{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:40:07Z","timestamp":1787236807081,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s11306-019-1571-9","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T11:03:00Z","timestamp":1564657380000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Beyond the antibodies: serum metabolomic profiling of myasthenia gravis"],"prefix":"10.1007","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-1602","authenticated-orcid":false,"given":"Derrick","family":"Blackmore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaeem","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Maksymowych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,1]]},"reference":[{"key":"1571_CR1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jneuroim.2017.01.019","volume":"305","author":"M Adamczyk-Sowa","year":"2017","unstructured":"Adamczyk-Sowa, M., Bieszczad-Bedrejczuk, E., Galiniak, S., Rozmi\u0142owska, I., Czy\u017cewski, D., Bartosz, G., et al. (2017). Oxidative modifications of blood serum proteins in myasthenia gravis. Journal of Neuroimmunology, 305, 145\u2013153. \n                    https:\/\/doi.org\/10.1016\/j.jneuroim.2017.01.019\n                    \n                  .","journal-title":"Journal of Neuroimmunology"},{"issue":"2","key":"1571_CR2","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bbalip.2011.11.006","volume":"1821","author":"AM Astudillo","year":"2012","unstructured":"Astudillo, A. M., Balgoma, D., Balboa, M. A., & Balsinde, J. (2012). Dynamics of arachidonic acid mobilization by inflammatory cells. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1821(2), 249\u2013256. \n                    https:\/\/doi.org\/10.1016\/j.bbalip.2011.11.006\n                    \n                  .","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"},{"key":"1571_CR3","unstructured":"Bass JD, D. A., & R. D. (2015). qvalue: Q-value estimation for false discovery rate control. R package version 2.10.0. \n                    http:\/\/github.com\/jdstorey\/qvalue"},{"issue":"6","key":"1571_CR4","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1002\/mus.23330","volume":"45","author":"M Benatar","year":"2012","unstructured":"Benatar, M., Sanders, D. B., Burns, T. M., Cutter, G. R., Guptill, J. T., Baggi, F., et al. (2012). Recommendations for myasthenia gravis clinical trials. Muscle and Nerve, 45(6), 909\u2013917. \n                    https:\/\/doi.org\/10.1002\/mus.23330\n                    \n                  .","journal-title":"Muscle and Nerve"},{"issue":"5","key":"1571_CR5","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.immuni.2017.04.009","volume":"46","author":"M Boothby","year":"2017","unstructured":"Boothby, M., & Rickert, R. C. (2017). Metabolic regulation of the immune humoral response. Immunity, 46(5), 743\u2013755. \n                    https:\/\/doi.org\/10.1016\/j.immuni.2017.04.009\n                    \n                  .","journal-title":"Immunity"},{"issue":"6","key":"1571_CR6","doi-asserted-by":"publisher","first-page":"988","DOI":"10.2337\/dc15-2752","volume":"39","author":"J Cobb","year":"2016","unstructured":"Cobb, J., Eckhart, A., Motsinger-Reif, A., Carr, B., Groop, L., & Ferrannini, E. (2016). \u03b1-hydroxybutyric acid is a selective metabolite biomarker of impaired glucose tolerance. Diabetes Care, 39(6), 988\u2013995. \n                    https:\/\/doi.org\/10.2337\/dc15-2752\n                    \n                  .","journal-title":"Diabetes Care"},{"issue":"1","key":"1571_CR7","doi-asserted-by":"publisher","first-page":"e185","DOI":"10.1212\/nxi.0000000000000185","volume":"3","author":"E Cocco","year":"2016","unstructured":"Cocco, E., Murgia, F., Lorefice, L., Barberini, L., Poddighe, S., Frau, J., et al. (2016). (1)H-NMR analysis provides a metabolomic profile of patients with multiple sclerosis. Neurology(R) Neuroimmunology & Neuroinflammation, 3(1), e185. \n                    https:\/\/doi.org\/10.1212\/nxi.0000000000000185\n                    \n                  .","journal-title":"Neurology(R) Neuroimmunology & Neuroinflammation"},{"issue":"3","key":"1571_CR8","first-page":"793","volume":"294","author":"BS Cummings","year":"2000","unstructured":"Cummings, B. S., McHowat, J., & Schnellmann, R. G. (2000). Phospholipase A2s in Cell Injury and Death. Journal of Pharmacology and Experimental Therapeutics, 294(3), 793\u2013799.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"5","key":"1571_CR9","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.2337\/db12-0707","volume":"62","author":"E Ferrannini","year":"2013","unstructured":"Ferrannini, E., Natali, A., Camastra, S., Nannipieri, M., Mari, A., Adam, K.-P., et al. (2013). Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance. Diabetes, 62(5), 1730\u20131737. \n                    https:\/\/doi.org\/10.2337\/db12-0707\n                    \n                  .","journal-title":"Diabetes"},{"issue":"2","key":"1571_CR10","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/J.IJHEH.2017.01.006","volume":"220","author":"C Franken","year":"2017","unstructured":"Franken, C., Lambrechts, N., Govarts, E., Koppen, G., Den Hond, E., Ooms, D., et al. (2017). Phthalate-induced oxidative stress and association with asthma-related airway inflammation in adolescents. International Journal of Hygiene and Environmental Health, 220(2), 468\u2013477. \n                    https:\/\/doi.org\/10.1016\/J.IJHEH.2017.01.006\n                    \n                  .","journal-title":"International Journal of Hygiene and Environmental Health"},{"issue":"5","key":"1571_CR11","doi-asserted-by":"publisher","first-page":"e10883","DOI":"10.1371\/journal.pone.0010883","volume":"5","author":"WE Gall","year":"2010","unstructured":"Gall, W. E., Beebe, K., Lawton, K. A., Adam, K.-P., Mitchell, M. W., Nakhle, P. J., et al. (2010a). \u03b1-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS ONE, 5(5), e10883. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0010883\n                    \n                  .","journal-title":"PLoS ONE"},{"issue":"5","key":"1571_CR12","doi-asserted-by":"publisher","first-page":"e10883","DOI":"10.1371\/journal.pone.0010883","volume":"5","author":"WE Gall","year":"2010","unstructured":"Gall, W. E., Beebe, K., Lawton, K. A., Adam, K. P., Mitchell, M. W., Nakhle, P. J., et al. (2010b). \u03b1-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS ONE, 5(5), e10883. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0010883\n                    \n                  .","journal-title":"PLoS ONE"},{"issue":"10","key":"1571_CR13","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., et al. (2004). Bioconductor: Open software development for computational biology and bioinformatics. Genome Biology, 5(10), R80. \n                    https:\/\/doi.org\/10.1186\/gb-2004-5-10-r80\n                    \n                  .","journal-title":"Genome Biology"},{"issue":"5","key":"1571_CR14","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1097\/WCO.0b013e32833c0982","volume":"23","author":"JT Guptill","year":"2010","unstructured":"Guptill, J. T., & Sanders, D. B. (2010). Update on muscle-specific tyrosine kinase antibody positive myasthenia gravis. Current Opinion in Neurology, 23(5), 530\u2013535. \n                    https:\/\/doi.org\/10.1097\/WCO.0b013e32833c0982\n                    \n                  .","journal-title":"Current Opinion in Neurology"},{"issue":"4","key":"1571_CR15","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1007\/BF00711898","volume":"16","author":"GF Hoffmann","year":"1993","unstructured":"Hoffmann, G. F., Meier-Augenstein, W., St\u00f6ckler, S., Surtees, R., Rating, D., & Nyhan, W. L. (1993). Physiology and pathophysiology of organic acids in cerebrospinal fluid. Journal of Inherited Metabolic Disease, 16(4), 648\u2013669. \n                    https:\/\/doi.org\/10.1007\/BF00711898\n                    \n                  .","journal-title":"Journal of Inherited Metabolic Disease"},{"key":"1571_CR16","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/j.1749-6632.1987.tb51321.x","volume":"505","author":"FM Howard","year":"1987","unstructured":"Howard, F. M., Lennon, V. A., Finley, J., Matsumoto, J., & Elveback, L. R. (1987). Clinical correlations of antibodies that bind, block, or modulate human acetylcholine receptors in myasthenia gravis. Annals of the New York Academy of Sciences, 505, 526\u2013538.","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"20","key":"1571_CR17","doi-asserted-by":"publisher","first-page":"10619","DOI":"10.1021\/acs.analchem.5b03126","volume":"87","author":"T Huan","year":"2015","unstructured":"Huan, T., Tang, C., Li, R., Shi, Y., Lin, G., & Li, L. (2015). MyCompoundID MS\/MS search: Metabolite identification using a library of predicted fragment-ion-spectra of 383,830 possible human metabolites. Analytical Chemistry, 87(20), 10619\u201310626. \n                    https:\/\/doi.org\/10.1021\/acs.analchem.5b03126\n                    \n                  .","journal-title":"Analytical Chemistry"},{"issue":"1","key":"1571_CR18","first-page":"13","volume":"1","author":"D Hutchinson","year":"1999","unstructured":"Hutchinson, D. (1999). Classification criteria: The 1987 American Rheumatism Association revised criteria for the classification of rheumatoid arthritis. CPD Rheumatology, 1(1), 13\u201314.","journal-title":"CPD Rheumatology"},{"issue":"1","key":"1571_CR19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1749-6632.2012.06787.x","volume":"1275","author":"HJ Kaminski","year":"2012","unstructured":"Kaminski, H. J., Kusner, L. L., Wolfe, G. I., Aban, I., Minisman, G., Conwit, R., et al. (2012). Biomarker development for myasthenia gravis. Annals of the New York Academy of Sciences, 1275(1), 101\u2013106. \n                    https:\/\/doi.org\/10.1111\/j.1749-6632.2012.06787.x\n                    \n                  .","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"11","key":"1571_CR20","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nrneurol.2012.168","volume":"8","author":"H Lassmann","year":"2012","unstructured":"Lassmann, H., Van Horssen, J., & Mahad, D. (2012). Progressive multiple sclerosis: Pathology and pathogenesis. Nature Reviews Neurology, 8(11), 647\u2013656. \n                    https:\/\/doi.org\/10.1038\/nrneurol.2012.168\n                    \n                  .","journal-title":"Nature Reviews Neurology"},{"issue":"7113","key":"1571_CR21","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin, M. T., & Beal, M. F. (2006). Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature, 443(7113), 787\u2013795. \n                    https:\/\/doi.org\/10.1038\/nature05292\n                    \n                  .","journal-title":"Nature"},{"issue":"3","key":"1571_CR22","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1016\/J.BBRC.2016.08.155","volume":"478","author":"A Lindahl","year":"2016","unstructured":"Lindahl, A., Forshed, J., & Nordstr\u00f6m, A. (2016). Overlap in serum metabolic profiles between non-related diseases: Implications for LC-MS metabolomics biomarker discovery. Biochemical and Biophysical Research Communications, 478(3), 1472\u20131477. \n                    https:\/\/doi.org\/10.1016\/J.BBRC.2016.08.155\n                    \n                  .","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"1571_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1074\/jbc.R115.693903","volume":"291","author":"RM Loftus","year":"2016","unstructured":"Loftus, R. M., & Finlay, D. K. (2016). Immunometabolism: Cellular metabolism turns immune regulator. The Journal of biological chemistry, 291(1), 1\u201310. \n                    https:\/\/doi.org\/10.1074\/jbc.R115.693903\n                    \n                  .","journal-title":"The Journal of biological chemistry"},{"key":"1571_CR24","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3389\/fimmu.2013.00130","volume":"4","author":"AM Lone","year":"2013","unstructured":"Lone, A. M., & Task\u00e9n, K. (2013). Proinflammatory and immunoregulatory roles of eicosanoids in T cells. Frontiers in Immunology, 4, 130. \n                    https:\/\/doi.org\/10.3389\/fimmu.2013.00130\n                    \n                  .","journal-title":"Frontiers in Immunology"},{"issue":"4","key":"1571_CR25","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1007\/s11306-011-0364-6","volume":"8","author":"Y Lu","year":"2012","unstructured":"Lu, Y., Wang, C., Chen, Z., Zhao, H., Chen, J., Liu, X., et al. (2012). Serum metabolomics for the diagnosis and classification of myasthenia gravis. Metabolomics, 8(4), 704\u2013713. \n                    https:\/\/doi.org\/10.1007\/s11306-011-0364-6\n                    \n                  .","journal-title":"Metabolomics"},{"issue":"1","key":"1571_CR26","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","volume":"27","author":"SY Lunt","year":"2011","unstructured":"Lunt, S. Y., & Vander Heiden, M. G. (2011). Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation. Annual Review of Cell and Developmental Biology, 27(1), 441\u2013464. \n                    https:\/\/doi.org\/10.1146\/annurev-cellbio-092910-154237\n                    \n                  .","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"1571_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/J.COTOX.2017.12.003","volume":"10","author":"K Manley","year":"2018","unstructured":"Manley, K., Han, W., Zelin, G., & Lawrence, D. A. (2018). Crosstalk between the immune, endocrine, and nervous systems in immunotoxicology. Current Opinion in Toxicology, 10, 37\u201345. \n                    https:\/\/doi.org\/10.1016\/J.COTOX.2017.12.003\n                    \n                  .","journal-title":"Current Opinion in Toxicology"},{"issue":"5","key":"1571_CR28","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1586\/eci.12.34","volume":"8","author":"MN Meriggioli","year":"2012","unstructured":"Meriggioli, M. N., & Sanders, D. B. (2012). Muscle autoantibodies in myasthenia gravis: Beyond diagnosis? Expert review of clinical immunology, 8(5), 427\u2013438. \n                    https:\/\/doi.org\/10.1586\/eci.12.34\n                    \n                  .","journal-title":"Expert review of clinical immunology"},{"key":"1571_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-20206-8","volume-title":"Excipient Applications in Formulation Design and Drug Delivery","year":"2015","unstructured":"Narang, A. S., & Boddu, S. H. S. (Eds.). (2015). Excipient applications in formulation design and drug delivery. Cham: Springer. \n                    https:\/\/doi.org\/10.1007\/978-3-319-20206-8"},{"issue":"12","key":"1571_CR30","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1016\/J.CELLSIG.2008.06.014","volume":"20","author":"A Nguyen","year":"2008","unstructured":"Nguyen, A., & Bouscarel, B. (2008). Bile acids and signal transduction: Role in glucose homeostasis. Cellular Signalling, 20(12), 2180\u20132197. \n                    https:\/\/doi.org\/10.1016\/J.CELLSIG.2008.06.014\n                    \n                  .","journal-title":"Cellular Signalling"},{"issue":"8","key":"1571_CR31","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/nri3261","volume":"12","author":"H Park","year":"2012","unstructured":"Park, H., Bourla, A. B., Kastner, D. L., Colbert, R. A., & Siegel, R. M. (2012). Lighting the fires within: The cell biology of autoinflammatory diseases. Nature Reviews Immunology, 12(8), 570\u2013580. \n                    https:\/\/doi.org\/10.1038\/nri3261\n                    \n                  .","journal-title":"Nature Reviews Immunology"},{"key":"1571_CR32","volume-title":"Cell biology","author":"TD Pollard","year":"2016","unstructured":"Pollard, T. D., Thomas, D., Earnshaw, W. C., Lippincott-Schwartz, J., & Johnson, G. T. (2016). Cell biology (3rd ed.). Amsterdam: Elsevier.","edition":"3"},{"issue":"7","key":"1571_CR33","doi-asserted-by":"publisher","first-page":"e102635","DOI":"10.1371\/journal.pone.0102635","volume":"9","author":"M Sengupta","year":"2014","unstructured":"Sengupta, M., Cheema, A., Kaminski, H. J., Kusner, L. L., Gribbestad, I., et al. (2014). serum metabolomic response of myasthenia gravis patients to chronic prednisone treatment. PLoS ONE, 9(7), e102635. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0102635\n                    \n                  .","journal-title":"PLoS ONE"},{"issue":"1","key":"1571_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00253-016-8006-6","volume":"101","author":"C Staley","year":"2017","unstructured":"Staley, C., Weingarden, A. R., Khoruts, A., & Sadowsky, M. J. (2017). Interaction of gut microbiota with bile acid metabolism and its influence on disease states. Applied Microbiology and Biotechnology, 101(1), 47\u201364. \n                    https:\/\/doi.org\/10.1007\/s00253-016-8006-6\n                    \n                  .","journal-title":"Applied Microbiology and Biotechnology"},{"issue":"6","key":"1571_CR35","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1214\/aos\/1074290335","volume":"31","author":"JD Storey","year":"2003","unstructured":"Storey, J. D. (2003). The positive false discovery rate: A Bayesian interpretation and the q-value. The Annals of Statistics, 31(6), 2013\u20132035. \n                    https:\/\/doi.org\/10.1214\/aos\/1074290335\n                    \n                  .","journal-title":"The Annals of Statistics"},{"issue":"7","key":"1571_CR36","first-page":"862","volume":"65","author":"HJ Stuerenburg","year":"2000","unstructured":"Stuerenburg, H. J. (2000). The roles of carnosine in aging of skeletal muscle and in neuromuscular diseases. Biochemistry (Moscow), 65(7), 862\u2013865.","journal-title":"Biochemistry (Moscow)"},{"issue":"2","key":"1571_CR37","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/0009-8981(83)90398-4","volume":"133","author":"K Tomiko","year":"1983","unstructured":"Tomiko, K., Toshihiro, S., Yoshito, I., Masahiro, M., Makoto, Y., Yusuke, S., et al. (1983). Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. Clinica Chimica Acta, 133(2), 133\u2013140. \n                    https:\/\/doi.org\/10.1016\/0009-8981(83)90398-4\n                    \n                  .","journal-title":"Clinica Chimica Acta"},{"issue":"10","key":"1571_CR38","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/jat.2835","volume":"33","author":"T-T Win-Shwe","year":"2013","unstructured":"Win-Shwe, T.-T., Yanagisawa, R., Koike, E., Nitta, H., & Takano, H. (2013). Expression levels of neuroimmune biomarkers in hypothalamus of allergic mice after phthalate exposure. Journal of Applied Toxicology, 33(10), 1070\u20131078. \n                    https:\/\/doi.org\/10.1002\/jat.2835\n                    \n                  .","journal-title":"Journal of Applied Toxicology"},{"issue":"W1","key":"1571_CR39","doi-asserted-by":"publisher","first-page":"W127","DOI":"10.1093\/nar\/gks374","volume":"40","author":"J Xia","year":"2012","unstructured":"Xia, J., Mandal, R., Sinelnikov, I. V., Broadhurst, D., & Wishart, D. S. (2012). MetaboAnalyst 2.0\u2013a comprehensive server for metabolomic data analysis. Nucleic Acids Research, 40(W1), W127\u2013W133. \n                    https:\/\/doi.org\/10.1093\/nar\/gks374\n                    \n                  .","journal-title":"Nucleic Acids Research"},{"issue":"2","key":"1571_CR40","doi-asserted-by":"publisher","first-page":"116","DOI":"10.2174\/1567205012666150204121719","volume":"12","author":"M Yegambaram","year":"2015","unstructured":"Yegambaram, M., Manivannan, B., Beach, T. G., & Halden, R. U. (2015). Role of environmental contaminants in the etiology of Alzheimer\u2019s disease: A review. Current Alzheimer Research, 12(2), 116\u2013146. \n                    https:\/\/doi.org\/10.2174\/1567205012666150204121719\n                    \n                  .","journal-title":"Current Alzheimer Research"},{"issue":"21","key":"1571_CR41","doi-asserted-by":"publisher","first-page":"10617","DOI":"10.1021\/acs.analchem.6b02967","volume":"88","author":"S Zhao","year":"2016","unstructured":"Zhao, S., Luo, X., & Li, L. (2016). Chemical isotope labeling LC-MS for high coverage and quantitative profiling of the hydroxyl submetabolome in metabolomics. Analytical Chemistry, 88(21), 10617\u201310623. \n                    https:\/\/doi.org\/10.1021\/acs.analchem.6b02967\n                    \n                  .","journal-title":"Analytical Chemistry"},{"issue":"10","key":"1571_CR42","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.1021\/ac5009089","volume":"86","author":"R Zhou","year":"2014","unstructured":"Zhou, R., Tseng, C.-L., Huan, T., & Li, L. (2014). IsoMS: automated processing of LC-MS data generated by a chemical isotope labeling metabolomics platform. Analytical Chemistry, 86(10), 4675\u20134679. \n                    https:\/\/doi.org\/10.1021\/ac5009089\n                    \n                  .","journal-title":"Analytical Chemistry"},{"issue":"4 Suppl 98","key":"1571_CR43","first-page":"25","volume":"34","author":"C Zhu","year":"2016","unstructured":"Zhu, C., Fuchs, C. D., Halilbasic, E., & Trauner, M. (2016). Bile acids in regulation of inflammation and immunity: Friend or foe? Clinical and Experimental Rheumatology, 34(4 Suppl 98), 25\u201331.","journal-title":"Clinical and Experimental Rheumatology"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-019-1571-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11306-019-1571-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-019-1571-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T20:03:05Z","timestamp":1596139385000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11306-019-1571-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["1571"],"URL":"https:\/\/doi.org\/10.1007\/s11306-019-1571-9","relation":{},"ISSN":["1573-3882","1573-3890"],"issn-type":[{"value":"1573-3882","type":"print"},{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"8 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This work received ethics approval from the University of Alberta Research Ethics Board and is in compliance with the ethical standards of this institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human research"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"109"}}