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The dysfunctional endothelial cells are a hallmark event that contributes to intestinal and liver damage mainly due to an increased monocyte adhesion, but the elevated morbidity unveils the lack of knowledge about disease pathogenesis. Purinergic P2Y\n                    <jats:sub>6<\/jats:sub>\n                    receptor (P2Y\n                    <jats:sub>6<\/jats:sub>\n                    R) expression is induced in some inflammatory models; therefore, we hypothesized that endothelial P2Y\n                    <jats:sub>6<\/jats:sub>\n                    R contributes to monocyte adhesion and mesenteric inflammation in\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    -infected mice. Our results show that, unlike control mice, P2Y\n                    <jats:sub>6<\/jats:sub>\n                    R stimulation failed to enhance monocyte adhesion to endothelial cells from infected animals. Molecular analyses using RT-qPCR and immunocytochemistry revealed significant downregulation of P2Y\n                    <jats:sub>6<\/jats:sub>\n                    R expression in endothelial cells from the infected group at both transcript and protein levels. Importantly, pretreatment with a proteasome inhibitor restored both P2Y\n                    <jats:sub>6<\/jats:sub>\n                    R expression and function, implicating proteasomal degradation as a key mechanism underlying receptor loss during infection. Elevated lipid peroxidation in endothelial cells from the infected group further supported a role for reactive oxygen species (ROS)-dependent proteasome activation and receptor degradation. Collectively, these findings suggest that infection selectively modulates P2Y\n                    <jats:sub>6<\/jats:sub>\n                    R signaling by promoting proteasome-dependent downregulation of P2Y\n                    <jats:sub>6<\/jats:sub>\n                    R in endothelial cells, which could be an adaptive mechanism to reduce mesenteric inflammation and limit host tissue damage and morbidity during chronic infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s11302-026-10141-x","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:24:26Z","timestamp":1774347866000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteasomal-dependent endothelial P2Y6 receptor downregulation as an adaptive mechanism limiting monocyte adhesion during intestinal schistosomiasis"],"prefix":"10.1007","volume":"22","author":[{"given":"Nathalia F.","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus M. 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