{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:47:18Z","timestamp":1782366438739,"version":"3.54.5"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019693","name":"Universidade Federal Da Fronteira Sul","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019693","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s11302-026-10163-5","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:51:29Z","timestamp":1778737889000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute effects of a single electroacupuncture session on purinergic signaling and inflammatory markers in patients with chronic nonspecific low back pain: a pilot study"],"prefix":"10.1007","volume":"22","author":[{"given":"Jardel Cristiano","family":"Ecco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius","family":"Ansolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adinei Abadio","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Makeli Kososki","family":"Dalagnol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Marafon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francini","family":"Franscescon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Chimelo","family":"Bianchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Tavares","family":"de Resende e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"issue":"12","key":"10163_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013814","volume":"12","author":"J Mu","year":"2020","unstructured":"Mu J, Furlan AD, Lam WY et al (2020) Acupuncture for chronic nonspecific low back pain. Cochrane Database Syst Rev 12(12):CD013814. https:\/\/doi.org\/10.1002\/14651858.CD013814","journal-title":"Cochrane Database Syst Rev"},{"key":"10163_CR2","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","volume":"396","author":"GBD 2019 Diseases and Injuries Collaborators","year":"2020","unstructured":"GBD 2019 Diseases and Injuries Collaborators (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396:1204\u20131222. https:\/\/doi.org\/10.1016\/S0140-6736(20)30925-9","journal-title":"Lancet"},{"key":"10163_CR3","doi-asserted-by":"publisher","first-page":"e316","DOI":"10.1016\/S2665-9913(23)00098-X","volume":"5","author":"ML Ferreira","year":"2023","unstructured":"Ferreira ML, de Luca K, Haile LM et al (2023) Global, regional, and national burden of low back pain, 1990\u20132020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol 5:e316\u2013e329. https:\/\/doi.org\/10.1016\/S2665-9913(23)00098-X","journal-title":"Lancet Rheumatol"},{"key":"10163_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-019-0757-1","volume":"23","author":"I Urits","year":"2019","unstructured":"Urits I, Burshtein A, Sharma M et al (2019) Low back pain, a comprehensive review: pathophysiology, diagnosis, and treatment. Curr Pain Headache Rep 23:23. https:\/\/doi.org\/10.1007\/s11916-019-0757-1","journal-title":"Curr Pain Headache Rep"},{"key":"10163_CR5","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/oncotarget.23208","volume":"9","author":"L Chen","year":"2018","unstructured":"Chen L, Deng H, Cui H et al (2018) Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9:7204\u20137218. https:\/\/doi.org\/10.18632\/oncotarget.23208","journal-title":"Oncotarget"},{"key":"10163_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004433","volume":"8","author":"C Liu","year":"2021","unstructured":"Liu C, Chu D, Kalantar-Zadeh K et al (2021) Cytokines: from clinical significance to quantification. Advanced Science 8:e2004433. https:\/\/doi.org\/10.1002\/advs.202004433","journal-title":"Advanced Science"},{"key":"10163_CR7","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S0140-6736(16)30970-9","volume":"389","author":"C Maher","year":"2017","unstructured":"Maher C, Underwood M, Buchbinder R (2017) Non-specific low back pain. Lancet 389:736\u2013747. https:\/\/doi.org\/10.1016\/S0140-6736(16)30970-9","journal-title":"Lancet"},{"key":"10163_CR8","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1089\/acu.2021.0057","volume":"34","author":"H Asano","year":"2022","unstructured":"Asano H, Plonka D, Weeger J (2022) Effectiveness of acupuncture for nonspecific chronic low back pain: a systematic review and meta-analysis. Medical Acupuncture 34:96\u2013106. https:\/\/doi.org\/10.1089\/acu.2021.0057","journal-title":"Medical Acupuncture"},{"key":"10163_CR9","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/ALN.0000000000000101","volume":"120","author":"R Zhang","year":"2014","unstructured":"Zhang R, Lao L, Ren K, Berman BM (2014) Mechanisms of acupuncture-electroacupuncture on persistent pain. Anesthesiology 120:482\u2013503. https:\/\/doi.org\/10.1097\/ALN.0000000000000101","journal-title":"Anesthesiology"},{"key":"10163_CR10","doi-asserted-by":"publisher","DOI":"10.1177\/17448069231202882","volume":"19","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Zhou M, Huo M et al (2023) Mechanisms of acupuncture-electroacupuncture on inflammatory pain. Mol Pain 19:17448069231202882. https:\/\/doi.org\/10.1177\/17448069231202882","journal-title":"Mol Pain"},{"key":"10163_CR11","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1002\/jcp.29148","volume":"235","author":"F Qu","year":"2020","unstructured":"Qu F, Cui Y, Zeng J et al (2020) Acupuncture induces adenosine in fibroblasts through energy metabolism and promotes proliferation by activating MAPK signaling pathway via adenosine3 receptor. J Cell Physiol 235:2441\u20132451. https:\/\/doi.org\/10.1002\/jcp.29148","journal-title":"J Cell Physiol"},{"key":"10163_CR12","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/JLB.3AB0420-361RR","volume":"108","author":"Y Gong","year":"2020","unstructured":"Gong Y, Li N, Lv Z et al (2020) The neuro-immune microenvironment of acupoints-initiation of acupuncture effectiveness. J Leukoc Biol 108:189\u2013198. https:\/\/doi.org\/10.1002\/JLB.3AB0420-361RR","journal-title":"J Leukoc Biol"},{"key":"10163_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.695670","volume":"15","author":"B Dou","year":"2021","unstructured":"Dou B, Li Y, Ma J et al (2021) Role of neuroimmune crosstalk in mediating the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain. Front Neurosci 15:695670. https:\/\/doi.org\/10.3389\/fnins.2021.695670","journal-title":"Front Neurosci"},{"key":"10163_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.bbi.2016.10.003","volume":"60","author":"DM Klyne","year":"2017","unstructured":"Klyne DM, Barbe MF, Hodges PW (2017) Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain. Brain Behav Immun 60:84\u201392. https:\/\/doi.org\/10.1016\/j.bbi.2016.10.003","journal-title":"Brain Behav Immun"},{"key":"10163_CR15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1097\/AJP.0000000000000810","volume":"36","author":"YZ Lim","year":"2020","unstructured":"Lim YZ, Wang Y, Cicuttini FM et al (2020) Association between inflammatory biomarkers and nonspecific low back pain: a systematic review. Clin J Pain 36:379\u2013389. https:\/\/doi.org\/10.1097\/AJP.0000000000000810","journal-title":"Clin J Pain"},{"key":"10163_CR16","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/AJP.0000000000000745","volume":"35","author":"JA Teodorczyk-Injeyan","year":"2019","unstructured":"Teodorczyk-Injeyan JA, Triano JJ, Injeyan HS (2019) Nonspecific low back pain. Clin J Pain 35:818\u2013825. https:\/\/doi.org\/10.1097\/AJP.0000000000000745","journal-title":"Clin J Pain"},{"key":"10163_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.649807","author":"G Magni","year":"2021","unstructured":"Magni G, Ceruti S (2021) Purines in pain as a gliopathy. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.649807","journal-title":"Front Pharmacol"},{"key":"10163_CR18","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1124\/pr.117.014878","volume":"71","author":"L Antonioli","year":"2019","unstructured":"Antonioli L, Blandizzi C, Pacher P, Hask\u00f3 G (2019) The purinergic system as a pharmacological target for the treatment of immune-mediated inflammatory diseases. Pharmacol Rev 71:345\u2013382. https:\/\/doi.org\/10.1124\/pr.117.014878","journal-title":"Pharmacol Rev"},{"key":"10163_CR19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s11302-011-9247-6","volume":"7","author":"B Hechler","year":"2011","unstructured":"Hechler B, Gachet C (2011) P2 receptors and platelet function. Purinergic Signal 7:293\u2013303. https:\/\/doi.org\/10.1007\/s11302-011-9247-6","journal-title":"Purinergic Signal"},{"key":"10163_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108700","volume":"262","author":"F Di Virgilio","year":"2024","unstructured":"Di Virgilio F, Vultaggio-Poma V, Tarantini M, Giuliani AL (2024) Overview of the role of purinergic signaling and insights into its role in cancer therapy. Pharmacol Ther 262:108700. https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108700","journal-title":"Pharmacol Ther"},{"key":"10163_CR21","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3389\/fphar.2017.00661","volume":"8","author":"G Burnstock","year":"2017","unstructured":"Burnstock G (2017) Purinergic signalling: therapeutic developments. Front Pharmacol 8:661. https:\/\/doi.org\/10.3389\/fphar.2017.00661","journal-title":"Front Pharmacol"},{"key":"10163_CR22","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nn.2562","volume":"13","author":"N Goldman","year":"2010","unstructured":"Goldman N, Chen M, Fujita T et al (2010) Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci 13:883\u2013888. https:\/\/doi.org\/10.1038\/nn.2562","journal-title":"Nat Neurosci"},{"key":"10163_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-025-02023-6","volume":"74","author":"JC Ecco","year":"2025","unstructured":"Ecco JC, Soares AA, da Silva KET et al (2025) Inflammatory pain and electroacupuncture: how the P2X3 receptor can help modulate inflammation-a review of current literature. Inflamm Res 74:58. https:\/\/doi.org\/10.1007\/s00011-025-02023-6","journal-title":"Inflamm Res"},{"key":"10163_CR24","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.2522\/ptj.2015.95.2.e1","volume":"95","author":"RA Deyo","year":"2015","unstructured":"Deyo RA, Dworkin SF, Amtmann D et al (2015) Report of the NIH Task Force on research standards for chronic low back pain. Phys Ther 95:e1\u2013e18. https:\/\/doi.org\/10.2522\/ptj.2015.95.2.e1","journal-title":"Phys Ther"},{"key":"10163_CR25","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.22787","volume":"3","author":"J-T Kong","year":"2020","unstructured":"Kong J-T, Puetz C, Tian L et al (2020) Effect of electroacupuncture vs sham treatment on change in pain severity among adults with chronic low back pain: a randomized clinical trial. JAMA Netw Open 3:e2022787. https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.22787","journal-title":"JAMA Netw Open"},{"key":"10163_CR26","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.apmr.2017.11.006","volume":"99","author":"H Ekedahl","year":"2018","unstructured":"Ekedahl H, J\u00f6nsson B, Annertz M, Frobell RB (2018) Accuracy of clinical tests in detecting disk herniation and nerve root compression in subjects with lumbar radicular symptoms. Arch Phys Med Rehabil 99:726\u2013735. https:\/\/doi.org\/10.1016\/j.apmr.2017.11.006","journal-title":"Arch Phys Med Rehabil"},{"key":"10163_CR27","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.bjpt.2021.07.004","volume":"25","author":"GZ Gonzalez","year":"2021","unstructured":"Gonzalez GZ, da Silva T, Avanzi MA et al (2021) Low back pain prevalence in Sao Paulo, Brazil: a cross-sectional study. Braz J Phys Ther 25:837\u2013845. https:\/\/doi.org\/10.1016\/j.bjpt.2021.07.004","journal-title":"Braz J Phys Ther"},{"key":"10163_CR28","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.apmr.2017.10.016","volume":"99","author":"G Bodes Pardo","year":"2018","unstructured":"Bodes Pardo G, Lluch Girb\u00e9s E, Roussel NA et al (2018) Pain neurophysiology education and therapeutic exercise for patients with chronic low back pain: a single-blind randomized controlled trial. Arch Phys Med Rehabil 99:338\u2013347. https:\/\/doi.org\/10.1016\/j.apmr.2017.10.016","journal-title":"Arch Phys Med Rehabil"},{"key":"10163_CR29","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1097\/00002508-200409000-00007","volume":"20","author":"GL Moseley","year":"2004","unstructured":"Moseley GL, Nicholas MK, Hodges PW (2004) A randomized controlled trial of intensive neurophysiology education in chronic low back pain. Clin J Pain 20:324\u2013330. https:\/\/doi.org\/10.1097\/00002508-200409000-00007","journal-title":"Clin J Pain"},{"key":"10163_CR30","doi-asserted-by":"publisher","first-page":"3496","DOI":"10.1111\/bph.15103","volume":"179","author":"KA Jacobson","year":"2022","unstructured":"Jacobson KA, Gao Z-G, Matricon P et al (2022) Adenosine A2A receptor antagonists: from caffeine to selective non-xanthines. Br J Pharmacol 179:3496\u20133511. https:\/\/doi.org\/10.1111\/bph.15103","journal-title":"Br J Pharmacol"},{"key":"10163_CR31","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1097\/01.brs.0000164099.92112.29","volume":"30","author":"JD Childs","year":"2005","unstructured":"Childs JD, Piva SR, Fritz JM (2005) Responsiveness of the numeric pain rating scale in patients with low back pain. Spine (Phila Pa 1976) 30:1331\u20131334. https:\/\/doi.org\/10.1097\/01.brs.0000164099.92112.29","journal-title":"Spine (Phila Pa 1976)"},{"key":"10163_CR32","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ejpain.2003.09.004","volume":"8","author":"F Salaffi","year":"2004","unstructured":"Salaffi F, Stancati A, Silvestri CA et al (2004) Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. Eur J Pain 8:283\u2013291. https:\/\/doi.org\/10.1016\/j.ejpain.2003.09.004","journal-title":"Eur J Pain"},{"key":"10163_CR33","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1590\/s0100-879x2001000200007","volume":"34","author":"L Nusbaum","year":"2001","unstructured":"Nusbaum L, Natour J, Ferraz MB, Goldenberg J (2001) Translation, adaptation and validation of the Roland-Morris questionnaire\u2013Brazil Roland-Morris. Braz J Med Biol Res 34:203\u2013210. https:\/\/doi.org\/10.1590\/s0100-879x2001000200007","journal-title":"Braz J Med Biol Res"},{"key":"10163_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3813-6","volume":"20","author":"S Francescato Torres","year":"2019","unstructured":"Francescato Torres S, Brandt de Macedo AC, Dias Antunes M et al (2019) Effects of electroacupuncture frequencies on chronic low back pain in older adults: Triple-blind, 12-months protocol for a randomized controlled trial. Trials 20:762. https:\/\/doi.org\/10.1186\/s13063-019-3813-6","journal-title":"Trials"},{"key":"10163_CR35","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bbamcr.2005.10.009","volume":"1746","author":"DBR Leal","year":"2005","unstructured":"Leal DBR, Streher CA, Bertoncheli C et al (2005) HIV infection is associated with increased NTPDase activity that correlates with CD39-positive lymphocytes. Biochim Biophys Acta 1746:129\u2013134. https:\/\/doi.org\/10.1016\/j.bbamcr.2005.10.009","journal-title":"Biochim Biophys Acta"},{"key":"10163_CR36","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3109\/09537109609023582","volume":"7","author":"C Pilla","year":"1996","unstructured":"Pilla C, Emanuelli T, Frassetto SS et al (1996) ATP diphosphohydrolase activity (apyrase, EC 3.6.1.5) in human blood platelets. Platelets 7:225\u2013230. https:\/\/doi.org\/10.3109\/09537109609023582","journal-title":"Platelets"},{"key":"10163_CR37","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22823","volume":"33","author":"L Silva Dalsasso Joaquim","year":"2019","unstructured":"Silva Dalsasso Joaquim L, Granzotto N, Dos Santos LF et al (2019) Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal 33:e22823. https:\/\/doi.org\/10.1002\/jcla.22823","journal-title":"J Clin Lab Anal"},{"key":"10163_CR38","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. https:\/\/doi.org\/10.1016\/0003-2697(76)90527-3","journal-title":"Anal Biochem"},{"key":"10163_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114322","volume":"187","author":"H Zimmermann","year":"2021","unstructured":"Zimmermann H (2021) History of ectonucleotidases and their role in purinergic signaling. Biochem Pharmacol 187:114322. https:\/\/doi.org\/10.1016\/j.bcp.2020.114322","journal-title":"Biochem Pharmacol"},{"key":"10163_CR40","doi-asserted-by":"publisher","DOI":"10.2196\/22324","volume":"22","author":"B-Y Yeh","year":"2020","unstructured":"Yeh B-Y, Liu G-H, Lee T-Y et al (2020) Efficacy of electronic acupuncture shoes for chronic low back pain: Double-blinded randomized controlled trial. J Med Internet Res 22:e22324. https:\/\/doi.org\/10.2196\/22324","journal-title":"J Med Internet Res"},{"key":"10163_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2023.114548","volume":"452","author":"Y Zheng","year":"2023","unstructured":"Zheng Y, Pan L, He J et al (2023) Electroacupuncture-modulated extracellular ATP levels in prefrontal cortex ameliorated depressive-like behavior of maternal separation rats. Behav Brain Res 452:114548. https:\/\/doi.org\/10.1016\/j.bbr.2023.114548","journal-title":"Behav Brain Res"},{"key":"10163_CR42","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11302-021-09833-3","volume":"19","author":"W-M Zuo","year":"2023","unstructured":"Zuo W-M, Li Y-J, Cui K-Y et al (2023) The real-time detection of acupuncture-induced extracellular ATP mobilization in acupoints and exploration of its role in acupuncture analgesia. Purinergic Signal 19:69\u201385. https:\/\/doi.org\/10.1007\/s11302-021-09833-3","journal-title":"Purinergic Signal"},{"key":"10163_CR43","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s11302-016-9552-1","volume":"13","author":"YH Gao","year":"2017","unstructured":"Gao YH, Li CW, Wang JY et al (2017) Effect of electroacupuncture on the cervicospinal P2X7 receptor\/fractalkine\/CX3CR1 signaling pathway in a rat neck-incision pain model. Purinergic Signal 13:215\u2013225. https:\/\/doi.org\/10.1007\/s11302-016-9552-1","journal-title":"Purinergic Signal"},{"key":"10163_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109333","volume":"224","author":"F Di Virgilio","year":"2023","unstructured":"Di Virgilio F, Vultaggio-Poma V, Falzoni S, Giuliani AL (2023) Extracellular ATP: a powerful inflammatory mediator in the central nervous system. Neuropharmacology 224:109333. https:\/\/doi.org\/10.1016\/j.neuropharm.2022.109333","journal-title":"Neuropharmacology"},{"key":"10163_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114309","volume":"187","author":"K Inoue","year":"2021","unstructured":"Inoue K, Tsuda M (2021) Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors. Biochem Pharmacol 187:114309. https:\/\/doi.org\/10.1016\/j.bcp.2020.114309","journal-title":"Biochem Pharmacol"},{"key":"10163_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111273","volume":"137","author":"KP Reichert","year":"2021","unstructured":"Reichert KP, Castro MFV, Assmann CE et al (2021) Diabetes and hypertension: pivotal involvement of purinergic signaling. Biomed Pharmacother 137:111273. https:\/\/doi.org\/10.1016\/j.biopha.2021.111273","journal-title":"Biomed Pharmacother"},{"key":"10163_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050809","volume":"11","author":"L-N Wang","year":"2022","unstructured":"Wang L-N, Wang X-Z, Li Y-J et al (2022) Activation of subcutaneous mast cells in acupuncture points triggers analgesia. Cells 11:809. https:\/\/doi.org\/10.3390\/cells11050809","journal-title":"Cells"},{"key":"10163_CR48","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s11302-021-09826-2","volume":"19","author":"M Zhou","year":"2023","unstructured":"Zhou M, Wu J, Chang H et al (2023) Adenosine signaling mediate pain transmission in the central nervous system. Purinergic Signal 19:245\u2013254. https:\/\/doi.org\/10.1007\/s11302-021-09826-2","journal-title":"Purinergic Signal"},{"key":"10163_CR49","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.autneu.2015.04.011","volume":"191","author":"F Di Virgilio","year":"2015","unstructured":"Di Virgilio F, Vuerich M (2015) Purinergic signaling in the immune system. Auton Neurosci 191:117\u2013123. https:\/\/doi.org\/10.1016\/j.autneu.2015.04.011","journal-title":"Auton Neurosci"},{"key":"10163_CR50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.mam.2017.01.002","volume":"55","author":"MM Faas","year":"2017","unstructured":"Faas MM, S\u00e1ez T, de Vos P (2017) Extracellular ATP and adenosine: the Yin and Yang in immune responses? Mol Aspects Med 55:9\u201319. https:\/\/doi.org\/10.1016\/j.mam.2017.01.002","journal-title":"Mol Aspects Med"},{"key":"10163_CR51","doi-asserted-by":"publisher","unstructured":"Cronstein BN, Hask\u00f3 G (2013) Regulation of inflammation by adenosine. Front Immunol 4. https:\/\/doi.org\/10.3389\/fimmu.2013.00085","DOI":"10.3389\/fimmu.2013.00085"},{"key":"10163_CR52","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/636848","volume":"2012","author":"W-H Chen","year":"2012","unstructured":"Chen W-H, Tzen JTC, Hsieh CL et al (2012) Attenuation of TRPV1 and TRPV4 expression and function in mouse inflammatory pain models using electroacupuncture. Evid Based Complement Alternat Med 2012:636848. https:\/\/doi.org\/10.1155\/2012\/636848","journal-title":"Evid Based Complement Alternat Med"},{"key":"10163_CR53","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neulet.2015.03.001","volume":"592","author":"J Khan","year":"2015","unstructured":"Khan J, Ramadan K, Korczeniewska O et al (2015) Interleukin-10 levels in rat models of nerve damage and neuropathic pain. Neurosci Lett 592:99\u2013106. https:\/\/doi.org\/10.1016\/j.neulet.2015.03.001","journal-title":"Neurosci Lett"},{"key":"10163_CR54","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.conb.2019.11.006","volume":"62","author":"O Chen","year":"2020","unstructured":"Chen O, Donnelly CR, Ji R-R (2020) Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons. Curr Opin Neurobiol 62:17\u201325. https:\/\/doi.org\/10.1016\/j.conb.2019.11.006","journal-title":"Curr Opin Neurobiol"},{"key":"10163_CR55","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1006\/exnr.2001.7677","volume":"169","author":"K Okamoto","year":"2001","unstructured":"Okamoto K, Martin DP, Schmelzer JD et al (2001) Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain. Exp Neurol 169:386\u2013391. https:\/\/doi.org\/10.1006\/exnr.2001.7677","journal-title":"Exp Neurol"},{"key":"10163_CR56","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.expneurol.2013.01.018","volume":"247","author":"K-F Shen","year":"2013","unstructured":"Shen K-F, Zhu H-Q, Wei X-H et al (2013) Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Exp Neurol 247:466\u2013475. https:\/\/doi.org\/10.1016\/j.expneurol.2013.01.018","journal-title":"Exp Neurol"},{"key":"10163_CR57","doi-asserted-by":"publisher","DOI":"10.2174\/1871526520666200820093924","volume":"21","author":"ES Banimostafavi","year":"2021","unstructured":"Banimostafavi ES, Fakhar M, Abediankenari S et al (2021) Determining serum levels of IL-10 and IL-17 in patients with low back pain caused by lumbar disc degeneration. Infect Disord Drug Targets 21:e270421185135. https:\/\/doi.org\/10.2174\/1871526520666200820093924","journal-title":"Infect Disord Drug Targets"},{"key":"10163_CR58","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1007\/s00586-023-07717-1","volume":"32","author":"EM Pinto","year":"2023","unstructured":"Pinto EM, Neves JR, Laranjeira M, Reis J (2023) The importance of inflammatory biomarkers in non-specific acute and chronic low back pain: a systematic review. Eur Spine J 32:3230\u20133244. https:\/\/doi.org\/10.1007\/s00586-023-07717-1","journal-title":"Eur Spine J"},{"key":"10163_CR59","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1097\/j.pain.0000000000001921","volume":"161","author":"G Laumet","year":"2020","unstructured":"Laumet G, Bavencoffe A, Edralin JD et al (2020) Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability. Pain 161:2344\u20132352. https:\/\/doi.org\/10.1097\/j.pain.0000000000001921","journal-title":"Pain"},{"key":"10163_CR60","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s10753-020-01203-2","volume":"43","author":"M-L Yu","year":"2020","unstructured":"Yu M-L, Wei R, Zhang T et al (2020) Electroacupuncture relieves pain and attenuates inflammation progression through inducing IL-10 production in CFA-induced mice. Inflammation 43:1233\u20131245. https:\/\/doi.org\/10.1007\/s10753-020-01203-2","journal-title":"Inflammation"},{"key":"10163_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109898","volume":"125","author":"U Ali","year":"2020","unstructured":"Ali U, Apryani E, Wu H-Y et al (2020) Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10\/\u03b2-endorphin pathway. Biomed Pharmacother 125:109898. https:\/\/doi.org\/10.1016\/j.biopha.2020.109898","journal-title":"Biomed Pharmacother"},{"key":"10163_CR62","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1189\/jlb.0113043","volume":"94","author":"B Koscs\u00f3","year":"2013","unstructured":"Koscs\u00f3 B, Cs\u00f3ka B, K\u00f3kai E et al (2013) Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol 94:1309\u20131315. https:\/\/doi.org\/10.1189\/jlb.0113043","journal-title":"J Leukoc Biol"},{"key":"10163_CR63","doi-asserted-by":"publisher","first-page":"8260","DOI":"10.4049\/jimmunol.175.12.8260","volume":"175","author":"ZH N\u00e9meth","year":"2005","unstructured":"N\u00e9meth ZH, Lutz CS, Cs\u00f3ka B et al (2005) Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J Immunol 175:8260\u20138270. https:\/\/doi.org\/10.4049\/jimmunol.175.12.8260","journal-title":"J Immunol"},{"issue":"1","key":"10163_CR64","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2119\/molmed.2014.00090","volume":"21","author":"CF Aguiar","year":"2015","unstructured":"Aguiar CF, Naffah-de-Souza C, Castoldi A, Corr\u00eaa-Costa M, Braga TT, Naka \u00c9L, Amano MT, Abate DT, Hiyane MI, Cenedeze MA, Pacheco e Silva Filho A, C\u00e2mara NO (2015) Administration of \u03b1-galactosylceramide improves adenine-induced renal injury. Mol Med 21(1):553\u2013562. https:\/\/doi.org\/10.2119\/molmed.2014.00090","journal-title":"Mol Med"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10163-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-026-10163-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10163-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:06:06Z","timestamp":1782363966000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-026-10163-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10163"],"URL":"https:\/\/doi.org\/10.1007\/s11302-026-10163-5","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"7 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and all described methods and protocols were approved by the Ethics Committee of the Federal University of Fronteira Sul (UFFS), registration number (CAAE: 70754123.0.0000.5564). Each participant has read and signed the Consent to Participate Declaration before the beginning of the experimental protocols.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"48"}}