{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:23:37Z","timestamp":1791332617323,"version":"4.3.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1007\/s11306-005-4810-1","type":"journal-article","created":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T10:02:36Z","timestamp":1116842556000},"page":"101-108","source":"Crossref","is-referenced-by-count":132,"title":["Metabolomic analysis and signatures in motor neuron disease"],"prefix":"10.1007","volume":"1","author":[{"given":"Steve","family":"Rozen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merit E.","family":"Cudkowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Bogdanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne R.","family":"Matson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce S.","family":"Kristal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Beecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Vouros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Flarakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Vigneau-Callahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore D.","family":"Matson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristyn M.","family":"Newhall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Flint","family":"Beal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert H.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Kaddurah-Daouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"4810_CR1","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1002\/ana.410420416","volume":"42","author":"M. Beal","year":"1997","journal-title":"Ann. Neurol"},{"key":"4810_CR2","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1056\/NEJM199403033300901","volume":"330","author":"G. Bensimon","year":"1994","journal-title":"N. Engl. J. Med"},{"key":"4810_CR3","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1097\/00001756-200011090-00003","volume":"11","author":"W. Beuche","year":"2000","journal-title":"Neuroreport"},{"key":"4810_CR4","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/S0891-5849(00)00349-X","volume":"29","author":"M. Bogdanov","year":"2000","journal-title":"Free Radic. Biol. Med"},{"key":"4810_CR5","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1038\/nm802","volume":"8","author":"J. Brindle","year":"2002","journal-title":"Nat. Med"},{"key":"4810_CR6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1039\/b209155k","volume":"128","author":"J. Brindle","year":"2003","journal-title":"Analyst"},{"key":"4810_CR7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1600-0404.1993.tb04186.x","volume":"88","author":"W. Camu","year":"1993","journal-title":"Acta Neurol. Scand"},{"key":"4810_CR8","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/35097565","volume":"2","author":"D. Cleveland","year":"2001","journal-title":"Nat. Rev. Neurosci"},{"key":"4810_CR9","volume-title":"Multi and Megavariate Analysis: Principles and Applications","author":"L. Eriksson","year":"2001"},{"key":"4810_CR10","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1126\/science.286.5439.531","volume":"286","author":"T.R. Golub","year":"1999","journal-title":"Science"},{"key":"4810_CR11","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/ng1001-166","volume":"29","author":"S. Hadano","year":"2001","journal-title":"Nat. Genet"},{"key":"4810_CR12","volume-title":"Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis","year":"2003"},{"key":"4810_CR13","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.mib.2004.04.012","volume":"7","author":"D.B. Kell","year":"2004","journal-title":"Curr. Opin. Microbiol"},{"key":"4810_CR14","volume-title":"Solving Data Mining Problems Through Pattern Recognition","author":"R. Kennedy","year":"1997"},{"key":"4810_CR15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1006\/abio.1998.2831","volume":"263","author":"B. Kristal","year":"1998","journal-title":"Anal Biochem"},{"key":"4810_CR16","first-page":"185","volume":"186","author":"B.S. Kristal","year":"2002","journal-title":"Meth. Mol. Biol"},{"key":"4810_CR17","first-page":"1","volume-title":"Clinical Neurology","author":"J. Kurtzke","year":"1989"},{"key":"4810_CR18","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0140-6736(96)91680-3","volume":"347","author":"L. Lacomblez","year":"1996","journal-title":"Lancet"},{"key":"4810_CR19","doi-asserted-by":"crossref","unstructured":"Lambrechts, D., Storkebaum, E., Morimoto, M., Del-Favero, J., Desmet, F., Marklund, S., S.W. and et al. (2003). VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat. Genet. 34, 383\u2013394","DOI":"10.1038\/ng1211"},{"key":"4810_CR20","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/S0140-6736(89)92218-6","volume":"1","author":"D.E. Lilienfeld","year":"1989","journal-title":"Lancet"},{"key":"4810_CR21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1586\/14737159.4.2.189","volume":"4","author":"J.C. Lindon","year":"2004","journal-title":"Expert Rev. Mo. Diagn"},{"key":"4810_CR22","volume-title":"Multivariate Statistical Methods: A Primer","author":"B. Manley","year":"1994","edition":"2"},{"key":"4810_CR23","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/clinchem\/30.9.1477","volume":"30","author":"W. Matson","year":"1984","journal-title":"Clin. Chem"},{"key":"4810_CR24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1212\/WNL.47.2.571","volume":"47","author":"V. McGuire","year":"1996","journal-title":"Neurology"},{"key":"4810_CR25","unstructured":"Milbury, P. (1997). CEAS generation of large multiparameter databases for determining categorical process involvement of biomolecules, Coulometric Array Detectors for HPLC, V.S.P. International Science, Utrecht, the Netherlands, pp. 125\u2013141"},{"key":"4810_CR26","volume-title":"Amyotrophic Lateral Sclerosis","author":"H. Mitsumoto","year":"1998"},{"key":"4810_CR27","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/nrd1157","volume":"2","author":"J. K. Nicholson","year":"2003","journal-title":"Nat. Rev. Drug Discov"},{"key":"4810_CR28","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/ng1123","volume":"33","author":"I. Puls","year":"2003","journal-title":"Nat. Genet"},{"key":"4810_CR29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/362059a0","volume":"362","author":"D. Rosen","year":"1993","journal-title":"Nature"},{"key":"4810_CR30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ana.410280106","volume":"28","author":"J. Rothstein","year":"1990","unstructured":"Rothstein, J., Tsai, G., Kuncl, R., et al. (1990). Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann. Neurol. 28, 18\u201325","journal-title":"Ann. Neurol"},{"key":"4810_CR31","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1056\/NEJM200105313442207","volume":"344","author":"L. Rowland","year":"2001","journal-title":"N Engl. J. Med"},{"key":"4810_CR32","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1006\/abio.2001.5568","volume":"302","author":"H. Shi","year":"2002","journal-title":"Anal. Biochem"},{"key":"4810_CR33","doi-asserted-by":"crossref","first-page":"A242","DOI":"10.1212\/01.WNL.0000063304.88470.D9","volume":"60","author":"E. Simpson","year":"2003","journal-title":"Neurology"},{"key":"4810_CR34","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1002\/ana.410440419","volume":"44","author":"R. Smith","year":"1998","journal-title":"Ann. Neurol"},{"key":"4810_CR35","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.cbpa.2004.08.013","volume":"8","author":"J. Greef van der","year":"2004","journal-title":"Curr. Opin. Chem. Biol"},{"key":"4810_CR36","doi-asserted-by":"crossref","first-page":"924S","DOI":"10.1093\/jn\/131.3.924S","volume":"131","author":"K. Vigneau-Callahan","year":"2001","journal-title":"J Nutr"},{"key":"4810_CR37","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/ng1001-160","volume":"29","author":"Y. Yang","year":"2001","journal-title":"Nat. Genet"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-005-4810-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11306-005-4810-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-005-4810-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-005-4810-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T17:28:48Z","timestamp":1581960528000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11306-005-4810-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["4810"],"URL":"https:\/\/doi.org\/10.1007\/s11306-005-4810-1","relation":{},"ISSN":["1573-3882","1573-3890"],"issn-type":[{"value":"1573-3882","type":"print"},{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}