{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:12:10Z","timestamp":1789783930247,"version":"4.0.1"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11302-025-10104-8","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:38:16Z","timestamp":1751603896000},"page":"863-871","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic potential of P2X7 receptor in retinal diseases"],"prefix":"10.1007","volume":"21","author":[{"given":"Min","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianlian","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"10104_CR1","doi-asserted-by":"crossref","unstructured":"Muchuchuti S, Viriri S (2023) Retinal disease detection using deep learning techniques: a comprehensive review. J Imaging 9","DOI":"10.3390\/jimaging9040084"},{"key":"10104_CR2","doi-asserted-by":"publisher","first-page":"1077669","DOI":"10.3389\/fendo.2022.1077669","volume":"13","author":"TE Tan","year":"2022","unstructured":"Tan TE, Wong TY (2022) Diabetic retinopathy: looking forward to 2030. Front Endocrinol (Lausanne) 13:1077669","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10104_CR3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.mcna.2021.01.004","volume":"105","author":"JM Kang","year":"2021","unstructured":"Kang JM, Tanna AP (2021) Glaucoma. Med Clin North Am 105:493\u2013510","journal-title":"Med Clin North Am"},{"key":"10104_CR4","first-page":"147","volume":"331","author":"M Fleckenstein","year":"2024","unstructured":"Fleckenstein M, Schmitz-Valckenberg S, Chakravarthy U (2024) Age-related macular degeneration: a review Jama 331:147\u2013157","journal-title":"Age-related macular degeneration: a review Jama"},{"key":"10104_CR5","doi-asserted-by":"crossref","unstructured":"Zuzic M, Rojo Arias JE, S.G. Wohl SG et al. (2019) Retinal miRNA functions in health and disease. Genes 10:377","DOI":"10.3390\/genes10050377"},{"key":"10104_CR6","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s11302-022-09894-y","volume":"18","author":"C Drysdale","year":"2022","unstructured":"Drysdale C, Park K, Vessey KA et al (2022) P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration. Purinergic Signal 18:469\u2013479","journal-title":"Purinergic Signal"},{"key":"10104_CR7","doi-asserted-by":"crossref","unstructured":"Pavlou S, Augustine J, Cunning R et al. (2019) Attenuating diabetic vascular and neuronal defects by targeting P2rx7. Int J Mol Sci 20","DOI":"10.3390\/ijms20092101"},{"key":"10104_CR8","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.brainresbull.2018.10.016","volume":"151","author":"ALM Ventura","year":"2019","unstructured":"Ventura ALM, Dos Santos-Rodrigues A, Mitchell CH et al (2019) Purinergic signaling in the retina: from development to disease. Brain Res Bull 151:92\u2013108","journal-title":"Brain Res Bull"},{"key":"10104_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029990","volume":"7","author":"KA Vessey","year":"2012","unstructured":"Vessey KA, Fletcher EL (2012) Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse. PLoS ONE 7:e29990","journal-title":"PLoS ONE"},{"key":"10104_CR10","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1016\/j.ajpath.2011.08.035","volume":"179","author":"S Notomi","year":"2011","unstructured":"Notomi S, Hisatomi T, Kanemaru T et al (2011) Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death. Am J Pathol 179:2798\u20132809","journal-title":"Am J Pathol"},{"key":"10104_CR11","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1089\/jop.2016.0131","volume":"32","author":"A Reichenbach","year":"2016","unstructured":"Reichenbach A, Bringmann A (2016) Role of purines in M\u00fcller Glia. J Ocul Pharmacol Ther 32:518\u2013533","journal-title":"J Ocul Pharmacol Ther"},{"key":"10104_CR12","doi-asserted-by":"publisher","first-page":"12389","DOI":"10.1038\/s41598-021-91989-4","volume":"11","author":"L Li","year":"2021","unstructured":"Li L, Liu J, Xu A et al (2021) Expression of purinergic receptors on microglia in the animal model of choroidal neovascularisation. Sci Rep 11:12389","journal-title":"Sci Rep"},{"key":"10104_CR13","doi-asserted-by":"crossref","unstructured":"Campagno KE, Sripinun P, See LP et al. (2024) Increased Pan-type, A1-type, and A2-type astrocyte activation and upstream inflammatory markers are induced by the P2X7 receptor. Int J Mol Sci 25","DOI":"10.3390\/ijms25168784"},{"key":"10104_CR14","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.drudis.2019.03.029","volume":"24","author":"EL Fletcher","year":"2019","unstructured":"Fletcher EL, Wang AY, Jobling AI et al (2019) Targeting P2X7 receptors as a means for treating retinal disease. Drug Discov Today 24:1598\u20131605","journal-title":"Drug Discov Today"},{"key":"10104_CR15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.visres.2017.05.009","volume":"139","author":"M D\u00edaz-Cor\u00e1nguez","year":"2017","unstructured":"D\u00edaz-Cor\u00e1nguez M, Ramos C, Antonetti DA (2017) The inner blood-retinal barrier: cellular basis and development. Vision Res 139:123\u2013137","journal-title":"Vision Res"},{"key":"10104_CR16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12974-025-03391-w","volume":"22","author":"X Ge","year":"2025","unstructured":"Ge X, Zhu X, Liu W et al (2025) cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia. J Neuroinflammation 22:58","journal-title":"J Neuroinflammation"},{"key":"10104_CR17","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1113\/jphysiol.2003.047977","volume":"551","author":"H Kawamura","year":"2003","unstructured":"Kawamura H, Sugiyama T, Wu DM et al (2003) ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina. J Physiol 551:787\u2013799","journal-title":"J Physiol"},{"key":"10104_CR18","doi-asserted-by":"publisher","first-page":"C568","DOI":"10.1152\/ajpcell.00380.2004","volume":"288","author":"T Sugiyama","year":"2005","unstructured":"Sugiyama T, Kawamura H, Yamanishi S et al (2005) Regulation of P2X7-induced pore formation and cell death in pericyte-containing retinal microvessels. Am J Physiol Cell Physiol 288:C568-576","journal-title":"Am J Physiol Cell Physiol"},{"key":"10104_CR19","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1167\/iovs.03-1062","volume":"45","author":"T Sugiyama","year":"2004","unstructured":"Sugiyama T, Kobayashi M, Kawamura H et al (2004) Enhancement of P2X(7)-induced pore formation and apoptosis: an early effect of diabetes on the retinal microvasculature. Invest Ophthalmol Vis Sci 45:1026\u20131032","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10104_CR20","doi-asserted-by":"crossref","unstructured":"Shibata M, Ishizaki E, Zhang T et al. (2018) Purinergic vasotoxicity: role of the pore\/oxidant\/K(ATP) channel\/Ca(2+) pathway in P2X(7)-induced cell death in retinal capillaries. Vision (Basel) 2","DOI":"10.3390\/vision2030025"},{"key":"10104_CR21","first-page":"244","volume":"65","author":"H Xu","year":"2013","unstructured":"Xu H, Liang SD (2013) Effect of P2X7 receptor on inflammatory diseases and its mechanism. Sheng Li Xue Bao 65:244\u2013252","journal-title":"Sheng Li Xue Bao"},{"key":"10104_CR22","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bcp.2019.07.010","volume":"168","author":"CBM Platania","year":"2019","unstructured":"Platania CBM, Lazzara F, Fidilio A et al (2019) Blood-retinal barrier protection against high glucose damage: The role of P2X7 receptor. Biochem Pharmacol 168:249\u2013258","journal-title":"Biochem Pharmacol"},{"key":"10104_CR23","doi-asserted-by":"crossref","unstructured":"Fresta CG, Caruso G, Fidilio A et al. (2020) Dihydrotanshinone, a natural diterpenoid, preserves blood-retinal barrier integrity via P2X7 receptor. Int J Mol Sci 21","DOI":"10.3390\/ijms21239305"},{"key":"10104_CR24","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.cmet.2013.09.003","volume":"18","author":"A Cerani","year":"2013","unstructured":"Cerani A, Tetreault N, Menard C et al (2013) Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cell Metab 18:505\u2013518","journal-title":"Cell Metab"},{"key":"10104_CR25","doi-asserted-by":"crossref","unstructured":"Klein R, Klein BE, Moss SE et al. (1998) The Wisconsin epidemiologic study of diabetic retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes. Ophthalmol 105:1801\u20131815","DOI":"10.1016\/S0161-6420(98)91020-X"},{"key":"10104_CR26","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1096\/fj.14-268714","volume":"29","author":"A Franceschini","year":"2015","unstructured":"Franceschini A, Capece M, Chiozzi P et al (2015) The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein. Faseb j 29:2450\u20132461","journal-title":"Faseb j"},{"key":"10104_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.108987","volume":"218","author":"L Liu","year":"2022","unstructured":"Liu L, Jiang Y, Steinle JJ (2022) Epac1 and PKA regulate of P2X7 and NLRP3 inflammasome proteins in the retinal vasculature. Exp Eye Res 218:108987","journal-title":"Exp Eye Res"},{"key":"10104_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114385","volume":"187","author":"P Pelegrin","year":"2021","unstructured":"Pelegrin P (2021) P2X7 receptor and the NLRP3 inflammasome: partners in crime. Biochem Pharmacol 187:114385","journal-title":"Biochem Pharmacol"},{"key":"10104_CR29","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1167\/iovs.17-22816","volume":"59","author":"H Chen","year":"2018","unstructured":"Chen H, Zhang X, Liao N et al (2018) Enhanced expression of NLRP3 inflammasome-related inflammation in diabetic retinopathy. Invest Ophthalmol Vis Sci 59:978\u2013985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10104_CR30","doi-asserted-by":"publisher","first-page":"1151185","DOI":"10.3389\/fimmu.2023.1151185","volume":"14","author":"X Zheng","year":"2023","unstructured":"Zheng X, Wan J, Tan G (2023) The mechanisms of NLRP3 inflammasome\/pyroptosis activation and their role in diabetic retinopathy. Front Immunol 14:1151185","journal-title":"Front Immunol"},{"key":"10104_CR31","volume-title":"Nucleotides and novel signaling pathways in endothelial cells: possible roles in angiogenesis, endothelial dysfunction and diabetes mellitus","author":"E Kaczmarek","year":"2010","unstructured":"Kaczmarek E (2010) Nucleotides and novel signaling pathways in endothelial cells: possible roles in angiogenesis, endothelial dysfunction and diabetes mellitus. Springer, Netherlands"},{"key":"10104_CR32","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","volume":"311","author":"RN Weinreb","year":"2014","unstructured":"Weinreb RN, Aung T, Medeiros FA (2014) The pathophysiology and treatment of glaucoma: a review. JAMA 311:1901\u20131911","journal-title":"JAMA"},{"key":"10104_CR33","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/cxo.13031","volume":"103","author":"AY Wang","year":"2020","unstructured":"Wang AY, Lee PY, Bui BV et al (2020) Potential mechanisms of retinal ganglion cell type-specific vulnerability in glaucoma. Clin Exp Optom 103:562\u2013571","journal-title":"Clin Exp Optom"},{"key":"10104_CR34","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1096\/fj.09-138883","volume":"24","author":"SD Skaper","year":"2010","unstructured":"Skaper SD, Debetto P, Giusti P (2010) The P2X7 purinergic receptor: from physiology to neurological disorders. Faseb j 24:337\u2013345","journal-title":"Faseb j"},{"key":"10104_CR35","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s12035-012-8263-z","volume":"46","author":"GA Weisman","year":"2012","unstructured":"Weisman GA, Camden JM, Peterson TS et al (2012) P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y\u2082 receptor interactions in neuroinflammation. Mol Neurobiol 46:96\u2013113","journal-title":"Mol Neurobiol"},{"key":"10104_CR36","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1097\/FBP.0000000000000072","volume":"25","author":"JM Catanzaro","year":"2014","unstructured":"Catanzaro JM, Hueston CM, Deak MM et al (2014) The impact of the P2X7 receptor antagonist A-804598 on neuroimmune and behavioral consequences of stress. Behav Pharmacol 25:582\u2013598","journal-title":"Behav Pharmacol"},{"key":"10104_CR37","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","volume":"31","author":"M Almasieh","year":"2012","unstructured":"Almasieh M, Wilson AM, Morquette B et al (2012) The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 31:152\u2013181","journal-title":"Prog Retin Eye Res"},{"key":"10104_CR38","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1113\/jphysiol.2012.227983","volume":"590","author":"J Xia","year":"2012","unstructured":"Xia J, Lim JC, Lu W et al (2012) Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. J Physiol 590:2285\u20132304","journal-title":"J Physiol"},{"key":"10104_CR39","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.exer.2010.06.017","volume":"91","author":"H Hu","year":"2010","unstructured":"Hu H, Lu W, Zhang M et al (2010) Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo. Exp Eye Res 91:425\u2013432","journal-title":"Exp Eye Res"},{"key":"10104_CR40","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1167\/iovs.12-10968","volume":"54","author":"N Niyadurupola","year":"2013","unstructured":"Niyadurupola N, Sidaway P, Ma N et al (2013) P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration. Invest Ophthalmol Vis Sci 54:2163\u20132170","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10104_CR41","first-page":"2080","volume":"19","author":"T Sugiyama","year":"2013","unstructured":"Sugiyama T, Lee SY, Horie T et al (2013) P2X\u2087 receptor activation may be involved in neuronal loss in the retinal ganglion cell layer after acute elevation of intraocular pressure in rats. Mol Vis 19:2080\u20132091","journal-title":"Mol Vis"},{"key":"10104_CR42","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.preteyeres.2009.07.001","volume":"28","author":"A Bringmann","year":"2009","unstructured":"Bringmann A, Iandiev I, Pannicke T et al (2009) Cellular signaling and factors involved in M\u00fcller cell gliosis: neuroprotective and detrimental effects. Prog Retin Eye Res 28:423\u2013451","journal-title":"Prog Retin Eye Res"},{"key":"10104_CR43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.preteyeres.2014.07.001","volume":"43","author":"N Cuenca","year":"2014","unstructured":"Cuenca N, Fern\u00e1ndez-S\u00e1nchez L, Campello L et al (2014) Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases. Prog Retin Eye Res 43:17\u201375","journal-title":"Prog Retin Eye Res"},{"key":"10104_CR44","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev-vision-091517-034425","volume":"4","author":"SM Silverman","year":"2018","unstructured":"Silverman SM, Wong WT (2018) Microglia in the retina: roles in development, maturity, and disease. Annu Rev Vis Sci 4:45\u201377","journal-title":"Annu Rev Vis Sci"},{"key":"10104_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.860070","volume":"13","author":"NPB Au","year":"2022","unstructured":"Au NPB, Ma CHE (2022) Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy. Front Immunol 13:860070","journal-title":"Front Immunol"},{"key":"10104_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2019.107771","volume":"188","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Xu Y, Sun Q et al (2019) Activation of P2X(7)R- NLRP3 pathway in retinal microglia contribute to retinal ganglion cells death in chronic ocular hypertension (COH). Exp Eye Res 188:107771","journal-title":"Exp Eye Res"},{"key":"10104_CR47","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/ICU.0000000000000125","volume":"26","author":"RS Chong","year":"2015","unstructured":"Chong RS, Martin KR (2015) Glial cell interactions and glaucoma. Curr Opin Ophthalmol 26:73\u201377","journal-title":"Curr Opin Ophthalmol"},{"key":"10104_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.610788","volume":"15","author":"X Zhao","year":"2021","unstructured":"Zhao X, Sun R, Luo X et al (2021) The interaction between microglia and macroglia in glaucoma. Front Neurosci 15:610788","journal-title":"Front Neurosci"},{"key":"10104_CR49","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/978-1-4614-3209-8_42","volume":"801","author":"M Wang","year":"2014","unstructured":"Wang M, Wong WT (2014) Microglia-M\u00fcller cell interactions in the retina. Adv Exp Med Biol 801:333\u2013338","journal-title":"Adv Exp Med Biol"},{"key":"10104_CR50","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1111\/febs.17075","volume":"291","author":"H Hu","year":"2024","unstructured":"Hu H, Nie D, Fang M et al (2024) M\u00fcller cells under hydrostatic pressure modulate retinal cell survival via TRPV1\/PLC\u03b31 complex-mediated calcium influx in experimental glaucoma. Febs j 291:2703\u20132714","journal-title":"Febs j"},{"key":"10104_CR51","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s12264-022-00833-w","volume":"38","author":"MX Xu","year":"2022","unstructured":"Xu MX, Zhao GL, Hu X et al (2022) P2X7\/P2X4 receptors mediate proliferation and migration of retinal microglia in experimental glaucoma in mice. Neurosci Bull 38:901\u2013915","journal-title":"Neurosci Bull"},{"key":"10104_CR52","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12974-023-02855-1","volume":"20","author":"M Wei","year":"2023","unstructured":"Wei M, Zhang G, Huang Z et al (2023) ATP-P2X(7)R-mediated microglia senescence aggravates retinal ganglion cell injury in chronic ocular hypertension. J Neuroinflammation 20:180","journal-title":"J Neuroinflammation"},{"key":"10104_CR53","doi-asserted-by":"publisher","first-page":"6461","DOI":"10.1167\/iovs.16-19494","volume":"57","author":"T Tsutsumi","year":"2016","unstructured":"Tsutsumi T, Iwao K, Hayashi H et al (2016) Potential neuroprotective effects of an LSD1 inhibitor in retinal ganglion cells via p38 MAPK activity. Invest Ophthalmol Vis Sci 57:6461\u20136473","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10104_CR54","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.freeradbiomed.2007.02.010","volume":"42","author":"ZA Pfeiffer","year":"2007","unstructured":"Pfeiffer ZA, Guerra AN, Hill LM et al (2007) Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation. Free Radic Biol Med 42:1506\u20131516","journal-title":"Free Radic Biol Med"},{"key":"10104_CR55","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.biopha.2018.02.107","volume":"101","author":"QL Zhang","year":"2018","unstructured":"Zhang QL, Wang W, Jiang Y et al (2018) GRGM-13 comprising 13 plant and animal products, inhibited oxidative stress induced apoptosis in retinal ganglion cells by inhibiting P2RX7\/p38 MAPK signaling pathway. Biomed Pharmacother 101:494\u2013500","journal-title":"Biomed Pharmacother"},{"key":"10104_CR56","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.brainresbull.2019.05.006","volume":"150","author":"MJ Perez de Lara","year":"2019","unstructured":"Perez de Lara MJ, Aviles-Trigueros M, Guzman-Aranguez A et al (2019) Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma. Brain Res Bull 150:61\u201374","journal-title":"Brain Res Bull"},{"key":"10104_CR57","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1097\/WNR.0000000000002071","volume":"35","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Li SY, Zhang LJ et al (2024) Neuroprotection of the P2X7 receptor antagonist A740003 on retinal ganglion cells in experimental glaucoma. NeuroReport 35:822\u2013831","journal-title":"NeuroReport"},{"key":"10104_CR58","first-page":"2289","volume":"17","author":"L Dong","year":"2018","unstructured":"Dong L, Hu Y, Zhou L et al (2018) P2X7 receptor antagonist protects retinal ganglion cells by inhibiting microglial activation in a rat chronic ocular hypertension model. Mol Med Rep 17:2289\u20132296","journal-title":"Mol Med Rep"},{"key":"10104_CR59","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/s41419-022-04786-w","volume":"13","author":"H Kong","year":"2022","unstructured":"Kong H, Zhao H, Chen T et al (2022) Targeted P2X7\/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy. Cell Death Dis 13:336","journal-title":"Cell Death Dis"},{"key":"10104_CR60","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.7150\/thno.79538","volume":"13","author":"X Cheng","year":"2023","unstructured":"Cheng X, Gao H, Tao Z et al (2023) Repopulated retinal microglia promote M\u00fcller glia reprogramming and preserve visual function in retinal degenerative mice. Theranostics 13:1698\u20131715","journal-title":"Theranostics"},{"key":"10104_CR61","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1167\/iovs.05-1407","volume":"47","author":"RM Sappington","year":"2006","unstructured":"Sappington RM, Chan M, Calkins DJ (2006) Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest Ophthalmol Vis Sci 47:2932\u20132942","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10104_CR62","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3389\/fncel.2016.00270","volume":"10","author":"JC Lim","year":"2016","unstructured":"Lim JC, Lu W, Beckel JM et al (2016) Neuronal release of cytokine IL-3 triggered by mechanosensitive autostimulation of the P2X7 receptor is neuroprotective. Front Cell Neurosci 10:270","journal-title":"Front Cell Neurosci"},{"key":"10104_CR63","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s12640-009-9020-6","volume":"15","author":"F Ortega","year":"2009","unstructured":"Ortega F, P\u00e9rez-Sen R, Delicado EG et al (2009) P2X7 nucleotide receptor is coupled to GSK-3 inhibition and neuroprotection in cerebellar granule neurons. Neurotox Res 15:193\u2013204","journal-title":"Neurotox Res"},{"key":"10104_CR64","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s11010-014-1967-9","volume":"390","author":"CS Bindra","year":"2014","unstructured":"Bindra CS, Jaggi AS, Singh N (2014) Role of P2X7 purinoceptors in neuroprotective mechanism of ischemic postconditioning in mice. Mol Cell Biochem 390:161\u2013173","journal-title":"Mol Cell Biochem"},{"key":"10104_CR65","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1038\/s41598-021-83669-0","volume":"11","author":"AYM Wang","year":"2021","unstructured":"Wang AYM, Wong VHY, Lee PY et al (2021) Retinal ganglion cell dysfunction in mice following acute intraocular pressure is exacerbated by P2X7 receptor knockout. Sci Rep 11:4184","journal-title":"Sci Rep"},{"key":"10104_CR66","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1159\/000510887","volume":"243","author":"Z Wu","year":"2020","unstructured":"Wu Z, Guymer RH (2020) Can the onset of atrophic age-related macular degeneration be an acceptable endpoint for preventative trials? Ophthalmologica 243:399\u2013403","journal-title":"Ophthalmologica"},{"key":"10104_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109332","volume":"223","author":"PA Dechelle-Marquet","year":"2023","unstructured":"Dechelle-Marquet PA, Guillonneau X, Sennlaub F et al (2023) P2X7-dependent immune pathways in retinal diseases. Neuropharmacology 223:109332","journal-title":"Neuropharmacology"},{"key":"10104_CR68","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/978-3-031-43883-7_14","volume":"1440","author":"E Olivier","year":"2024","unstructured":"Olivier E, Rat P (2024) Role of oxysterols in ocular degeneration mechanisms and involvement of P2X7 receptor. Adv Exp Med Biol 1440:277\u2013292","journal-title":"Adv Exp Med Biol"},{"key":"10104_CR69","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.preteyeres.2011.02.004","volume":"30","author":"K Ohno-Matsui","year":"2011","unstructured":"Ohno-Matsui K (2011) Parallel findings in age-related macular degeneration and Alzheimer\u2019s disease. Prog Retin Eye Res 30:217\u2013238","journal-title":"Prog Retin Eye Res"},{"key":"10104_CR70","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41392-021-00537-z","volume":"6","author":"S Narendran","year":"2021","unstructured":"Narendran S, Pereira F, Yerramothu P et al (2021) Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-beta induced retinal pigmented epithelium degeneration. Signal Transduct Target Ther 6:149","journal-title":"Signal Transduct Target Ther"},{"key":"10104_CR71","doi-asserted-by":"publisher","first-page":"7395","DOI":"10.1167\/iovs.13-12500","volume":"54","author":"N Kerur","year":"2013","unstructured":"Kerur N, Hirano Y, Tarallo V et al (2013) TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest Ophthalmol Vis Sci 54:7395\u20137401","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10104_CR72","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.molimm.2016.11.016","volume":"84","author":"MJ Geerlings","year":"2017","unstructured":"Geerlings MJ, de Jong EK, den Hollander AI (2017) The complement system in age-related macular degeneration: a review of rare genetic variants and implications for personalized treatment. Mol Immunol 84:65\u201376","journal-title":"Mol Immunol"},{"key":"10104_CR73","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.1167\/iovs.14-16089","volume":"56","author":"B Aredo","year":"2015","unstructured":"Aredo B, Li T, Chen X et al (2015) A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice. Invest Ophthalmol Vis Sci 56:3427\u20133440","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10104_CR74","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1111\/bph.14470","volume":"175","author":"BJ Gu","year":"2018","unstructured":"Gu BJ, Wiley JS (2018) P2X7 as a scavenger receptor for innate phagocytosis in the brain. Br J Pharmacol 175:4195\u20134208","journal-title":"Br J Pharmacol"},{"key":"10104_CR75","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.ajpath.2017.04.016","volume":"187","author":"KA Vessey","year":"2017","unstructured":"Vessey KA, Gu BJ, Jobling AI et al (2017) Loss of function of P2X7 receptor scavenger activity in aging mice: a novel model for investigating the early pathogenesis of age-related macular degeneration. Am J Pathol 187:1670\u20131685","journal-title":"Am J Pathol"},{"key":"10104_CR76","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.apsb.2019.11.010","volume":"10","author":"C Zhuang","year":"2020","unstructured":"Zhuang C, Pannecouque C, De Clercq E et al (2020) Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years. Acta Pharm Sin B 10:961\u2013978","journal-title":"Acta Pharm Sin B"},{"key":"10104_CR77","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41586-018-0784-9","volume":"566","author":"M De Cecco","year":"2019","unstructured":"De Cecco M, Ito T, Petrashen AP et al (2019) L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature 566:73\u201378","journal-title":"Nature"},{"key":"10104_CR78","doi-asserted-by":"crossref","unstructured":"Vall\u00e9s-Saiz L, \u00c1vila J, Hern\u00e1ndez F (2023) Lamivudine (3TC), a nucleoside reverse transcriptase inhibitor, prevents the neuropathological alterations present in mutant tau transgenic mice. Int J Mol Sci 24","DOI":"10.1101\/2023.06.02.543424"},{"key":"10104_CR79","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1080\/08164622.2023.2246480","volume":"107","author":"KY Wong","year":"2024","unstructured":"Wong KY, Phan CM, Chan YT et al (2024) A review of using traditional chinese medicine in the management of glaucoma and cataract. Clin Exp Optom 107:156\u2013170","journal-title":"Clin Exp Optom"},{"key":"10104_CR80","first-page":"1101","volume":"8","author":"S Yin","year":"2015","unstructured":"Yin S, Wang ZF, Duan JG et al (2015) Extraction (DSX) from Erigeron breviscapus modulates outward potassium currents in rat retinal ganglion cells. Int J Ophthalmol 8:1101\u20131106","journal-title":"Int J Ophthalmol"},{"key":"10104_CR81","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13020-016-0109-6","volume":"11","author":"HM Chao","year":"2016","unstructured":"Chao HM, Hu L, Cheng JM et al (2016) Chi-Ju-Di-Huang-Wan protects rats against retinal ischemia by downregulating matrix metalloproteinase-9 and inhibiting p38 mitogen-activated protein kinase. Chin Med 11:39","journal-title":"Chin Med"},{"key":"10104_CR82","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1007\/s00417-024-06507-9","volume":"262","author":"KM Woo","year":"2024","unstructured":"Woo KM, Mahrous MA, D\u2019Amico DJ et al (2024) Prevalence of age-related macular degeneration in patients with chronic exposure to P2X7R inhibitors. Graefes Arch Clin Exp Ophthalmol 262:3493\u20133499","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10104_CR83","doi-asserted-by":"crossref","unstructured":"Karasawa A, Kawate T (2016) Structural basis for subtype-specific inhibition of the P2X7 receptor. Elife 5","DOI":"10.7554\/eLife.22153"},{"key":"10104_CR84","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12974-021-02251-7","volume":"18","author":"KE Campagno","year":"2021","unstructured":"Campagno KE, Lu W, Jassim AH et al (2021) Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure. J Neuroinflammation 18:217","journal-title":"J Neuroinflammation"},{"key":"10104_CR85","doi-asserted-by":"crossref","unstructured":"Shao X, Guha S, Lu W, et al. (2020) Polarized cytokine release triggered by P2X7 receptor from retinal pigmented epithelial cells dependent on calcium influx. Cells 9","DOI":"10.3390\/cells9122537"},{"key":"10104_CR86","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s00592-019-01343-4","volume":"56","author":"C Clapp","year":"2019","unstructured":"Clapp C, Diaz-Lezama N, Adan-Castro E et al (2019) Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes. Acta Diabetol 56:1031\u20131036","journal-title":"Acta Diabetol"},{"key":"10104_CR87","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/tvst.11.4.4","volume":"11","author":"RA Gallo","year":"2022","unstructured":"Gallo RA, Qureshi F, Strong TA et al (2022) Derivation and characterization of murine and amphibian Muller glia cell lines. Transl Vis Sci Technol 11:4","journal-title":"Transl Vis Sci Technol"},{"key":"10104_CR88","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13098-018-0332-7","volume":"10","author":"JE Mancini","year":"2018","unstructured":"Mancini JE, Ortiz G, Potilinstki C et al (2018) Possible neuroprotective role of P2X2 in the retina of diabetic rats. Diabetol Metab Syndr 10:31","journal-title":"Diabetol Metab Syndr"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-025-10104-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-025-10104-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-025-10104-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:03:38Z","timestamp":1758535418000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-025-10104-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":88,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10104"],"URL":"https:\/\/doi.org\/10.1007\/s11302-025-10104-8","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"6 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This article does not contain any studies with human participants or animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}