{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:55:58Z","timestamp":1787684158493,"version":"build-2784847793"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100019693","name":"Universidade Federal da Fronteira Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s11302-025-10101-x","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T22:08:42Z","timestamp":1751580522000},"page":"1103-1111","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-8541","authenticated-orcid":false,"given":"Kailane Paula","family":"Pretto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-0716","authenticated-orcid":false,"given":"Let\u00edcia","family":"de Souza Matias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3931-1108","authenticated-orcid":false,"given":"Bruna Dias","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3572-4586","authenticated-orcid":false,"given":"Adinei Abadio","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5206-7023","authenticated-orcid":false,"given":"Camila Ferreira","family":"Puntel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-8318","authenticated-orcid":false,"given":"Yghor Augusto","family":"da Rocha Ricardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4925-8606","authenticated-orcid":false,"given":"Yenidis Teilor","family":"Scheibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3813-7139","authenticated-orcid":false,"given":"D\u00e9bora Tavares","family":"de Resende e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"issue":"4","key":"10101_CR1","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1210\/er.2018-00242","volume":"40","author":"SE Bulun","year":"2019","unstructured":"Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei JJ (2019) Endometriosis. Endocr Rev 40(4):1048\u20131079. https:\/\/doi.org\/10.1210\/er.2018-00242","journal-title":"Endocr Rev"},{"key":"10101_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154847","volume":"251","author":"E Pa\u0161ali\u0107","year":"2023","unstructured":"Pa\u0161ali\u0107 E, Tambuwala MM, Hromi\u0107-Jahjefendi\u0107 A (2023) Endometriosis: classification, pathophysiology, and treatment options. Pathol Res Pract 251:154847. https:\/\/doi.org\/10.1016\/j.prp.2023.154847","journal-title":"Pathol Res Pract"},{"issue":"10","key":"10101_CR3","doi-asserted-by":"publisher","first-page":"E363","DOI":"10.1503\/cmaj.220637","volume":"195","author":"C Allaire","year":"2023","unstructured":"Allaire C, Bedaiwy MA, Yong PJ (2023) Diagnosis and management of endometriosis. Can Med Assoc J 195(10):E363\u2013E371. https:\/\/doi.org\/10.1503\/cmaj.220637","journal-title":"Can Med Assoc J"},{"key":"10101_CR4","doi-asserted-by":"publisher","unstructured":"Crump J, Suker A, White L (2024) Endometriosis: a review of recent evidence and guidelines. Aust J Gen Pract 53(1\u20132):11\u201318. https:\/\/doi.org\/10.31128\/AJGP\/04-23-6805","DOI":"10.31128\/AJGP\/04-23-6805"},{"issue":"22","key":"10101_CR5","doi-asserted-by":"publisher","first-page":"5532","DOI":"10.3390\/ijms20225532","volume":"20","author":"C Trapero","year":"2019","unstructured":"Trapero C, Vidal A, Fern\u00e1ndez-Montol\u00ed ME, Coroleu B, Tresserra F, Barri P, G\u00f3mez de Aranda IG, S\u00e9vigny J, Ponce J, Matias-Guiu X, Mart\u00edn-Satu\u00e9 M (2019) Impaired expression of ectonucleotidases in ectopic and eutopic endometrial tissue is in favor of ATP accumulation in the tissue microenvironment in endometriosis. Int J Mol Sci 20(22):5532. https:\/\/doi.org\/10.3390\/ijms20225532","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10101_CR6","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s00011-025-02023-6","volume":"74","author":"JC Ecco","year":"2025","unstructured":"Ecco JC, Soares AA, da Silva KET, Ansolin V, Sousa Silva GV, Silva RE, DT, (2025) Inflammatory pain and electroacupuncture: how the P2X3 receptor can help modulate inflammation-a review of current literature. Inflamm Res 74(1):58. https:\/\/doi.org\/10.1007\/s00011-025-02023-6","journal-title":"Inflamm Res"},{"key":"10101_CR7","doi-asserted-by":"crossref","unstructured":"Schrader J (2022) Ectonucleotidases as a bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock. Purinergic Signal 18:193\u2013198. https:\/\/doi.org\/10.1007%2Fs11302-022-09862-6","DOI":"10.1007\/s11302-022-09862-6"},{"key":"10101_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114205","volume":"158","author":"JP Liu","year":"2023","unstructured":"Liu JP, Liu SC, Hu SQ, Lu JF, Wu CL, Hu DX, Zhang WJ (2023) ATP ion channel P2X purinergic receptors in inflammation response. Biomed Pharmacother 158:114205. https:\/\/doi.org\/10.1016\/j.biopha.2022.114205","journal-title":"Biomed Pharmacother"},{"issue":"10276","key":"10101_CR9","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","volume":"397","author":"HS Taylor","year":"2021","unstructured":"Taylor HS, Kotlyar AM, Flores VA (2021) Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 397(10276):839\u2013852. https:\/\/doi.org\/10.1016\/S0140-6736(21)00389-5","journal-title":"Lancet"},{"issue":"7","key":"10101_CR10","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1093\/humrep\/deae086","volume":"39","author":"P Vercellini","year":"2024","unstructured":"Vercellini P, Salmeri N, Somigliana E, Piccini M, Caprara F, Vigan\u00f2 P, De Matteis S (2024) M\u00fcllerian anomalies and endometriosis as potential explanatory models for the retrograde menstruation\/implantation and the embryonic remnants\/celomic metaplasia pathogenic theories: a systematic review and meta-analysis. Hum Reprod 39(7):1460\u20131470. https:\/\/doi.org\/10.1093\/humrep\/deae086","journal-title":"Hum Reprod"},{"issue":"10","key":"10101_CR11","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.autrev.2018.03.017","volume":"17","author":"T Zhang","year":"2018","unstructured":"Zhang T, De Carolis C, Man GCW, Wang CC (2018) The link between immunity, autoimmunity, and endometriosis: a literature update. Autoimmun Rev 17(10):945\u2013955. https:\/\/doi.org\/10.1016\/j.autrev.2018.03.017","journal-title":"Autoimmun Rev"},{"key":"10101_CR12","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12974-020-01752-1","volume":"17","author":"Y Wei","year":"2020","unstructured":"Wei Y, Liang Y, Lin H, Dai Y, Yao S (2020) Autonomic nervous system and inflammation interaction in? Endometriosis-associated pain J Neuroinflammation 17:80. https:\/\/doi.org\/10.1186\/s12974-020-01752-1","journal-title":"Endometriosis-associated pain J Neuroinflammation"},{"key":"10101_CR13","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12958-019-0513-8","volume":"17","author":"HM Atkins","year":"2019","unstructured":"Atkins HM, Bharadwaj MS, Cox AO, Furdui CM, Appt SE, Caudell DL (2019) Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model. Reprod Biol Endocrinol 17:70. https:\/\/doi.org\/10.1186\/s12958-019-0513-8","journal-title":"Reprod Biol Endocrinol"},{"issue":"7","key":"10101_CR14","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.3390\/ijms25073680","volume":"25","author":"KA Toniyan","year":"2024","unstructured":"Toniyan KA, Malkov AA, Biryukov NS, Gorbacheva EY, Boyarintsev VV, Ogneva IV (2024) The cellular respiration of endometrial biopsies from patients with various forms of endometriosis. Int J Mol Sci 25(7):3680. https:\/\/doi.org\/10.3390\/ijms25073680","journal-title":"Int J Mol Sci"},{"key":"10101_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166895","volume":"1","author":"L Zhou","year":"1870","unstructured":"Zhou L, Cai E, Liu H, Cheng H, Ye X, Zhu H (1870) Chang X (2023) Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages. Biochim Biophys Acta Mol Basis Dis 1:166895. https:\/\/doi.org\/10.1016\/j.bbadis.2023.166895","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"4","key":"10101_CR16","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/j.1476-5381.1970.tb10646.x","volume":"40","author":"G Burnstock","year":"1970","unstructured":"Burnstock G, Campbell G, Satchell D, Smythe A (1970) Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol 40(4):668\u2013688. https:\/\/doi.org\/10.1111\/j.1476-5381.1970.tb10646.x","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10101_CR17","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1476-5381.1972.tb06868.x","volume":"46","author":"G Burnstock","year":"1972","unstructured":"Burnstock G, Satchell DG, Smythe A (1972) A comparison of the excitatory and inhibitory effects of non-adrenergic, non-cholinergic nerve stimulation and exogenously applied ATP on a variety of smooth muscle preparations from different vertebrate species. Br J Pharmacol 46(2):234\u2013242. https:\/\/doi.org\/10.1111\/j.1476-5381.1972.tb06868.x","journal-title":"Br J Pharmacol"},{"key":"10101_CR18","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0031-6997(25)06930-3","volume":"24","author":"G Burnstock","year":"1972","unstructured":"Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24:509\u2013581","journal-title":"Pharmacol Rev"},{"issue":"1","key":"10101_CR19","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.coph.2011.10.008","volume":"12","author":"G Burnstock","year":"2012","unstructured":"Burnstock G (2012) Targeting the visceral purinergic system for pain control. Curr Opin Pharmacol 12(1):80\u201386. https:\/\/doi.org\/10.1016\/j.coph.2011.10.008","journal-title":"Curr Opin Pharmacol"},{"key":"10101_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114322","volume":"187","author":"H Zimmermann","year":"2021","unstructured":"Zimmermann H (2021) History of ectonucleotidases and their role in purinergic signaling. Biochem Pharmacol 187:114322. https:\/\/doi.org\/10.1016\/j.bcp.2020.114322","journal-title":"Biochem Pharmacol"},{"key":"10101_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-024-10053-8","author":"AA Soares","year":"2024","unstructured":"Soares AA, dos Santos HM, Domann KN, Alves NPR, B\u00f6hm BR, Haack CM, Pretto KP, Guimar\u00e3es ES, Rocha GF, de Paula IR, de Alc\u00e2ntara Guimar\u00e3es LE, de \u00c1vila Pessoa HC, Rodrigues RD, Dalagnol AMK, da Cunha MLV, de Resende e Silva DT, (2024) Purines and purinergic receptors in primary tumors of the central nervous system. Purinergic Signal. https:\/\/doi.org\/10.1007\/s11302-024-10053-8","journal-title":"Purinergic Signal"},{"issue":"15","key":"10101_CR22","doi-asserted-by":"publisher","first-page":"8068","DOI":"10.3390\/ijms22158068","volume":"22","author":"E Timperi","year":"2021","unstructured":"Timperi E, Barnaba V (2021) CD39 Regulation and functions in T cells. Int J Mol Sci 22(15):8068. https:\/\/doi.org\/10.3390\/ijms22158068","journal-title":"Int J Mol Sci"},{"key":"10101_CR23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.imlet.2018.11.006","volume":"205","author":"AL Giuliani","year":"2019","unstructured":"Giuliani AL, Sarti AC, Di Virgilio F (2019) Extracellular nucleotides and nucleosides as signaling molecules. Immunol Lett 205:16\u201324. https:\/\/doi.org\/10.1016\/j.imlet.2018.11.006","journal-title":"Immunol Lett"},{"key":"10101_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.653561","volume":"12","author":"A Spinaci","year":"2021","unstructured":"Spinaci A, Buccioni M, Dal Ben D, Marucci G, Volpini R, Lambertucci C (2021) P2X3 Receptor ligands: structural features and potential therapeutic applications. Front Pharmacol 12:653561. https:\/\/doi.org\/10.3389\/fphar.2021.653561","journal-title":"Front Pharmacol"},{"issue":"3","key":"10101_CR25","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1007\/s13311-020-00934-2","volume":"17","author":"JL Krajewski","year":"2020","unstructured":"Krajewski JL (2020) P2X3-containing receptors as targets for the treatment of chronic pain. Neurotherapeutics 17(3):826\u2013838. https:\/\/doi.org\/10.1007\/s13311-020-00934-2","journal-title":"Neurotherapeutics"},{"key":"10101_CR26","doi-asserted-by":"publisher","unstructured":"Parke S, Gude K, Roth K, Messina F (2024) Efficacy and safety of eliapixant in endometriosis-associated pelvic pain: the randomized, placebo-controlled phase 2b SCHUMANN study. BMC Womens Health 24:353. \u200chttps:\/\/doi.org\/10.1186\/s12905-024-03188-8","DOI":"10.1186\/s12905-024-03188-8"},{"issue":"9","key":"10101_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184647","volume":"12","author":"S Ding","year":"2017","unstructured":"Ding S, Zhu L, Tian Y, Zhu T, Huang X, Zhang X (2017) P2X3 receptor involvement in endometriosis pain via ERK signaling pathway. PLoS ONE 12(9):e0184647. https:\/\/doi.org\/10.1371\/journal.pone.0184647","journal-title":"PLoS ONE"},{"key":"10101_CR28","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s11302-012-9345-0","volume":"9","author":"E Aliagas","year":"2013","unstructured":"Aliagas E, Vidal A, Torrej\u00f3n-Escribano B, del Rosario TM, Ponce J, de Aranda IG, S\u00e9vigny J, Condom E, Mart\u00edn-Satu\u00e9 M (2013) Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium. Purinergic Signal 9:227\u2013237. https:\/\/doi.org\/10.1007\/s11302-012-9345-0","journal-title":"Purinergic Signal"},{"key":"10101_CR29","doi-asserted-by":"publisher","first-page":"33811","DOI":"10.1038\/srep33811","volume":"6","author":"NR Boggavarapu","year":"2016","unstructured":"Boggavarapu NR, Lalitkumar S, Joshua V, Kasvandik S, Salumets A, Lalitkumar PG, Gemzell-Danielsson K (2016) Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form. Sci Rep 6:33811. https:\/\/doi.org\/10.1038\/srep33811","journal-title":"Sci Rep"},{"issue":"22","key":"10101_CR30","doi-asserted-by":"publisher","first-page":"8512","DOI":"10.3390\/ijms21228512","volume":"21","author":"C Trapero","year":"2020","unstructured":"Trapero C, Mart\u00edn-Satu\u00e9 M (2020) Purinergic signaling in endometriosis-associated pain. Int J Mol Sci 21(22):8512. https:\/\/doi.org\/10.3390\/ijms21228512","journal-title":"Int J Mol Sci"},{"key":"10101_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.590823","volume":"14","author":"J Maddern","year":"2020","unstructured":"Maddern J, Grundy L, Castro J, Brierley SM (2020) Pain in endometriosis Front Cell Neurosci 14:590823. https:\/\/doi.org\/10.3389\/fncel.2020.590823","journal-title":"Pain in endometriosis Front Cell Neurosci"},{"issue":"6","key":"10101_CR32","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/s0015-0282(16)46691-4","volume":"38","author":"JH Strathy","year":"1982","unstructured":"Strathy JH, Molgaard CA, Coulam CB, Melton LJ 3rd (1982) Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women. Fertil Steril 38(6):667\u2013672. https:\/\/doi.org\/10.1016\/s0015-0282(16)46691-4","journal-title":"Fertil Steril"},{"issue":"5","key":"10101_CR33","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1093\/humrep\/deaa061","volume":"35","author":"S Ding","year":"2020","unstructured":"Ding S, Yu Q, Wang J, Zhu L, Li T, Guo X, Zhang X (2020) Activation of ATF3\/AP-1 signaling pathway is required for P2X3-induced endometriosis pain. Hum Reprod 35(5):1130\u20131144. https:\/\/doi.org\/10.1093\/humrep\/deaa061","journal-title":"Hum Reprod"},{"key":"10101_CR34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12974-023-02713-0","volume":"20","author":"ST Bashir","year":"2023","unstructured":"Bashir ST, Redden CR, Raj K, Arcanjo RB, Stasiak S, Li Q, Steelman AJ, Nowak RA (2023) Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis. J Neuroinflammation 20:59. https:\/\/doi.org\/10.1186\/s12974-023-02713-0","journal-title":"J Neuroinflammation"},{"issue":"9","key":"10101_CR35","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1097\/wnr.0b013e328353fabc","volume":"23","author":"T Cho","year":"2012","unstructured":"Cho T, Chaban VV (2012) Expression of P2X3 and TRPV1 receptors in primary sensory neurons from estrogen receptors-\u03b1 and estrogen receptor-\u03b2 knockout mice. NeuroReport 23(9):530\u2013534. https:\/\/doi.org\/10.1097\/wnr.0b013e328353fabc","journal-title":"NeuroReport"},{"key":"10101_CR36","doi-asserted-by":"publisher","unstructured":"Seol SH, Chung G (2022) Estrogen-dependent regulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3): Implication in burning mouth syndrome. J Dent Sci 17(1):8\u201313. \u200chttps:\/\/doi.org\/10.1016\/j.jds.2021.06.007","DOI":"10.1016\/j.jds.2021.06.007"},{"key":"10101_CR37","doi-asserted-by":"publisher","unstructured":"Xu S, Cheng Y, Keast JR, Osborne PB (2008). 17beta-estradiol activates estrogen receptor beta-signalling and inhibits transient receptor potential vanilloid receptor 1 activation by capsaicin in adult rat nociceptor neurons. Endocrinology. 149(11):5540\u20138.\u200chttps:\/\/doi.org\/10.1210\/en.2008-0278","DOI":"10.1210\/en.2008-0278"},{"key":"10101_CR38","doi-asserted-by":"publisher","unstructured":"Yamagata K, Sugimura M, Yoshida M, Sekine S, Kawano A, Oyamaguchi A, Maegawa H, Niwa H (2016). Estrogens exacerbate nociceptive pain via up-regulation of TRPV1 and ANO1 in trigeminal primary neurons of female rats. Endocrinology. 157(11):4309\u20134317. \u200chttps:\/\/doi.org\/10.1210\/en.2016-1218","DOI":"10.1210\/en.2016-1218"},{"key":"10101_CR39","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3389\/fphys.2020.00444","volume":"11","author":"R Ram\u00edrez-Barrantes","year":"2020","unstructured":"Ram\u00edrez-Barrantes R, Carvajal-Zamorano K, Rodriguez B, Cordova C, Lozano C, Simon F, D\u00edaz P, Mu\u00f1oz P, Marchant I, Latorre R, Castillo K, Olivero P (2020) TRPV1-estradiol stereospecific relationship underlies cell survival in oxidative cell death. Front Physiol 11:444. https:\/\/doi.org\/10.3389\/fphys.2020.00444","journal-title":"Front Physiol"},{"issue":"1","key":"10101_CR40","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s11302-010-9212-9","volume":"7","author":"B Ma","year":"2011","unstructured":"Ma B, Yu LH, Fan J, Cong B, He P, Ni X, Burnstock G (2011) Estrogen modulation of peripheral pain signal transduction: involvement of P2X(3) receptors. Purinergic Signal 7(1):73\u201383. https:\/\/doi.org\/10.1007\/s11302-010-9212-9","journal-title":"Purinergic Signal"},{"issue":"7","key":"10101_CR41","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1210\/en.2012-2119","volume":"154","author":"Y Lu","year":"2013","unstructured":"Lu Y, Jiang Q, Yu L, Lu ZY, Meng SP, Su D, Burnstock G, Ma B (2013) 17\u03b2-Estradiol rapidly attenuates P2X3 receptor-mediated peripheral pain signal transduction via ER\u03b1 and GPR30. Endocrinology 154(7):2421\u20132433. https:\/\/doi.org\/10.1210\/en.2012-2119","journal-title":"Endocrinology"},{"key":"10101_CR42","unstructured":"Yu LH, Li N, Liu CY, Ma B (2011) Estrogen altered facial mechanical pain threshold and trigeminal P2X3 receptor expression. Neuro Endocrinol Lett 32(6):811\u2013815. Available from http:\/\/pubmed.ncbi.nlm.nih.gov\/22286789\/"},{"issue":"2","key":"10101_CR43","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3390\/jcm11020467","volume":"11","author":"S Mechsner","year":"2022","unstructured":"Mechsner S (2022) Endometriosis, an ongoing pain\u2014step-by-step treatment. J Clin Med 11(2):467. https:\/\/doi.org\/10.3390\/jcm11020467","journal-title":"J Clin Med"},{"issue":"6","key":"10101_CR44","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1590\/S0100-72032010000600008","volume":"32","author":"AP N\u00e1cul","year":"2010","unstructured":"N\u00e1cul AP, Spritzer PM (2010) Aspectos atuais do diagn\u00f3stico e tratamento da endometriose. Rev Bras Ginecol Obstet 32(6):298\u2013307. https:\/\/doi.org\/10.1590\/S0100-72032010000600008","journal-title":"Rev Bras Ginecol Obstet"},{"key":"10101_CR45","doi-asserted-by":"publisher","first-page":"19877","DOI":"10.1038\/s41598-021-99177-0","volume":"11","author":"AJ Davenport","year":"2021","unstructured":"Davenport AJ, Neagoe I, Br\u00e4uer N, Koch M, Rotgeri A, Nagel J, Laux-Biehlmann A, Machet F, Coelho AM, Boyce S, Carty N, Gemkow MJ, Hess SD, Zollner TM, Fischer OM (2021) Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers. Sci Rep 11:19877. https:\/\/doi.org\/10.1038\/s41598-021-99177-0","journal-title":"Sci Rep"},{"key":"10101_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11302-021-09831-5","volume":"18","author":"MC Fletcher","year":"2022","unstructured":"Fletcher MC (2022) Selectivity of the P2X3 receptor antagonist Eliapixant and its potential use in treating endometriosis. Purinergic Signal 18:1\u20133. https:\/\/doi.org\/10.1007\/s11302-021-09831-5","journal-title":"Purinergic Signal"},{"issue":"12","key":"10101_CR47","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1080\/13543776.2019.1693542","volume":"29","author":"G Marucci","year":"2019","unstructured":"Marucci G, Dal Ben D, Buccioni M, Mart\u00ed Navia A, Spinaci A, Volpini R, Lambertucci C (2019) Update on novel purinergic P2X3 and P2X2\/3 receptor antagonists and their potential therapeutic applications. Expert Opin Ther Pat 29(12):943\u2013963. https:\/\/doi.org\/10.1080\/13543776.2019.1693542","journal-title":"Expert Opin Ther Pat"},{"key":"10101_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.128384","volume":"52","author":"H Kai","year":"2021","unstructured":"Kai H, Horiguchi T, Kameyma T, Onodera N, Itoh N, Fujii Y, Ichihashi Y, Hirai K, Shintani T, Nakamura K, Minami K, Kasai E, Yoneda S, Murakami Y, Ogawa H, Sekimoto R, Shinohara S, Yoshida O, Kurose N (2021) Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists. Bioorg Med Chem Lett 52:128384. https:\/\/doi.org\/10.1016\/j.bmcl.2021.128384","journal-title":"Bioorg Med Chem Lett"},{"key":"10101_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.177052","volume":"984","author":"M\u00c1 Huerta","year":"2024","unstructured":"Huerta M\u00c1, Marcos-Frutos D, de la Nava J, Garc\u00eda-Ramos A, Tejada M\u00c1, Roza C (2024) P2X3 and P2X2\/3 receptors inhibition produces a consistent analgesic efficacy: a systematic review and meta-analysis of preclinical studies. Eur J Pharmacol 984:177052. https:\/\/doi.org\/10.1016\/j.ejphar.2024.177052","journal-title":"Eur J Pharmacol"},{"key":"10101_CR50","doi-asserted-by":"publisher","unstructured":"Amaral MH, de Figueiredo MER, Lib\u00e2nio PS, Rocha RVS (2023) Endometriose: Uma Revis\u00e3o De Novas Propostas Terap\u00eauticas. Anais do II Congresso Brasileiro de Doen\u00e7as Cr\u00f4nicas On-line. Rev Multidiscipli Sa\u00fade, 4(2). https:\/\/doi.org\/10.51161\/cronics2023\/25179","DOI":"10.51161\/cronics2023\/25179"},{"issue":"2","key":"10101_CR51","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.fertnstert.2024.09.013","volume":"123","author":"F Arbelaez","year":"2025","unstructured":"Arbelaez F, Joeng HK, Hussain A, Sunga S, Guan Y, Chawla A, Carmona F, Lines C, Mendizabal G (2025) Randomized, controlled, proof-of-concept trial of gefapixant for endometriosis-related pain. Fertil Steril 123(2):280\u2013288. https:\/\/doi.org\/10.1016\/j.fertnstert.2024.09.013","journal-title":"Fertil Steril"}],"updated-by":[{"DOI":"10.1007\/s11302-025-10106-6","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000}}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-025-10101-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-025-10101-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-025-10101-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:06:24Z","timestamp":1762880784000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-025-10101-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10101"],"URL":"https:\/\/doi.org\/10.1007\/s11302-025-10101-x","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"5 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11302-025-10106-6","URL":"https:\/\/doi.org\/10.1007\/s11302-025-10106-6","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}