{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:45:34Z","timestamp":1778791534228,"version":"3.51.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL104129"],"award-info":[{"award-number":["R01HL104129"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["11CVD04"],"award-info":[{"award-number":["11CVD04"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s11306-017-1303-y","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T06:47:02Z","timestamp":1512370022000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Untargeted metabolomics analysis of ischemia\u2013reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats"],"prefix":"10.1007","volume":"14","author":[{"given":"Traci L.","family":"Parry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph W.","family":"Starnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara K.","family":"O\u2019Neal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Muehlbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aubree","family":"Honcoop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amro","family":"Ilaiwy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Christopher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cam","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0769-5816","authenticated-orcid":false,"given":"Monte S.","family":"Willis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"1303_CR1","doi-asserted-by":"publisher","first-page":"H1360","DOI":"10.1152\/ajpheart.00858.2015","volume":"310","author":"RJ Alleman","year":"2016","unstructured":"Alleman, R. J., Tsang, A. M., Ryan, T. E., Patteson, D. J., Mcclung, J. M., Spangenburg, E. E., Shaikh, S. R., Neufer, P. D., & Brown, D. A. (2016). Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. American Journal of Physiology Heart and Circulatory Physiology, 310, H1360\u2013H1370.","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"key":"1303_CR2","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1002\/clc.4960210904","volume":"21","author":"M Arsenian","year":"1998","unstructured":"Arsenian, M. (1998). Potential cardiovascular applications of glutamate, aspartate, and other amino acids. Clinical Cardiology, 21, 620\u2013624.","journal-title":"Clinical Cardiology"},{"key":"1303_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ijcard.2006.04.076","volume":"117","author":"A Ascensao","year":"2007","unstructured":"Ascensao, A., Ferreira, R., & Magalhaes, J. (2007). Exercise-induced cardioprotection\u2013biochemical, morphological and functional evidence in whole tissue and isolated mitochondria. International Journal of Cardiology, 117, 16\u201330.","journal-title":"International Journal of Cardiology"},{"key":"1303_CR4","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1054\/plef.2001.0273","volume":"64","author":"AB Awad","year":"2001","unstructured":"Awad, A. B., Smith, A. J., & Fink, C. S. (2001). Plant sterols regulate rat vascular smooth muscle cell growth and prostacyclin release in culture. Prostaglandins Leukot Essent Fatty Acids, 64, 323\u2013330.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1303_CR5","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/s11306-015-0786-7","volume":"11","author":"R Banerjee","year":"2015","unstructured":"Banerjee, R., Bultman, S. J., Holley, D., Hillhouse, C., Bain, J. R., Newgard, C. B., Muehlbauer, M. J., & Willis, M. S. (2015). Non-targeted metabolomics of Brg1\/Brm double-mutant cardiomyocytes reveals a novel role for SWI\/SNF complexes in metabolic homeostasis. Metabolomics, 11, 1287\u20131301.","journal-title":"Metabolomics"},{"key":"1303_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1177\/021849230701500603","volume":"15","author":"G Bolotin","year":"2007","unstructured":"Bolotin, G., Raman, J., Williams, U., Bacha, E., Kocherginsky, M., & Jeevanandam, V. (2007). Glutamine improves myocardial function following ischemia\u2013reperfusion injury. Asian Cardiovascular and Thoracic Annals, 15, 463\u2013467.","journal-title":"Asian Cardiovascular and Thoracic Annals"},{"key":"1303_CR7","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.1002\/pmic.200401356","volume":"6","author":"MO Boluyt","year":"2006","unstructured":"Boluyt, M. O., Brevick, J. L., Rogers, D. S., Randall, M. J., Scalia, A. F., & Li, Z. B. (2006). Changes in the rat heart proteome induced by exercise training: Increased abundance of heat shock protein HSP20. Proteomics, 6, 3154\u20133169.","journal-title":"Proteomics"},{"key":"1303_CR8","first-page":"71","volume":"105","author":"JP Borges","year":"2015","unstructured":"Borges, J. P., & Lessa, M. A. (2015). mechanisms involved in exercise-induced cardioprotection: A systematic review. Arquivos Brasileiros de Cardiologia, 105, 71\u201381.","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"1303_CR9","first-page":"H804","volume":"263","author":"DK Bowles","year":"1992","unstructured":"Bowles, D. K., Farrar, R. P., & Starnes, J. W. (1992). Exercise training improves cardiac function after ischemia in the isolated, working rat heart. American Journal of Physiology, 263, H804\u2013H809.","journal-title":"American Journal of Physiology"},{"key":"1303_CR10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0003-2697(91)90437-X","volume":"198","author":"D Constantin-Teodosiu","year":"1991","unstructured":"Constantin-Teodosiu, D., Cederblad, G., & Hultman, E. (1991). A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue. Analytical Biochemistry, 198, 347\u2013351.","journal-title":"Analytical Biochemistry"},{"key":"1303_CR11","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/0022-2828(91)91642-5","volume":"23","author":"SC Dennis","year":"1991","unstructured":"Dennis, S. C., Gevers, W., & Opie, L. H. (1991). Protons in ischemia: Where do they come from; where do they go to? Journal of Molecular and Cellular Cardiology, 23, 1077\u20131086.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"1303_CR12","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1258\/ebm.2012.012025","volume":"237","author":"KJ Drake","year":"2012","unstructured":"Drake, K. J., Sidorov, V. Y., Mcguinness, O. P., Wasserman, D. H., & Wikswo, J. P. (2012). Amino acids as metabolic substrates during cardiac ischemia. Experimental Biology and Medicine (Maywood), 237, 1369\u20131378.","journal-title":"Experimental Biology and Medicine (Maywood)"},{"key":"1303_CR13","first-page":"844","volume":"53","author":"GA Dudley","year":"1982","unstructured":"Dudley, G. A., Abraham, W. M., & Terjung, R. L. (1982). Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle. Journal of Applied Physiology Respiratory, Environmental and Exercise Physiology, 53, 844\u2013850.","journal-title":"Journal of Applied Physiology Respiratory, Environmental and Exercise Physiology"},{"key":"1303_CR14","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1042\/BST20110673","volume":"40","author":"HV Edwards","year":"2012","unstructured":"Edwards, H. V., Scott, J. D., & Baillie, G. S. (2012). PKA phosphorylation of the small heat-shock protein HSP20 enhances its cardioprotective effects. Biochemical Society Transactions, 40, 210\u2013214.","journal-title":"Biochemical Society Transactions"},{"key":"1303_CR15","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.atherosclerosis.2006.10.032","volume":"196","author":"K Fassbender","year":"2008","unstructured":"Fassbender, K., Lutjohann, D., Dik, M. G., Bremmer, M., Konig, J., Walter, S., Liu, Y., Letiembre, M., Von Bergmann, K., & Jonker, C. (2008). Moderately elevated plant sterol levels are associated with reduced cardiovascular risk\u2013the LASA study. Atherosclerosis, 196, 283\u2013288.","journal-title":"Atherosclerosis"},{"key":"1303_CR16","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.ijcard.2012.10.046","volume":"168","author":"JA Finegold","year":"2013","unstructured":"Finegold, J. A., Asaria, P., & Francis, D. P. 2013. Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations. International Journal of Cardiology, 168, 934\u2013945.","journal-title":"International Journal of Cardiology"},{"key":"1303_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1139\/o73-003","volume":"51","author":"L Gailis","year":"1973","unstructured":"Gailis, L., & Benmouyal, E. (1973). Endogenous alanine, glutamate, aspartate, and glutamine in the perfused guinea-pig heart: Effect of substrates and cardioactive agents. Canadian Journal of Biochemistry, 51, 11\u201320.","journal-title":"Canadian Journal of Biochemistry"},{"key":"1303_CR18","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S0197-0186(99)00149-7","volume":"36","author":"D Huster","year":"2000","unstructured":"Huster, D., Reichenbach, A., & Reichelt, W. (2000). The glutathione content of retinal Muller (glial) cells: Effect of pathological conditions. Neurochemistry International, 36, 461\u2013469.","journal-title":"Neurochemistry International"},{"key":"1303_CR19","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.me.42.020191.001301","volume":"42","author":"RB Jennings","year":"1991","unstructured":"Jennings, R. B., & Reimer, K. A. (1991). The cell biology of acute myocardial ischemia. Annual Review of Medicine, 42, 225\u2013246.","journal-title":"Annual Review of Medicine"},{"key":"1303_CR20","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1001\/archderm.1990.01670350099017","volume":"126","author":"MD Koone","year":"1990","unstructured":"Koone, M. D., Rizzo, W. B., Elias, P. M., Williams, M. L., Lightner, V., & Pinnell, S. R. (1990). Ichthyosis, mental retardation, and asymptomatic spasticity. A new neurocutaneous syndrome with normal fatty alcohol:NAD+ oxidoreductase activity. Archives of Dermatology, 126, 1485\u20131490.","journal-title":"Archives of Dermatology"},{"key":"1303_CR21","first-page":"373","volume":"113","author":"AO Kumerova","year":"1992","unstructured":"Kumerova, A. O., Utno, L., Lipsberga, Z. E., & Shkestere, I. (1992). [Study of pantothenic acid derivatives as cardiac protectors in a model of experimental ischemia and reperfusion of the isolated heart]. Biulleten Eksperimentalnoi Biologii I Meditsiny, 113, 373\u2013375.","journal-title":"Biulleten Eksperimentalnoi Biologii I Meditsiny"},{"key":"1303_CR22","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1249\/MSS.0b013e318231c037","volume":"44","author":"Y Lee","year":"2012","unstructured":"Lee, Y., Min, K., Talbert, E. E., Kavazis, A. N., Smuder, A. J., Willis, W. T., & Powers, S. K. (2012). Exercise protects cardiac mitochondria against ischemia\u2013reperfusion injury. Medicine and Science in Sports and Exercise, 44, 397\u2013405.","journal-title":"Medicine and Science in Sports and Exercise"},{"key":"1303_CR23","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.yjmcc.2006.09.015","volume":"42","author":"J Liu","year":"2007","unstructured":"Liu, J., Marchase, R. B., & Chatham, J. C. (2007). Glutamine-induced protection of isolated rat heart from ischemia\/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels. Journal of Molecular and Cellular Cardiology, 42, 177\u2013185.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"1303_CR24","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1039\/c3mb70222g","volume":"9","author":"YT Liu","year":"2013","unstructured":"Liu, Y. T., Jia, H. M., Chang, X., Ding, G., Zhang, H. W., & ZOU, Z. M. (2013). The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics. Molecular BioSystems, 9, 2823\u20132834.","journal-title":"Molecular BioSystems"},{"key":"1303_CR25","doi-asserted-by":"publisher","first-page":"C1387","DOI":"10.1152\/ajpcell.1995.268.6.C1387","volume":"268","author":"M Locke","year":"1995","unstructured":"Locke, M., Noble, E. G., Tanguay, R. M., Feild, M. R., Ianuzzo, S. E., & Ianuzzo, C. D. (1995). Activation of heat-shock transcription factor in rat heart after heat shock and exercise. American Journal of Physiology, 268, C1387\u2013C1394.","journal-title":"American Journal of Physiology"},{"key":"1303_CR26","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.yjmcc.2004.05.021","volume":"37","author":"CW Melling","year":"2004","unstructured":"Melling, C. W., Thorp, D. B., & Noble, E. G. (2004). Regulation of myocardial heat shock protein 70 gene expression following exercise. Journal of Molecular and Cellular Cardiology, 37, 847\u2013855.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"1303_CR27","first-page":"397","volume":"81","author":"P Miller-Graber","year":"1991","unstructured":"Miller-Graber, P., Lawrence, L., Fisher, M., Bump, K., Foreman, J., & Kurcz, E. (1991). Metabolic responses to ammonium acetate infusion in exercising horses. The Cornell Veterinarian, 81, 397\u2013410.","journal-title":"The Cornell Veterinarian"},{"key":"1303_CR28","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1152\/japplphysiol.00536.2001","volume":"93","author":"CR Mitchell","year":"2002","unstructured":"Mitchell, C. R., Harris, M. B., Cordaro, A. R., & Starnes, J. W. (2002). Effect of body temperature during exercise on skeletal muscle cytochrome c oxidase content. Journal of Applied Physiology(1985), 93, 526\u2013530.","journal-title":"Journal of Applied Physiology(1985)"},{"key":"1303_CR29","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1161\/CIRCULATIONAHA.113.004042","volume":"129","author":"AE Moran","year":"2014","unstructured":"Moran, A. E., Forouzanfar, M. H., Roth, G. A., Mensah, G. A., Ezzati, M., Murray, C. J., & Naghavi, M. (2014). Temporal trends in ischemic heart disease mortality in 21 world regions, 1980 to 2010: The Global Burden of Disease 2010 study. Circulation, 129, 1483\u20131492.","journal-title":"Circulation"},{"key":"1303_CR30","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.freeradbiomed.2016.10.496","volume":"101","author":"J Musman","year":"2016","unstructured":"Musman, J., Pons, S., Barau, C., Caccia, C., Leoni, V., Berdeaux, A., Ghaleh, B., & Morin, D. (2016). Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia\u2013reperfusion in wild-type and ob\/ob mice. Free Radical Biology & Medicine, 101, 317\u2013324.","journal-title":"Free Radical Biology & Medicine"},{"key":"1303_CR31","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.ijcard.2014.04.096","volume":"174","author":"AN Nowbar","year":"2014","unstructured":"Nowbar, A. N., Howard, J. P., Finegold, J. A., Asaria, P., & Francis, D. P. (2014). 2014 global geographic analysis of mortality from ischaemic heart disease by country, age and income: Statistics from World Health Organisation and United Nations. International Journal of Cardiology, 174, 293\u2013298.","journal-title":"International Journal of Cardiology"},{"key":"1303_CR32","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/j.bbalip.2016.01.019","volume":"1861","author":"X Palomer","year":"2016","unstructured":"Palomer, X., Barroso, E., Zarei, M., Botteri, G., & Vazquez-Carrera, M (2016). PPARbeta\/delta and lipid metabolism in the heart. Biochim Biophys Acta, 1861, 1569\u20131578.","journal-title":"Biochim Biophys Acta"},{"key":"1303_CR33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0167-5273(98)00117-X","volume":"65","author":"JW Park","year":"1998","unstructured":"Park, J. W., Chun, Y. S., Kim, M. S., Park, Y. C., Kwak, S. J., & Park, S. C. (1998). Metabolic modulation of cellular redox potential can improve cardiac recovery from ischemia\u2013reperfusion injury. International Journal of Cardiology, 65, 139\u2013147.","journal-title":"International Journal of Cardiology"},{"key":"1303_CR34","doi-asserted-by":"publisher","first-page":"C404","DOI":"10.1152\/ajpcell.00051.2002","volume":"283","author":"Z Paroo","year":"2002","unstructured":"Paroo, Z., Meredith, M. J., Locke, M., Haist, J. V., Karmazyn, M., & Noble, E. G. (2002). Redox signaling of cardiac HSF1 DNA binding. American Journal of Physiology Cell Physiology, 283, C404\u2013C411.","journal-title":"American Journal of Physiology Cell Physiology"},{"key":"1303_CR35","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1097\/00001573-200209000-00009","volume":"17","author":"SK Powers","year":"2002","unstructured":"Powers, S. K., Lennon, S. L., Quindry, J., & Mehta, J. L. (2002). Exercise and cardioprotection. Current Opinion in Cardiology, 17, 495\u2013502.","journal-title":"Current Opinion in Cardiology"},{"key":"1303_CR36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.freeradbiomed.2007.02.006","volume":"44","author":"SK Powers","year":"2008","unstructured":"Powers, S. K., Quindry, J. C., & Kavazis, A. N. (2008). Exercise-induced cardioprotection against myocardial ischemia\u2013reperfusion injury. Free Radical Biology & Medicine, 44, 193\u2013201.","journal-title":"Free Radical Biology & Medicine"},{"key":"1303_CR37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3109\/10715762.2013.825371","volume":"48","author":"SK Powers","year":"2014","unstructured":"Powers, S. K., Sollanek, K. J., Wiggs, M. P., Demirel, H. A., & Smuder, A. J. (2014). Exercise-induced improvements in myocardial antioxidant capacity: The antioxidant players and cardioprotection. Free Radical Research, 48, 43\u201351.","journal-title":"Free Radical Research"},{"key":"1303_CR38","first-page":"H873","volume":"236","author":"EE Rau","year":"1979","unstructured":"Rau, E. E., Shine, K. I., Gervais, A., Douglas, A. M., & Amos, E. C. 3rd (1979). Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion. American Journal of Physiology, 236, H873\u2013H879.","journal-title":"American Journal of Physiology"},{"key":"1303_CR39","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","volume":"123","author":"PG Reeves","year":"1993","unstructured":"Reeves, P. G., Nielsen, F. H., & Fahey, G. C., Jr. (1993). AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition, 123, 1939\u20131951.","journal-title":"Journal of Nutrition"},{"key":"1303_CR40","doi-asserted-by":"publisher","first-page":"2488S","DOI":"10.1093\/jn\/131.9.2488S","volume":"131","author":"MJ Rennie","year":"2001","unstructured":"Rennie, M. J., Bowtell, J. L., Bruce, M., & Khogali, S. E. (2001). Interaction between glutamine availability and metabolism of glycogen, tricarboxylic acid cycle intermediates and glutathione. Journal of Nutrition, 131, 2488S\u20132490S. (Discussion 2496S\u20132497S).","journal-title":"Journal of Nutrition"},{"key":"1303_CR41","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1006\/bmmb.1993.1050","volume":"50","author":"WB Rizzo","year":"1993","unstructured":"Rizzo, W. B., Craft, D. A., Judd, L. L., Moser, H. W., & Moser, A. B. (1993). Fatty alcohol accumulation in the autosomal recessive form of rhizomelic chondrodysplasia punctata. Biochemical Medicine and Metabolic Biology, 50, 93\u2013102.","journal-title":"Biochemical Medicine and Metabolic Biology"},{"key":"1303_CR42","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.cardiores.2005.02.010","volume":"66","author":"A Robinet","year":"2005","unstructured":"Robinet, A., Hoizey, G., & Millart, H. (2005). PI 3-kinase, protein kinase C, and protein kinase A are involved in the trigger phase of beta1-adrenergic preconditioning. Cardiovascular Research, 66, 530\u2013542.","journal-title":"Cardiovascular Research"},{"key":"1303_CR43","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1042\/bj1190193","volume":"119","author":"ED Saggerson","year":"1970","unstructured":"Saggerson, E. D., & Greenbaum, A. L. (1970). The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue. Biochemistry Journal, 119, 193\u2013219.","journal-title":"Biochemistry Journal"},{"key":"1303_CR44","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1111\/j.1440-1681.2006.04497.x","volume":"33","author":"NB Stottrup","year":"2006","unstructured":"Stottrup, N. B., Kristiansen, S. B., Lofgren, B., Hansen, B. F., Kimose, H. H., Botker, H. E., & Nielsen, T. T. (2006). l-glutamate and glutamine improve haemodynamic function and restore myocardial glycogen content during postischaemic reperfusion: A radioactive tracer study in the rat isolated heart. Clinical and Experimental Pharmacology and Physiology, 33, 1099\u20131103.","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"1303_CR45","doi-asserted-by":"publisher","first-page":"D463","DOI":"10.1093\/nar\/gkv1042","volume":"44","author":"M Sud","year":"2016","unstructured":"Sud, M., Fahy, E., Cotter, D., Azam, K., Vadivelu, I., Burant, C., Edison, A., Fiehn, O., Higashi, R., Nair, K. S., Sumner, S., & Subramaniam, S. (2016). Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools. Nucleic Acids Research, 44, D463\u2013D470.","journal-title":"Nucleic Acids Research"},{"key":"1303_CR46","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1016\/S0021-9258(17)40153-0","volume":"252","author":"H Taegtmeyer","year":"1977","unstructured":"Taegtmeyer, H., Peterson, M. B., Ragavan, V. V., Ferguson, A. G., & Lesch, M. (1977). De novo alanine synthesis in isolated oxygen-deprived rabbit myocardium. Journal of Biological Chemistry, 252, 5010\u20135018.","journal-title":"Journal of Biological Chemistry"},{"key":"1303_CR47","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/cvr\/cvr052","volume":"90","author":"H Tuunanen","year":"2011","unstructured":"Tuunanen, H., & Knuuti, J. (2011). Metabolic remodelling in human heart failure. Cardiovascular Research, 90, 251\u2013257.","journal-title":"Cardiovascular Research"},{"key":"1303_CR48","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1177\/0148607103027006396","volume":"27","author":"PE Wischmeyer","year":"2003","unstructured":"Wischmeyer, P. E., Jayakar, D., Williams, U., Singleton, K. D., Riehm, J., Bacha, E. A., Jeevanandam, V., Christians, U., & Serkova, N. (2003). Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia\u2013reperfusion injury. JPEN Journal of Parenteral and Enteral Nutrition, 27, 396\u2013403.","journal-title":"JPEN Journal of Parenteral and Enteral Nutrition"},{"key":"1303_CR49","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/ajcn\/68.2.291","volume":"68","author":"A Wolk","year":"1998","unstructured":"Wolk, A., Vessby, B., Ljung, H., & Barrefors, P. (1998). Evaluation of a biological marker of dairy fat intake. American Journal of Clinical Nutrition, 68, 291\u2013295.","journal-title":"American Journal of Clinical Nutrition"},{"key":"1303_CR50","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1002\/ptr.5087","volume":"28","author":"HS Wong","year":"2014","unstructured":"Wong, H. S., Chen, N., Leong, P. K., & Ko, K. M. (2014). beta-Sitosterol enhances cellular glutathione redox cycling by reactive oxygen species generated from mitochondrial respiration: Protection against oxidant injury in H9c2 cells and rat hearts. Phytotherapy Research, 28, 999\u20131006.","journal-title":"Phytotherapy Research"},{"key":"1303_CR51","doi-asserted-by":"publisher","first-page":"W652","DOI":"10.1093\/nar\/gkp356","volume":"37","author":"J Xia","year":"2009","unstructured":"Xia, J., Psychogios, N., Young, N., & Wishart, D. S. (2009). MetaboAnalyst: A web server for metabolomic data analysis and interpretation. Nucleic Acids Research, 37, W652\u2013W660.","journal-title":"Nucleic Acids Research"},{"key":"1303_CR52","first-page":"W251-W257","volume":"43","author":"J Xia","year":"2015","unstructured":"Xia, J., Sinelnikov, I. V., Han, B., & Wishart, D. S. (2015). MetaboAnalyst 3.0\u2014making metabolomics more meaningful. Nucleic Acids Research, 43, W251\u2013W257.","journal-title":"Nucleic Acids Research"},{"key":"1303_CR53","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/aps.2010.45","volume":"31","author":"S Zhang","year":"2010","unstructured":"Zhang, S., Li, H., & Yang, S. J. (2010). Tribulosin protects rat hearts from ischemia\/reperfusion injury. Acta Pharmacologica Sinica, 31, 671\u2013678.","journal-title":"Acta Pharmacologica Sinica"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11306-017-1303-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-017-1303-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-017-1303-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T21:15:51Z","timestamp":1660079751000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11306-017-1303-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["1303"],"URL":"https:\/\/doi.org\/10.1007\/s11306-017-1303-y","relation":{},"ISSN":["1573-3882","1573-3890"],"issn-type":[{"value":"1573-3882","type":"print"},{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]},"assertion":[{"value":"7 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This investigation was approved by the UNC-Greensboro\u2019s Animal Care and Use Committee and conforms to the <i>Guide for the Care and Use of Laboratory Animals<\/i> published by the National Institutes of Health (NIH Publication No. 85\u201323, Revised 1996). All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"8"}}