{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:13:48Z","timestamp":1777914828102,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2024zd029"],"award-info":[{"award-number":["2024zd029"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2024JDHJ0043, 2025YFHZ0121"],"award-info":[{"award-number":["2024JDHJ0043, 2025YFHZ0121"]}]},{"name":"Sino-German Centre","award":["GZ919, M-0679"],"award-info":[{"award-number":["GZ919, M-0679"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Previous studies have suggested that running exerts anti-tumor effects on various cancers through multiple pathways. It has been reported that the P2X7 receptor (P2X7R) may display anti-tumor activity in cervical cancer cells, and running can regulate P2X7R expression and function in mice. However, the specific impact of running on cervical cancer and whether its underlying mechanism is associated with the regulation of P2X7R levels remains to be elucidated. In this study, mice bearing U14 cervical cancer tumors were used as a model to explore the association between running and P2X7R in cervical cancer. The results showed that running significantly inhibited tumor progression in mice, accompanied by an increase in P2X7R protein expression in tumor tissues. Additionally, treatment with the P2X7R antagonist JNJ-47965567 alone or in combination with running intervention promoted tumor growth and attenuated the anti-tumor effect of running. In contrast, the P2X7R agonist BzATP alone or combined with running intervention exerted anti-tumor effects and enhanced the anti-tumor effect of running. In conclusion, the present findings suggest only a pharmacological association between P2X7R and the anti-tumor effect of running against cervical cancer progression, given that genetic validation was not performed in this study. The potential involvement of immune mechanisms remains an inference and requires further experimental validation. As a possible therapeutic target, P2X7R provides supportive data for the treatment of cervical cancer and the clinical exploration of running as an adjuvant intervention.<\/jats:p>","DOI":"10.1007\/s11302-026-10143-9","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:11:25Z","timestamp":1776237085000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["P2X7\u00a0receptor mediates the anti-tumor effect of running on cervical cancer in mice"],"prefix":"10.1007","volume":"22","author":[{"given":"Hai-Yun","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Rubini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Illes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"10143_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71:209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"10143_CR2","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1016\/S2214-109X(22)00501-0","volume":"11","author":"D Singh","year":"2023","unstructured":"Singh D, Vignat J, Lorenzoni V et al (2023) Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Glob Health 11:e197\u2013e206. https:\/\/doi.org\/10.1016\/S2214-109X(22)00501-0","journal-title":"Lancet Glob Health"},{"key":"10143_CR3","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S1470-2045(23)00380-7","volume":"24","author":"K Senior","year":"2023","unstructured":"Senior K (2023) Africa needs to boost HPV vaccine uptake to stem rise in cervical cancer. Lancet Oncol 24:955. https:\/\/doi.org\/10.1016\/S1470-2045(23)00380-7","journal-title":"Lancet Oncol"},{"key":"10143_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02055-2","volume":"23","author":"M Yu","year":"2024","unstructured":"Yu M, Ni M, Xu F et al (2024) NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer. Mol Cancer 23:139. https:\/\/doi.org\/10.1186\/s12943-024-02055-2","journal-title":"Mol Cancer"},{"issue":"6","key":"10143_CR5","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1001\/jamainternmed.2016.1548","volume":"176","author":"SC Moore","year":"2016","unstructured":"Moore SC, Lee I-M, Weiderpass E et al (2016) Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults. JAMA Intern Med 176:816. https:\/\/doi.org\/10.1001\/jamainternmed.2016.1548","journal-title":"JAMA Intern Med"},{"key":"10143_CR6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa2502760","volume":"393","author":"KS Courneya","year":"2025","unstructured":"Courneya KS, Vardy JL, O\u2019Callaghan CJ et al (2025) Structured exercise after adjuvant chemotherapy for colon cancer. N Engl J Med 393:13\u201325. https:\/\/doi.org\/10.1056\/NEJMoa2502760","journal-title":"N Engl J Med"},{"key":"10143_CR7","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1038\/s41591-024-03143-y","volume":"30","author":"AE Hiensch","year":"2024","unstructured":"Hiensch AE, Depenbusch J, Schmidt ME et al (2024) Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial. Nat Med 30:2957\u20132966. https:\/\/doi.org\/10.1038\/s41591-024-03143-y","journal-title":"Nat Med"},{"key":"10143_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare8030260","volume":"8","author":"CW Chang","year":"2020","unstructured":"Chang CW, Yang S-F, Gordon CJ et al (2020) Physical Activity of \u22657.5 MET-h\/Week Is Significantly Associated with a Decreased Risk of Cervical Neoplasia. Healthcare 8:260. https:\/\/doi.org\/10.3390\/healthcare8030260","journal-title":"Healthcare"},{"key":"10143_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-025-01725-z","volume":"18","author":"Y Wang","year":"2025","unstructured":"Wang Y, Malek M (2025) Molecular, cellular, biochemical, and rehabilitative insights into exercise interventions for gynecological cancer prevention and survivorship: a narrative review. J Ovarian Res 18:147. https:\/\/doi.org\/10.1186\/s13048-025-01725-z","journal-title":"J Ovarian Res"},{"key":"10143_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2025.101064","volume":"14","author":"ME Schmidt","year":"2025","unstructured":"Schmidt ME, Goldschmidt S, Kreutz C et al (2025) Effects of aerobic or resistance exercise during neoadjuvant chemotherapy on tumor response and therapy completion in women with breast cancer: the randomized controlled BENEFIT trial. J Sport Health Sci 14:101064. https:\/\/doi.org\/10.1016\/j.jshs.2025.101064","journal-title":"J Sport Health Sci"},{"key":"10143_CR11","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/s41416-025-03129-8","volume":"133","author":"M Harvie","year":"2025","unstructured":"Harvie M, Pegington M, Howell A et al (2025) Randomised phase-2 screening trial of intermittent energy restriction plus resistance exercise versus resistance exercise alone during chemotherapy for advanced breast cancer. Br J Cancer 133:1010\u20131019. https:\/\/doi.org\/10.1038\/s41416-025-03129-8","journal-title":"Br J Cancer"},{"key":"10143_CR12","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.ccell.2022.05.006","volume":"40","author":"E Kurz","year":"2022","unstructured":"Kurz E, Hirsch CA, Dalton T et al (2022) Exercise-induced engagement of the IL-15\/IL-15R\u03b1 axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell 40:720-737.e5. https:\/\/doi.org\/10.1016\/j.ccell.2022.05.006","journal-title":"Cancer Cell"},{"key":"10143_CR13","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.cmet.2016.01.011","volume":"23","author":"L Pedersen","year":"2016","unstructured":"Pedersen L, Idorn M, Olofsson GH et al (2016) Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution. Cell Metab 23:554\u2013562. https:\/\/doi.org\/10.1016\/j.cmet.2016.01.011","journal-title":"Cell Metab"},{"key":"10143_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114697","volume":"43","author":"Z Luo","year":"2024","unstructured":"Luo Z, Mei J, Wang X et al (2024) Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment. Cell Rep 43:114697. https:\/\/doi.org\/10.1016\/j.celrep.2024.114697","journal-title":"Cell Rep"},{"key":"10143_CR15","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.jshs.2023.12.001","volume":"13","author":"F Bettariga","year":"2024","unstructured":"Bettariga F, Taaffe DR, Galv\u00e3o DA et al (2024) Suppressive effects of exercise-conditioned serum on cancer cells: a narrative review of the influence of exercise mode, volume, and intensity. J Sport Health Sci 13:484\u2013498. https:\/\/doi.org\/10.1016\/j.jshs.2023.12.001","journal-title":"J Sport Health Sci"},{"key":"10143_CR16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/ijc.33982","volume":"151","author":"ST Orange","year":"2022","unstructured":"Orange ST, Jordan AR, Odell A et al (2022) Acute aerobic exercise\u2010conditioned serum reduces colon cancer cell proliferation in vitro through interleukin\u20106\u2010induced regulation of DNA damage. Int J Cancer 151:265\u2013274. https:\/\/doi.org\/10.1002\/ijc.33982","journal-title":"Int J Cancer"},{"key":"10143_CR17","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10549-025-07772-w","volume":"213","author":"F Bettariga","year":"2025","unstructured":"Bettariga F, Taaffe DR, Crespo-Garcia C et al (2025) A single bout of resistance or high-intensity interval training increases anti-cancer myokines and suppresses cancer cell growth in vitro in survivors of breast cancer. Breast Cancer Res Treat 213:171\u2013180. https:\/\/doi.org\/10.1007\/s10549-025-07772-w","journal-title":"Breast Cancer Res Treat"},{"key":"10143_CR18","doi-asserted-by":"publisher","first-page":"5680","DOI":"10.1016\/j.cell.2025.06.018","volume":"188","author":"CM Phelps","year":"2025","unstructured":"Phelps CM, Willis NB, Duan T et al (2025) Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy. Cell 188:5680-5700.e28. https:\/\/doi.org\/10.1016\/j.cell.2025.06.018","journal-title":"Cell"},{"key":"10143_CR19","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1056\/NEJMra1205750","volume":"367","author":"HK Eltzschig","year":"2012","unstructured":"Eltzschig HK, Sitkovsky MV, Robson SC (2012) Purinergic signaling during inflammation. N Engl J Med 367:2322\u20132333. https:\/\/doi.org\/10.1056\/NEJMra1205750","journal-title":"N Engl J Med"},{"key":"10143_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1287310","volume":"14","author":"RM Sainz","year":"2023","unstructured":"Sainz RM, Rodriguez-Quintero JH, Maldifassi MC et al (2023) Tumour immune escape via P2X7 receptor signalling. Front Immunol 14:1287310. https:\/\/doi.org\/10.3389\/fimmu.2023.1287310","journal-title":"Front Immunol"},{"key":"10143_CR21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.coph.2019.02.012","volume":"47","author":"E Adinolfi","year":"2019","unstructured":"Adinolfi E, De Marchi E, Orioli E et al (2019) Role of the P2X7 receptor in tumor-associated inflammation. Curr Opin Pharmacol 47:59\u201364. https:\/\/doi.org\/10.1016\/j.coph.2019.02.012","journal-title":"Curr Opin Pharmacol"},{"key":"10143_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228454","volume":"21","author":"M\u00c1 Mart\u00ednez-Cuesta","year":"2020","unstructured":"Mart\u00ednez-Cuesta M\u00c1, Blanch-Ruiz MA, Ortega-Luna R et al (2020) Structural and functional basis for understanding the biological significance of P2X7 receptor. IJMS 21:8454. https:\/\/doi.org\/10.3390\/ijms21228454","journal-title":"IJMS"},{"key":"10143_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.immuni.2017.06.020","volume":"47","author":"F Di Virgilio","year":"2017","unstructured":"Di Virgilio F, Dal Ben D, Sarti AC et al (2017) The P2X7 receptor in infection and inflammation. Immunity 47:15\u201331. https:\/\/doi.org\/10.1016\/j.immuni.2017.06.020","journal-title":"Immunity"},{"key":"10143_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.autneu.2015.04.011","volume":"191","author":"F Di Virgilio","year":"2015","unstructured":"Di Virgilio F, Vuerich M (2015) Purinergic signaling in the immune system. Auton Neurosci 191:117\u2013123. https:\/\/doi.org\/10.1016\/j.autneu.2015.04.011","journal-title":"Auton Neurosci"},{"key":"10143_CR25","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1038\/s41388-019-0684-y","volume":"38","author":"E De Marchi","year":"2019","unstructured":"De Marchi E, Orioli E, Pegoraro A et al (2019) The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment. Oncogene 38:3636\u20133650. https:\/\/doi.org\/10.1038\/s41388-019-0684-y","journal-title":"Oncogene"},{"key":"10143_CR26","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1158\/0008-5472.CAN-11-1947","volume":"72","author":"E Adinolfi","year":"2012","unstructured":"Adinolfi E, Raffaghello L, Giuliani AL et al (2012) Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res 72:2957\u20132969. https:\/\/doi.org\/10.1158\/0008-5472.CAN-11-1947","journal-title":"Cancer Res"},{"key":"10143_CR27","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1158\/0008-5472.CAN-14-1259","volume":"75","author":"E Adinolfi","year":"2015","unstructured":"Adinolfi E, Capece M, Franceschini A et al (2015) Accelerated tumor progression in mice lacking the ATP receptor P2X7. Cancer Res 75:635\u2013644. https:\/\/doi.org\/10.1158\/0008-5472.CAN-14-1259","journal-title":"Cancer Res"},{"key":"10143_CR28","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-025-02932-w","volume":"42","author":"R Zhao","year":"2025","unstructured":"Zhao R, Xue Y, Cao Y et al (2025) Blocking or knockdown of P2X7 receptor inhibits invasion and migration of mouse breast cancer cells via PI3K\/Akt\/GSK-3\u03b2 pathways and EMT. Med Oncol 42:340. https:\/\/doi.org\/10.1007\/s12032-025-02932-w","journal-title":"Med Oncol"},{"key":"10143_CR29","doi-asserted-by":"publisher","first-page":"10830","DOI":"10.1111\/jcmm.15708","volume":"24","author":"C Yang","year":"2020","unstructured":"Yang C, Shi S, Su Y et al (2020) P2X7R promotes angiogenesis and tumour\u2010associated macrophage recruitment by regulating the NF\u2010\u03baB signalling pathway in colorectal cancer cells. J Cell Mol Med 24:10830\u201310841. https:\/\/doi.org\/10.1111\/jcmm.15708","journal-title":"J Cell Mol Med"},{"key":"10143_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04378-0","volume":"12","author":"A Pegoraro","year":"2021","unstructured":"Pegoraro A, De Marchi E, Ferracin M et al (2021) P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells. Cell Death Dis 12:1088. https:\/\/doi.org\/10.1038\/s41419-021-04378-0","journal-title":"Cell Death Dis"},{"key":"10143_CR31","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41568-018-0037-0","volume":"18","author":"F Di Virgilio","year":"2018","unstructured":"Di Virgilio F, Sarti AC, Falzoni S et al (2018) Extracellular ATP and P2 purinergic signalling in the tumour microenvironment. Nat Rev Cancer 18:601\u2013618. https:\/\/doi.org\/10.1038\/s41568-018-0037-0","journal-title":"Nat Rev Cancer"},{"key":"10143_CR32","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s11302-022-09854-6","volume":"19","author":"Y Han","year":"2023","unstructured":"Han Y, Bai C, He X-M, Ren Q-L (2023) P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells. Purinergic Signal 19:145\u2013153. https:\/\/doi.org\/10.1007\/s11302-022-09854-6","journal-title":"Purinergic Signal"},{"key":"10143_CR33","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12880","volume":"48","author":"M Comassi","year":"2018","unstructured":"Comassi M, Santini E, Rossi C et al (2018) The level of physical training modulates cytokine levels through P2X7 receptor in healthy subjects. Eur J Clin Invest 48:e12880. https:\/\/doi.org\/10.1111\/eci.12880","journal-title":"Eur J Clin Invest"},{"key":"10143_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.828020","volume":"13","author":"T Wang","year":"2022","unstructured":"Wang T, Li J, Li H et al (2022) Aerobic exercise inhibited P2X7 purinergic receptors to improve cardiac remodeling in mice with type 2 diabetes. Front Physiol 13:828020. https:\/\/doi.org\/10.3389\/fphys.2022.828020","journal-title":"Front Physiol"},{"key":"10143_CR35","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.045732","volume":"13","author":"C Ruiz-Ruiz","year":"2020","unstructured":"Ruiz-Ruiz C, Garc\u00eda-Magro N, Negredo P et al (2020) Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice. Dis Model Mech 13:dmm045732. https:\/\/doi.org\/10.1242\/dmm.045732","journal-title":"Dis Model Mech"},{"key":"10143_CR36","unstructured":"Riebe D, Ehrman JK, Liguori G eds et al (2018) ACSM\u2019s Guidelines for exercise testing and prescription. 10th edn, Wolters Kluwer, Philadelphia"},{"key":"10143_CR37","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1158\/2326-6066.CIR-20-0499","volume":"9","author":"IL Gomes-Santos","year":"2021","unstructured":"Gomes-Santos IL, Amoozgar Z, Kumar AS et al (2021) Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade. Cancer Immunol Res 9:765\u2013778. https:\/\/doi.org\/10.1158\/2326-6066.CIR-20-0499","journal-title":"Cancer Immunol Res"},{"key":"10143_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1339232","volume":"15","author":"IL Gomes-Santos","year":"2024","unstructured":"Gomes-Santos IL, Kumar AS, Hausmann F et al (2024) Exercise intensity governs tumor control in mice with breast cancer. Front Immunol 15:1339232. https:\/\/doi.org\/10.3389\/fimmu.2024.1339232","journal-title":"Front Immunol"},{"key":"10143_CR39","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1515\/biol-2022-0009","volume":"17","author":"J Li","year":"2022","unstructured":"Li J, Liu L, Cheng Y et al (2022) Swimming attenuates tumor growth in CT-26 tumor-bearing mice and suppresses angiogenesis by mediating the HIF-1\u03b1\/VEGFA pathway. Open Life Sci 17:121\u2013130. https:\/\/doi.org\/10.1515\/biol-2022-0009","journal-title":"Open Life Sci"},{"key":"10143_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01286","volume":"10","author":"X Chen","year":"2019","unstructured":"Chen X, Li H, Wang K et al (2019) Aerobic exercise ameliorates myocardial inflammation, fibrosis and apoptosis in high-fat-diet rats by inhibiting P2X7 purinergic receptors. Front Physiol 10:1286. https:\/\/doi.org\/10.3389\/fphys.2019.01286","journal-title":"Front Physiol"},{"key":"10143_CR41","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1097\/JS9.0000000000002406","volume":"111","author":"W-J Zhang","year":"2025","unstructured":"Zhang W-J, Luo H-L, Liu J-P et al (2025) P2X7 receptor promotes the growth and metastasis of gastric cancer by activating P13\/AKT\/GSK-3 beta signaling (experimental research). Int J Surg 111:3752\u20133766. https:\/\/doi.org\/10.1097\/JS9.0000000000002406","journal-title":"Int J Surg"},{"key":"10143_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-20912-2","volume":"12","author":"L Douguet","year":"2021","unstructured":"Douguet L, Janho Dit Hreich S, Benzaquen J et al (2021) A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy. Nat Commun 12:653. https:\/\/doi.org\/10.1038\/s41467-021-20912-2","journal-title":"Nat Commun"},{"key":"10143_CR43","doi-asserted-by":"publisher","first-page":"8858","DOI":"10.1093\/cercor\/bhad166","volume":"33","author":"W-J Ren","year":"2023","unstructured":"Ren W-J, Zhao Y-F, Li J et al (2023) P2X7 receptor-mediated depression-like reactions arising in the mouse medial prefrontal cortex. Cereb Cortex 33:8858\u20138875. https:\/\/doi.org\/10.1093\/cercor\/bhad166","journal-title":"Cereb Cortex"},{"key":"10143_CR44","doi-asserted-by":"publisher","unstructured":"Pegoraro A, De Marchi, E, Ruo L et al (2025) P2X7 a new therapeutic target to block vesicle-dependent metastasis in colon carcinoma: role of the A2A\/CD39\/CD73 axis. Cell death & disease 16(1):587. https:\/\/doi.org\/10.1038\/s41419-025-07897-2","DOI":"10.1038\/s41419-025-07897-2"},{"issue":"7","key":"10143_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112696","volume":"42","author":"T Randic","year":"2023","unstructured":"Randic T, Magni S, Philippidou D et al (2023) Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response. Cell Rep 42(7):112696. https:\/\/doi.org\/10.1016\/j.celrep.2023.112696","journal-title":"Cell Rep"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10143-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-026-10143-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10143-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:02:22Z","timestamp":1777654942000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-026-10143-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10143"],"URL":"https:\/\/doi.org\/10.1007\/s11302-026-10143-9","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"24 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Chengdu University of TCM Animal Ethics Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors consent to publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"39"}}