{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:01:32Z","timestamp":1777888892785,"version":"3.51.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC82274668"],"award-info":[{"award-number":["NSFC82274668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11302-026-10148-4","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T01:36:24Z","timestamp":1774402584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adenosine A2A receptors in the chorioid plexus are causal in mediating the development of hydrocephalus"],"prefix":"10.1007","volume":"22","author":[{"given":"Xing-Ying","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Illes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"10148_CR1","doi-asserted-by":"publisher","unstructured":"Zheng W, Hu L, Yang Y et al (2025) Aberrant adenosine A(2A) receptor signaling in the choroid plexus drives CSF hypersecretion and ventriculomegaly in hydrocephalus. Nat Commun 17:83. https:\/\/doi.org\/10.1038\/s41467-025-66776-8","DOI":"10.1038\/s41467-025-66776-8"},{"key":"10148_CR2","doi-asserted-by":"publisher","unstructured":"Bramall AN, Anton ES, Kahle KT et al (2022) Navigating the ventricles: novel insights into the pathogenesis of hydrocephalus. EBioMedicine 78:103931. https:\/\/doi.org\/10.1016\/j.ebiom.2022.103931","DOI":"10.1016\/j.ebiom.2022.103931"},{"key":"10148_CR3","doi-asserted-by":"publisher","unstructured":"Yoshida Y, Une F, Utatsu Y et al (1999) Adenosine and neopterin levels in cerebrospinal fluid of patients with neurological disorders. Intern Med 38:133\u2013139. https:\/\/doi.org\/10.2169\/internalmedicine.38.133","DOI":"10.2169\/internalmedicine.38.133"},{"key":"10148_CR4","doi-asserted-by":"publisher","unstructured":"Robert SM, Reeves BC, Kiziltug E et al (2023) The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell 186:764\u2013785.e21. https:\/\/doi.org\/10.1016\/j.cell.2023.01.017","DOI":"10.1016\/j.cell.2023.01.017"},{"key":"10148_CR5","doi-asserted-by":"publisher","first-page":"6115","DOI":"10.3748\/wjg.14.6115","volume":"14","author":"Y Yan","year":"2008","unstructured":"Yan Y, Merlin D (2008) Ste20-related proline\/alanine-rich kinase: a novel regulator of intestinal inflammation. World J Gastroenterol 14:6115\u20136121. https:\/\/doi.org\/10.3748\/wjg.14.6115","journal-title":"World J Gastroenterol"},{"key":"10148_CR6","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1161\/HYPERTENSIONAHA.112.201509","volume":"60","author":"H Nishida","year":"2012","unstructured":"Nishida H, Sohara E, Nomura N et al (2012) Phosphatidylinositol 3-kinase\/Akt signaling pathway activates the WNK-OSR1\/SPAK-NCC phosphorylation cascade in hyperinsulinemic db\/db mice. Hypertension 60:981\u2013990. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.112.201509","journal-title":"Hypertension"},{"key":"10148_CR7","doi-asserted-by":"publisher","first-page":"18492","DOI":"10.1523\/JNEUROSCI.1828-13.2013","volume":"33","author":"M Matos","year":"2013","unstructured":"Matos M, Augusto E, Agostinho P et al (2013) Antagonistic interaction between adenosine A2A receptors and Na+\/K+-ATPase-\u03b12 controlling glutamate uptake in astrocytes. J Neurosci 33:18492\u201318502. https:\/\/doi.org\/10.1523\/JNEUROSCI.1828-13.2013","journal-title":"J Neurosci"},{"key":"10148_CR8","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s11302-012-9309-4","volume":"8","author":"H Zimmermann","year":"2012","unstructured":"Zimmermann H, Zebisch M, Str\u00e4ter N (2012) Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal 8:437\u2013502. https:\/\/doi.org\/10.1007\/s11302-012-9309-4","journal-title":"Purinergic Signal"},{"key":"10148_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1080\/15257770.2016.1210805","volume":"36","author":"RC Boswell-Casteel","year":"2017","unstructured":"Boswell-Casteel RC, Hays FA (2017) Equilibrative nucleoside transporters-a review. Nucleosides Nucleotides Nucleic Acids 36:7\u201330. https:\/\/doi.org\/10.1080\/15257770.2016.1210805","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10148_CR10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11302-020-09694-2","volume":"16","author":"J-F Chen","year":"2020","unstructured":"Chen J-F, Cunha RA (2020) The belated US FDA approval of the adenosine A(2A) receptor antagonist istradefylline for treatment of Parkinson\u2019s disease. Purinergic Signal 16:167\u2013174. https:\/\/doi.org\/10.1007\/s11302-020-09694-2","journal-title":"Purinergic Signal"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10148-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-026-10148-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10148-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:01:40Z","timestamp":1777611700000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-026-10148-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10148"],"URL":"https:\/\/doi.org\/10.1007\/s11302-026-10148-4","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]},"assertion":[{"value":"15 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"33"}}