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However, whether the clinic case of epilepsy would be associated with <jats:italic>P2Y12<\/jats:italic> receptor gene polymorphisms is presented with few data. In our study, a total of 176 patients with epilepsy and 50 healthy controls were enrolled. Two single-nucleotide polymorphisms, namely rs1491974 and rs6798347, were selected for analysis. The results revealed that carriers of the G allele of rs1491974 G&gt;A or rs6798347 G&gt;A may be associated with an increased risk of epilepsy (OR = 0.576, 95% CI = 0.368\u20130.901, <jats:italic>p<\/jats:italic> = 0.015; OR = 0.603, 95% CI = 0.367\u20130.988, <jats:italic>p<\/jats:italic> = 0.043). Interestingly, we found that the rs1491974 G&gt;A genotype and allele frequencies have only a significant difference in female instead of male case (<jats:italic>p<\/jats:italic> = 0.004 for genotype; <jats:italic>p<\/jats:italic> = 0.001 for allele). The subgroup analysis demonstrated that individuals with the rs1491974 G&gt;A genotype might have more frequent seizure (OR = 0.476, 95% CI = 0.255\u20130.890; <jats:italic>p<\/jats:italic> = 0.019). These data implied that both rs1491974 and rs6798347 polymorphisms of <jats:italic>P2Y12R<\/jats:italic> would be able to play import roles in epilepsy susceptibility, whereas the rs1491974 polymorphism may be specifically related to seizure frequency.<\/jats:p>","DOI":"10.1007\/s11302-022-09848-4","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T16:03:05Z","timestamp":1645113785000},"page":"155-162","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["P2Y12 receptor gene polymorphisms are associated with epilepsy"],"prefix":"10.1007","volume":"19","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Rui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Zhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin-Lu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qin","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"issue":"4","key":"9848_CR1","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/S1474-4422(19)30042-0","volume":"18","author":"WA Hauser","year":"2019","unstructured":"Hauser WA (2019) An unparalleled assessment of the global burden of epilepsy. 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