi.org\/10.1371\/journal.pone.0036693","journal-title":"PLoS One"},{"key":"9764_CR61","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jneuroim.2004.10.026","volume":"160","author":"O Schulte-Herbr\u00fcggen","year":"2005","unstructured":"Schulte-Herbr\u00fcggen O, Nassenstein C, Lommatzsch M, Quarcoo D, Renz H, Braun A (2005) Tumor necrosis factor-\u03b1 and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes. J Neuroimmunol 160:204\u2013209. https:\/\/doi.org\/10.1016\/j.jneuroim.2004.10.026","journal-title":"J Neuroimmunol"},{"key":"9764_CR62","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jneuroim.2007.11.006","volume":"194","author":"J Kawanokuchi","year":"2008","unstructured":"Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H, Suzumura A (2008) Production and functions of IL-17 in microglia. J Neuroimmunol 194:54\u201361. https:\/\/doi.org\/10.1016\/j.jneuroim.2007.11.006","journal-title":"J Neuroimmunol"},{"key":"9764_CR63","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1523\/JNEUROSCI.5714-08.2009","volume":"29","author":"T Trang","year":"2009","unstructured":"Trang T, Beggs S, Wan X, Salter MW (2009) P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J Neuro-Oncol 29:3518\u20133528. https:\/\/doi.org\/10.1523\/JNEUROSCI.5714-08.2009","journal-title":"J Neuro-Oncol"},{"key":"9764_CR64","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s10753-013-9723-y","volume":"37","author":"F Li","year":"2014","unstructured":"Li F, Guo N, Ma Y, Ning B, Wang Y, Kou L (2014) Inhibition of P2X4 suppresses joint inflammation and damage in collagen-induced arthritis. Inflammation 37:146\u2013153. https:\/\/doi.org\/10.1007\/s10753-013-9723-y","journal-title":"Inflammation"},{"key":"9764_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-19301-5","volume":"8","author":"S Lalisse","year":"2018","unstructured":"Lalisse S, Hua J, Lenoir M, Linkc N, Rassendren F, Ulmann L (2018) Sensory neuronal P2RX4 receptors controls BDNF signaling in inflammatory pain. Sci Rep 8:1\u201312. https:\/\/doi.org\/10.1038\/s41598-018-19301-5","journal-title":"Sci Rep"},{"key":"9764_CR66","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bbrc.2012.02.122","volume":"420","author":"A Kawano","year":"2012","unstructured":"Kawano A, Tsukimoto M, Mori D, Noguchi T, Harada H, Takenouchi T, Kitani H, Kojima S (2012) Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages. Biochem Biophys Res Commun 420:102\u2013107. https:\/\/doi.org\/10.1016\/j.bbrc.2012.02.122","journal-title":"Biochem Biophys Res Commun"},{"key":"9764_CR67","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1097\/j.pain.0000000000000366","volume":"156","author":"S Liu","year":"2015","unstructured":"Liu S, Liu Y-P, Huang Y-K, Zhang Y-K, Song AA, Ma P-C, Song X-J (2015) Wnt\/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats. Pain 156:2572\u20132584. https:\/\/doi.org\/10.1097\/j.pain.0000000000000366","journal-title":"Pain"},{"key":"9764_CR68","doi-asserted-by":"publisher","first-page":"9006","DOI":"10.1523\/JNEUROSCI.2370-06.2006","volume":"26","author":"JA Sim","year":"2006","unstructured":"Sim JA, Chaumont S, Jo J, Ulmann L, Young MT, Cho K, Buell G, North RA, Rassendren F (2006) Altered hippocampal synaptic potentiation in P2X4 knock-out mice. J Neurosci 26:9006\u20139009. https:\/\/doi.org\/10.1523\/JNEUROSCI.2370-06.2006","journal-title":"J Neurosci"},{"key":"9764_CR69","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1113\/JP277377","volume":"597","author":"BJ Chun","year":"2019","unstructured":"Chun BJ, Stewart BD, Vaughan DD, Bachstetter AD, Kekenes-Huskey PM (2019) Simulation of P2X-mediated calcium signalling in microglia. J Physiol 597:799\u2013818. https:\/\/doi.org\/10.1113\/JP277377","journal-title":"J Physiol"},{"key":"9764_CR70","doi-asserted-by":"publisher","first-page":"174480691879593","DOI":"10.1177\/1744806918795930","volume":"14","author":"C Liu","year":"2018","unstructured":"Liu C, Zhang Y, Liu Q, Jiang L, Li M, Wang S, Long T, He W, Kong X, Qin G (2018) P2X4-receptor participates in EAAT3 regulation via BDNF-TrkB signaling in a model of trigeminal allodynia. Mol Pain 14:1744806918795930. https:\/\/doi.org\/10.1177\/1744806918795930","journal-title":"Mol Pain"},{"key":"9764_CR71","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.brainresbull.2018.07.003","volume":"142","author":"Z Deng","year":"2018","unstructured":"Deng Z, Li C, Liu C, Du E, Xu C (2018) Catestatin is involved in neuropathic pain mediated by purinergic receptor P2X4 in the spinal microglia of rats. Brain Res Bull 142:138\u2013146. https:\/\/doi.org\/10.1016\/j.brainresbull.2018.07.003","journal-title":"Brain Res Bull"},{"key":"9764_CR72","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ejphar.2008.09.016","volume":"598","author":"M Egger","year":"2008","unstructured":"Egger M, Beer AGE, Theurl M, Schgoer W, Hotter B, Tatarczyk T, Vasiljevic D, Frauscher S, Marksteiner J, Patsch JR (2008) Monocyte migration: a novel effect and signaling pathways of catestatin. Eur J Pharmacol 598:104\u2013111. https:\/\/doi.org\/10.1016\/j.ejphar.2008.09.016","journal-title":"Eur J Pharmacol"},{"key":"9764_CR73","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0304-3959(02)00257-9","volume":"100","author":"SM Sweitzer","year":"2002","unstructured":"Sweitzer SM, Hickey WF, Rutkowski MD, Pahl JL, DeLeo JA (2002) Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain. Pain 100:163\u2013170. https:\/\/doi.org\/10.1016\/S0304-3959(02)00257-9","journal-title":"Pain"},{"key":"9764_CR74","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.pain.2013.06.022","volume":"154","author":"R-R Ji","year":"2013","unstructured":"Ji R-R, Berta T, Nedergaard M (2013) Glia and pain: is chronic pain a gliopathy? Pain 154:S10\u2013S28. https:\/\/doi.org\/10.1016\/j.pain.2013.06.022","journal-title":"Pain"},{"key":"9764_CR75","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s12264-012-1058-4","volume":"28","author":"Y-X Chu","year":"2012","unstructured":"Chu Y-X, Zhang Y-Q, Zhao Z-Q (2012) Involvement of microglia and interleukin-18 in the induction of long-term potentiation of spinal nociceptive responses induced by tetanic sciatic stimulation. Neurosci Bull 28:49\u201360","journal-title":"Neurosci Bull"},{"key":"9764_CR76","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1529-8027.2001.01010.x","volume":"6","author":"C Sommer","year":"2008","unstructured":"Sommer C, Sch\u00e4fers M, Marziniak M, Toyka KV (2008) Etanercept reduces hyperalgesia in experimental painful neuropathy. J Peripher Nerv Syst 6:67\u201372. https:\/\/doi.org\/10.1111\/j.1529-8027.2001.01010.x","journal-title":"J Peripher Nerv Syst"},{"key":"9764_CR77","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1523\/JNEUROSCI.21-02-00641.2001","volume":"21","author":"ME Rubio","year":"2001","unstructured":"Rubio ME, Soto F (2001) Distinct localization of P2X receptors at excitatory postsynaptic specializations. J Neurosci 21:641\u2013653. https:\/\/doi.org\/10.1523\/JNEUROSCI.21-02-00641.2001","journal-title":"J Neurosci"},{"key":"9764_CR78","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1073\/pnas.93.8.3684","volume":"93","author":"F Soto","year":"1996","unstructured":"Soto F, Garcia-Guzman M, Gomez-Hernandez JM, Holmann M, Karschin C, St\u00fchmer W (1996) P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proc Natl Acad Sci U S A 93:3684\u20133688. https:\/\/doi.org\/10.1073\/pnas.93.8.3684","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9764_CR79","doi-asserted-by":"publisher","unstructured":"Franklin KM, Asatryan L, Jakowec MW, Trudell JR, Bell RL, Davies DL (2014) P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and\/or treat alcohol use disorders. Front Neurosci 8. https:\/\/doi.org\/10.3389\/fnins.2014.00176","DOI":"10.3389\/fnins.2014.00176"},{"key":"9764_CR80","doi-asserted-by":"publisher","unstructured":"Tsuda M, Masuda T, Tozaki-Saitoh H, Inoue K (2013) P2X4 Receptors and neuropathic pain. front cell neurosci. https:\/\/doi.org\/10.3389\/fncel.2013.00191","DOI":"10.3389\/fncel.2013.00191"},{"key":"9764_CR81","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s11302-007-9069-8","volume":"3","author":"S Amadio","year":"2007","unstructured":"Amadio S, Montilli C, Picconi B, Calabresi P, Volont\u00e9 C (2007) Mapping P2X and P2Y receptor proteins in striatum and substantia nigra: an immunohistological study. Purinergic Signal 3:389\u2013398. https:\/\/doi.org\/10.1007\/s11302-007-9069-8","journal-title":"Purinergic Signal"},{"key":"9764_CR82","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.tem.2009.05.005","volume":"20","author":"SS Stojilkovic","year":"2009","unstructured":"Stojilkovic SS (2009) Purinergic regulation of hypothalamopituitary functions. Trends Endocrinol Metab 20:460\u2013468. https:\/\/doi.org\/10.1016\/j.tem.2009.05.005","journal-title":"Trends Endocrinol Metab"},{"key":"9764_CR83","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11302-004-4745-4","volume":"1","author":"U Kru gel","year":"2004","unstructured":"Kru gel U, Spies O, Regenthal R, Illes P, Kittner H (2004) P2 receptors are involved in the mediation of motivation-related behaviour. Purinergic Signal 1:21\u201329. https:\/\/doi.org\/10.1007\/s11302-004-4745-4","journal-title":"Purinergic Signal"},{"key":"9764_CR84","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/syn.10162","volume":"47","author":"U Kru gel","year":"2003","unstructured":"Kru gel U, Kittner H, Franke H, Illes P (2003) Purinergic modulation of neuronal activity in the mesolimbic dopaminergic system in vivo. Synapse 47:134\u2013142. https:\/\/doi.org\/10.1002\/syn.10162","journal-title":"Synapse"},{"key":"9764_CR85","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/jnc.13734","volume":"139","author":"S Khoja","year":"2016","unstructured":"Khoja S, Shah V, Garcia D, Asatryan L, Jakowec MW, Davies DL (2016) Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviours. J Neurochem 139:134\u2013148. https:\/\/doi.org\/10.1111\/jnc.13734","journal-title":"J Neurochem"},{"key":"9764_CR86","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.neuron.2018.11.009","volume":"100","author":"G Chen","year":"2018","unstructured":"Chen G, Zhang Y-Q, Qadri YJ, Serhan CN, Ji R-R (2018) Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain. Neuron 100:1292\u20131311. https:\/\/doi.org\/10.1016\/j.neuron.2018.11.009","journal-title":"Neuron"},{"key":"9764_CR87","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/oxfordjournals.aje.a112878","volume":"111","author":"A Linos","year":"1980","unstructured":"Linos A, Worthington JW, O\u2019Fallon WM, Kurland LT (1980) The epidemiology of rheumatoid arthritis in Rochester, Minnesota: a study of incidence, prevalence and mortality. Am J Epidemiol 111:87\u201398. https:\/\/doi.org\/10.1093\/oxfordjournals.aje.a112878","journal-title":"Am J Epidemiol"},{"key":"9764_CR88","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1007\/s11064-010-0336-7","volume":"36","author":"JA Smith","year":"2011","unstructured":"Smith JA, Das A, Butler JT, Ray SK, Banik NL (2011) Estrogen or estrogen receptor agonist inhibits lipopolysaccharide-induced microglial activation and death. Neurochem Res 36:1587\u20131593. https:\/\/doi.org\/10.1007\/s11064-010-0336-7","journal-title":"Neurochem Res"},{"key":"9764_CR89","doi-asserted-by":"publisher","first-page":"18980","DOI":"10.1038\/srep18980","volume":"6","author":"V Vacca","year":"2016","unstructured":"Vacca V, Marinelli S, Pieroni L, Urbani A, Luvisetto S, Pavone F (2016) 17\u03b2-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical and proteomic investigation on sex-related differences in mice. Sci Rep 6:18980. https:\/\/doi.org\/10.1038\/srep18980","journal-title":"Sci Rep"},{"key":"9764_CR90","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/nn.4053","volume":"18","author":"RE Sorge","year":"2015","unstructured":"Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS (2015) Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci 18:1081\u20131083. https:\/\/doi.org\/10.1038\/nn.4053","journal-title":"Nat Neurosci"},{"key":"9764_CR91","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1097\/j.pain.0000000000001265","volume":"159","author":"JCS Mapplebeck","year":"2018","unstructured":"Mapplebeck JCS, Dalgarno R, Tu Y, Moriarty O, Beggs S, Kwok CHT, Halievski K, Assi S, Mogil JS, Trang T, Salter MW (2018) Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats. Pain 159:1752\u20131763. https:\/\/doi.org\/10.1097\/j.pain.0000000000001265","journal-title":"Pain"},{"key":"9764_CR92","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1007\/s002100000312","volume":"362","author":"G Lambrecht","year":"2000","unstructured":"Lambrecht G (2000) Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications. Naunyn Schmiedeberg's Arch Pharmacol 362:340\u2013350. https:\/\/doi.org\/10.1007\/s002100000312","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"9764_CR93","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/j.1460-2075.1996.tb00333.x","volume":"15","author":"G Buell","year":"1996","unstructured":"Buell G, Lewis C, Collo G, North RA, Surprenant A (1996) An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J 15:55\u201362. https:\/\/doi.org\/10.1002\/j.1460-2075.1996.tb00333.x","journal-title":"EMBO J"},{"key":"9764_CR94","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1124\/pr.110.003129","volume":"63","author":"C Coddou","year":"2011","unstructured":"Coddou C, Yan Z, Obsil T, Huidobro-Toro JP, Stojilkovic S (2011) Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev 63:641\u2013683. https:\/\/doi.org\/10.1124\/pr.110.003129","journal-title":"Pharmacol Rev"},{"issue":"1744-8069","key":"9764_CR95","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1744-8069-5-20","volume":"5","author":"K Nagata","year":"2009","unstructured":"Nagata K, Imai T, Yamashita T, Tsuda M, Tozaki-Saitoh H, Inoue K (2009) Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief. Mol Pain 5(1744-8069):5\u201320. https:\/\/doi.org\/10.1186\/1744-8069-5-20","journal-title":"Mol Pain"},{"key":"9764_CR96","doi-asserted-by":"publisher","first-page":"94","DOI":"10.6091\/ibj.1282.2013","volume":"18","author":"M Zarei","year":"2014","unstructured":"Zarei M, Sabetkasei M, Zanjani TM (2014) Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain. Iran Biomed J 18:94\u2013100. https:\/\/doi.org\/10.6091\/ibj.1282.2013","journal-title":"Iran Biomed J"},{"key":"9764_CR97","doi-asserted-by":"publisher","first-page":"9576","DOI":"10.1021\/jm300845v","volume":"55","author":"V Hernandez-Olmos","year":"2012","unstructured":"Hernandez-Olmos V, Abdelrahman A, El-Tayeb A, Freudendahl D, Weinhausen S, M\u00fcller CE (2012) N-substituted phenoxazine and acridone derivatives: structure\u2013activity relationships of potent P2X4 receptor antagonists. J Med Chem 55:9576\u20139588. https:\/\/doi.org\/10.1021\/jm300845v","journal-title":"J Med Chem"},{"key":"9764_CR98","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1124\/mol.114.096222","volume":"87","author":"AR Ase","year":"2015","unstructured":"Ase AR, Honson NS, Zaghdane H, Pfeifer TA, S\u00e9gu\u00e9la P (2015) Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol Pharmacol 87:606\u2013616. https:\/\/doi.org\/10.1124\/mol.114.096222","journal-title":"Mol Pharmacol"},{"key":"9764_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s10194-019-1070-4","volume":"21","author":"T Long","year":"2020","unstructured":"Long T, He W, Pan Q, Zhang S, Zhang D, Qin G, Chen L, Zhou J (2020) Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model. J Headache Pain 21:1\u201317. https:\/\/doi.org\/10.1186\/s10194-019-1070-4","journal-title":"J Headache Pain"},{"key":"9764_CR100","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.4049\/jimmunol.1700965","volume":"200","author":"JA Layhadi","year":"2018","unstructured":"Layhadi JA, Turner J, Crossman D, Fountain SJ (2018) ATP evokes Ca2+ responses and CXCL5 secretion via P2X4 receptor activation in human monocyte-derived macrophages. J Immunol 200:1159\u20131168. https:\/\/doi.org\/10.4049\/jimmunol.1700965","journal-title":"J Immunol"},{"key":"9764_CR101","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.pharep.2015.08.016","volume":"68","author":"AM Jurga","year":"2016","unstructured":"Jurga AM, Piotrowska A, Starnowska J, Rojewska E, Makuch W, Mika J (2016) Treatment with a carbon monoxide-releasing molecule (CORM-2) inhibits neuropathic pain and enhances opioid effectiveness in rats. Pharmacol Rep 68:206\u2013213. https:\/\/doi.org\/10.1016\/j.pharep.2015.08.016","journal-title":"Pharmacol Rep"},{"key":"9764_CR102","doi-asserted-by":"publisher","unstructured":"Jurga AM, Piotrowska A, Makuch W, Przewlocka B, Mika J (2017) Blockade of P2X4 receptors inhibits neuropathic pain-related behavior by preventing MMP-9 activation and, consequently, pronociceptive interleukin release in a rat model. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2017.00048","DOI":"10.3389\/fphar.2017.00048"},{"key":"9764_CR103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1744-8069-9-16","volume":"7","author":"A Hervera","year":"2012","unstructured":"Hervera A, Lea\u2019nez S, Negrete R, Motterlini R, Pol O (2012) Carbon monoxide reduced neuropathic pain and spinal microglial actuvation by inhibiting nitric oxide synthesis in mice. PLoS One 7:1\u201310. https:\/\/doi.org\/10.1186\/1744-8069-9-16","journal-title":"PLoS One"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-021-09764-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-021-09764-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-021-09764-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T10:26:21Z","timestamp":1622024781000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-021-09764-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":103,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["9764"],"URL":"https:\/\/doi.org\/10.1007\/s11302-021-09764-z","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"type":"print","value":"1573-9538"},{"type":"electronic","value":"1573-9546"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"31 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Nurul Ajilah Mohamed Khir declares that she has no conflict of interest. Ain\u2019 Sabreena Mohd Noh declares that she has no conflict of interest. Nazlahshaniza Shafin declares that she has no conflict of interest. Che Aishah Nazariah Ismail declares that she has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}