{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:06:48Z","timestamp":1788923208061,"version":"build-2803163510"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Sino-German-Center","award":["GZ919"],"award-info":[{"award-number":["GZ919"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s11302-026-10181-3","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:07:03Z","timestamp":1788919623000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antagonism of P2X7 receptor function in synovial fibroblasts is a potential therapeutic manipulation in rheumatoid arthritis"],"prefix":"10.1007","volume":"22","author":[{"given":"Shi-Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Illes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"10181_CR1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adw9543","volume":"12","author":"P Rao","year":"2026","unstructured":"Rao P, Jin S, Xiao S, Ma Y, Li J, Liao Y, Wang Z, Tang Y, Cai X, Zeng X, Hong Y, Wang X, He J, Ma S, Jiang J, Zhang W, Zhang B, Li R, Zhang L, Xu C, Jin Q, Wang Q, Chu M, Sun X, Li Z (2026) P2X7R of synovial fibroblasts is a potential therapeutic target associated with refractory rheumatoid arthritis. Sci Adv 12:eadw9543. https:\/\/doi.org\/10.1126\/sciadv.adw9543","journal-title":"Sci Adv"},{"key":"10181_CR2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41584-022-00827-y","volume":"18","author":"A Finckh","year":"2022","unstructured":"Finckh A, Gilbert B, Hodkinson B et al (2022) Global epidemiology of rheumatoid arthritis. Nat Rev Rheumatol 18:591\u2013602. https:\/\/doi.org\/10.1038\/s41584-022-00827-y","journal-title":"Nat Rev Rheumatol"},{"key":"10181_CR3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41584-020-00541-7","volume":"17","author":"MH Buch","year":"2021","unstructured":"Buch MH, Eyre S, McGonagle D (2021) Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis. Nat Rev Rheumatol 17:17\u201333. https:\/\/doi.org\/10.1038\/s41584-020-00541-7","journal-title":"Nat Rev Rheumatol"},{"key":"10181_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11302-017-9593-0","volume":"14","author":"G Burnstock","year":"2018","unstructured":"Burnstock G, Knight GE (2018) The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression. Purinergic Signal 14:1\u201318. https:\/\/doi.org\/10.1007\/s11302-017-9593-0","journal-title":"Purinergic Signal"},{"key":"10181_CR5","doi-asserted-by":"publisher","first-page":"720","DOI":"10.3899\/jrheum.110874","volume":"39","author":"TC Stock","year":"2012","unstructured":"Stock TC, Bloom BJ, Wei N et al (2012) Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J Rheumatol 39:720\u2013727. https:\/\/doi.org\/10.3899\/jrheum.110874","journal-title":"J Rheumatol"},{"key":"10181_CR6","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","volume":"49","author":"V Krenn","year":"2006","unstructured":"Krenn V, Morawietz L, Burmester G-R et al (2006) Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology 49:358\u2013364. https:\/\/doi.org\/10.1111\/j.1365-2559.2006.02508.x","journal-title":"Histopathology"},{"key":"10181_CR7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1189\/jlb.0507276","volume":"83","author":"K Christenson","year":"2008","unstructured":"Christenson K, Bj\u00f6rkman L, T\u00e4ngemo C et al (2008) Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1. J Leukoc Biol 83:139\u2013148. https:\/\/doi.org\/10.1189\/jlb.0507276","journal-title":"J Leukoc Biol"},{"key":"10181_CR8","first-page":"S93","volume":"23","author":"J Fransen","year":"2005","unstructured":"Fransen J, van Riel PLCM (2005) The disease activity score and the EULAR response criteria. Clin Exp Rheumatol 23:S93\u2013S99","journal-title":"Clin Exp Rheumatol"},{"key":"10181_CR9","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s11302-015-9466-3","volume":"11","author":"D Gentile","year":"2015","unstructured":"Gentile D, Natale M, Lazzerini PE et al (2015) The role of P2X7 receptors in tissue fibrosis: a brief review. Purinergic Signal 11:435\u2013440. https:\/\/doi.org\/10.1007\/s11302-015-9466-3","journal-title":"Purinergic Signal"},{"key":"10181_CR10","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7956274","author":"J Zhou","year":"2020","unstructured":"Zhou J, Tian G, Quan Y et al (2020) Inhibition of P2X7 purinergic receptor ameliorates cardiac fibrosis by suppressing NLRP3\/IL-1\u03b2 pathway. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2020\/7956274","journal-title":"Oxid Med Cell Longev"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10181-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11302-026-10181-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-026-10181-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:07:04Z","timestamp":1788919624000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11302-026-10181-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10181"],"URL":"https:\/\/doi.org\/10.1007\/s11302-026-10181-3","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"30 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}],"article-number":"69"}}