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Increasing evidence indicated that purinergic A\n                    <jats:sub>1<\/jats:sub>\n                    , A\n                    <jats:sub>2A<\/jats:sub>\n                    , A\n                    <jats:sub>3<\/jats:sub>\n                    , P2X4, P2X7, P2Y\n                    <jats:sub>1<\/jats:sub>\n                    , P2Y\n                    <jats:sub>2<\/jats:sub>\n                    , and P2Y\n                    <jats:sub>4<\/jats:sub>\n                    receptors play an important role in the regulation of inflammation in DED: A\n                    <jats:sub>1<\/jats:sub>\n                    adenosine receptor (A\n                    <jats:sub>1R<\/jats:sub>\n                    ) is a systemic pro-inflammatory factor; A\n                    <jats:sub>2AR<\/jats:sub>\n                    is involved in the activation of the MAPK\/NF-kB pathway; A\n                    <jats:sub>3R<\/jats:sub>\n                    combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1\u03b2 and IL-18; P2Y receptors affect the phospholipase C(PLC)\/IP3\/Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future.\n                  <\/jats:p>","DOI":"10.1007\/s11302-022-09851-9","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T02:02:43Z","timestamp":1645840963000},"page":"199-206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Targeting purinergic receptors to attenuate inflammation of dry eye"],"prefix":"10.1007","volume":"19","author":[{"given":"Jia-Ning","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Tao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,26]]},"reference":[{"key":"9851_CR1","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","volume":"15","author":"AJ Bron","year":"2017","unstructured":"Bron AJ, De Paiva CS, Chauhan SK et al (2017) TFOS DEWS II pathophysiology report. 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