{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:57:07Z","timestamp":1780451827423,"version":"3.54.1"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["314687\/2021-1"],"award-info":[{"award-number":["314687\/2021-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["24\/2551-0001297-4"],"award-info":[{"award-number":["24\/2551-0001297-4"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s11302-025-10089-4","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T03:32:35Z","timestamp":1746675155000},"page":"1093-1102","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["P2 receptors signaling in the esophagus: from inflammation to cancer"],"prefix":"10.1007","volume":"21","author":[{"given":"Aline","family":"Zaparte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda F.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia B.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda B.","family":"Morrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"issue":"3","key":"10089_CR1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0031-6997(25)06930-3","volume":"24","author":"G Burnstock","year":"1972","unstructured":"Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24(3):509\u2013581","journal-title":"Pharmacol Rev"},{"issue":"4","key":"10089_CR2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0031-6997(24)01511-4","volume":"53","author":"BB Fredholm","year":"2001","unstructured":"Fredholm BB, Jacobson IJAPKA, Klotz KN, Linden J (2001) International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53(4):527\u2013552","journal-title":"Pharmacol Rev"},{"issue":"3","key":"10089_CR3","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/0163-7258(94)00048-4","volume":"64","author":"MP Abbracchio","year":"1994","unstructured":"Abbracchio MP, Burnstock G (1994) Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther 64(3):445\u2013475. https:\/\/doi.org\/10.1016\/0163-7258(94)00048-4","journal-title":"Pharmacol Ther"},{"issue":"8","key":"10089_CR4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2174\/1568026043451014","volume":"4","author":"G Burnstock","year":"2004","unstructured":"Burnstock G (2004) Introduction: P2 receptors. Curr Top Med Chem 4(8):793\u2013803","journal-title":"Curr Top Med Chem"},{"issue":"3","key":"10089_CR5","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s11302-012-9300-0","volume":"8","author":"H Franke","year":"2012","unstructured":"Franke H, Verkhratsky A, Burnstock G, Illes P (2012) Pathophysiology of astroglial purinergic signalling. Purinergic Signal 8(3):629\u2013657. https:\/\/doi.org\/10.1007\/s11302-012-9300-0","journal-title":"Purinergic Signal"},{"issue":"2","key":"10089_CR6","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1124\/mol.114.095711","volume":"88","author":"KA Jacobson","year":"2015","unstructured":"Jacobson KA et al (2015) Nucleotides acting at P2Y receptors: connecting structure and function. Mol Pharmacol 88(2):220\u2013230. https:\/\/doi.org\/10.1124\/mol.114.095711","journal-title":"Mol Pharmacol"},{"issue":"4","key":"10089_CR7","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/7233","volume":"2","author":"BS Khakh","year":"1999","unstructured":"Khakh BS, Bao XR, Labarca C, Lester HA (1999) Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat Neurosci 2(4):322\u2013330. https:\/\/doi.org\/10.1038\/7233","journal-title":"Nat Neurosci"},{"key":"10089_CR8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pharmthera.2018.04.002","volume":"190","author":"M Rafehi","year":"2018","unstructured":"Rafehi M, Muller CE (2018) Tools and drugs for uracil nucleotide-activated P2Y receptors. Pharmacol Ther 190:24\u201380. https:\/\/doi.org\/10.1016\/j.pharmthera.2018.04.002","journal-title":"Pharmacol Ther"},{"issue":"1","key":"10089_CR9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1124\/pr.58.1.5","volume":"58","author":"G Burnstock","year":"2006","unstructured":"Burnstock G (2006) Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol Rev 58(1):58\u201386. https:\/\/doi.org\/10.1124\/pr.58.1.5","journal-title":"Pharmacol Rev"},{"issue":"3","key":"10089_CR10","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s12035-009-8063-2","volume":"39","author":"A Verkhratsky","year":"2009","unstructured":"Verkhratsky A, Krishtal OA, Burnstock G (2009) Purinoceptors on neuroglia. Mol Neurobiol 39(3):190\u2013208. https:\/\/doi.org\/10.1007\/s12035-009-8063-2","journal-title":"Mol Neurobiol"},{"issue":"4","key":"10089_CR11","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s11302-013-9372-5","volume":"9","author":"G Burnstock","year":"2013","unstructured":"Burnstock G, Di Virgilio F (2013) Purinergic signalling and cancer. Purinergic Signal 9(4):491\u2013540. https:\/\/doi.org\/10.1007\/s11302-013-9372-5","journal-title":"Purinergic Signal"},{"issue":"3","key":"10089_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nri.2016.4","volume":"16","author":"C Cekic","year":"2016","unstructured":"Cekic C, Linden J (2016) Purinergic regulation of the immune system. Nat Rev Immunol 16(3):177\u2013192. https:\/\/doi.org\/10.1038\/nri.2016.4","journal-title":"Nat Rev Immunol"},{"issue":"7261","key":"10089_CR13","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nature08296","volume":"461","author":"MR Elliott","year":"2009","unstructured":"Elliott MR et al (2009) Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature 461(7261):282\u2013286. https:\/\/doi.org\/10.1038\/nature08296","journal-title":"Nature"},{"issue":"3","key":"10089_CR14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s11302-012-9304-9","volume":"8","author":"ER Lazarowski","year":"2012","unstructured":"Lazarowski ER (2012) Vesicular and conductive mechanisms of nucleotide release. Purinergic Signal 8(3):359\u2013373. https:\/\/doi.org\/10.1007\/s11302-012-9304-9","journal-title":"Purinergic Signal"},{"issue":"6","key":"10089_CR15","doi-asserted-by":"publisher","first-page":"705","DOI":"10.2174\/187152712803581137","volume":"11","author":"C Volont\u00e9","year":"2012","unstructured":"Volont\u00e9 C, Apolloni S, Skaper SD, Burnstock G (2012) P2X7 receptors: channels, pores and more. CNS Neurol Disord Drug Targets 11(6):705\u2013721. https:\/\/doi.org\/10.2174\/187152712803581137","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10089_CR16","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0079-6123(08)63551-7","volume":"120","author":"TK Harden","year":"1999","unstructured":"Harden TK, Lazarowski ER (1999) Chapter 11 release of ATP and UTP from astrocytoma cells. Prog Brain Res 120:135\u2013143. https:\/\/doi.org\/10.1016\/S0079-6123(08)63551-7","journal-title":"Prog Brain Res"},{"issue":"3","key":"10089_CR17","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/onc.2016.206","volume":"36","author":"F Di Virgilio","year":"2017","unstructured":"Di Virgilio F, Adinolfi E (2017) Extracellular purines, purinergic receptors and tumor growth. Oncogene 36(3):293\u2013303. https:\/\/doi.org\/10.1038\/onc.2016.206","journal-title":"Oncogene"},{"issue":"1","key":"10089_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11302-015-9483-2","volume":"12","author":"H Zimmermann","year":"2016","unstructured":"Zimmermann H (2016) Extracellular ATP and other nucleotides\u2014ubiquitous triggers of intercellular messenger release. Purinergic Signal 12(1):25\u201357. https:\/\/doi.org\/10.1007\/s11302-015-9483-2","journal-title":"Purinergic Signal"},{"issue":"6","key":"10089_CR19","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.molmed.2013.03.005","volume":"19","author":"L Antonioli","year":"2013","unstructured":"Antonioli L, Pacher P, Vizi ES, Hasko G (2013) CD39 and CD73 in immunity and inflammation. Trends Mol Med 19(6):355\u2013367. https:\/\/doi.org\/10.1016\/j.molmed.2013.03.005","journal-title":"Trends Mol Med"},{"issue":"7","key":"10089_CR20","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s11883-014-0425-1","volume":"16","author":"YM Kanthi","year":"2014","unstructured":"Kanthi YM, Sutton NR, Pinsky DJ (2014) CD39: interface between vascular thrombosis and inflammation. Curr Atheroscler Rep 16(7):425. https:\/\/doi.org\/10.1007\/s11883-014-0425-1","journal-title":"Curr Atheroscler Rep"},{"issue":"12","key":"10089_CR21","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1038\/nrc3613","volume":"13","author":"L Antonioli","year":"2013","unstructured":"Antonioli L, Blandizzi C, Pacher P, Hasko G (2013) Immunity, inflammation and cancer: a leading role for adenosine. Nat Rev Cancer 13(12):842\u2013857. https:\/\/doi.org\/10.1038\/nrc3613","journal-title":"Nat Rev Cancer"},{"issue":"39","key":"10089_CR22","doi-asserted-by":"publisher","first-page":"5346","DOI":"10.1038\/onc.2010.292","volume":"29","author":"J Stagg","year":"2010","unstructured":"Stagg J, Smyth MJ (2010) Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 29(39):5346\u20135358. https:\/\/doi.org\/10.1038\/onc.2010.292","journal-title":"Oncogene"},{"issue":"7","key":"10089_CR23","doi-asserted-by":"publisher","first-page":"e2599","DOI":"10.1371\/journal.pone.0002599","volume":"3","author":"P Pellegatti","year":"2008","unstructured":"Pellegatti P, Raffaghello L, Bianchi G, Piccardi F, Pistoia V, Di Virgilio F (2008) Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase. PLoS One 3(7):e2599. https:\/\/doi.org\/10.1371\/journal.pone.0002599","journal-title":"PLoS One"},{"issue":"3","key":"10089_CR24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s11302-013-9357-4","volume":"9","author":"F Jacob","year":"2013","unstructured":"Jacob F, Novo CP, Bachert C, Van Crombruggen K (2013) Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signal 9(3):285\u2013306. https:\/\/doi.org\/10.1007\/s11302-013-9357-4","journal-title":"Purinergic Signal"},{"issue":"1","key":"10089_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s11302-013-9400-5","volume":"10","author":"G Burnstock","year":"2014","unstructured":"Burnstock G, Evans LC, Bailey MA (2014) Purinergic signalling in the kidney in health and disease. Purinergic Signal 10(1):71\u2013101. https:\/\/doi.org\/10.1007\/s11302-013-9400-5","journal-title":"Purinergic Signal"},{"issue":"1","key":"10089_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11302-013-9397-9","volume":"10","author":"G Burnstock","year":"2014","unstructured":"Burnstock G (2014) Purinergic signalling in the gastrointestinal tract and related organs in health and disease. Purinergic Signal 10(1):3\u201350. https:\/\/doi.org\/10.1007\/s11302-013-9397-9","journal-title":"Purinergic Signal"},{"key":"10089_CR27","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neuropharm.2015.11.007","volume":"104","author":"F Pedata","year":"2016","unstructured":"Pedata F et al (2016) Purinergic signalling in brain ischemia. Neuropharmacology 104:105\u2013130. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.11.007","journal-title":"Neuropharmacology"},{"key":"10089_CR28","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170710110630","author":"G Magni","year":"2017","unstructured":"Magni G, Riccio D, Ceruti S (2017) Tackling chronic pain and inflammation through the purinergic system. Curr Med Chem. https:\/\/doi.org\/10.2174\/0929867324666170710110630","journal-title":"Curr Med Chem"},{"key":"10089_CR29","doi-asserted-by":"publisher","unstructured":"Lim AW, Talley NJ, Walker MM, Storm G, Hua S (2023) Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors. Drug Deliv 30(1). https:\/\/doi.org\/10.1080\/10717544.2023.2219423","DOI":"10.1080\/10717544.2023.2219423"},{"key":"10089_CR30","unstructured":"Standring S (2020) Gray\u2019s anatomy international edition: the anatomical basis of clinical practice, 42nd edn. Elsevier Health Sciences"},{"key":"10089_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999","author":"DJ Roberts","year":"2000","unstructured":"Roberts DJ (2000) Molecular mechanisms of development of thegastrointestinal tract. Dev Dyn. https:\/\/doi.org\/10.1002\/1097-0177(2000)9999:9999","journal-title":"Dev Dyn"},{"key":"10089_CR32","doi-asserted-by":"publisher","unstructured":"Di Pietro M, Fitzgerald RC (2013) Research advances in esophageal diseases: bench to bedside. F1000Prime Rep 5. https:\/\/doi.org\/10.12703\/P5-44","DOI":"10.12703\/P5-44"},{"issue":"6\u20137","key":"10089_CR33","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1177\/2040622317710010","volume":"8","author":"Z Arora","year":"2017","unstructured":"Arora Z, Thota PN, Sanaka MR (2017) Achalasia: current therapeutic options. Ther Adv Chronic Dis 8(6\u20137):101. https:\/\/doi.org\/10.1177\/2040622317710010","journal-title":"Ther Adv Chronic Dis"},{"key":"10089_CR34","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3389\/fphar.2017.00661","volume":"8","author":"G Burnstock","year":"2017","unstructured":"Burnstock G (2017) Purinergic Signalling: Therapeutic Developments. Front Pharmacol 8:661. https:\/\/doi.org\/10.3389\/fphar.2017.00661","journal-title":"Front Pharmacol"},{"key":"10089_CR35","doi-asserted-by":"publisher","unstructured":"Kuo B, Urma (2006) Esophagus - anatomy and development. GI Motility online. https:\/\/doi.org\/10.1038\/gimo6","DOI":"10.1038\/gimo6"},{"issue":"4","key":"10089_CR36","doi-asserted-by":"publisher","first-page":"G608","DOI":"10.1152\/ajpgi.00207.2010","volume":"300","author":"EG Lavoie","year":"2011","unstructured":"Lavoie EG, Gulbransen BD, Martin-Satue M, Aliagas E, Sharkey KA, Sevigny J (2011) Ectonucleotidases in the digestive system: focus on NTPDase3 localization. Am J Physiol Gastrointest Liver Physiol 300(4):G608\u2013G620. https:\/\/doi.org\/10.1152\/ajpgi.00207.2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"10089_CR37","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/sj.bjc.6600100","volume":"86","author":"K Maaser","year":"2002","unstructured":"Maaser K et al (2002) Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y(2)-receptors. Br J Cancer 86(4):636\u2013644. https:\/\/doi.org\/10.1038\/sj.bjc.6600100","journal-title":"Br J Cancer"},{"issue":"9","key":"10089_CR38","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.2174\/1566524014666141021145419","volume":"14","author":"KR Shieh","year":"2014","unstructured":"Shieh KR, Yang SC, Tseng HL, Yi CH, Liu TT, Chen CL (2014) Evidence for up-regulation of purinergic receptor genes associating with TRPV1 Receptors and neurotrophic factors in the inflamed human esophagus. Curr Mol Med 14(9):1205\u20131214. https:\/\/doi.org\/10.2174\/1566524014666141021145419","journal-title":"Curr Mol Med"},{"issue":"6","key":"10089_CR39","doi-asserted-by":"publisher","first-page":"G1075","DOI":"10.1152\/ajpgi.00336.2011","volume":"301","author":"J Ma","year":"2011","unstructured":"Ma J, Altomare A, Rieder F, Behar J, Biancani P, Harnett KM (2011) ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. Am J Physiol Gastrointest Liver Physiol 301(6):G1075\u2013G1082. https:\/\/doi.org\/10.1152\/ajpgi.00336.2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"5","key":"10089_CR40","doi-asserted-by":"publisher","first-page":"G782","DOI":"10.1152\/ajpgi.00514.2009","volume":"300","author":"B Lecea","year":"2011","unstructured":"Lecea B et al (2011) Regional functional specialization and inhibitory nitrergic and nonnitrergic coneurotransmission in the human esophagus. Am J Physiol Gastrointest Liver Physiol 300(5):G782\u2013G794. https:\/\/doi.org\/10.1152\/ajpgi.00514.2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"10089_CR41","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s11302-017-9559-2","volume":"13","author":"AA Santos Jr","year":"2017","unstructured":"Santos AA Jr et al (2017) Potential role of P2X7R in esophageal squamous cell carcinoma proliferation. Purinergic Signal 13(3):279\u2013292. https:\/\/doi.org\/10.1007\/s11302-017-9559-2","journal-title":"Purinergic Signal"},{"issue":"7","key":"10089_CR42","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1111\/jgh.13672","volume":"32","author":"L Wu","year":"2017","unstructured":"Wu L, Oshima T, Fukui H, Watari J, Miwa H (2017) Adenosine triphosphate induces P2Y2 activation and interleukin-8 release in human esophageal epithelial cells. J Gastroenterol Hepatol 32(7):1341\u20131347. https:\/\/doi.org\/10.1111\/jgh.13672","journal-title":"J Gastroenterol Hepatol"},{"issue":"8","key":"10089_CR43","doi-asserted-by":"publisher","first-page":"G695","DOI":"10.1152\/ajpgi.00162.2015","volume":"309","author":"L Wu","year":"2015","unstructured":"Wu L et al (2015) PAR-2 activation enhances weak acid-induced ATP release through TRPV1 and ASIC sensitization in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol 309(8):G695-702. https:\/\/doi.org\/10.1152\/ajpgi.00162.2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"19","key":"10089_CR44","doi-asserted-by":"publisher","first-page":"28736","DOI":"10.18632\/ONCOTARGET.7518","volume":"7","author":"HX Wan","year":"2016","unstructured":"Wan HX, Hu JH, Xie R, Yang SM, Dong H (2016) Important roles of P2Y receptors in the inflammation and cancer of digestive system. Oncotarget 7(19):28736\u201328747. https:\/\/doi.org\/10.18632\/ONCOTARGET.7518","journal-title":"Oncotarget"},{"issue":"2","key":"10089_CR45","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0143-4160(97)90034-8","volume":"21","author":"R Levin","year":"1997","unstructured":"Levin R, Braiman A, Priel Z (1997) Protein kinase C induced calcium influx and sustained enhancement of ciliary beating by extracellular ATP. Cell Calcium 21(2):103\u2013113. https:\/\/doi.org\/10.1016\/S0143-4160(97)90034-8","journal-title":"Cell Calcium"},{"issue":"1","key":"10089_CR46","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/S12576-024-00916-5","volume":"74","author":"T Shiina","year":"2024","unstructured":"Shiina T et al (2024) Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats. J Physiol Sci 74(1):26. https:\/\/doi.org\/10.1186\/S12576-024-00916-5","journal-title":"J Physiol Sci"},{"key":"10089_CR47","doi-asserted-by":"publisher","first-page":"173687","DOI":"10.1016\/J.EJPHAR.2020.173687","volume":"891","author":"A Zaparte","year":"2021","unstructured":"Zaparte A et al (2021) P2Y2 receptor activation promotes esophageal cancer cells proliferation via ERK1\/2 pathway. Eur J Pharmacol 891:173687. https:\/\/doi.org\/10.1016\/J.EJPHAR.2020.173687","journal-title":"Eur J Pharmacol"},{"issue":"20","key":"10089_CR48","doi-asserted-by":"publisher","first-page":"33285","DOI":"10.18632\/ONCOTARGET.16635","volume":"8","author":"Y Guo","year":"2017","unstructured":"Guo Y et al (2017) Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma. Oncotarget 8(20):33285\u201333299. https:\/\/doi.org\/10.18632\/ONCOTARGET.16635","journal-title":"Oncotarget"},{"issue":"2","key":"10089_CR49","doi-asserted-by":"publisher","first-page":"G107","DOI":"10.1152\/AJPGI.00108.2023\/ASSET\/IMAGES\/MEDIUM\/GI-00108-2023R01.PNG","volume":"326","author":"KA Engevik","year":"2024","unstructured":"Engevik KA, Scribano FJ, Gebert JT, Perry JL, Crawford SE, Hyser JM (2024) Distribution of P2Y and P2X purinergic receptor expression within the intestine. Am J Physiol Gastrointest Liver Physiol 326(2):G107\u2013G119. https:\/\/doi.org\/10.1152\/AJPGI.00108.2023\/ASSET\/IMAGES\/MEDIUM\/GI-00108-2023R01.PNG","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"10089_CR50","doi-asserted-by":"publisher","first-page":"e1227","DOI":"10.1002\/CTM2.1227","volume":"13","author":"P Zhong","year":"2023","unstructured":"Zhong P et al (2023) P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis. Clin Transl Med 13(4):e1227. https:\/\/doi.org\/10.1002\/CTM2.1227","journal-title":"Clin Transl Med"},{"issue":"1","key":"10089_CR51","doi-asserted-by":"publisher","first-page":"e12724","DOI":"10.15252\/EMMM.202012724","volume":"13","author":"R Schneider","year":"2020","unstructured":"Schneider R et al (2020) A novel P2X2-dependent purinergic mechanism of enteric gliosis in intestinal inflammation. EMBO Mol Med 13(1):e12724. https:\/\/doi.org\/10.15252\/EMMM.202012724","journal-title":"EMBO Mol Med"},{"key":"10089_CR52","doi-asserted-by":"publisher","unstructured":"An Q, et al (2021) Pathophysiological role of purinergic P2X receptors in digestive system diseases. Front Media SA. https:\/\/doi.org\/10.3389\/fphys.2021.781069","DOI":"10.3389\/fphys.2021.781069"},{"issue":"5","key":"10089_CR53","doi-asserted-by":"publisher","first-page":"311","DOI":"10.4196\/KJPP.2010.14.5.311","volume":"14","author":"YR Cho","year":"2010","unstructured":"Cho YR, Jang HS, Kim W, Park SY, Sohn UD (2010) P2X and P2Y receptors mediate contraction induced by electrical field stimulation in feline esophageal smooth muscle. Korean J Physiol Pharmacol 14(5):311\u2013316. https:\/\/doi.org\/10.4196\/KJPP.2010.14.5.311","journal-title":"Korean J Physiol Pharmacol"},{"issue":"6","key":"10089_CR54","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/S11096-005-7116-5","volume":"27","author":"M Pettit","year":"2005","unstructured":"Pettit M (2005) Gastroesophageal reflux disease: clinical features. Pharm World Sci 27(6):417\u2013420. https:\/\/doi.org\/10.1007\/S11096-005-7116-5","journal-title":"Pharm World Sci"},{"issue":"1","key":"10089_CR55","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4103\/jrms.JRMS_283_17","volume":"22","author":"A Keshteli","year":"2017","unstructured":"Keshteli A, Shaabani P, Tabibian S-R, Saneei P, Esmaillzadeh A, Adibi P (2017) The relationship between fruit and vegetable intake with gastroesophageal reflux disease in Iranian adults. J Res Med Sci 22(1):125. https:\/\/doi.org\/10.4103\/jrms.JRMS_283_17","journal-title":"J Res Med Sci"},{"key":"10089_CR56","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/J.COPH.2017.10.004","volume":"37","author":"RF Souza","year":"2017","unstructured":"Souza RF, Bayeh L, Spechler SJ, Tambar UK, Bruick RK (2017) A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2\u03b1: a potential role for targeting HIF-2\u03b1 to prevent and treat reflux esophagitis. Curr Opin Pharmacol 37:93\u201399. https:\/\/doi.org\/10.1016\/J.COPH.2017.10.004","journal-title":"Curr Opin Pharmacol"},{"issue":"5","key":"10089_CR57","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1053\/J.GASTRO.2009.07.055","volume":"137","author":"RF Souza","year":"2009","unstructured":"Souza RF et al (2009) Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology 137(5):1776\u20131784. https:\/\/doi.org\/10.1053\/J.GASTRO.2009.07.055","journal-title":"Gastroenterology"},{"key":"10089_CR58","doi-asserted-by":"publisher","unstructured":"Keshteli AH, Shaabani P, Tabibian SR, Saneei P, Esmaillzadeh A, Adibi P (2017) The relationship between fruit and vegetable intake with gastroesophageal reflux disease in Iranian adults. J Res Med Sci 22(11). https:\/\/doi.org\/10.4103\/JRMS.JRMS_283_17","DOI":"10.4103\/JRMS.JRMS_283_17"},{"issue":"4","key":"10089_CR59","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/J.GTC.2008.09.009","volume":"37","author":"JE Pandolfino","year":"2008","unstructured":"Pandolfino JE, Kwiatek MA, Kahrilas PJ (2008) The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux disease. Gastroenterol Clin North Am 37(4):827\u2013843. https:\/\/doi.org\/10.1016\/J.GTC.2008.09.009","journal-title":"Gastroenterol Clin North Am"},{"issue":"3","key":"10089_CR60","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/J.ASJSUR.2016.10.005","volume":"41","author":"FL Huang","year":"2018","unstructured":"Huang FL, Yu SJ (2018) Esophageal cancer: risk factors, genetic association, and treatment. Asian J Surg 41(3):210\u2013215. https:\/\/doi.org\/10.1016\/J.ASJSUR.2016.10.005","journal-title":"Asian J Surg"},{"issue":"2","key":"10089_CR61","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1001\/JAMAOTO.2017.2561","volume":"144","author":"CA Riley","year":"2018","unstructured":"Riley CA, Wu EL, Hsieh MC, Marino MJ, Wu XC, McCoul ED (2018) Association of gastroesophageal reflux with malignancy of the upper aerodigestive tract in elderly patients. JAMA Otolaryngol Head Neck Surg 144(2):140\u2013148. https:\/\/doi.org\/10.1001\/JAMAOTO.2017.2561","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"7","key":"10089_CR62","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.ejso.2017.02.004","volume":"43","author":"WK Tan","year":"2017","unstructured":"Tan WK, di Pietro M, Fitzgerald RC (2017) Past, present and future of Barrett\u2019s oesophagus. Eur J Surg Oncol 43(7):1148\u20131160. https:\/\/doi.org\/10.1016\/j.ejso.2017.02.004","journal-title":"Eur J Surg Oncol"},{"issue":"6","key":"10089_CR63","doi-asserted-by":"publisher","first-page":"311","DOI":"10.4103\/SJG.SJG_161_17","volume":"23","author":"K Wijarnpreecha","year":"2017","unstructured":"Wijarnpreecha K, Panjawatanan P, Thongprayoon C, Jaruvongvanich V, Ungprasert P (2017) Association between gastroesophageal reflux disease and nonalcoholic fatty liver disease: a meta-analysis. Saudi J Gastroenterol 23(6):311\u2013317. https:\/\/doi.org\/10.4103\/SJG.SJG_161_17","journal-title":"Saudi J Gastroenterol"},{"issue":"3","key":"10089_CR64","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/J.HOC.2017.01.003","volume":"31","author":"S Rajendra","year":"2017","unstructured":"Rajendra S, Sharma P (2017) Barrett esophagus and intramucosal esophageal adenocarcinoma. Hematol Oncol Clin North Am 31(3):409\u2013426. https:\/\/doi.org\/10.1016\/J.HOC.2017.01.003","journal-title":"Hematol Oncol Clin North Am"},{"issue":"9","key":"10089_CR65","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1136\/GUTJNL-2016-312595","volume":"66","author":"X Huo","year":"2017","unstructured":"Huo X et al (2017) Hypoxia-inducible factor-2\u03b1 plays a role in mediating oesophagitis in GORD. Gut 66(9):1542\u20131554. https:\/\/doi.org\/10.1136\/GUTJNL-2016-312595","journal-title":"Gut"},{"issue":"3","key":"10089_CR66","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1136\/GUT.50.3.368","volume":"50","author":"HB El-Serag","year":"2002","unstructured":"El-Serag HB, Mason AC, Petersen N, Key CR (2002) Epidemiological differences between adenocarcinoma of the oesophagus and adenocarcinoma of the gastric cardia in the USA. Gut 50(3):368. https:\/\/doi.org\/10.1136\/GUT.50.3.368","journal-title":"Gut"},{"issue":"5","key":"10089_CR67","doi-asserted-by":"publisher","first-page":"G635","DOI":"10.1152\/ajpgi.00097.2012","volume":"303","author":"J Ma","year":"2012","unstructured":"Ma J et al (2012) HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol 303(5):G635\u2013G645. https:\/\/doi.org\/10.1152\/ajpgi.00097.2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"2","key":"10089_CR68","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"LA Torre","year":"2015","unstructured":"Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65(2):87\u2013108. https:\/\/doi.org\/10.3322\/caac.21262","journal-title":"CA Cancer J Clin"},{"key":"10089_CR69","doi-asserted-by":"publisher","unstructured":"Smyth EC,\u00a0et al (2017) Oesophageal cancer.\u00a0Nat Rev Dis Primers\u00a03.\u00a0https:\/\/doi.org\/10.1038\/NRDP.2017.48","DOI":"10.1038\/NRDP.2017.48"},{"issue":"34","key":"10089_CR70","doi-asserted-by":"publisher","first-page":"5598","DOI":"10.3748\/WJG.V19.I34.5598","volume":"19","author":"Y Zhang","year":"2013","unstructured":"Zhang Y (2013) Epidemiology of esophageal cancer. World J Gastroenterol 19(34):5598\u20135606. https:\/\/doi.org\/10.3748\/WJG.V19.I34.5598","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10089_CR71","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/S10147-010-0056-7","volume":"15","author":"M Morita","year":"2010","unstructured":"Morita M et al (2010) Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention. Int J Clin Oncol 15(2):126\u2013134. https:\/\/doi.org\/10.1007\/S10147-010-0056-7","journal-title":"Int J Clin Oncol"},{"issue":"5","key":"10089_CR72","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4251\/WJGO.V6.I5.112","volume":"6","author":"KJ Napier","year":"2014","unstructured":"Napier KJ, Scheerer M, Misra S (2014) Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol 6(5):112\u2013120. https:\/\/doi.org\/10.4251\/WJGO.V6.I5.112","journal-title":"World J Gastrointest Oncol"},{"issue":"11","key":"10089_CR73","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1002\/ijc.23173","volume":"121","author":"S Perwez Hussain","year":"2007","unstructured":"Perwez Hussain S, Harris CC (2007) Inflammation and cancer: an ancient link with novel potentials. Int J Cancer 121(11):2373\u20132380. https:\/\/doi.org\/10.1002\/ijc.23173","journal-title":"Int J Cancer"},{"key":"10089_CR74","doi-asserted-by":"publisher","first-page":"e16150485","DOI":"10.1590\/1678-4324-2016150485","volume":"59","author":"M Gon\u00e7alves","year":"2016","unstructured":"Gon\u00e7alves M et al (2016) Effect of LPS on the viability and proliferation of human oral and esophageal cancer cell lines. Braz Arch Biol Technol 59:e16150485. https:\/\/doi.org\/10.1590\/1678-4324-2016150485","journal-title":"Braz Arch Biol Technol"},{"key":"10089_CR75","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/nature09413","volume":"467","author":"FB Chekeni","year":"2010","unstructured":"Chekeni FB et al (2010) Pannexin 1 channels mediate \u2018find-me\u2019 signal release and membrane permeability during apoptosis. Nature 467:863\u2013867. https:\/\/doi.org\/10.1038\/nature09413","journal-title":"Nature"},{"issue":"5","key":"10089_CR76","doi-asserted-by":"publisher","first-page":"C1349","DOI":"10.1152\/ajpcell.00256.2004","volume":"287","author":"Q Wang","year":"2004","unstructured":"Wang Q, Wang L, Feng YH, Li X, Zeng R, Gorodeski GI (2004) P2X7 receptor-mediated apoptosis of human cervical epithelial cells. Am J Physiol Cell Physiol 287(5):C1349\u2013C1358. https:\/\/doi.org\/10.1152\/ajpcell.00256.2004","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"10089_CR77","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.biocel.2013.03.005","volume":"45","author":"J Fang","year":"2013","unstructured":"Fang J et al (2013) P2X7R suppression promotes glioma growth through epidermal growth factor receptor signal pathway. Int J Biochem Cell Biol 45(6):1109\u20131120. https:\/\/doi.org\/10.1016\/j.biocel.2013.03.005","journal-title":"Int J Biochem Cell Biol"},{"issue":"25","key":"10089_CR78","doi-asserted-by":"publisher","first-page":"20840","DOI":"10.18632\/oncotarget.4428","volume":"6","author":"E Vacchelli","year":"2015","unstructured":"Vacchelli E et al (2015) Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy. Oncotarget 6(25):20840\u201320850. https:\/\/doi.org\/10.18632\/oncotarget.4428","journal-title":"Oncotarget"},{"issue":"9","key":"10089_CR79","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1002\/EJI.200939688","volume":"39","author":"S Sakaguchi","year":"2009","unstructured":"Sakaguchi S, Wing K, Yamaguchi T (2009) Dynamics of peripheral tolerance and immune regulation mediated by Treg. Eur J Immunol 39(9):2331\u20132336. https:\/\/doi.org\/10.1002\/EJI.200939688","journal-title":"Eur J Immunol"},{"issue":"38","key":"10089_CR80","doi-asserted-by":"publisher","first-page":"5915","DOI":"10.3748\/wjg.v11.i38.5915","volume":"11","author":"MX Wang","year":"2005","unstructured":"Wang MX, Ren LM, Shan BE (2005) Inhibitory effects of extracellular adenosine triphosphate on growth of esophageal carcinoma cells. World J Gastroenterol 11(38):5915\u20135919. https:\/\/doi.org\/10.3748\/wjg.v11.i38.5915","journal-title":"World J Gastroenterol"},{"key":"10089_CR81","doi-asserted-by":"publisher","first-page":"CD010511","DOI":"10.1002\/14651858.CD010511.pub2","volume":"8","author":"BA Vellayappan","year":"2017","unstructured":"Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC (2017) Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer. Cochrane Database Syst Rev 8:CD010511. https:\/\/doi.org\/10.1002\/14651858.CD010511.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"10089_CR82","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/J.BIOCEL.2015.09.001","volume":"68","author":"MP Gehring","year":"2015","unstructured":"Gehring MP et al (2015) P2X7 receptor as predictor gene for glioma radiosensitivity and median survival. Int J Biochem Cell Biol 68:92\u2013100. https:\/\/doi.org\/10.1016\/J.BIOCEL.2015.09.001","journal-title":"Int J Biochem Cell Biol"},{"issue":"4","key":"10089_CR83","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/S11302-012-9319-2","volume":"8","author":"MP Gehring","year":"2012","unstructured":"Gehring MP et al (2012) P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line. Purinergic Signal 8(4):729\u2013739. https:\/\/doi.org\/10.1007\/S11302-012-9319-2","journal-title":"Purinergic Signal"},{"key":"10089_CR84","doi-asserted-by":"publisher","first-page":"e28518","DOI":"10.4161\/onci.28518","volume":"3","author":"EB Golden","year":"2014","unstructured":"Golden EB, Frances D, Pellicciotta I, Demaria S, Helen Barcellos-Hoff M, Formenti SC (2014) Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death. Oncoimmunology 3:e28518. https:\/\/doi.org\/10.4161\/onci.28518","journal-title":"Oncoimmunology"},{"issue":"3","key":"10089_CR85","doi-asserted-by":"publisher","first-page":"271","DOI":"10.4161\/ONCI.18684","volume":"1","author":"E Vacchelli","year":"2012","unstructured":"Vacchelli E et al (2012) Loss-of-function alleles of P2RX7 and TLR4 fail to affect the response to chemotherapy in non-small cell lung cancer. Oncoimmunology 1(3):271\u2013278. https:\/\/doi.org\/10.4161\/ONCI.18684","journal-title":"Oncoimmunology"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-025-10089-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-025-10089-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-025-10089-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:04:03Z","timestamp":1762880643000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-025-10089-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":85,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10089"],"URL":"https:\/\/doi.org\/10.1007\/s11302-025-10089-4","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]},"assertion":[{"value":"21 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}