{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:11:38Z","timestamp":1790727098917,"version":"4.1.0"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11302-026-10140-y","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:36:03Z","timestamp":1773113763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The P2X7 receptor\/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3140-0755","authenticated-orcid":false,"given":"Hilal","family":"\u00dcst\u00fcnda\u011f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"10140_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW et al (2016) The third \u0131nternational consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:801\u2013810","journal-title":"JAMA"},{"key":"10140_CR2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM et al (2020) Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study. Lancet 395:200\u2013211","journal-title":"Lancet"},{"key":"10140_CR3","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s13054-019-2478-6","volume":"23","author":"JL Vincent","year":"2019","unstructured":"Vincent JL, Jones G, David S, Olariu E, Cadwell KK (2019) Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis. Crit Care 23:196","journal-title":"Crit Care"},{"key":"10140_CR4","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","volume":"47","author":"L Evans","year":"2021","unstructured":"Evans L, Rhodes A, Alhazzani W et al (2021) Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 47:1181\u20131247","journal-title":"Intensive Care Med"},{"key":"10140_CR5","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nri3552","volume":"13","author":"RS Hotchkiss","year":"2013","unstructured":"Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862\u2013874","journal-title":"Nat Rev Immunol"},{"key":"10140_CR6","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2017.36","volume":"17","author":"T van der Poll","year":"2017","unstructured":"van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG (2017) The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol 17:407\u2013420","journal-title":"Nat Rev Immunol"},{"key":"10140_CR7","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","volume":"140","author":"O Takeuchi","year":"2010","unstructured":"Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805\u2013820","journal-title":"Cell"},{"key":"10140_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.immuni.2017.06.020","volume":"47","author":"F Di Virgilio","year":"2017","unstructured":"Di Virgilio F, Dal Ben D, Sarti AC, Bhondoekhan AC, Bhondoekhan S (2017) The P2X7 receptor in infection and inflammation. Immunity 47:15\u201331","journal-title":"Immunity"},{"key":"10140_CR9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fphar.2018.00052","volume":"9","author":"LEB Savio","year":"2018","unstructured":"Savio LEB, de Andra Mello P, da Silva CG, Coutinho-Silva R (2018) The P2X7 receptor in inflammatory diseases: angel or demon? Front Pharmacol 9:52","journal-title":"Front Pharmacol"},{"key":"10140_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1159\/000371388","volume":"7","author":"PT Santana","year":"2015","unstructured":"Santana PT, Martel J, Bhondoekhan HC et al (2015) The P2X7 receptor contributes to the development of the exacerbated inflammatory response associated with sepsis. J Innate Immun 7:417\u2013427","journal-title":"J Innate Immun"},{"key":"10140_CR11","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nature13085","volume":"509","author":"M Idzko","year":"2014","unstructured":"Idzko M, Ferrari D, Eltzschig HK (2014) Nucleotide signalling during inflammation. Nature 509:310\u2013317","journal-title":"Nature"},{"key":"10140_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nri.2016.4","volume":"16","author":"C Cekic","year":"2016","unstructured":"Cekic C, Linden J (2016) Purinergic regulation of the immune system. Nat Rev Immunol 16:177\u2013192","journal-title":"Nat Rev Immunol"},{"key":"10140_CR13","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.bcp.2017.12.021","volume":"151","author":"E Adinolfi","year":"2018","unstructured":"Adinolfi E, Giuliani AL, De Marchi E, Pegoraro A, Orioli E, Di Virgilio F (2018) The P2X7 receptor: a main player in inflammation. Biochem Pharmacol 151:234\u2013244","journal-title":"Biochem Pharmacol"},{"key":"10140_CR14","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.2174\/0929867324666170303161659","volume":"24","author":"E Orioli","year":"2017","unstructured":"Orioli E, De Marchi E, Giuliani AL, Adinolfi E (2017) P2X7 receptor orchestrates multiple signalling pathways triggering inflammation, autophagy and metabolic\/trophic responses. Curr Med Chem 24:2261\u20132275","journal-title":"Curr Med Chem"},{"key":"10140_CR15","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/s41420-021-00729-0","volume":"7","author":"G Wang","year":"2021","unstructured":"Wang G, Jin S, Huang W et al (2021) LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome. Cell Death Discov 7:322","journal-title":"Cell Death Discov"},{"key":"10140_CR16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s10020-018-0006-9","volume":"24","author":"S Li","year":"2018","unstructured":"Li S, Liang F, Kwan K et al (2018) Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity. Mol Med 24:8","journal-title":"Mol Med"},{"key":"10140_CR17","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1053\/gast.2002.35391","volume":"123","author":"PL Sappington","year":"2002","unstructured":"Sappington PL, Yang R, Yang H et al (2002) HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology 123:790\u2013802","journal-title":"Gastroenterology"},{"key":"10140_CR18","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV, Deng M, Bhondoekhan JP (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19:477\u2013489","journal-title":"Nat Rev Immunol"},{"key":"10140_CR19","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2016.58","volume":"16","author":"P Broz","year":"2016","unstructured":"Broz P, Dixit VM (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 16:407\u2013420","journal-title":"Nat Rev Immunol"},{"key":"10140_CR20","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"J Shi","year":"2015","unstructured":"Shi J, Zhao Y, Wang K et al (2015) Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526:660\u2013665","journal-title":"Nature"},{"key":"10140_CR21","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature15541","volume":"526","author":"N Kayagaki","year":"2015","unstructured":"Kayagaki N, Stowe IB, Lee BL et al (2015) Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526:666\u2013671","journal-title":"Nature"},{"key":"10140_CR22","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","volume":"82","author":"RA North","year":"2002","unstructured":"North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013\u20131067","journal-title":"Physiol Rev"},{"key":"10140_CR23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1146\/annurev.physiol.70.113006.100630","volume":"71","author":"A Surprenant","year":"2009","unstructured":"Surprenant A, North RA (2009) Signaling at purinergic P2X receptors. Annu Rev Physiol 71:333\u2013359","journal-title":"Annu Rev Physiol"},{"key":"10140_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11302-011-9215-1","volume":"7","author":"HM Costa-Junior","year":"2011","unstructured":"Costa-Junior HM, Sarmento Vieira F, Coutinho-Silva R (2011) C terminus of the P2X7 receptor: treasure hunting. Purinergic Signal 7:7\u201319","journal-title":"Purinergic Signal"},{"key":"10140_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature11010","volume":"485","author":"M Hattori","year":"2012","unstructured":"Hattori M, Gouaux E (2012) Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature 485:207\u2013212","journal-title":"Nature"},{"key":"10140_CR26","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.cell.2019.09.017","volume":"179","author":"AE McCarthy","year":"2019","unstructured":"McCarthy AE, Bhondoekhan C, Bhondoekhan SE (2019) Full-length P2X7 structures reveal how palmitoylation prevents channel desensitization. Cell 179:659\u2013670","journal-title":"Cell"},{"key":"10140_CR27","doi-asserted-by":"publisher","first-page":"6673","DOI":"10.3390\/ijms25126673","volume":"25","author":"A Pegoraro","year":"2024","unstructured":"Pegoraro A, Grignolo M, Ruo L, Ricci L, Adinolfi E (2024) P2X7 variants in pathophysiology. Int J Mol Sci 25:6673","journal-title":"Int J Mol Sci"},{"key":"10140_CR28","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","volume":"38","author":"R Mu\u00f1oz-Planillo","year":"2013","unstructured":"Mu\u00f1oz-Planillo R, Kuffa P, Bhondoekhan G, Franchi L, N\u00fa\u00f1ez G (2013) K\u207a efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 38:1142\u20131153","journal-title":"Immunity"},{"key":"10140_CR29","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1002\/eji.201646557","volume":"46","author":"J Rivers-Auty","year":"2016","unstructured":"Rivers-Auty J, Bhondoekhan D (2016) Potassium efflux fires the canon: potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. Eur J Immunol 46:2749\u20132752","journal-title":"Eur J Immunol"},{"key":"10140_CR30","doi-asserted-by":"crossref","unstructured":"Ren, R., Guo, J., Chen, Y., Zhang, Y., Chen, L., & Xiong, W. (2021). The role of Ca2+\/Calcineurin\/NFAT signalling pathway in osteoblastogenesis. Cell Proliferation, 54(11), e13122.","DOI":"10.1111\/cpr.13122"},{"key":"10140_CR31","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.tcb.2018.01.005","volume":"28","author":"F Di Virgilio","year":"2018","unstructured":"Di Virgilio F, Schmalzing G, Markwardt F (2018) The elusive P2X7 macropore. Trends Cell Biol 28:392\u2013404","journal-title":"Trends Cell Biol"},{"key":"10140_CR32","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11302-009-9141-7","volume":"5","author":"P Pelegrin","year":"2009","unstructured":"Pelegrin P, Surprenant A (2009) The P2X7 receptor-pannexin connection to dye uptake and IL-1\u03b2 release. Purinergic Signal 5:129\u2013137","journal-title":"Purinergic Signal"},{"key":"10140_CR33","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.4049\/jimmunol.176.7.3877","volume":"176","author":"D Ferrari","year":"2006","unstructured":"Ferrari D, Pizzirani C, Adinolfi E et al (2006) The P2X7 receptor: a key player in IL-1 processing and release. J Immunol 176:3877\u20133883","journal-title":"J Immunol"},{"key":"10140_CR34","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1038\/s41467-019-10626-x","volume":"10","author":"JJ Mart\u00ednez-Garc\u00eda","year":"2019","unstructured":"Mart\u00ednez-Garc\u00eda JJ, Mart\u00ednez-Banaclocha H, Angosto-Bazarra D et al (2019) P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis. Nat Commun 10:2711","journal-title":"Nat Commun"},{"key":"10140_CR35","doi-asserted-by":"publisher","first-page":"114385","DOI":"10.1016\/j.bcp.2020.114385","volume":"187","author":"P Pelegrin","year":"2021","unstructured":"Pelegrin P (2021) P2X7 receptor and the NLRP3 inflammasome: partners in crime. Biochem Pharmacol 187:114385","journal-title":"Biochem Pharmacol"},{"key":"10140_CR36","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","volume":"157","author":"M Lamkanfi","year":"2014","unstructured":"Lamkanfi M, Dixit VM (2014) Mechanisms and functions of inflammasomes. Cell 157:1013\u20131022","journal-title":"Cell"},{"key":"10140_CR37","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","volume":"156","author":"A Lu","year":"2014","unstructured":"Lu A, Magupalli VG, Ruan J et al (2014) Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 156:1193\u20131206","journal-title":"Cell"},{"key":"10140_CR38","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1038\/ncomms11929","volume":"7","author":"MS Dick","year":"2016","unstructured":"Dick MS, Sborgi L, R\u00fchl S et al (2016) ASC filament formation serves as a signal amplification mechanism for inflammasomes. Nat Commun 7:11929","journal-title":"Nat Commun"},{"key":"10140_CR39","doi-asserted-by":"publisher","first-page":"787","DOI":"10.4049\/jimmunol.0901363","volume":"183","author":"FG Bauernfeind","year":"2009","unstructured":"Bauernfeind FG, Horvath G, Stutz A et al (2009) Cutting edge: NF-\u03baB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation. J Immunol 183:787\u2013791","journal-title":"J Immunol"},{"key":"10140_CR40","doi-asserted-by":"publisher","first-page":"36617","DOI":"10.1074\/jbc.M112.407130","volume":"287","author":"C Juliana","year":"2012","unstructured":"Juliana C, Fernandes-Alnemri t, Kang S et al (2012) Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem 287:36617\u201336622","journal-title":"J Biol Chem"},{"key":"10140_CR41","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.molcel.2017.08.017","volume":"68","author":"N Song","year":"2017","unstructured":"Song N, Liu ZS, Xue W et al (2017) NLRP3 phosphorylation is an essential priming event for inflammasome activation. Mol Cell 68:185\u2013197","journal-title":"Mol Cell"},{"key":"10140_CR42","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/ni.1631","volume":"9","author":"V Hornung","year":"2008","unstructured":"Hornung V, Bauernfeind F, Halle A et al (2008) Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9:847\u2013856","journal-title":"Nat Immunol"},{"key":"10140_CR43","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, Yazdi AS et al (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469:221\u2013225","journal-title":"Nature"},{"key":"10140_CR44","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","volume":"36","author":"K Shimada","year":"2012","unstructured":"Shimada K, Crother TR et al (2012) Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36:401\u2013414","journal-title":"Immunity"},{"key":"10140_CR45","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41586-018-0761-3","volume":"559","author":"J Chen","year":"2018","unstructured":"Chen J, Chen ZJ (2018) Ptdins4p on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature 559:71\u201376","journal-title":"Nature"},{"key":"10140_CR46","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/nature16959","volume":"530","author":"Y He","year":"2016","unstructured":"He Y, Zeng MY et al (2016) NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530:354\u2013357","journal-title":"Nature"},{"key":"10140_CR47","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/ni.3333","volume":"17","author":"H Shi","year":"2016","unstructured":"Shi H, Wang Y, Li X et al (2016) NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7. Nat Immunol 17:250\u2013258","journal-title":"Nat Immunol"},{"key":"10140_CR48","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature10558","volume":"479","author":"N Kayagaki","year":"2011","unstructured":"Kayagaki N, Warming S, Lamkanfi M et al (2011) Non-canonical inflammasome activation targets caspase-11. Nature 479:117\u2013121","journal-title":"Nature"},{"key":"10140_CR49","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature13683","volume":"514","author":"J Shi","year":"2014","unstructured":"Shi J, Zhao Y, Wang Y et al (2014) Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514:187\u2013192","journal-title":"Nature"},{"key":"10140_CR50","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.immuni.2016.01.012","volume":"44","author":"MM Gaidt","year":"2016","unstructured":"Gaidt MM, Ebert TS, Chauhan D et al (2016) Human monocytes engage an alternative inflammasome pathway. Immunity 44:833\u2013846","journal-title":"Immunity"},{"key":"10140_CR51","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","volume":"7","author":"T Bergsbaken","year":"2009","unstructured":"Bergsbaken T, Fink SL, Cookson BT (2009) Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 7:99\u2013109","journal-title":"Nat Rev Microbiol"},{"key":"10140_CR52","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nature18590","volume":"535","author":"J Ding","year":"2016","unstructured":"Ding J, Wang K, Liu W et al (2016) Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535:111\u2013116","journal-title":"Nature"},{"key":"10140_CR53","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nature18629","volume":"535","author":"X Liu","year":"2016","unstructured":"Liu X, Zhang Z, Ruan J et al (2016) Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535:153\u2013158","journal-title":"Nature"},{"key":"10140_CR54","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.immuni.2017.11.013","volume":"48","author":"CL Evavold","year":"2018","unstructured":"Evavold CL, Ruan J et al (2018) The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages. Immunity 48:35\u201344","journal-title":"Immunity"},{"key":"10140_CR55","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1126\/science.aar7607","volume":"362","author":"S R\u00fchl","year":"2018","unstructured":"R\u00fchl S, Shkarina K, Demarco B et al (2018) ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation. Science 362:956\u2013960","journal-title":"Science"},{"key":"10140_CR56","doi-asserted-by":"publisher","first-page":"e12449","DOI":"10.1111\/jpi.12449","volume":"64","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Li X, Grailer JJ et al (2018) Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. J Pineal Res 64:e12449","journal-title":"J Pineal Res"},{"key":"10140_CR57","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1172\/JCI94495","volume":"127","author":"KT Cheng","year":"2017","unstructured":"Cheng KT, Xiong S, Ye Z et al (2017) Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest 127:4124\u20134135","journal-title":"J Clin Invest"},{"issue":"10","key":"10140_CR58","doi-asserted-by":"publisher","first-page":"e1039","DOI":"10.1002\/iid3.1039","volume":"11","author":"Y Wen","year":"2023","unstructured":"Wu, W., Lan, W., Jiao, X., Wang, K., Deng, Y., Chen, R., ... & Li, J. (2025). Pyroptosis in sepsis-associated acute kidney injury: mechanisms and therapeutic perspectives. Critical Care, 29(1), 168.","journal-title":"Immunity Inflamm Dis"},{"key":"10140_CR59","doi-asserted-by":"crossref","unstructured":"Wei XB, Fu YB, Xu J et al (2021) Melatonin alleviates lipopolysaccharide-induced myocardial injury by inhibiting inflammation and pyroptosis in cardiomyocytes. Ann Transl Med 9(5):413","DOI":"10.21037\/atm-20-8196"},{"key":"10140_CR60","doi-asserted-by":"publisher","first-page":"121875","DOI":"10.1016\/j.lfs.2023.121875","volume":"329","author":"H \u00dcst\u00fcnda\u011f","year":"2023","unstructured":"\u00dcst\u00fcnda\u011f H, Do\u011fanay S, Dan\u0131\u015fman F et al (2023) A new treatment approach: melatonin and ascorbic acid synergy shields against sepsis-induced heart and kidney damage in male rats. Life Sci 329:121875","journal-title":"Life Sci"},{"key":"10140_CR61","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.1096\/fj.15-272450","volume":"29","author":"B Cs\u00f3ka","year":"2015","unstructured":"Cs\u00f3ka B, N\u00e9meth ZH, T\u00f6ro G et al (2015) Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing. FASEB J 29:3626\u20133637","journal-title":"FASEB J"},{"key":"10140_CR62","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.jhep.2017.05.021","volume":"67","author":"LEB Savio","year":"2017","unstructured":"Savio LEB, de Andrade MP, Figliuolo VR et al (2017) CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury. J Hepatol 67:716\u2013726","journal-title":"J Hepatol"},{"key":"10140_CR63","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.coph.2019.02.012","volume":"47","author":"E Adinolfi","year":"2019","unstructured":"Adinolfi E, De Marchi E, Orioli E (2019) Role of the P2X7 receptor in tumor-associated inflammation. Curr Opin Pharmacol 47:59\u201364","journal-title":"Curr Opin Pharmacol"},{"key":"10140_CR64","doi-asserted-by":"publisher","first-page":"e60849","DOI":"10.7554\/eLife.60849","volume":"9","author":"C Alarc\u00f3n-Vila","year":"2020","unstructured":"Alarc\u00f3n-Vila C, Baroja Mazo A, de Torre-Minguela C et al (2020) CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis. eLife 9:e60849","journal-title":"eLife"},{"key":"10140_CR65","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s11302-020-09746-7","volume":"16","author":"ML Larrouyet-Sarto","year":"2020","unstructured":"Larrouyet-Sarto ML, Tamura AS, Alves VS et al (2020) P2X7 receptor deletion attenuates oxidative stress and liver damage in sepsis. Purinergic Signal 16:561\u2013572","journal-title":"Purinergic Signal"},{"key":"10140_CR66","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s11302-023-09936-z","volume":"19","author":"S Ozkanlar","year":"2023","unstructured":"Ozkanlar S, Ulas N, Kaynar O et al (2023) P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats. Purinergic Signal 19:699\u2013707","journal-title":"Purinergic Signal"},{"key":"10140_CR67","doi-asserted-by":"crossref","unstructured":"Molina-L\u00f3pez, C., Hurtado-Navarro, L., Garc\u00eda, C. J., Angosto-Bazarra, D., Vallejo, F., Tapia-Abell\u00e1n, A., ... & Pelegrin, P. (2024). Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1\u03b2 production. Nature communications, 15(1), 1096.","DOI":"10.1038\/s41467-024-44990-0"},{"key":"10140_CR68","doi-asserted-by":"crossref","unstructured":"Arulkumaran, N., Unwin, R. J., & Tam, F. W. (2011). A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases. Expert opinion on investigational drugs, 20(7), 897-915.","DOI":"10.1517\/13543784.2011.578068"},{"key":"10140_CR69","doi-asserted-by":"publisher","first-page":"e3261","DOI":"10.1002\/jgm.3261","volume":"22","author":"Z Zou","year":"2020","unstructured":"Zou Z, Wang Q, Zhou M et al (2020) Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression. J Gene Med 22:e3261","journal-title":"J Gene Med"},{"key":"10140_CR70","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1111\/1440-1681.13780","volume":"50","author":"H \u00dcst\u00fcnda\u011f","year":"2023","unstructured":"\u00dcst\u00fcnda\u011f H, Demir \u00d6, \u00c7i\u00e7ek B, Huyut MT, Y\u00fcce N, Tavac\u0131 T (2023) Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: an experimental study. Clin Exp Pharmacol Physiol 50:634\u2013646","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10140_CR71","doi-asserted-by":"publisher","first-page":"e13622","DOI":"10.14814\/phy2.13622","volume":"6","author":"N Arulkumaran","year":"2018","unstructured":"Arulkumaran N et al (2018) P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis. Physiol Rep 6:e13622","journal-title":"Physiol Rep"},{"key":"10140_CR72","doi-asserted-by":"crossref","unstructured":"Arulkumaran, N., Sixma, M. L., Pollen, S., Ceravola, E., Jentho, E., Prendecki, M., ... & Singer, M. (2018). P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis. Physiological Reports, 6(5), e13622.","DOI":"10.14814\/phy2.13622"},{"key":"10140_CR73","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Yuan, F., Cao, X., Zhai, Z., Du, X., Wang, Y., ... & Hou, W. (2014). P2X7 receptor blockade protects against cisplatin-induced nephrotoxicity in mice by decreasing the activities of inflammasome components, oxidative stress and caspase-3. Toxicology and applied pharmacology, 281(1), 1-10.","DOI":"10.1016\/j.taap.2014.09.016"},{"key":"10140_CR74","doi-asserted-by":"publisher","first-page":"115497","DOI":"10.1016\/j.biopha.2023.115497","volume":"167","author":"H Zhang","year":"2023","unstructured":"Zhang H, Liao J, Jin L et al (2023) NLRP3 inflammasome involves in the pathophysiology of sepsis-induced myocardial dysfunction by multiple mechanisms. Biomed Pharmacother 167:115497","journal-title":"Biomed Pharmacother"},{"key":"10140_CR75","doi-asserted-by":"publisher","first-page":"6459","DOI":"10.1007\/s12035-016-0168-9","volume":"54","author":"LEB Savio","year":"2017","unstructured":"Savio LEB, Andrade MGJ, de Andrade MP et al (2017) P2X7 receptor signaling contributes to sepsis-associated brain dysfunction. Mol Neurobiol 54:6459\u20136470","journal-title":"Mol Neurobiol"},{"key":"10140_CR76","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/s10753-018-0894-4","volume":"42","author":"Q Fu","year":"2019","unstructured":"Fu Q, Wu J, Zhou XY et al (2019) NLRP3\/caspase-1 pathway-induced pyroptosis mediated cognitive deficits in a mouse model of sepsis-associated encephalopathy. Inflammation 42:306\u2013318","journal-title":"Inflammation"},{"issue":"1","key":"10140_CR77","doi-asserted-by":"publisher","first-page":"4364","DOI":"10.1038\/s41598-017-04231-5","volume":"7","author":"X Wu","year":"2017","unstructured":"Wu X, Ren J, Chen G et al (2017) Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption. Sci Rep 7(1):4364","journal-title":"Sci Rep"},{"key":"10140_CR78","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nm.3806","volume":"21","author":"RC Coll","year":"2015","unstructured":"Coll RC, Robertson AA, Chae JJ et al (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med 21:248\u2013255","journal-title":"Nat Med"},{"key":"10140_CR79","doi-asserted-by":"crossref","unstructured":"Vande Walle, L., Stowe, I. B., \u0160\u00e1cha, P., Lee, B. L., Demon, D., Fossoul, A., ... & Lamkanfi, M. (2019). MCC950\/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition. PLoS biology, 17(9), e3000354.","DOI":"10.1371\/journal.pbio.3000354"},{"key":"10140_CR80","doi-asserted-by":"publisher","first-page":"5247","DOI":"10.1007\/s12035-020-02089-9","volume":"57","author":"LG Danielski","year":"2020","unstructured":"Danielski LG, Giustina AD, Bonfante S et al (2020) NLRP3 activation contributes to acute brain damage leading to memory impairment in sepsis-surviving rats. Mol Neurobiol 57:5247\u20135262","journal-title":"Mol Neurobiol"},{"key":"10140_CR81","doi-asserted-by":"publisher","first-page":"5974","DOI":"10.4049\/jimmunol.1400368","volume":"192","author":"JJ Grailer","year":"2014","unstructured":"Grailer JJ, Canning BA, Kalbitz M et al (2014) Critical role for the NLRP3 inflammasome during acute lung injury. J Immunol 192:5974\u20135983","journal-title":"J Immunol"},{"key":"10140_CR82","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrd.2018.97","volume":"17","author":"MS Mangan","year":"2018","unstructured":"Mangan MS, Olhava EJ, Roush WR et al (2018) Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov 17:588\u2013606","journal-title":"Nat Rev Drug Discov"},{"key":"10140_CR83","doi-asserted-by":"publisher","first-page":"1345625","DOI":"10.3389\/fimmu.2024.1345625","volume":"15","author":"H Zheng","year":"2024","unstructured":"Zheng H, Liu Q, Zhou S, Luo H, Zhang W (2024) Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases. Front Immunol 15:1345625","journal-title":"Front Immunol"},{"key":"10140_CR84","doi-asserted-by":"publisher","first-page":"1450704","DOI":"10.3389\/fphar.2024.1450704","volume":"15","author":"X Liu","year":"2024","unstructured":"Liu X, Li Y, Huang L et al (2024) Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders. Front Pharmacol 15:1450704","journal-title":"Front Pharmacol"},{"key":"10140_CR85","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1038\/s41467-018-04947-6","volume":"9","author":"H He","year":"2018","unstructured":"He H, Jiang H, Chen Y et al (2018) Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun 9:2550","journal-title":"Nat Commun"},{"key":"10140_CR86","doi-asserted-by":"publisher","first-page":"E1530","DOI":"10.1073\/pnas.1716095115","volume":"115","author":"C Marchetti","year":"2018","unstructured":"Marchetti C, Swartzwelter B, Gamboni F et al (2018) OLT1177, a \u03b2-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome. Proc Natl Acad Sci USA 115:E1530\u2013E1539","journal-title":"Proc Natl Acad Sci USA"},{"key":"10140_CR87","doi-asserted-by":"publisher","first-page":"e8689","DOI":"10.15252\/emmm.201708689","volume":"10","author":"Y Huang","year":"2018","unstructured":"Huang Y, Jiang H, Chen Y et al (2018) Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol Med 10:e8689","journal-title":"EMBO Mol Med"},{"key":"10140_CR88","doi-asserted-by":"publisher","first-page":"768","DOI":"10.3892\/mmr.2016.6070","volume":"15","author":"XH Wang","year":"2017","unstructured":"Wang XH, Xie H, Luo X et al (2017) Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson\u2019s disease. Mol Med Rep 15:768\u2013776","journal-title":"Mol Med Rep"},{"key":"10140_CR89","doi-asserted-by":"publisher","first-page":"174235","DOI":"10.1016\/j.ejphar.2021.174235","volume":"906","author":"A Mishra","year":"2021","unstructured":"Mishra A, Behura A, Kumar A et al (2021) P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases. Eur J Pharmacol 906:174235","journal-title":"Eur J Pharmacol"},{"key":"10140_CR90","doi-asserted-by":"crossref","unstructured":"Ozkanlar, S., Ulas, N., Kaynar, O., & Satici, E. (2023). P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats. Purinergic Signalling, 19(4), 699-707.","DOI":"10.1007\/s11302-023-09936-z"},{"key":"10140_CR91","doi-asserted-by":"crossref","unstructured":"Park, J. H., & Kim, Y. C. (2017). P2X7 receptor antagonists: a patent review (2010\u20132015). Expert opinion on therapeutic patents, 27(3), 257-267.","DOI":"10.1080\/13543776.2017.1246538"},{"key":"10140_CR92","doi-asserted-by":"crossref","unstructured":"Jacobson, K. A. (2023). Development of Purinergic Receptor Agonists and Antagonists. In Purinergic Signaling in Neurodevelopment, Neuroinflammation and Neurodegeneration (pp. 339-358). Cham: Springer International Publishing.","DOI":"10.1007\/978-3-031-26945-5_14"},{"key":"10140_CR93","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/CCM.0000000000001402","volume":"44","author":"B Shakoory","year":"2016","unstructured":"Shakoory B, Carcillo JA, Chatham WW et al (2016) Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial. Crit Care Med 44:275\u2013281","journal-title":"Crit Care Med"},{"key":"10140_CR94","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1038\/s41591-021-01499-z","volume":"27","author":"E Kyriazopoulou","year":"2021","unstructured":"Kyriazopoulou E, Poulakou G, Milionis H et al (2021) Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial. Nat Med 27:1752\u20131760","journal-title":"Nat Med"},{"key":"10140_CR95","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","volume":"21","author":"JJ Hu","year":"2020","unstructured":"Hu JJ, Liu X, Xia S et al (2020) FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol 21:736\u2013745","journal-title":"Nat Immunol"},{"key":"10140_CR96","doi-asserted-by":"publisher","first-page":"5460302","DOI":"10.1155\/2016\/5460302","volume":"2016","author":"J T\u0151zs\u00e9r","year":"2016","unstructured":"T\u0151zs\u00e9r J, Bhondoekhan S (2016) Natural compounds as regulators of NLRP3 inflammasome-mediated IL-1\u03b2 production. Mediators Inflamm 2016:5460302","journal-title":"Mediators Inflamm"},{"key":"10140_CR97","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","volume":"25","author":"WT He","year":"2015","unstructured":"He WT, Wan H, Hu L et al (2015) Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion. Cell Res 25:1285\u20131298","journal-title":"Cell Res"},{"key":"10140_CR98","doi-asserted-by":"publisher","first-page":"104921","DOI":"10.1016\/j.phrs.2020.104921","volume":"159","author":"S Hasanzadeh","year":"2020","unstructured":"Hasanzadeh S, Read MI et al (2020) Curcumin: an inflammasome silencer. Pharmacol Res 159:104921","journal-title":"Pharmacol Res"},{"key":"10140_CR99","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1002\/jcp.24903","volume":"230","author":"YP Chang","year":"2015","unstructured":"Chang YP, Ka SM, Hsu WH et al (2015) Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy. J Cell Physiol 230:1567\u20131579","journal-title":"J Cell Physiol"},{"key":"10140_CR100","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/sc.2015.227","volume":"54","author":"W Jiang","year":"2016","unstructured":"Jiang W, Huang Y, Han N et al (2016) Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury. Spinal Cord 54:592\u2013596","journal-title":"Spinal Cord"},{"key":"10140_CR101","doi-asserted-by":"publisher","first-page":"107412","DOI":"10.1016\/j.intimp.2021.107412","volume":"93","author":"C Zhang","year":"2021","unstructured":"Zhang C, Li X, Hu X et al (2021) Epigallocatechin-3-gallate prevents inflammation and diabetes-induced glucose tolerance through inhibition of NLRP3 inflammasome activation. Int Immunopharmacol 93:107412","journal-title":"Int Immunopharmacol"},{"key":"10140_CR102","doi-asserted-by":"publisher","first-page":"5658","DOI":"10.1039\/D1FO01154E","volume":"12","author":"ZL Luo","year":"2021","unstructured":"Luo ZL, Sun HY, Wu XB et al (2021) Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation. Food Funct 12:5658\u20135667","journal-title":"Food Funct"},{"key":"10140_CR103","doi-asserted-by":"crossref","unstructured":"Zhou, Z. J., Dong, J. Y., Qiu, Y., Zhang, G. L., Wei, K., He, L. H., ... & Chen, D. P. (2024). Sulforaphane decreases oxidative stress and inhibits NLRP3 inflammasome activation in a mouse model of ulcerative colitis. Biomedicine & Pharmacotherapy, 175, 116706.","DOI":"10.1016\/j.biopha.2024.116706"},{"key":"10140_CR104","doi-asserted-by":"crossref","unstructured":"Rahim, I., Sayed, R. K., Fern\u00e1ndez-Ortiz, M., Aranda-Mart\u00ednez, P., Guerra-Librero, A., Fernandez-Martinez, J., ... & Acuna-Castroviejo, D. (2021). Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome. Naunyn-Schmiedeberg's archives of pharmacology, 394(2), 261-277.","DOI":"10.1007\/s00210-020-01972-5"},{"key":"10140_CR105","doi-asserted-by":"crossref","unstructured":"Qin, Y., Li, W., Liu, J., Wang, F., Zhou, W., Xiao, L., ... & Zhang, D. (2024). Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE\/PI3K\/AKT\/mTOR pathway. International Immunopharmacology, 139, 112719.","DOI":"10.1016\/j.intimp.2024.112719"},{"key":"10140_CR106","doi-asserted-by":"crossref","unstructured":"Ahmed, S., Kwatra, M., Panda, S. R., Murty, U. S. N., & Naidu, V. G. M. (2021). Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease. Brain, behavior, and immunity, 91, 142-158.","DOI":"10.1016\/j.bbi.2020.09.017"},{"issue":"5","key":"10140_CR107","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1097\/SHK.0000000000002218","volume":"60","author":"H \u00dcst\u00fcnda\u011f","year":"2023","unstructured":"\u00dcst\u00fcnda\u011f H, Kalindemirta\u015f FD, Do\u011fanay S et al (2023) Enhanced efficacy of resveratrol-loaded silver nanoparticle in attenuating sepsis-induced acute liver injury: modulation of inflammation, oxidative stress, and SIRT1 activation. Shock 60(5):688\u2013697","journal-title":"Shock"},{"key":"10140_CR108","doi-asserted-by":"publisher","first-page":"108330","DOI":"10.1016\/j.toxicon.2025.108330","volume":"258","author":"H \u00dcst\u00fcnda\u011f","year":"2025","unstructured":"\u00dcst\u00fcnda\u011f H, Kara A, Ta\u015f NG et al (2025) Alleviation of LPS-induced acute lung injury by propolis-based nanocomposites through the TLR4\/NFKB and P2X7\/AKT pathways: randomized-controlled experimental study. Toxicon 258:108330","journal-title":"Toxicon"},{"issue":"5","key":"10140_CR109","doi-asserted-by":"publisher","first-page":"7521","DOI":"10.1021\/acsami.4c21010","volume":"17","author":"E Wen","year":"2025","unstructured":"Wen E, Tian Y, Fang M et al (2025) The P2X7-mediated mitochondrial ROS as an emerging core target of tuftsin nanoparticles in severe acute pancreatitis therapy via regulating mitophagy. ACS Appl Mater Interfaces 17(5):7521\u20137538","journal-title":"ACS Appl Mater Interfaces"},{"issue":"11","key":"10140_CR110","doi-asserted-by":"publisher","first-page":"4960","DOI":"10.1002\/tox.24369","volume":"39","author":"S Yakut","year":"2024","unstructured":"Yakut S, Gelen V, Kara H, \u00d6zkanlar S, Ye\u015filda\u011f A (2024) Silver nanoparticles loaded with oleuropein alleviates LPS-induced acute lung injury by modulating the TLR4\/P2X7 receptor-mediated inflammation and apoptosis in rats. Environ Toxicol 39(11):4960\u20134973","journal-title":"Environ Toxicol"},{"key":"10140_CR111","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1001\/jama.2019.5791","volume":"321","author":"CW Seymour","year":"2019","unstructured":"Seymour CW, Kennedy JN, Wang S et al (2019) Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis. JAMA 321:2003\u20132017","journal-title":"JAMA"},{"key":"10140_CR112","doi-asserted-by":"crossref","unstructured":"Wang, W., & Liu, C. F. (2023). Sepsis heterogeneity. World Journal of Pediatrics, 19(10), 919-927.","DOI":"10.1007\/s12519-023-00689-8"},{"key":"10140_CR113","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Zhang, X., Wang, Z., Zhang, R., Wei, H., Yan, X., ... & Yang, L. (2024). MCC950 as a promising candidate for blocking NLRP3 inflammasome activation: A review of preclinical research and future directions. Archiv der Pharmazie, 357(11), e2400459.","DOI":"10.1002\/ardp.202400459"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10140-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-026-10140-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10140-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:02:14Z","timestamp":1777654934000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-026-10140-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":113,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10140"],"URL":"https:\/\/doi.org\/10.1007\/s11302-026-10140-y","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"assertion":[{"value":"4 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"In this manuscript, AI was only used to check grammar and spelling.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of generative AI and AI-assisted technology in the writing process"}}],"article-number":"26"}}