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Despite significant advancements in short term graft survival, longer term survival rates have not improved greatly mediated in large by chronic antibody mediated rejection. Strategies to reduce the donor kidney antigenic load may translate to improved transplant survival. CD39 on the vascular endothelium and on circulating cells, in particular regulatory T cells (Treg), is upregulated in response to hypoxic stimuli and plays a critical role in regulating the immune response removing proinflammatory ATP and generating anti-inflammatory adenosine. Herein, the role of CD39 in reducing ischaemia\u2013reperfusion injury (IRI) and on Treg within the context of kidney transplantation is reviewed.<\/jats:p>","DOI":"10.1007\/s11302-022-09865-3","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T05:15:00Z","timestamp":1650950100000},"page":"387-393","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Burnstock oration \u2014 purinergic signalling in kidney transplantation"],"prefix":"10.1007","volume":"18","author":[{"given":"Karen M.","family":"Dwyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"9865_CR1","unstructured":"G. Burnstock, \u201cProfessor Geoffrey Burnstock, neurobiologist,\u201d in Conversations with Australian Scientists, R. Williams, Ed., ed. 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