{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:06:28Z","timestamp":1792548388928,"version":"4.5.0"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["480097\/2013-5"],"award-info":[{"award-number":["480097\/2013-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["440993\/2023-7 and 406396\/2021-3"],"award-info":[{"award-number":["440993\/2023-7 and 406396\/2021-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/13691-1 and 2019\/03.348-4"],"award-info":[{"award-number":["2013\/13691-1 and 2019\/03.348-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/07366-4"],"award-info":[{"award-number":["2018\/07366-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/13691-1 and 2019\/03.348-4"],"award-info":[{"award-number":["2013\/13691-1 and 2019\/03.348-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Code 001, 2019\/03348-4"],"award-info":[{"award-number":["Code 001, 2019\/03348-4"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s11302-024-10037-8","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T05:02:15Z","timestamp":1721451735000},"page":"99-112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Partners in health and disease: pineal gland and purinergic signalling"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-6120","authenticated-orcid":false,"given":"Regina P.","family":"Markus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-658X","authenticated-orcid":false,"given":"Kassiano S.","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-3815","authenticated-orcid":false,"given":"Henning","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-837X","authenticated-orcid":false,"given":"Zulma S.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"10037_CR1","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12974-022-02601-z","volume":"19","author":"M Wilmes","year":"2022","unstructured":"Wilmes M, Pinto Espinoza C, Ludewig P et al (2022) Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions. J Neuroinflammation 19:256. https:\/\/doi.org\/10.1186\/s12974-022-02601-z","journal-title":"J Neuroinflammation"},{"key":"10037_CR2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fnins.2015.00148","volume":"9","author":"RJ Rodrigues","year":"2015","unstructured":"Rodrigues RJ, Tom\u00e9 AR, Cunha RA (2015) ATP as a multi-target danger signal in the brain. Front Neurosci 9:148. https:\/\/doi.org\/10.3389\/fnins.2015.00148","journal-title":"Front Neurosci"},{"key":"10037_CR3","doi-asserted-by":"publisher","first-page":"114385","DOI":"10.1016\/j.bcp.2020.114385","volume":"187","author":"P Pelegrin","year":"2021","unstructured":"Pelegrin P (2021) P2X7 receptor and the NLRP3 inflammasome: partners in crime. Biochem Pharmacol 187:114385. https:\/\/doi.org\/10.1016\/j.bcp.2020.114385","journal-title":"Biochem Pharmacol"},{"key":"10037_CR4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.neulet.2017.11.044","volume":"695","author":"PHM De Freitas","year":"2019","unstructured":"De Freitas PHM, Da Silva Ferreira NC, Fioravante-Rezende JG et al (2019) Dispelling myths about connexins, pannexins and P2X7 in hypoxic-ischemic central nervous system. Neurosci Lett 695:76\u201385. https:\/\/doi.org\/10.1016\/j.neulet.2017.11.044","journal-title":"Neurosci Lett"},{"key":"10037_CR5","doi-asserted-by":"publisher","first-page":"5996","DOI":"10.3390\/ijms21175996","volume":"21","author":"P Illes","year":"2020","unstructured":"Illes P (2020) P2X7 receptors amplify CNS damage in neurodegenerative diseases. Int J Mol Sci 21:5996. https:\/\/doi.org\/10.3390\/ijms21175996","journal-title":"Int J Mol Sci"},{"key":"10037_CR6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.6030\/1939-067X-3.1.47","volume":"3","author":"S Liu","year":"2010","unstructured":"Liu S, Levine SR, Winn HR (2010) Targeting ischemic penumbra part I: from pathophysiology to therapeutic strategy. J Exp Stroke Transl Med 3:47\u201355. https:\/\/doi.org\/10.6030\/1939-067X-3.1.47","journal-title":"J Exp Stroke Transl Med"},{"key":"10037_CR7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11302-005-6312-z","volume":"1","author":"F Di Virgilio","year":"2005","unstructured":"Di Virgilio F (2005) Purinergic mechanism in the immune system: a signal of danger for dendritic cells. Purinergic Signal 1:205. https:\/\/doi.org\/10.1007\/s11302-005-6312-z","journal-title":"Purinergic Signal"},{"key":"10037_CR8","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3389\/fncel.2019.00401","volume":"13","author":"JM Kanellopoulos","year":"2019","unstructured":"Kanellopoulos JM, Delarasse C (2019) Pleiotropic roles of P2X7 in the central nervous system. Front Cell Neurosci 13:401. https:\/\/doi.org\/10.3389\/fncel.2019.00401","journal-title":"Front Cell Neurosci"},{"key":"10037_CR9","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.tips.2007.07.002","volume":"28","author":"F Di Virgilio","year":"2007","unstructured":"Di Virgilio F (2007) Liaisons dangereuses: P2X7 and the inflammasome. Trends Pharmacol Sci 28:465\u2013472. https:\/\/doi.org\/10.1016\/j.tips.2007.07.002","journal-title":"Trends Pharmacol Sci"},{"key":"10037_CR10","doi-asserted-by":"publisher","first-page":"662935","DOI":"10.3389\/fncel.2021.662935","volume":"15","author":"\u00c1 Oliveira-Giacomelli","year":"2021","unstructured":"Oliveira-Giacomelli \u00c1, Petiz LL, Andrejew R et al (2021) Role of P2X7 Receptors in immune responses during neurodegeneration. Front Cell Neurosci 15:662935. https:\/\/doi.org\/10.3389\/fncel.2021.662935","journal-title":"Front Cell Neurosci"},{"key":"10037_CR11","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s11302-017-9579-y","volume":"13","author":"X Liu","year":"2017","unstructured":"Liu X, Zhao Z, Ji R et al (2017) Inhibition of P2X7 receptors improves outcomes after traumatic brain injury in rats. Purinergic Signal 13:529\u2013544. https:\/\/doi.org\/10.1007\/s11302-017-9579-y","journal-title":"Purinergic Signal"},{"key":"10037_CR12","doi-asserted-by":"publisher","first-page":"9465","DOI":"10.3390\/ijms24119465","volume":"24","author":"F Di Virgilio","year":"2023","unstructured":"Di Virgilio F, Vultaggio-Poma V, Falzoni S, Giuliani AL (2023) The coming of age of the P2X7 receptor in diagnostic medicine. Int J Mol Sci 24:9465. https:\/\/doi.org\/10.3390\/ijms24119465","journal-title":"Int J Mol Sci"},{"key":"10037_CR13","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuroscience.2022.06.039","volume":"499","author":"KS Sousa","year":"2022","unstructured":"Sousa KS, Quiles CL, Muxel SM et al (2022) Brain damage-linked ATP promotes P2X7 receptors mediated pineal N-acetylserotonin release. Neuroscience 499:12\u201322. https:\/\/doi.org\/10.1016\/j.neuroscience.2022.06.039","journal-title":"Neuroscience"},{"key":"10037_CR14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fendo.2011.00010","volume":"2","author":"CE Carvalho-Sousa","year":"2011","unstructured":"Carvalho-Sousa CE, da Silveira C-M, Tamura EK et al (2011) Molecular basis for defining the pineal gland and pinealocytes as targets for tumor necrosis factor. Front Endocrinol 2:10. https:\/\/doi.org\/10.3389\/fendo.2011.00010","journal-title":"Front Endocrinol"},{"key":"10037_CR15","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.1210\/endo.140.10.7074","volume":"140","author":"DC Skinner","year":"1999","unstructured":"Skinner DC, Malpaux B (1999) High melatonin concentrations in third ventricular cerebrospinal fluid are not due to galen vein blood recirculating through the choroid plexus1. Endocrinology 140:4399\u20134405. https:\/\/doi.org\/10.1210\/endo.140.10.7074","journal-title":"Endocrinology"},{"key":"10037_CR16","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1080\/01616412.2000.11740753","volume":"22","author":"HM Duvernoy","year":"2000","unstructured":"Duvernoy HM, Parratte B, Tatu L, Vuillier F (2000) The human pineal gland: relationships with surrounding structures and blood supply. Neurol Res 22:747\u2013790. https:\/\/doi.org\/10.1080\/01616412.2000.11740753","journal-title":"Neurol Res"},{"key":"10037_CR17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00785.x","author":"C-M Da Silveira","year":"2010","unstructured":"Da Silveira C-M, Carvalho-Sousa CE, Tamura EK et al (2010) TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway: LPS triggers pineal gland NFKB. J Pineal Res no-no. https:\/\/doi.org\/10.1111\/j.1600-079X.2010.00785.x","journal-title":"J Pineal Res no-no"},{"key":"10037_CR18","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0024-3205(02)02256-7","volume":"72","author":"T Kondoh","year":"2002","unstructured":"Kondoh T, Uneyama H, Nishino H, Torii K (2002) Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats. Life Sci 72:583\u2013590. https:\/\/doi.org\/10.1016\/S0024-3205(02)02256-7","journal-title":"Life Sci"},{"key":"10037_CR19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1046\/j.1600-079x.2003.00097.x","volume":"36","author":"K Torii","year":"2004","unstructured":"Torii K, Uneyama H, Nishino H, Kondoh T (2004) Melatonin suppresses cerebral edema caused by middle cerebral artery occlusion\/reperfusion in rats assessed by magnetic resonance imaging. J Pineal Res 36:18\u201324. https:\/\/doi.org\/10.1046\/j.1600-079x.2003.00097.x","journal-title":"J Pineal Res"},{"key":"10037_CR20","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1159\/000110635","volume":"14","author":"RP Markus","year":"2007","unstructured":"Markus RP, Ferreira ZS, Fernandes PACM, Cecon E (2007) The immune-pineal axis: a shuttle between endocrine and paracrine melatonin sources. NeuroImmunoModulation 14:126\u2013133. https:\/\/doi.org\/10.1159\/000110635","journal-title":"NeuroImmunoModulation"},{"key":"10037_CR21","doi-asserted-by":"publisher","first-page":"e13958","DOI":"10.1371\/journal.pone.0013958","volume":"5","author":"EK Tamura","year":"2010","unstructured":"Tamura EK, Fernandes PA, Mar\u00e7ola M et al (2010) Long-lasting priming of endothelial cells by plasma melatonin levels. PLoS ONE 5:e13958. https:\/\/doi.org\/10.1371\/journal.pone.0013958","journal-title":"PLoS ONE"},{"key":"10037_CR22","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/s0014-2999(01)01369-3","volume":"430","author":"CM Lotufo","year":"2001","unstructured":"Lotufo CM, Lopes C, Dubocovich ML et al (2001) Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation. Eur J Pharmacol 430:351\u2013357. https:\/\/doi.org\/10.1016\/s0014-2999(01)01369-3","journal-title":"Eur J Pharmacol"},{"key":"10037_CR23","doi-asserted-by":"publisher","first-page":"8844","DOI":"10.1073\/pnas.1105114108","volume":"108","author":"P Sompol","year":"2011","unstructured":"Sompol P, Liu X, Baba K et al (2011) N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice. Proc Natl Acad Sci U S A 108:8844\u20138849. https:\/\/doi.org\/10.1073\/pnas.1105114108","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10037_CR24","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1177\/1073858412446634","volume":"18","author":"G Tosini","year":"2012","unstructured":"Tosini G, Ye K, Iuvone PM (2012) N -Acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain. Neuroscientist 18:645\u2013653. https:\/\/doi.org\/10.1177\/1073858412446634","journal-title":"Neuroscientist"},{"key":"10037_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.freeradbiomed.2018.10.402","volume":"130","author":"C Luo","year":"2019","unstructured":"Luo C, Yang Q, Liu Y et al (2019) The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med 130:215\u2013233. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.10.402","journal-title":"Free Radic Biol Med"},{"key":"10037_CR26","doi-asserted-by":"publisher","first-page":"109278","DOI":"10.1016\/j.neuropharm.2022.109278","volume":"221","author":"C Volont\u00e9","year":"2022","unstructured":"Volont\u00e9 C, Amadio S (2022) Rethinking purinergic concepts and updating the emerging role of P2X7 and P2X4 in amyotrophic lateral sclerosis. Neuropharmacology 221:109278. https:\/\/doi.org\/10.1016\/j.neuropharm.2022.109278","journal-title":"Neuropharmacology"},{"key":"10037_CR27","first-page":"307","volume":"52","author":"DC Klein","year":"1997","unstructured":"Klein DC, Coon SL, Roseboom PH et al (1997) The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Prog Horm Res 52:307\u2013357 (discussion 357-358)","journal-title":"Recent Prog Horm Res"},{"key":"10037_CR28","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1124\/pr.55.2.2","volume":"55","author":"V Simonneaux","year":"2003","unstructured":"Simonneaux V, Ribelayga C (2003) Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 55:325\u2013395. https:\/\/doi.org\/10.1124\/pr.55.2.2","journal-title":"Pharmacol Rev"},{"key":"10037_CR29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00441-002-0579-y","volume":"309","author":"S Ganguly","year":"2002","unstructured":"Ganguly S, Coon SL, Klein DC (2002) Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell Tissue Res 309:127\u2013137. https:\/\/doi.org\/10.1007\/s00441-002-0579-y","journal-title":"Cell Tissue Res"},{"key":"10037_CR30","doi-asserted-by":"publisher","unstructured":"Pires-Lapa MA, Carvalho-Sousa CE, Cecon E, et al (2018) \u03b2-Adrenoceptors trigger melatonin synthesis in phagocytes. Int J Mol Sci 19. https:\/\/doi.org\/10.3390\/ijms19082182","DOI":"10.3390\/ijms19082182"},{"key":"10037_CR31","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.stem.2018.08.002","volume":"23","author":"K Golan","year":"2018","unstructured":"Golan K, Kumari A, Kollet O et al (2018) Daily onset of light and darkness differentially controls hematopoietic stem cell differentiation and maintenance. Cell Stem Cell 23:572-585.e7. https:\/\/doi.org\/10.1016\/j.stem.2018.08.002","journal-title":"Cell Stem Cell"},{"key":"10037_CR32","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1210\/endo-116-6-2167","volume":"116","author":"J Vanecek","year":"1985","unstructured":"Vanecek J, Sugden D, Weller J, Klein DC (1985) Atypical synergistic alpha 1- and beta-adrenergic regulation of adenosine 3\u2032,5\u2032-monophosphate and guanosine 3\u2032,5\u2032-monophosphate in rat pinealocytes. Endocrinology 116:2167\u20132173. https:\/\/doi.org\/10.1210\/endo-116-6-2167","journal-title":"Endocrinology"},{"key":"10037_CR33","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3389\/fendo.2019.00249","volume":"10","author":"D Zhao","year":"2019","unstructured":"Zhao D, Yu Y, Shen Y et al (2019) Melatonin synthesis and function: evolutionary history in animals and plants. Front Endocrinol 10:249. https:\/\/doi.org\/10.3389\/fendo.2019.00249","journal-title":"Front Endocrinol"},{"key":"10037_CR34","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1111\/bph.14083","volume":"175","author":"RP Markus","year":"2018","unstructured":"Markus RP, Fernandes PA, Kinker GS et al (2018) Immune-pineal axis \u2013 acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes. Br J Pharmacol 175:3239\u20133250. https:\/\/doi.org\/10.1111\/bph.14083","journal-title":"Br J Pharmacol"},{"key":"10037_CR35","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1159\/000046903","volume":"10","author":"GA Bubenik","year":"2001","unstructured":"Bubenik GA (2001) Localization, physiological significance and possible clinical implication of gastrointestinal melatonin. Neurosignals 10:350\u2013366. https:\/\/doi.org\/10.1159\/000046903","journal-title":"Neurosignals"},{"key":"10037_CR36","doi-asserted-by":"publisher","first-page":"4799","DOI":"10.1038\/s41598-020-61652-5","volume":"10","author":"MO C\u00f3rdoba-Moreno","year":"2020","unstructured":"C\u00f3rdoba-Moreno MO, de Souza E, da S, Quiles CL, et al (2020) Rhythmic expression of the melatonergic biosynthetic pathway and its differential modulation in vitro by LPS and IL10 in bone marrow and spleen. Sci Rep 10:4799. https:\/\/doi.org\/10.1038\/s41598-020-61652-5","journal-title":"Sci Rep"},{"key":"10037_CR37","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1600-079X.2005.00273.x","volume":"40","author":"TW Fischer","year":"2006","unstructured":"Fischer TW, Zbytek B, Sayre RM et al (2006) Melatonin increases survival of HaCaT keratinocytes by suppressing UV-induced apoptosis. J Pineal Res 40:18\u201326. https:\/\/doi.org\/10.1111\/j.1600-079X.2005.00273.x","journal-title":"J Pineal Res"},{"key":"10037_CR38","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1182\/bloodadvances.2018027722","volume":"3","author":"K Golan","year":"2019","unstructured":"Golan K, Lapidot T (2019) Daily light-and-darkness onset regulates mouse hematopoietic stem cells. Blood Adv 3:704\u2013704. https:\/\/doi.org\/10.1182\/bloodadvances.2018027722","journal-title":"Blood Adv"},{"key":"10037_CR39","doi-asserted-by":"publisher","first-page":"2742","DOI":"10.1096\/fj.12-224691","volume":"27","author":"T Kim","year":"2013","unstructured":"Kim T, Kleszczy\u0144ski K, Janjetovic Z et al (2013) Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells. FASEB J 27:2742\u20132755. https:\/\/doi.org\/10.1096\/fj.12-224691","journal-title":"FASEB J"},{"key":"10037_CR40","doi-asserted-by":"publisher","first-page":"e12520","DOI":"10.1111\/jpi.12520","volume":"65","author":"L Sagrillo-Fagundes","year":"2018","unstructured":"Sagrillo-Fagundes L, Assun\u00e7\u00e3o Salustiano EM, Ruano R et al (2018) Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia\/reoxygenation. J Pineal Res 65:e12520. https:\/\/doi.org\/10.1111\/jpi.12520","journal-title":"J Pineal Res"},{"key":"10037_CR41","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1600-079X.2008.00630.x","volume":"45","author":"I Semak","year":"2008","unstructured":"Semak I, Korik E, Antonova M et al (2008) Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes. J Pineal Res 45:515\u2013523. https:\/\/doi.org\/10.1111\/j.1600-079X.2008.00630.x","journal-title":"J Pineal Res"},{"key":"10037_CR42","doi-asserted-by":"publisher","first-page":"eadd1967","DOI":"10.1126\/sciimmunol.add1967","volume":"9","author":"J Zhao","year":"2024","unstructured":"Zhao J, Andreev I, Silva HM (2024) Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity. Sci Immunol 9:eadd1967. https:\/\/doi.org\/10.1126\/sciimmunol.add1967","journal-title":"Sci Immunol"},{"key":"10037_CR43","doi-asserted-by":"publisher","first-page":"e52010","DOI":"10.1371\/journal.pone.0052010","volume":"7","author":"SM Muxel","year":"2012","unstructured":"Muxel SM, Pires-Lapa MA, Monteiro AWA et al (2012) NF-\u03baB drives the synthesis of melatonin in raw 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. PloS One 7:e52010. https:\/\/doi.org\/10.1371\/journal.pone.0052010","journal-title":"PloS One"},{"key":"10037_CR44","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/jpi.12321","volume":"60","author":"SM Muxel","year":"2016","unstructured":"Muxel SM, Laranjeira-Silva MF, Carvalho-Sousa CE et al (2016) The RelA\/cRel nuclear factor-\u03baB (NF-\u03baB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages. J Pineal Res 60:394\u2013404. https:\/\/doi.org\/10.1111\/jpi.12321","journal-title":"J Pineal Res"},{"key":"10037_CR45","doi-asserted-by":"publisher","first-page":"55","DOI":"10.32794\/mr112500120","volume":"5","author":"ES Souza","year":"2022","unstructured":"Souza ES, Santos AA, Ribeiro-Paz EE et al (2022) Melatonin synthesized by activated microglia orchestrates the progression of microglia from a pro-inflammatory to a recovery\/repair phenotype. Melatonin Res 5:55\u201367. https:\/\/doi.org\/10.32794\/mr112500120","journal-title":"Melatonin Res"},{"key":"10037_CR46","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3390\/metabo13050629","volume":"13","author":"A Haduch","year":"2023","unstructured":"Haduch A, Bromek E, Kuban W, Daniel WA (2023) The engagement of cytochrome P450 enzymes in tryptophan metabolism. Metabolites 13:629. https:\/\/doi.org\/10.3390\/metabo13050629","journal-title":"Metabolites"},{"key":"10037_CR47","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3109\/00498254.2015.1107656","volume":"46","author":"L Luo","year":"2016","unstructured":"Luo L, Zhou C, Kurogi K et al (2016) Sulfation of 6-hydroxymelatonin, N-acetylserotonin and 4-hydroxyramelteon by the human cytosolic sulfotransferases (SULTs). Xenobiotica Fate Foreign Compd Biol Syst 46:612\u2013619. https:\/\/doi.org\/10.3109\/00498254.2015.1107656","journal-title":"Xenobiotica Fate Foreign Compd Biol Syst"},{"key":"10037_CR48","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.bcp.2015.02.010","volume":"94","author":"X Tian","year":"2015","unstructured":"Tian X, Huo X, Dong P et al (2015) Sulfation of melatonin: enzymatic characterization, differences of organs, species and genders, and bioactivity variation. Biochem Pharmacol 94:282\u2013296. https:\/\/doi.org\/10.1016\/j.bcp.2015.02.010","journal-title":"Biochem Pharmacol"},{"key":"10037_CR49","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1080\/00498254.2018.1440656","volume":"49","author":"Y Asai","year":"2019","unstructured":"Asai Y, Sakakibara Y, Kondo M et al (2019) Expression and activities of sulfotransferase in rat brain. Xenobiotica Fate Foreign Compd Biol Syst 49:270\u2013275. https:\/\/doi.org\/10.1080\/00498254.2018.1440656","journal-title":"Xenobiotica Fate Foreign Compd Biol Syst"},{"key":"10037_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/03602532.2020.1858856","volume":"53","author":"W Kuban","year":"2021","unstructured":"Kuban W, Daniel WA (2021) Cytochrome P450 expression and regulation in the brain. Drug Metab Rev 53:1\u201329. https:\/\/doi.org\/10.1080\/03602532.2020.1858856","journal-title":"Drug Metab Rev"},{"key":"10037_CR51","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1600-079X.2004.00120.x","volume":"36","author":"DK Lahiri","year":"2004","unstructured":"Lahiri DK, Ge Y-W, Sharman EH, Bondy SC (2004) Age-related changes in serum melatonin in mice: higher levels of combined melatonin and 6-hydroxymelatonin sulfate in the cerebral cortex than serum, heart, liver and kidney tissues. J Pineal Res 36:217\u2013223. https:\/\/doi.org\/10.1111\/j.1600-079X.2004.00120.x","journal-title":"J Pineal Res"},{"key":"10037_CR52","doi-asserted-by":"publisher","first-page":"168","DOI":"10.2174\/157015910792246244","volume":"8","author":"R Hardeland","year":"2010","unstructured":"Hardeland R (2010) Melatonin metabolism in the central nervous system. Curr Neuropharmacol 8:168\u2013181. https:\/\/doi.org\/10.2174\/157015910792246244","journal-title":"Curr Neuropharmacol"},{"key":"10037_CR53","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/bph.15299","volume":"178","author":"P Illes","year":"2021","unstructured":"Illes P, M\u00fcller CE, Jacobson KA et al (2021) Update of P2X receptor properties and their pharmacology: IUPHAR Review 30. Br J Pharmacol 178:489\u2013514. https:\/\/doi.org\/10.1111\/bph.15299","journal-title":"Br J Pharmacol"},{"key":"10037_CR54","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neuropharm.2015.10.030","volume":"104","author":"I von K\u00fcgelgen","year":"2016","unstructured":"von K\u00fcgelgen I, Hoffmann K (2016) Pharmacology and structure of P2Y receptors. Neuropharmacol 104:50\u201361. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.10.030","journal-title":"Neuropharmacol"},{"key":"10037_CR55","first-page":"1","volume-title":"Glioma Signaling","author":"G Burnstock","year":"2020","unstructured":"Burnstock G (2020) Introduction to purinergic signalling in the brain. In: Bara\u0144ska J (ed) Glioma Signaling. Springer International Publishing, Cham, pp 1\u201312"},{"key":"10037_CR56","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-3565(25)12791-2","volume":"255","author":"RC Carneiro","year":"1990","unstructured":"Carneiro RC, Markus RP (1990) Presynaptic nicotinic receptors involved in release of noradrenaline and ATP from the prostatic portion of the rat vas deferens. J Pharmacol Exp Ther 255:95\u2013100","journal-title":"J Pharmacol Exp Ther"},{"key":"10037_CR57","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0022-3565(25)20376-7","volume":"259","author":"RC Carneiro","year":"1991","unstructured":"Carneiro RC, Cipolla-Neto J, Markus RP (1991) Diurnal variation of the rat vas deferens contraction induced by stimulation of presynaptic nicotinic receptors and pineal function. J Pharmacol Exp Ther 259:614\u2013619","journal-title":"J Pharmacol Exp Ther"},{"key":"10037_CR58","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1476-5381.1994.tb13037.x","volume":"112","author":"ZS Ferreira","year":"1994","unstructured":"Ferreira ZS, Cipolla-Neto J, Markus RP (1994) Presence of P2-purinoceptors in the rat pineal gland. Br J Pharmacol 112:107\u2013110. https:\/\/doi.org\/10.1111\/j.1476-5381.1994.tb13037.x","journal-title":"Br J Pharmacol"},{"key":"10037_CR59","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0014-2999(01)00823-8","volume":"415","author":"ZS Ferreira","year":"2001","unstructured":"Ferreira ZS, Markus RP (2001) Characterisation of P2Y1-like receptor in cultured rat pineal glands. Eur J Pharmacol 415:151\u2013156. https:\/\/doi.org\/10.1016\/S0014-2999(01)00823-8","journal-title":"Eur J Pharmacol"},{"key":"10037_CR60","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000071264","volume":"69","author":"ZS Ferreira","year":"2003","unstructured":"Ferreira ZS, Garcia CRS, Spray DC, Markus RP (2003) P2Y1 Receptor activation enhances the rate of rat pinealocyte-induced extracellular acidification via a calcium-dependent mechanism. Pharmacology 69:33\u201337. https:\/\/doi.org\/10.1159\/000071264","journal-title":"Pharmacology"},{"key":"10037_CR61","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/s0014-2999(00)00416-7","volume":"401","author":"EJ Mortani Barbosa","year":"2000","unstructured":"Mortani Barbosa EJ, Ferreira ZS, Markus RP (2000) Purinergic and noradrenergic cotransmission in the rat pineal gland. Eur J Pharmacol 401:59\u201362. https:\/\/doi.org\/10.1016\/s0014-2999(00)00416-7","journal-title":"Eur J Pharmacol"},{"key":"10037_CR62","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/jpi.12309","volume":"60","author":"LH Souza-Teodoro","year":"2016","unstructured":"Souza-Teodoro LH, Dargenio-Garcia L, Petrilli-Lapa CL et al (2016) Adenosine triphosphate inhibits melatonin synthesis in the rat pineal gland. J Pineal Res 60:242\u2013249. https:\/\/doi.org\/10.1111\/jpi.12309","journal-title":"J Pineal Res"},{"key":"10037_CR63","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s00429-013-0686-4","volume":"220","author":"L Pinato","year":"2015","unstructured":"Pinato L, da Silveira C-M, Franco DG et al (2015) Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis. Brain Struct Funct 220:827\u2013840. https:\/\/doi.org\/10.1007\/s00429-013-0686-4","journal-title":"Brain Struct Funct"},{"key":"10037_CR64","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s12975-017-0559-x","volume":"9","author":"Z Wang","year":"2018","unstructured":"Wang Z, Zhou F, Dou Y et al (2018) Melatonin alleviates intracerebral hemorrhage-induced secondary brain injury in rats via suppressing apoptosis, inflammation, oxidative stress, DNA damage, and mitochondria injury. Transl Stroke Res 9:74\u201391. https:\/\/doi.org\/10.1007\/s12975-017-0559-x","journal-title":"Transl Stroke Res"},{"key":"10037_CR65","doi-asserted-by":"publisher","first-page":"11391","DOI":"10.18632\/aging.102537","volume":"11","author":"W Qin","year":"2019","unstructured":"Qin W, Li J, Zhu R et al (2019) Melatonin protects blood-brain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3\/NF-\u03baB pathway. Aging 11:11391\u201311415. https:\/\/doi.org\/10.18632\/aging.102537","journal-title":"Aging"},{"key":"10037_CR66","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3109\/08916934.2015.1027816","volume":"48","author":"DW Melton","year":"2015","unstructured":"Melton DW, McManus LM, Gelfond JAL, Shireman PK (2015) Temporal phenotypic features distinguish polarized macrophages in vitro. Autoimmunity 48:161\u2013176. https:\/\/doi.org\/10.3109\/08916934.2015.1027816","journal-title":"Autoimmunity"},{"key":"10037_CR67","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1600-079X.2006.00345.x","volume":"41","author":"GN Pontes","year":"2006","unstructured":"Pontes GN, Cardoso EC, Carneiro-Sampaio MMS, Markus RP (2006) Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytes. J Pineal Res 41:136\u2013141. https:\/\/doi.org\/10.1111\/j.1600-079X.2006.00345.x","journal-title":"J Pineal Res"},{"key":"10037_CR68","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/jpi.12066","volume":"55","author":"MA Pires-Lapa","year":"2013","unstructured":"Pires-Lapa MA, Tamura EK, Salustiano EMA, Markus RP (2013) Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells. J Pineal Res 55:240\u2013246. https:\/\/doi.org\/10.1111\/jpi.12066","journal-title":"J Pineal Res"},{"key":"10037_CR69","doi-asserted-by":"publisher","first-page":"100230","DOI":"10.1016\/j.bbih.2021.100230","volume":"13","author":"SCM Titon","year":"2021","unstructured":"Titon SCM, Titon Junior B, Gomes FR, Assis VR (2021) Short-term stressors and corticosterone effects on immunity in male toads (Rhinella icterica): a neuroimmune-endocrine approach. Brain Behav Immun - Health 13:100230. https:\/\/doi.org\/10.1016\/j.bbih.2021.100230","journal-title":"Brain Behav Immun - Health"},{"key":"10037_CR70","doi-asserted-by":"publisher","first-page":"e106332","DOI":"10.1371\/journal.pone.0106332","volume":"9","author":"DG Franco","year":"2014","unstructured":"Franco DG, Markus RP (2014) The cellular state determines the effect of melatonin on the survival of mixed cerebellar cell culture. PLoS ONE 9:e106332. https:\/\/doi.org\/10.1371\/journal.pone.0106332","journal-title":"PLoS ONE"},{"key":"10037_CR71","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1097\/WNR.0000000000000286","volume":"25","author":"M Ridderstr\u00f6m","year":"2014","unstructured":"Ridderstr\u00f6m M, Ohlsson M (2014) Brilliant blue G treatment facilitates regeneration after optic nerve injury in the adult rat. NeuroReport 25:1405\u20131410. https:\/\/doi.org\/10.1097\/WNR.0000000000000286","journal-title":"NeuroReport"},{"key":"10037_CR72","doi-asserted-by":"publisher","first-page":"100062","DOI":"10.1016\/j.bbih.2020.100062","volume":"4","author":"A Bernal-Chico","year":"2020","unstructured":"Bernal-Chico A, Manterola A, Cipriani R et al (2020) P2x7 receptors control demyelination and inflammation in the cuprizone model. Brain Behav Immun - Health 4:100062. https:\/\/doi.org\/10.1016\/j.bbih.2020.100062","journal-title":"Brain Behav Immun - Health"},{"key":"10037_CR73","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.neuint.2005.05.014","volume":"47","author":"A Melani","year":"2005","unstructured":"Melani A, Turchi D, Vannucchi MG et al (2005) ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia. Neurochem Int 47:442\u2013448. https:\/\/doi.org\/10.1016\/j.neuint.2005.05.014","journal-title":"Neurochem Int"},{"key":"10037_CR74","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1186\/s12974-018-1353-8","volume":"15","author":"L Janks","year":"2018","unstructured":"Janks L, Sharma CVR, Egan TM (2018) A central role for P2X7 receptors in human microglia. J Neuroinflammation 15:325. https:\/\/doi.org\/10.1186\/s12974-018-1353-8","journal-title":"J Neuroinflammation"},{"key":"10037_CR75","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.nbd.2011.12.014","volume":"45","author":"J Arbeloa","year":"2012","unstructured":"Arbeloa J, P\u00e9rez-Samart\u00edn A, Gottlieb M, Matute C (2012) P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia. Neurobiol Dis 45:954\u2013961. https:\/\/doi.org\/10.1016\/j.nbd.2011.12.014","journal-title":"Neurobiol Dis"},{"key":"10037_CR76","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s12264-020-00582-8","volume":"36","author":"T Glaser","year":"2020","unstructured":"Glaser T, Andrejew R, Oliveira-Giacomelli \u00c1 et al (2020) Purinergic receptors in basal ganglia diseases: shared molecular mechanisms between Huntington\u2019s and Parkinson\u2019s disease. Neurosci Bull 36:1299\u20131314. https:\/\/doi.org\/10.1007\/s12264-020-00582-8","journal-title":"Neurosci Bull"},{"key":"10037_CR77","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/mp.2017.188","volume":"23","author":"A Cheffer","year":"2018","unstructured":"Cheffer A, Castillo ARG, Corr\u00eaa-Velloso J et al (2018) Purinergic system in psychiatric diseases. Mol Psychiatry 23:94\u2013106. https:\/\/doi.org\/10.1038\/mp.2017.188","journal-title":"Mol Psychiatry"},{"key":"10037_CR78","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.coi.2018.03.026","volume":"52","author":"F Di Virgilio","year":"2018","unstructured":"Di Virgilio F, Sarti AC, Grassi F (2018) Modulation of innate and adaptive immunity by P2X ion channels. Curr Opin Immunol 52:51\u201359. https:\/\/doi.org\/10.1016\/j.coi.2018.03.026","journal-title":"Curr Opin Immunol"},{"key":"10037_CR79","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1038\/sj.cdd.4402132","volume":"14","author":"BB Fredholm","year":"2007","unstructured":"Fredholm BB (2007) Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ 14:1315\u20131323. https:\/\/doi.org\/10.1038\/sj.cdd.4402132","journal-title":"Cell Death Differ"},{"key":"10037_CR80","doi-asserted-by":"publisher","unstructured":"Glaser T, de Oliveira SLB, Cheffer A et al (2014) Modulation of mouse embryonic stem cell proliferation and neural differentiation by the P2X7 receptor. PLoS ONE 9. https:\/\/doi.org\/10.1371\/journal.pone.0096281","DOI":"10.1371\/journal.pone.0096281"},{"key":"10037_CR81","doi-asserted-by":"publisher","unstructured":"Di Virgilio F, Vultaggio-Poma V, Sarti AC (2021) P2X receptors in cancer growth and progression. Biochem Pharmacol 187. https:\/\/doi.org\/10.1016\/j.bcp.2020.114350","DOI":"10.1016\/j.bcp.2020.114350"},{"key":"10037_CR82","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/nn1472","volume":"8","author":"D Davalos","year":"2005","unstructured":"Davalos D, Grutzendler J, Yang G et al (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8:752\u2013758. https:\/\/doi.org\/10.1038\/nn1472","journal-title":"Nat Neurosci"},{"key":"10037_CR83","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.pharmthera.2005.06.002","volume":"109","author":"H Franke","year":"2006","unstructured":"Franke H, Illes P (2006) Involvement of P2 receptors in the growth and survival of neurons in the CNS. Pharmacol Ther 109:297\u2013324. https:\/\/doi.org\/10.1016\/j.pharmthera.2005.06.002","journal-title":"Pharmacol Ther"},{"key":"10037_CR84","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/brain\/aws286","volume":"136","author":"AM Choo","year":"2013","unstructured":"Choo AM, Miller WJ, Chen Y-C et al (2013) Antagonism of purinergic signalling improves recovery from traumatic brain injury. Brain J Neurol 136:65\u201380. https:\/\/doi.org\/10.1093\/brain\/aws286","journal-title":"Brain J Neurol"},{"key":"10037_CR85","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0006-8993(97)00719-1","volume":"769","author":"PL Lutz","year":"1997","unstructured":"Lutz PL, Kabler S (1997) Release of adenosine and ATP in the brain of the freshwater turtle (Trachemys scripta) during long-term anoxia. Brain Res 769:281\u2013286. https:\/\/doi.org\/10.1016\/S0006-8993(97)00719-1","journal-title":"Brain Res"},{"key":"10037_CR86","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0006-8993(99)01169-5","volume":"823","author":"Z Jur\u00e1nyi","year":"1999","unstructured":"Jur\u00e1nyi Z, Sperl\u00e1gh B, Vizi ES (1999) Involvement of P2 purinoceptors and the nitric oxide pathway in [3H]purine outflow evoked by short-term hypoxia and hypoglycemia in rat hippocampal slices. Brain Res 823:183\u2013190. https:\/\/doi.org\/10.1016\/S0006-8993(99)01169-5","journal-title":"Brain Res"},{"key":"10037_CR87","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0304-3940(89)90178-X","volume":"106","author":"A Wieraszko","year":"1989","unstructured":"Wieraszko A, Seyfried TN (1989) Increased amount of extracellular ATP in stimulated hippocampal slices of seizure prone mice. Neurosci Lett 106:287\u2013293. https:\/\/doi.org\/10.1016\/0304-3940(89)90178-X","journal-title":"Neurosci Lett"},{"key":"10037_CR88","doi-asserted-by":"publisher","first-page":"160","DOI":"10.2174\/157015909789152146","volume":"7","author":"N Dale","year":"2009","unstructured":"Dale N, Frenguelli B (2009) Release of adenosine and ATP during ischemia and epilepsy. Curr Neuropharmacol 7:160\u2013179. https:\/\/doi.org\/10.2174\/157015909789152146","journal-title":"Curr Neuropharmacol"},{"key":"10037_CR89","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s12975-013-0265-2","volume":"4","author":"SS Kang","year":"2013","unstructured":"Kang SS, Keasey MP, Hagg T (2013) P2X7 receptor inhibition increases CNTF in the subventricular zone, but not neurogenesis or neuroprotection after stroke in adult mice. Transl Stroke Res 4:533\u2013545. https:\/\/doi.org\/10.1007\/s12975-013-0265-2","journal-title":"Transl Stroke Res"},{"key":"10037_CR90","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1002\/glia.23109","volume":"65","author":"Y Hirayama","year":"2017","unstructured":"Hirayama Y, Koizumi S (2017) Hypoxia-independent mechanisms of HIF-1\u03b1 expression in astrocytes after ischemic preconditioning. Glia 65:523\u2013530. https:\/\/doi.org\/10.1002\/glia.23109","journal-title":"Glia"},{"key":"10037_CR91","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fphar.2018.00052","volume":"9","author":"LEB Savio","year":"2018","unstructured":"Savio LEB, de Andrade MP, da Silva CG, Coutinho-Silva R (2018) The P2X7 receptor in inflammatory diseases: angel or demon? Front Pharmacol 9:52. https:\/\/doi.org\/10.3389\/fphar.2018.00052","journal-title":"Front Pharmacol"},{"key":"10037_CR92","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1002\/glia.23998","volume":"69","author":"Y Hirayama","year":"2021","unstructured":"Hirayama Y, Anzai N, Koizumi S (2021) Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance. Glia 69:2100\u20132110. https:\/\/doi.org\/10.1002\/glia.23998","journal-title":"Glia"},{"key":"10037_CR93","doi-asserted-by":"publisher","first-page":"a001271","DOI":"10.1101\/cshperspect.a001271","volume":"1","author":"B Kaltschmidt","year":"2009","unstructured":"Kaltschmidt B, Kaltschmidt C (2009) NF- B in the nervous system. Cold Spring Harb Perspect Biol 1:a001271\u2013a001271. https:\/\/doi.org\/10.1101\/cshperspect.a001271","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10037_CR94","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/bph.12428","volume":"171","author":"M Aparicio-Soto","year":"2014","unstructured":"Aparicio-Soto M, Alarc\u00f3n-de-la-Lastra C, C\u00e1rdeno A et al (2014) Melatonin modulates microsomal PGE synthase 1 and NF-E2-related factor-2-regulated antioxidant enzyme expression in LPS-induced murine peritoneal macrophages. Br J Pharmacol 171:134\u2013144. https:\/\/doi.org\/10.1111\/bph.12428","journal-title":"Br J Pharmacol"},{"key":"10037_CR95","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1600-079X.2008.00596.x","volume":"46","author":"R Liang","year":"2009","unstructured":"Liang R, Nickkholgh A, Hoffmann K et al (2009) Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation. J Pineal Res 46:8\u201314. https:\/\/doi.org\/10.1111\/j.1600-079X.2008.00596.x","journal-title":"J Pineal Res"},{"key":"10037_CR96","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.1073\/pnas.0912531107","volume":"107","author":"S-W Jang","year":"2010","unstructured":"Jang S-W, Liu X, Pradoldej S et al (2010) N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A 107:3876\u20133881. https:\/\/doi.org\/10.1073\/pnas.0912531107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10037_CR97","doi-asserted-by":"publisher","first-page":"104606","DOI":"10.1016\/j.neuint.2019.104606","volume":"132","author":"T Rui","year":"2020","unstructured":"Rui T, Wang Z, Li Q et al (2020) A TrkB receptor agonist N-acetyl serotonin provides cerebral protection after traumatic brain injury by mitigating apoptotic activation and autophagic dysfunction. Neurochem Int 132:104606. https:\/\/doi.org\/10.1016\/j.neuint.2019.104606","journal-title":"Neurochem Int"},{"key":"10037_CR98","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1136\/jnnp-2020-324283","volume":"92","author":"\u00c1 Chamorro","year":"2021","unstructured":"Chamorro \u00c1, Lo EH, Ren\u00fa A et al (2021) The future of neuroprotection in stroke. J Neurol Neurosurg Psychiatry 92:129\u2013135. https:\/\/doi.org\/10.1136\/jnnp-2020-324283","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10037_CR99","doi-asserted-by":"publisher","first-page":"189","DOI":"10.32794\/mr11250090","volume":"4","author":"PA Fernandes","year":"2021","unstructured":"Fernandes PA, Kinker GS, Navarro BV et al (2021) Melatonin-index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers. Melatonin Res 4:189\u2013205. https:\/\/doi.org\/10.32794\/mr11250090","journal-title":"Melatonin Res"},{"key":"10037_CR100","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1600-079X.2007.00487.x","volume":"43","author":"GN Pontes","year":"2007","unstructured":"Pontes GN, Cardoso EC, Carneiro-Sampaio MMS, Markus RP (2007) Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production. J Pineal Res 43:365\u2013371. https:\/\/doi.org\/10.1111\/j.1600-079X.2007.00487.x","journal-title":"J Pineal Res"},{"key":"10037_CR101","doi-asserted-by":"publisher","first-page":"e12636","DOI":"10.1111\/jpi.12636","volume":"68","author":"CE Carvalho-Sousa","year":"2020","unstructured":"Carvalho-Sousa CE, Pereira EP, Kinker GS et al (2020) Immune-pineal axis protects rat lungs exposed to polluted air. J Pineal Res 68:e12636. https:\/\/doi.org\/10.1111\/jpi.12636","journal-title":"J Pineal Res"},{"key":"10037_CR102","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1600-079X.2006.00373.x","volume":"41","author":"PACM Fernandes","year":"2006","unstructured":"Fernandes PACM, Cecon E, Markus RP, Ferreira ZS (2006) Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a \u201cfeedback\u201d of the immune response on circadian timing. J Pineal Res 41:344\u2013350. https:\/\/doi.org\/10.1111\/j.1600-079X.2006.00373.x","journal-title":"J Pineal Res"},{"key":"10037_CR103","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1096\/fj.14-265678","volume":"29","author":"E Cecon","year":"2015","unstructured":"Cecon E, Chen M, Mar\u00e7ola M et al (2015) Amyloid \u03b2 peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway. FASEB J Off Publ Fed Am Soc Exp Biol 29:2566\u20132582. https:\/\/doi.org\/10.1096\/fj.14-265678","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-024-10037-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-024-10037-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-024-10037-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T01:27:02Z","timestamp":1743643622000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-024-10037-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,20]]},"references-count":103,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10037"],"URL":"https:\/\/doi.org\/10.1007\/s11302-024-10037-8","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,20]]},"assertion":[{"value":"28 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}