{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:54:00Z","timestamp":1784548440323,"version":"3.55.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s11306-014-0711-5","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T12:45:56Z","timestamp":1406637956000},"page":"477-486","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model"],"prefix":"10.1007","volume":"11","author":[{"given":"Roel","family":"Van Assche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbet","family":"Temmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berin","family":"Boughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Boonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart P.","family":"Braeckman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Schoofs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Roessner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"issue":"4","key":"711_CR1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00702-010-0383-x","volume":"117","author":"X-H Bi","year":"2010","unstructured":"Bi, X.-H., Zhao, H.-L., Zhang, Z. X., et al. (2010). Association analysis of CbetaS 844ins68 and MTHFD1 G1958A polymorphisms with Alzheimer\u2019s disease in Chinese. Journal of Neural Transmission, 117(4), 499\u2013503. doi: 10.1007\/s00702-010-0383-x .","journal-title":"Journal of Neural Transmission"},{"issue":"9","key":"711_CR2","doi-asserted-by":"crossref","first-page":"a006221","DOI":"10.1101\/cshperspect.a006221","volume":"2","author":"K Blennow","year":"2012","unstructured":"Blennow, K., Zetterberg, H., & Fagan, A. M. (2012). Fluid biomarkers in Alzheimer\u2019s disease. Cold Spring Harbor Perspectives in Medicine, 2(9), a006221. doi: 10.1101\/cshperspect.a006221 .","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"issue":"9","key":"711_CR3","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.neurobiolaging.2005.07.001","volume":"27","author":"D Boyd-Kimball","year":"2006","unstructured":"Boyd-Kimball, D., Poon, H. F., Lynn, B. C., et al. (2006). Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): Implications for Alzheimer\u2019s disease. Neurobiology of Aging, 27(9), 1239\u20131249. doi: 10.1016\/j.neurobiolaging.2005.07.001 .","journal-title":"Neurobiology of Aging"},{"issue":"01","key":"711_CR4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","volume":"77","author":"S Brenner","year":"1974","unstructured":"Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics, 77(01), 71\u201394.","journal-title":"Genetics"},{"key":"711_CR5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-62703-577-4_20","volume":"1055","author":"AM Livera De","year":"2013","unstructured":"De Livera, A. M., Olshansky, M., & Speed, T. P. (2013). Statistical analysis of metabolomics data. Methods in Molecular Biology, 1055, 291\u2013307. doi: 10.1007\/978-1-62703-577-4_20 .","journal-title":"Methods in Molecular Biology"},{"key":"711_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4061\/2011\/428970","volume":"2011","author":"A Vos De","year":"2011","unstructured":"De Vos, A., Anandhakumar, J., Van den Brande, J., et al. (2011). Yeast as a model system to study tau biology. International Journal of Alzheimer\u2019s Disease, 2011, 1\u201316. doi: 10.4061\/2011\/428970 .","journal-title":"International Journal of Alzheimer\u2019s Disease"},{"issue":"4","key":"711_CR7","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1021\/pr401081b","volume":"13","author":"G Depuydt","year":"2014","unstructured":"Depuydt, G., Xie, F., Petyuk, V. A., et al. (2014). LC-MS proteomics analysis of the insulin\/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism. Journal of Proteome Research, 13(4), 1938\u20131956. doi: 10.1021\/pr401081b .","journal-title":"Journal of Proteome Research"},{"issue":"2","key":"711_CR8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3233\/JAD-2010-1267","volume":"19","author":"LE Dosanjh","year":"2010","unstructured":"Dosanjh, L. E., Brown, M. K., Rao, G., et al. (2010). Behavioral phenotyping of a trangenic C. elegans expression neuronal amyloid beta. Journal of Alzheimer\u2019s Disease, 19(2), 9.","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"711_CR9","first-page":"10","volume":"44","author":"V Dostal","year":"2010","unstructured":"Dostal, V., & Link, C. D. (2010). Assaying \u03b2-amyloid toxicity using a transgenic C. elegans model. Journal of Visualized Experiments, 44, 10\u201312. doi: 10.3791\/2252 .","journal-title":"Journal of Visualized Experiments"},{"key":"711_CR10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/msj.20159","volume":"77","author":"GA Elder","year":"2010","unstructured":"Elder, G. A., Sosa, M. A. G., & De Gasperi, R. (2010). Transgenic mouse models of Alzheimer\u2019 s disease. Mount Sinai School of Medicine, 77, 69\u201381. doi: 10.1002\/MSJ.20159 .","journal-title":"Mount Sinai School of Medicine"},{"issue":"4","key":"711_CR11","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1046\/j.1471-4159.1998.71041616.x","volume":"71","author":"DS Fay","year":"1998","unstructured":"Fay, D. S., Fluet, A., Johnson, C. J., et al. (1998). In vivo aggregation of beta-amyloid peptide variants. Journal of Neurochemistry, 71(4), 1616\u20131625.","journal-title":"Journal of Neurochemistry"},{"key":"711_CR12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1741-7007-8-14","volume":"8","author":"S Fuchs","year":"2010","unstructured":"Fuchs, S., Bundy, J. G., Davies, S. K., et al. (2010). A metabolic signature of long life in Caenorhabditis elegans. BMC Biology, 8, 14. doi: 10.1186\/1741-7007-8-14 .","journal-title":"BMC Biology"},{"issue":"2","key":"711_CR13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3164\/jcbn.12-118","volume":"52","author":"K Fukuhara","year":"2013","unstructured":"Fukuhara, K., Ohno, A., Ota, Y., et al. (2013). NMR-based metabolomics of urine in a mouse model of Alzheimer\u2019s disease: Identification of oxidative stress biomarkers. Journal of Clinical Biochemistry and Nutrition, 52(2), 133\u2013138. doi: 10.3164\/jcbn.12 .","journal-title":"Journal of Clinical Biochemistry and Nutrition"},{"key":"711_CR14","first-page":"3730","volume":"83","author":"FM Geier","year":"2011","unstructured":"Geier, F. M., Want, E. J., Leroi, A. M., et al. (2011). Cross-platform comparison of Caenorhabditis elegans tissue. Analytical Chemistry and Bioanalytical Chemistry, 83, 3730\u20133736.","journal-title":"Analytical Chemistry and Bioanalytical Chemistry"},{"key":"711_CR15","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1021\/ac303163f","volume":"85","author":"SF Graham","year":"2013","unstructured":"Graham, S. F., Chevallier, O. P., Roberts, D., et al. (2013a). Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer\u2019s disease. Analytical Chemistry, 85, 1803\u20131811.","journal-title":"Analytical Chemistry"},{"issue":"5","key":"711_CR16","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1007\/s11306-013-0516-y","volume":"9","author":"SF Graham","year":"2013","unstructured":"Graham, S. F., Holscher, C., McClean, P., et al. (2013b). 1H NMR metabolomics investigation of an Alzheimer\u2019s disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma. Metabolomics, 9(5), 974\u2013983. doi: 10.1007\/s11306-013-0516-y .","journal-title":"Metabolomics"},{"issue":"5","key":"711_CR17","doi-asserted-by":"crossref","first-page":"a006270","DOI":"10.1101\/cshperspect.a006270","volume":"2","author":"C Haass","year":"2012","unstructured":"Haass, C., Kaether, C., Thinakaran, G., et al. (2012). Trafficking and proteolytic processing of APP. Cold Spring Harbor Perspectives in Medicine, 2(5), a006270. doi: 10.1101\/cshperspect.a006270 .","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"711_CR18","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1021\/pr9001806","volume":"8","author":"SL Hughes","year":"2009","unstructured":"Hughes, S. L., Bundy, J. G., Want, E. J., et al. (2009). The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins research articles. Journal of Proteome Research, 8, 3512\u20133519.","journal-title":"Journal of Proteome Research"},{"issue":"2\u20133","key":"711_CR19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00429-009-0234-4","volume":"214","author":"K Iijima-Ando","year":"2010","unstructured":"Iijima-Ando, K., & Iijima, K. (2010). Transgenic Drosophila models of Alzheimer\u2019s disease and tauopathies. Brain Structure & Function, 214(2\u20133), 245\u2013262. doi: 10.1007\/s00429-009-0234-4 .","journal-title":"Brain Structure & Function"},{"issue":"2","key":"711_CR20","first-page":"67","volume":"12","author":"LM Ittner","year":"2011","unstructured":"Ittner, L. M., & G\u00f6tz, J. (2011). Amyloid-\u03b2 and tau: A toxic pas de deux in Alzheimer\u2019s disease. Nature, 12(2), 67\u201372. doi: 10.1038\/nrn2967 .","journal-title":"Nature"},{"issue":"4","key":"711_CR21","doi-asserted-by":"crossref","first-page":"a006213","DOI":"10.1101\/cshperspect.a006213","volume":"2","author":"KA Johnson","year":"2012","unstructured":"Johnson, K. A., Johnson, K. A., Fox, N. C., Sperling, R. A., et al. (2012). Brain imaging in Alzheimer\u2019s disease. Cold Spring Harbor Perspectives in Medicine, 2(4), a006213. doi: 10.1101\/cshperspect.a006213 .","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"issue":"3","key":"711_CR22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jalz.2010.06.001","volume":"7","author":"R Kaddurah-Daouk","year":"2011","unstructured":"Kaddurah-Daouk, R., Rozen, S., Matson, W., et al. (2011). Metabolomic changes in autopsy-confirmed Alzheimer\u2019s disease. Alzheimer\u2019s & Dementia, 7(3), 309\u2013317. doi: 10.1016\/j.jalz.2010.06.001 .","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"4","key":"711_CR23","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1038\/tp.2013.18","volume":"3","author":"R Kaddurah-Daouk","year":"2013","unstructured":"Kaddurah-Daouk, R., Zhu, H., Sharma, S., et al. (2013). Alterations in metabolic pathways and networks in Alzheimer\u2019s disease. Translational Psychiatry, 3(4), e244. doi: 10.1038\/tp.2013.18 .","journal-title":"Translational Psychiatry"},{"issue":"1","key":"711_CR24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1021\/ac202450g","volume":"84","author":"C Kuhl","year":"2012","unstructured":"Kuhl, C., Tautenhahn, R., B\u00f6ttcher, C., et al. (2012). CAMERA: An integrated strategy for compound spectra extraction and annotation of liquid chromatography\/mass spectrometry data sets. Analytical Chemistry, 84(1), 283\u2013289. doi: 10.1021\/ac202450g .","journal-title":"Analytical Chemistry"},{"issue":"15","key":"711_CR25","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1007\/s00216-013-6825-1","volume":"405","author":"S Lin","year":"2013","unstructured":"Lin, S., Liu, H., Kanawati, B., et al. (2013). Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer\u2019s disease in CRND8 mice. Analytical and Bioanalytical Chemistry, 405(15), 5105\u20135117. doi: 10.1007\/s00216-013-6825-1 .","journal-title":"Analytical and Bioanalytical Chemistry"},{"issue":"20","key":"711_CR26","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1073\/pnas.92.20.9368","volume":"92","author":"CD Link","year":"1995","unstructured":"Link, C. D. (1995). Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 92(20), 9368\u20139372.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"711_CR27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0197-4580(02)00224-5","volume":"24","author":"C Link","year":"2003","unstructured":"Link, C. (2003). Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer\u2019s disease model. Neurobiology of Aging, 24(3), 397\u2013413. doi: 10.1016\/S0197-4580(02)00224-5 .","journal-title":"Neurobiology of Aging"},{"issue":"10","key":"711_CR28","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.exger.2006.06.059","volume":"41","author":"CD Link","year":"2006","unstructured":"Link, C. D. (2006). C. elegans models of age-associated neurodegenerative diseases: Lessons from transgenic worm models of Alzheimer\u2019s disease. Experimental Gerontology, 41(10), 1007\u20131013. doi: 10.1016\/j.exger.2006.06.059 .","journal-title":"Experimental Gerontology"},{"issue":"7","key":"711_CR29","first-page":"a006247","volume":"2","author":"E-M Mandelkow","year":"2012","unstructured":"Mandelkow, E.-M., & Mandelkow, E. (2012). Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harbor Perspectives in Medicine, 2(7), a006247. doi: 10.1101\/cshperspect.a006247 .","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"711_CR30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nm.3466","volume":"20","author":"M Mapstone","year":"2014","unstructured":"Mapstone, M., Cheema, A. K., Fiandaca, M. S., et al. (2014). Plasma phospholipids identify antecedent memory impairment in older adults. Nature Medicine, 20, 415\u2013418. doi: 10.1038\/nm.3466 .","journal-title":"Nature Medicine"},{"issue":"1","key":"711_CR31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/2051-5960-1-28","volume":"1","author":"A Motsinger-Reif","year":"2013","unstructured":"Motsinger-Reif, A., Zhu, H., Kling, M. A., et al. (2013). Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer\u2019s disease from normal cognitive aging. Acta Neuropathologica Communications, 1(1), 28. doi: 10.1186\/2051-5960-1-28 .","journal-title":"Acta Neuropathologica Communications"},{"issue":"57","key":"711_CR32","first-page":"1","volume":"1","author":"M Ore\u0161i\u010d","year":"2011","unstructured":"Ore\u0161i\u010d, M., Hy\u00f6tyl\u00e4inen, T., Herukka, S.-K., et al. (2011). Metabolome in progression to Alzheimer\u2019s disease. Translational Psychiatry, 1(57), 1\u20139. doi: 10.1038\/tp.2011.55 .","journal-title":"Translational Psychiatry"},{"key":"711_CR33","doi-asserted-by":"crossref","first-page":"724904","DOI":"10.1155\/2012\/724904","volume":"2012","author":"M Perluigi","year":"2012","unstructured":"Perluigi, M., & Butterfield, D. A. (2012). Oxidative Stress and Down Syndrome: A route toward Alzheimer-like dementia. Current Gerontology and Geriatrics Research, 2012, 724904. doi: 10.1155\/2012\/724904 .","journal-title":"Current Gerontology and Geriatrics Research"},{"issue":"3","key":"711_CR34","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1155\/S1110724302203010","volume":"2","author":"G Perry","year":"2002","unstructured":"Perry, G., Cash, A. D., & Smith, M. A. (2002). Alzheimer disease and oxidative stress. Journal of Biomedicine & Biotechnology, 2(3), 120\u2013123. doi: 10.1155\/S1110724302203010 .","journal-title":"Journal of Biomedicine & Biotechnology"},{"issue":"1","key":"711_CR35","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/1471-2105-11-395","volume":"11","author":"T Pluskal","year":"2010","unstructured":"Pluskal, T., Castillo, S., Villar-Briones, A., et al. (2010). MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinformatics, 11(1), 395. doi: 10.1186\/1471-2105-11-395 .","journal-title":"BMC Bioinformatics"},{"issue":"47","key":"711_CR36","doi-asserted-by":"crossref","first-page":"20057","DOI":"10.1073\/pnas.0905529106","volume":"106","author":"V Rhein","year":"2009","unstructured":"Rhein, V., Song, X., Wiesner, A., et al. (2009). Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer\u2019s disease mice. PNAS, 106(47), 20057\u201320062.","journal-title":"PNAS"},{"issue":"5","key":"711_CR37","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2144\/000113133","volume":"46","author":"U Roessner","year":"2009","unstructured":"Roessner, U., & Bowne, J. (2009). What is metabolomics all about? BioTechniques, 46(5), 363\u2013365. doi: 10.2144\/000113133 .","journal-title":"BioTechniques"},{"issue":"8","key":"711_CR38","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.neuint.2010.04.001","volume":"56","author":"RM Salek","year":"2010","unstructured":"Salek, R. M., Xia, J., Innes, A., et al. (2010). A metabolomic study of the CRND8 transgenic mouse model of Alzheimer\u2019s disease. Neurochemistry International, 56(8), 937\u2013947. doi: 10.1016\/j.neuint.2010.04.001 .","journal-title":"Neurochemistry International"},{"issue":"3","key":"711_CR39","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1194\/jlr.M022376","volume":"53","author":"Y Sato","year":"2012","unstructured":"Sato, Y., Suzuki, I., Nakamura, T., et al. (2012). Identification of a new plasma biomarker of Alzheimer\u2019s disease using metabolomics technology. Journal of Lipid Research, 53(3), 567\u2013576. doi: 10.1194\/jlr.M022376 .","journal-title":"Journal of Lipid Research"},{"issue":"5","key":"711_CR40","doi-asserted-by":"crossref","first-page":"a006148","DOI":"10.1101\/cshperspect.a006148","volume":"2","author":"R Tarawneh","year":"2012","unstructured":"Tarawneh, R., & Holtzman, D. M. (2012). The clinical problem of symptomatic Alzheimer\u2019s disease and mild cognitive impairment. Cold Spring Harbor Perspectives in Medicine, 2(5), a006148. doi: 10.1101\/cshperspect.a006148 .","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"711_CR41","first-page":"01","volume":"S6","author":"L Temmerman","year":"2013","unstructured":"Temmerman, L., De Livera, A. M., Bowne, J. B., et al. (2013). Cross-platform urine metabolomics of experimental hyperglycemia in Type 2 diabetes. Journal of Diabetes & Metabolism, S6, 01. doi: 10.4172\/2155-6156 .","journal-title":"Journal of Diabetes & Metabolism"},{"issue":"8","key":"711_CR42","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.neubiorev.2013.05.008","volume":"37","author":"L Trillo","year":"2013","unstructured":"Trillo, L., Das, D., Hsieh, W., et al. (2013). Ascending monoaminergic systems alterations in Alzheimer\u2019s disease. Translating basic science into clinical care. Neuroscience and Biobehavioral Reviews, 37(8), 1363\u20131379. doi: 10.1016\/j.neubiorev.2013.05.008 .","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"5","key":"711_CR43","doi-asserted-by":"crossref","first-page":"e63644","DOI":"10.1371\/journal.pone.0063644","volume":"8","author":"E Trushina","year":"2013","unstructured":"Trushina, E., Dutta, T., Persson, X., et al. (2013). Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer\u2019s disease using metabolomics. PLoS One, 8(5), e63644. doi: 10.1371\/journal.pone.0063644 .","journal-title":"PLoS One"},{"key":"711_CR44","author":"E Trushina","year":"2013","unstructured":"Trushina, E., & Mielke, M. M. (2013). Recent advances in the application of metabolomics to Alzheimer\u2019s disease. Biochimica et Biophysica Acta,. doi: 10.1016\/j.bbadis.2013.06.014 .","journal-title":"Biochimica et Biophysica Acta"},{"issue":"4","key":"711_CR45","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1471-4159.2006.04404.x","volume":"101","author":"J Wiltfang","year":"2007","unstructured":"Wiltfang, J., Esselmann, H., Bibl, M., et al. (2007). Amyloid beta peptide ratio 42\/40 but not Abeta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load. Journal of Neurochemistry, 101(4), 1053\u20131059. doi: 10.1111\/j.1471-4159.2006.04404.x .","journal-title":"Journal of Neurochemistry"},{"issue":"Web Server issu","key":"711_CR46","doi-asserted-by":"crossref","first-page":"W127","DOI":"10.1093\/nar\/gks374","volume":"40","author":"J Xia","year":"2012","unstructured":"Xia, J., Mandal, R., Sinelnikov, I. V., et al. (2012). MetaboAnalyst 2.0: A comprehensive server for metabolomic data analysis. Nucleic acids Research, 40(Web Server issue), W127\u2013W133. doi: 10.1093\/nar\/gks374 .","journal-title":"Nucleic acids Research"},{"issue":"1","key":"711_CR47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/03009740510026878","volume":"35","author":"S Yardim-Akaydin","year":"2006","unstructured":"Yardim-Akaydin, S., Sepici, A., Ozkan, Y., et al. (2006). Evaluation of allantoin levels as a new marker of oxidative stress in Beh\u00e7et\u2019s disease. Scandinavian Journal of Rheumatology, 35(1), 61\u201364. doi: 10.1080\/03009740510026878 .","journal-title":"Scandinavian Journal of Rheumatology"},{"issue":"2","key":"711_CR48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","volume":"4","author":"J-H Zhang","year":"1999","unstructured":"Zhang, J.-H. (1999). A simple statistical parameter for use in evaluation and validation of high throughput screening assays. Journal of Biomolecular Screening, 4(2), 67\u201373. doi: 10.1177\/108705719900400206 .","journal-title":"Journal of Biomolecular Screening"},{"key":"711_CR49","first-page":"316523","volume":"2013","author":"Y Zhao","year":"2013","unstructured":"Zhao, Y., & Zhao, B. (2013). Oxidative stress and the pathogenesis of Alzheimer\u2019s disease. Oxidative Medicine and Cellular Longevity, 2013, 316523. doi: 10.1155\/2013\/316523 .","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"1\u20132","key":"711_CR50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cccn.2003.11.020","volume":"341","author":"I Zitnanov\u00e1","year":"2004","unstructured":"Zitnanov\u00e1, I., Koryt\u00e1r, P., Aruoma, O. I., et al. (2004). Uric acid and allantoin levels in Down syndrome: Antioxidant and oxidative stress mechanisms? Clinica Chimica Acta; International Journal of Clinical Chemistry, 341(1\u20132), 139\u2013146. doi: 10.1016\/j.cccn.2003.11.020 .","journal-title":"Clinica Chimica Acta; International Journal of Clinical Chemistry"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-014-0711-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11306-014-0711-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-014-0711-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T23:54:03Z","timestamp":1746316443000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11306-014-0711-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,30]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["711"],"URL":"https:\/\/doi.org\/10.1007\/s11306-014-0711-5","relation":{},"ISSN":["1573-3882","1573-3890"],"issn-type":[{"value":"1573-3882","type":"print"},{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,30]]}}}