{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:41:08Z","timestamp":1793410868110,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430056"],"award-info":[{"award-number":["81430056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s11306-018-1375-3","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T09:35:52Z","timestamp":1527845752000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Unbiased lipidomic profiling reveals metabolomic changes during the onset and antipsychotics treatment of schizophrenia disease"],"prefix":"10.1007","volume":"14","author":[{"given":"Lailai","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntuo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-182X","authenticated-orcid":false,"given":"Lijun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"1375_CR1","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1073\/pnas.052023499","volume":"99","author":"TD Cannon","year":"2002","unstructured":"Cannon, T. D., Thompson, P. M., van Erp, T. G., Toga, A. W., Poutanen, V. P., Huttunen, M., Lonnqvist, J., Standerskjold-Nordenstam, C. G., Narr, K. L., Khaledy, M., Zoumalan, C. I., Dail, R., & Kaprio, J. (2002). Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia. Proceedings of the National Academy of Sciences of USA, 99, 3228\u20133233.","journal-title":"Proceedings of the National Academy of Sciences of USA"},{"key":"1375_CR2","doi-asserted-by":"publisher","unstructured":"Divac, N., Prostran, M., Jakovcevski, I., & Cerovac, N. (2014). Second-generation antipsychotics and extrapyramidal adverse effects. Biomedical Research International. \n                    https:\/\/doi.org\/10.1155\/2014\/656370\n                    \n                  .","DOI":"10.1155\/2014\/656370"},{"key":"1375_CR3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.biopsych.2010.06.031","volume":"69","author":"JA English","year":"2011","unstructured":"English, J. A., Pennington, K., Dunn, M. J., & Cotter, D. R. (2011). The neuroproteomics of schizophrenia. Biol Psychiatry, 69, 163\u2013172.","journal-title":"Biol Psychiatry"},{"key":"1375_CR4","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/nn.4228","volume":"19","author":"B Franke","year":"2016","unstructured":"Franke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., Arias-Vasquez, A., Smoller, J. W., Nichols, T. E., Neale, M. C., McIntosh, A. M., Lee, P., McMahon, F. J., Meyer-Lindenberg, A., Mattheisen, M., Andreassen, O. A., Gruber, O., Sachdev, P. S., Roiz-Santianez, R., Saykin, A. J., Ehrlich, S., Mather, K. A., Turner, J. A., Schwarz, E., Thalamuthu, A., Shugart, Y. Y., Ho, Y. Y., Martin, N. G., Wright, M. J., C. Schizophrenia Working Group of the Psychiatric Genomics, E. Consortium, O\u2019Donovan, M. C., Thompson, P. M., Neale, B. M., Medland, S. E., & Sullivan, P. F. (2016). Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept. Nature Neuroscience, 19, 420\u2013431.","journal-title":"Nature Neuroscience"},{"key":"1375_CR5","doi-asserted-by":"publisher","first-page":"7863","DOI":"10.1073\/pnas.0906232107","volume":"107","author":"J Gauthier","year":"2010","unstructured":"Gauthier, J., Champagne, N., Lafreniere, R. G., Xiong, L., Spiegelman, D., Brustein, E., Lapointe, M., Peng, H., Cote, M., Noreau, A., Hamdan, F. F., Addington, A. M., Rapoport, J. L., Delisi, L. E., Krebs, M. O., Joober, R., Fathalli, F., Mouaffak, F., Haghighi, A. P., Neri, C., Dube, M. P., Samuels, M. E., Marineau, C., Stone, E. A., Awadalla, P., Barker, P. A., Carbonetto, S., Drapeau, P., Rouleau, G. A., & S. D. Team (2010). De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proceedings of the National Academy of Sciences of USA, 107, 7863\u20137868.","journal-title":"Proceedings of the National Academy of Sciences of USA"},{"key":"1375_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11306-005-1102-8","volume":"1","author":"JB German","year":"2005","unstructured":"German, J. B., Hammock, B. D., & Watkins, S. M. (2005). Metabolomics: Building on a century of biochemistry to guide human health. Metabolomics, 1, 3\u20139.","journal-title":"Metabolomics"},{"key":"1375_CR7","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroscience.2012.04.044","volume":"251","author":"JR Glausier","year":"2013","unstructured":"Glausier, J. R., & Lewis, D. A. (2013). Dendritic spine pathology in schizophrenia. Neuroscience, 251, 90\u2013107.","journal-title":"Neuroscience"},{"key":"1375_CR8","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/sj.mp.4002000","volume":"12","author":"R Kaddurah-Daouk","year":"2007","unstructured":"Kaddurah-Daouk, R., McEvoy, J., Baillie, R. A., Lee, D., Yao, J. K., Doraiswamy, P. M., & Krishnan, K. R. (2007). Metabolomic mapping of atypical antipsychotic effects in schizophrenia. Molecular Psychiatry, 12, 934\u2013945.","journal-title":"Molecular Psychiatry"},{"key":"1375_CR9","doi-asserted-by":"crossref","unstructured":"Kay, S. R., Opler, L. A., & Lindenmayer, J. P. (1989). The Positive and Negative Syndrome Scale (PANSS): Rationale and standardisation. The British Journal of Psychiatry Supplement, 59\u201367.","DOI":"10.1192\/S0007125000291514"},{"key":"1375_CR10","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1089\/ars.2010.3459","volume":"15","author":"D Martins-de-Souza","year":"2011","unstructured":"Martins-de-Souza, D., Harris, L. W., Guest, P. C., & Bahn, S. (2011). The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics. Antioxidants and Redox Signaling, 15, 2067\u20132079.","journal-title":"Antioxidants and Redox Signaling"},{"key":"1375_CR11","doi-asserted-by":"publisher","first-page":"e68717","DOI":"10.1371\/journal.pone.0068717","volume":"8","author":"J McEvoy","year":"2013","unstructured":"McEvoy, J., Baillie, R. A., Zhu, H., Buckley, P., Keshavan, M. S., Nasrallah, H. A., Dougherty, G. G., Yao, J. K., & Kaddurah-Daouk, R. (2013). Lipidomics reveals early metabolic changes in subjects with schizophrenia: Effects of atypical antipsychotics. PLoS ONE, 8, e68717.","journal-title":"PLoS ONE"},{"key":"1375_CR12","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/sj.mp.4000866","volume":"6","author":"K Mirnics","year":"2001","unstructured":"Mirnics, K., Middleton, F. A., Stanwood, G. D., Lewis, D. A., & Levitt, P. (2001). Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Molecular Psychiatry, 6, 293\u2013301.","journal-title":"Molecular Psychiatry"},{"key":"1375_CR13","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1093\/hmg\/ddg162","volume":"12","author":"JA Morris","year":"2003","unstructured":"Morris, J. A. (2003). DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4\/5 and NUDEL: Regulation and loss of interaction with mutation. Human Molecular Genetics, 12, 1591\u20131608.","journal-title":"Human Molecular Genetics"},{"key":"1375_CR14","doi-asserted-by":"publisher","first-page":"7933","DOI":"10.1021\/acs.analchem.7b00925","volume":"89","author":"S Naz","year":"2017","unstructured":"Naz, S., Gallart-Ayala, H., Reinke, S. N., Mathon, C., Blankley, R., Chaleckis, R., & Wheelock, C. E. (2017). Development of a liquid chromatography\u2013high resolution mass spectrometry metabolomics method with high specificity for metabolite identification using all ion fragmentation acquisition. Analytical Chemistry, 89, 7933\u20137942.","journal-title":"Analytical Chemistry"},{"key":"1375_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gm300","volume":"4","author":"M Oresic","year":"2012","unstructured":"Oresic, M., Seppanen-Laakso, T., Sun, D., Tang, J., Therman, S., Viehman, R., Mustonen, U., van Erp, T. G., Hyotylainen, T., Thompson, P., Toga, A. W., Huttunen, M. O., Suvisaari, J., Kaprio, J., Lonnqvist, J., & Cannon, T. D. (2012). Phospholipids and insulin resistance in psychosis: A lipidomics study of twin pairs discordant for schizophrenia. Genome Medicine, 4, 1.","journal-title":"Genome Medicine"},{"key":"1375_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/gm233","volume":"3","author":"M Oresic","year":"2011","unstructured":"Oresic, M., Tang, J., Seppanen-Laakso, T., Mattila, I., Saarni, S. E., Saarni, S. I., Lonnqvist, J., Sysi-Aho, M., Hyotylainen, T., Perala, J., & Suvisaari, J. (2011). Metabolome in schizophrenia and other psychotic disorders: A general population-based study. Genome Medicine, 3, 19.","journal-title":"Genome Medicine"},{"key":"1375_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nrm3314","volume":"13","author":"GJ Patti","year":"2012","unstructured":"Patti, G. J., Yanes, O., & Siuzdak, G. (2012). Innovation: Metabolomics: The apogee of the omics trilogy. Nature Reviews Molecular Cell Biology, 13, 263\u2013269.","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"1375_CR18","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1002\/rcm.2550","volume":"20","author":"RS Plumb","year":"2006","unstructured":"Plumb, R. S., Johnson, K. A., Rainville, P., Smith, B. W., Wilson, I. D., Castro-Perez, J. M., & Nicholson, J. K. (2006). UPLC\/MS(E); a new approach for generating molecular fragment information for biomarker structure elucidation. Rapid Communications in Mass Spectrometry, 20, 1989\u20131994.","journal-title":"Rapid Communications in Mass Spectrometry"},{"issue":"Suppl 1","key":"1375_CR19","first-page":"S255","volume":"27","author":"SX Poo","year":"2015","unstructured":"Poo, S. X., & Agius, M. (2015). Atypical antipsychotics for schizophrenia and\/or bipolar disorder in pregnancy: Current recommendations and updates in the NICE guidelines. Psychiatria Danubina, 27(Suppl 1), S255\u2013S260.","journal-title":"Psychiatria Danubina"},{"key":"1375_CR30","doi-asserted-by":"crossref","unstructured":"Ripke, S., O\u2019Dushlaine, C., Chambert, K., Moran, J. L., Kahler, A. K., Akterin, S., Bergen, S. E., Collins, A. L., Crowley, J. J., Fromer, M., Kim, Y., Lee, S. H., Magnusson, P. K., Sanchez, N., Stahl, E. A., Williams, S., Wray, N. R., Xia, K., Bettella, F., Borglum, A. D., Bulik-Sullivan, B. K., Cormican, P., Craddock, N., de Leeuw, C., Durmishi, N., Gill, M., Golimbet, V., Hamshere, M. L., Holmans, P., Hougaard, D. M., Kendler, K. S., Lin, K., Morris, D. W., Mors, O., Mortensen, P. B., Neale, B. M., O\u2019Neill, F. A., Owen, M. J., Milovancevic, M. P., Posthuma, D., Powell, J., Richards, A. L., Riley, B. P., Ruderfer, D., Rujescu, D., Sigurdsson, E., Silagadze, T., Smit, A. B., Stefansson, H., Steinberg, S., Suvisaari, J., Tosato, S., Verhage, M., Walters, J. T., C. Multicenter Genetic Studies of Schizophrenia, Levinson, D. F., Gejman, P. V., Kendler, K. S., Laurent, C., Mowry, B. J., O\u2019Donovan, M. C., Owen, M. J., Pulver, A. E., Riley, B. P., Schwab, S. G., Wildenauer, D. B., Dudbridge, F., Holmans, P., Shi, J., Albus, M., Alexander, M., Campion, D., Cohen, D., Dikeos, D., Duan, J., Eichhammer, P., Godard, S., Hansen, M., Lerer, F. B., Liang, K. Y., Maier, W., Mallet, J., Nertney, D. A., Nestadt, G., Norton, N., O\u2019Neill, F. A., Papadimitriou, G. N., Ribble, R., Sanders, A. R., Silverman, J. M., Walsh, D., Williams, N. M., Wormley, B., C. Psychosis Endophenotypes International, Arranz, M. J., Bakker, S., Bender, S., Bramon, E., Collier, D., Crespo-Facorro, B., Hall, J., Iyegbe, C., Jablensky, A., Kahn, R. S., Kalaydjieva, L., Lawrie, S., Lewis, C. M., Lin, K., Linszen, D. H., Mata, I., McIntosh, A., Murray, R. M., Ophoff, R. A., Powell, J., Rujescu, D., Van Os, J., Walshe, M., Weisbrod, M., Wiersma, D., C. Wellcome Trust Case Control, Donnelly, P., Barroso, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A. P., Deloukas, P., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Spencer, C. C., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, R. D., Strange, A., Su, Z., Vukcevic, D., Donnelly, P., Langford, C., Hunt, S. E., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Tashakkori-Ghanbaria, A., Waller, M. J., Weston, P., Widaa, S., Whittaker, P., Barroso, I., Deloukas, P., Mathew, C. G., Blackwell, J. M., Brown, M. A., Corvin, A. P., McCarthy, M. I., Spencer, C. C., Bramon, E., Corvin, A. P., O\u2019Donovan, M. C., Stefansson, K., Scolnick, E., Purcell, S., McCarroll, S. A., Sklar, P., Hultman, C. M., & Sullivan, P. F. (2013). Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics, 45, 1150\u20131159.","DOI":"10.1038\/ng.2742"},{"key":"1375_CR20","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1146\/annurev.arplant.043008.092035","volume":"61","author":"K Saito","year":"2010","unstructured":"Saito, K., & Matsuda, F. (2010). Metabolomics for functional genomics, systems biology, and biotechnology. Annual Review of Plant Biology, 61, 463\u2013489.","journal-title":"Annual Review of Plant Biology"},{"key":"1375_CR21","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s11306-009-0168-0","volume":"5","author":"A Scalbert","year":"2009","unstructured":"Scalbert, A., Brennan, L., Fiehn, O., Hankemeier, T., Kristal, B. S., van Ommen, B., Pujos-Guillot, E., Verheij, E., Wishart, D., & Wopereis, S. (2009). Mass-spectrometry-based metabolomics: Limitations and recommendations for future progress with particular focus on nutrition research. Metabolomics, 5, 435\u2013458.","journal-title":"Metabolomics"},{"key":"1375_CR22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature16549","volume":"530","author":"A Sekar","year":"2016","unstructured":"Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., Genovese, G., Rose, S. A., Handsaker, R. E., C. Schizophrenia Working Group of the Psychiatric Genomics, Daly, M. J., Carroll, M. C., Stevens, B., & McCarroll, S. A. (2016). Schizophrenia risk from complex variation of complement component 4. Nature, 530, 177\u2013183.","journal-title":"Nature"},{"key":"1375_CR23","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nbt.2348","volume":"30","author":"R Tautenhahn","year":"2012","unstructured":"Tautenhahn, R., Cho, K., Uritboonthai, W., Zhu, Z., Patti, G. J., & Siuzdak, G. (2012). An accelerated workflow for untargeted metabolomics using the METLIN database. Nature Biotechnology, 30, 826\u2013828.","journal-title":"Nature Biotechnology"},{"key":"1375_CR24","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nmeth.3393","volume":"12","author":"H Tsugawa","year":"2015","unstructured":"Tsugawa, H., Cajka, T., Kind, T., Ma, Y., Higgins, B., Ikeda, K., Kanazawa, M., VanderGheynst, J., Fiehn, O., & Arita, M. (2015). MS-DIAL: Data-independent MS\/MS deconvolution for comprehensive metabolome analysis. Nature Methods, 12, 523\u2013526.","journal-title":"Nature Methods"},{"key":"1375_CR25","doi-asserted-by":"publisher","unstructured":"Velasquez, E., Nogueira, F. C. S., Velasquez, I., Schmitt, A., Falkai, P., Domont, G. B., & Martins-de-Souza, D. (2017). Synaptosomal proteome of the orbitofrontal cortex from schizophrenia patients using quantitative label-free and iTRAQ-based shotgun proteomics. J Proteome Res. \n                    https:\/\/doi.org\/10.1021\/acs.jproteome.7b00422\n                    \n                  .","DOI":"10.1021\/acs.jproteome.7b00422"},{"key":"1375_CR26","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.schres.2014.11.032","volume":"161","author":"PL Wood","year":"2015","unstructured":"Wood, P. L., Unfried, G., Whitehead, W., Phillipps, A., & Wood, J. A. (2015). Dysfunctional plasmalogen dynamics in the plasma and platelets of patients with schizophrenia. Schizophrenia Research, 161, 506\u2013510.","journal-title":"Schizophrenia Research"},{"key":"1375_CR27","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/s11306-012-0482-9","volume":"9","author":"J Xia","year":"2013","unstructured":"Xia, J., Broadhurst, D. I., Wilson, M., & Wishart, D. S. (2013). Translational biomarker discovery in clinical metabolomics: An introductory tutorial. Metabolomics, 9, 280\u2013299.","journal-title":"Metabolomics"},{"key":"1375_CR28","doi-asserted-by":"publisher","first-page":"W251","DOI":"10.1093\/nar\/gkv380","volume":"43","author":"J Xia","year":"2015","unstructured":"Xia, J., Sinelnikov, I. V., Han, B., & Wishart, D. S. (2015). MetaboAnalyst 3.0\u2014Making metabolomics more meaningful. Nucleic Acids Research, 43, W251\u2013W257.","journal-title":"Nucleic Acids Research"},{"key":"1375_CR29","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.talanta.2016.11.048","volume":"164","author":"J Zhou","year":"2017","unstructured":"Zhou, J., Li, Y., Chen, X., Zhong, L., & Yin, Y. (2017). Development of data-independent acquisition workflows for metabolomic analysis on a quadrupole-orbitrap platform. Talanta, 164, 128\u2013136.","journal-title":"Talanta"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11306-018-1375-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-018-1375-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-018-1375-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T02:19:11Z","timestamp":1559355551000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11306-018-1375-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1375"],"URL":"https:\/\/doi.org\/10.1007\/s11306-018-1375-3","relation":{},"ISSN":["1573-3882","1573-3890"],"issn-type":[{"value":"1573-3882","type":"print"},{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"11 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This study was conducted in accordance with the guidelines of the Declaration of Helsinki and the Principles of Good Clinical Practice. The Ethical Review Board of the Peking University Health Science Center approved the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all patients who were asked to donate blood.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"80"}}