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We randomly took dried blood spots of newborns from 267 pairs of IHPS cases and controls matched by sex and day of birth. We used a mixed-effects linear regression model to evaluate associations between 148 metabolites and IHPS in a matched case\u2013control design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The phosphatidylcholine PC(38:4) showed significantly lower levels in IHPS cases (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20094.68\u2009\u00d7\u200910\n                      <jats:sup>\u22128<\/jats:sup>\n                      ) as did six other correlated metabolites (four phosphatidylcholines, acylcarnitine AC(2:0), and histidine). Associations were driven by 98 case\u2013control pairs born before 2009, when median age at sampling was 6 days. No association was seen in 169 pairs born in 2009 or later, when median age at sampling was 2 days. More IHPS cases than controls had a diagnosis for neonatal difficulty in feeding at breast (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20096.15\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      ). Genetic variants known to be associated with PC(38:4) levels did not associate with IHPS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We detected lower levels of certain metabolites in IHPS, possibly reflecting different feeding patterns in the first days of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11306-020-01763-2","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T09:03:29Z","timestamp":1610096609000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Integrating genetics with newborn metabolomics in infantile hypertrophic pyloric stenosis"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2539-634X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Fadista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Skotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Courraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Geller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"G\u00f8rtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wohlfahrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Melbye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arieh S.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarke","family":"Feenstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"1763_CR1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1080\/07315724.2000.10718943","volume":"19","author":"C Agostoni","year":"2000","unstructured":"Agostoni, C., Carrat\u00f9, B., Boniglia, C., Riva, E., & Sanzini, E. 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