{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:01:32Z","timestamp":1777888892822,"version":"3.51.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science of China","doi-asserted-by":"crossref","award":["NSFC 82274668"],"award-info":[{"award-number":["NSFC 82274668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11302-026-10151-9","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:48:35Z","timestamp":1774374515000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Light flickering with 40\u00a0Hz causes analgesia via activation of a retina-amygdala pathway and the local release of adenosine"],"prefix":"10.1007","volume":"22","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Illes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"10151_CR1","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1016\/S0140-6736(21)00393-7","volume":"397","author":"SP Cohen","year":"2021","unstructured":"Cohen SP, Vase L, Hooten WM (2021) Chronic pain: an update on burden, best practices, and new advances. Lancet 397:2082\u20132097. https:\/\/doi.org\/10.1016\/S0140-6736(21)00393-7","journal-title":"Lancet"},{"key":"10151_CR2","doi-asserted-by":"publisher","first-page":"3247","DOI":"10.2147\/IJGM.S419239","volume":"16","author":"NM Alorfi","year":"2023","unstructured":"Alorfi NM (2023) Pharmacological methods of pain management: narrative review of medication used. Int J Gen Med 16:3247\u20133256. https:\/\/doi.org\/10.2147\/IJGM.S419239","journal-title":"Int J Gen Med"},{"key":"10151_CR3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.cobeha.2018.09.012","volume":"26","author":"B Li","year":"2019","unstructured":"Li B (2019) Central amygdala cells for learning and expressing aversive emotional memories. Curr Opin Behav Sci 26:40\u201345. https:\/\/doi.org\/10.1016\/j.cobeha.2018.09.012","journal-title":"Curr Opin Behav Sci"},{"key":"10151_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-026-01227-7","author":"J Chen","year":"2026","unstructured":"Chen J, Xu T, Zhang C et al (2026) 40 hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway. Cell Res. https:\/\/doi.org\/10.1038\/s41422-026-01227-7","journal-title":"Cell Res"},{"key":"10151_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.10.031","volume":"338","author":"J Sawynok","year":"2016","unstructured":"Sawynok J (2016) Adenosine receptor targets for pain. Neuroscience 338:1\u201318. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.10.031","journal-title":"Neuroscience"},{"key":"10151_CR6","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s11302-012-9309-4","volume":"8","author":"H Zimmermann","year":"2012","unstructured":"Zimmermann H, Zebisch M, Str\u00e4ter N (2012) Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal 8:437\u2013502. https:\/\/doi.org\/10.1007\/s11302-012-9309-4","journal-title":"Purinergic Signal"},{"key":"10151_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1080\/15257770.2016.1210805","volume":"36","author":"RC Boswell-Casteel","year":"2017","unstructured":"Boswell-Casteel RC, Hays FA (2017) Equilibrative nucleoside transporters-a review. Nucleosides Nucleotides Nucleic Acids 36:7\u201330. https:\/\/doi.org\/10.1080\/15257770.2016.1210805","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10151_CR8","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1517\/13543784.14.6.729","volume":"14","author":"P Jenner","year":"2005","unstructured":"Jenner P (2005) Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson\u2019s disease. Expert Opin Investig Drugs 14:729\u2013738. https:\/\/doi.org\/10.1517\/13543784.14.6.729","journal-title":"Expert Opin Investig Drugs"},{"key":"10151_CR9","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.1172\/JCI81156","volume":"125","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Zhao S, Rodriguez E et al (2015) Identifying local and descending inputs for primary sensory neurons. J Clin Invest 125:3782\u20133794. https:\/\/doi.org\/10.1172\/JCI81156","journal-title":"J Clin Invest"},{"key":"10151_CR10","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G et al (2009) Cellular and molecular mechanisms of pain. Cell 139:267\u2013284. https:\/\/doi.org\/10.1016\/j.cell.2009.09.028","journal-title":"Cell"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10151-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-026-10151-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10151-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:01:38Z","timestamp":1777611698000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-026-10151-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10151"],"URL":"https:\/\/doi.org\/10.1007\/s11302-026-10151-9","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"18 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"32"}}