{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:58:48Z","timestamp":1761897528890,"version":"3.37.3"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006144","name":"Kerala State Council for Science, Technology and Environment","doi-asserted-by":"publisher","award":["005\/SRSHS\/2014\/CSTE"],"award-info":[{"award-number":["005\/SRSHS\/2014\/CSTE"]}],"id":[{"id":"10.13039\/501100006144","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s11306-021-01798-z","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T15:03:09Z","timestamp":1620572589000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment"],"prefix":"10.1007","volume":"17","author":[{"given":"A. Aneesh","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanaja R.","family":"Anusree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopika","family":"Satheesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gadadharan","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhadra","family":"Lakshmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhavan R.","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-9093","authenticated-orcid":false,"given":"Abdul","family":"Jaleel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,9]]},"reference":[{"issue":"3","key":"1798_CR1","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1079\/bjn19820063","volume":"47","author":"B \u00c5kesson","year":"1982","unstructured":"\u00c5kesson, B., Fehling, C., J\u00e4gerstad, M., & Stenram, U. (1982). Effect of experimental folate deficiency on lipid metabolism in liver and brain. British Journal of Nutrition, 47(3), 505\u2013520. https:\/\/doi.org\/10.1079\/bjn19820063.","journal-title":"British Journal of Nutrition"},{"issue":"8","key":"1798_CR2","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3945\/jn.111.138859","volume":"141","author":"TW Chew","year":"2011","unstructured":"Chew, T. W., Jiang, X., Yan, J., Wang, W., Lusa, A. L., Carrier, B. J., West, B. J., Malysheva, O. V., Brenna, J. T., Gregory III, J. F., Caudill, M. A. (2011). Folate intake, Mthfr genotype, and sex modulate choline metabolism in mice. Journal of Nutrition, 141(8), 1475\u20131481. https:\/\/doi.org\/10.3945\/jn.111.138859.","journal-title":"Journal of Nutrition"},{"issue":"W1","key":"1798_CR3","doi-asserted-by":"publisher","first-page":"W486","DOI":"10.1093\/nar\/gky310","volume":"46","author":"J Chong","year":"2018","unstructured":"Chong, J., Soufan, O., Li, C., Caraus, I., Li, S., Bourque, G., Wishart, D.S., Xia, J. (2018). MetaboAnalyst 4.0: Towards more transparent and integrative metabolomics analysis. Nucleic Acids Research, 46(W1), W486\u2013W494. https:\/\/doi.org\/10.1093\/nar\/gky310.","journal-title":"Nucleic Acids Research"},{"issue":"10","key":"1798_CR4","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.3945\/jn.110.124917","volume":"140","author":"KE Christensen","year":"2010","unstructured":"Christensen, K. E., Wu, Q., Wang, X., Deng, L., Caudill, M. A., & Rozen, R. (2010). Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism. Journal of Nutrition, 140(10), 1736\u20131741. https:\/\/doi.org\/10.3945\/jn.110.124917.","journal-title":"Journal of Nutrition"},{"issue":"7135","key":"1798_CR5","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1136\/bmj.316.7135.894","volume":"316","author":"Collaboration HLT","year":"1998","unstructured":"Collaboration HLT. (1998). Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials. British Medical Journal, 316(7135), 894\u2013898. https:\/\/doi.org\/10.1136\/bmj.316.7135.894.","journal-title":"British Medical Journal"},{"issue":"4","key":"1798_CR6","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/ajcn\/82.4.806","volume":"82","author":"Collaboration HLT","year":"2005","unstructured":"Collaboration HLT. (2005). Dose-dependent effects of folic acid on blood concentrations of homocysteine: A meta-analysis of the randomized trials. American Journal of Clinical Nutrition, 82(4), 806\u2013812. https:\/\/doi.org\/10.1093\/ajcn\/82.4.806.","journal-title":"American Journal of Clinical Nutrition"},{"key":"1798_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1154","author":"RP da Silva","year":"2014","unstructured":"da Silva, R. P., Kelly, K. B., Al Rajabi, A., & Jacobs, R. L. (2014). Novel insights on interactions between folate and lipid metabolism. BioFactors. https:\/\/doi.org\/10.1002\/biof.1154.","journal-title":"BioFactors"},{"issue":"6","key":"1798_CR8","doi-asserted-by":"publisher","first-page":"467","DOI":"10.2174\/138920106779116856","volume":"7","author":"U Das","year":"2006","unstructured":"Das, U. (2006). Essential fatty acids\u2014A review. Current Pharmaceutical Biotechnology, 7(6), 467\u2013482. https:\/\/doi.org\/10.2174\/138920106779116856.","journal-title":"Current Pharmaceutical Biotechnology"},{"issue":"51","key":"1798_CR9","doi-asserted-by":"publisher","first-page":"37082","DOI":"10.1074\/jbc.M704256200","volume":"282","author":"AM Devlin","year":"2007","unstructured":"Devlin, A. M., Singh, R., Wade, R. E., Innis, S. M., Bottiglieri, T., & Lentz, S. R. (2007). Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. Journal of Biological Chemistry, 282(51), 37082\u201337090. https:\/\/doi.org\/10.1074\/jbc.M704256200.","journal-title":"Journal of Biological Chemistry"},{"issue":"7","key":"1798_CR10","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1038\/nprot.2011.335","volume":"6","author":"WB Dunn","year":"2011","unstructured":"Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-Mcintyre, S., Anderson, N., Brown, M., Knowles, J. D., Halsall, A., Haselden, J. N., Nicholls, A. W., Wilson, I. D., Kell, D. B., Goodacre, R. (2011). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nature Protocols, 6(7), 1060\u20131083. https:\/\/doi.org\/10.1038\/nprot.2011.335.","journal-title":"Nature Protocols"},{"issue":"2","key":"1798_CR11","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0021-9150(95)06724-8","volume":"121","author":"P Durand","year":"1996","unstructured":"Durand, P., Prost, M., & Blache, D. (1996). Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids. Atherosclerosis, 121(2), 231\u2013243. https:\/\/doi.org\/10.1016\/0021-9150(95)06724-8.","journal-title":"Atherosclerosis"},{"issue":"3","key":"1798_CR12","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1001\/jama.293.3.320","volume":"293","author":"JP Forman","year":"2005","unstructured":"Forman, J. P., Rimm, E. B., Stampfer, M. J., & Curhan, G. C. (2005). Folate intake and the risk of incident hypertension among US women. Journal of the American Medical Association, 293(3), 320\u2013329. https:\/\/doi.org\/10.1001\/jama.293.3.320.","journal-title":"Journal of the American Medical Association"},{"key":"1798_CR13","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2018.22","author":"ME Hefni","year":"2018","unstructured":"Hefni, M. E., Witth\u00f6ft, C. M., & Moazzami, A. A. (2018). Plasma metabolite profiles in healthy women differ after intervention with supplemental folic acid v. folate-rich foods. Journal of Nutritional Science. https:\/\/doi.org\/10.1017\/jns.2018.22.","journal-title":"Journal of Nutritional Science"},{"issue":"1","key":"1798_CR14","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1017\/S0007114516004414","volume":"117","author":"I Iglesia","year":"2017","unstructured":"Iglesia, I., Huybrechts, I., Gonz\u00e1lez-Gross, M., Mouratidou, T., Santab\u00e1rbara, J., Chaj\u00e8s, V., Gonzalez-Gil, E. M., Park, J. Y., Bel-Serrat, S., Cuenca-Garcia, M., Castillo, M., Kersting, M., Widhalam, K., De Henauw, S., Sjostrom, M., Gottrand, F., Molnar, D., Manois, Y., Kaftos, A., Ferrari, M., Stehle, A., Marcos, A., Sanchez-Muniz, F. J., Moreno, L. A. (2017). Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. British Journal of Nutrition, 117(1), 124\u2013133. https:\/\/doi.org\/10.1017\/S0007114516004414.","journal-title":"British Journal of Nutrition"},{"key":"1798_CR15","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-018-1016-4","author":"J Kim","year":"2018","unstructured":"Kim, J., Kim, H., Roh, H., & Kwon, Y. (2018). Causes of hyperhomocysteinemia and its pathological significance. Archives of Pharmacal Research. https:\/\/doi.org\/10.1007\/s12272-018-1016-4.","journal-title":"Archives of Pharmacal Research"},{"issue":"11","key":"1798_CR16","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1093\/jn\/124.11.2197","volume":"124","author":"YI Kim","year":"1994","unstructured":"Kim, Y. I., Miller, J. W., Da Costa, K. A., Nadeau, M., Smith, D., Selhub, J., Zeisel, S. H., Mason, J. B. (1994). Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver. Journal of Nutrition, 124(11), 2197\u20132203. https:\/\/doi.org\/10.1093\/jn\/124.11.2197.","journal-title":"Journal of Nutrition"},{"issue":"1","key":"1798_CR17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41598-019-57257-2","volume":"10","author":"AA Kumar","year":"2020","unstructured":"Kumar, A. A., Satheesh, G., Vijayakumar, G., Chandran, M., Prabhu, P. R., Simon, L., Kutty, V. R., Kartha, C. C., Jaleel, A. (2020). Postprandial metabolism is impaired in overweight normoglycemic young adults without family history of diabetes. Scientific Reports, 10(1), 353. https:\/\/doi.org\/10.1038\/s41598-019-57257-2.","journal-title":"Scientific Reports"},{"issue":"6","key":"1798_CR18","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1161\/STROKEAHA.109.573410","volume":"41","author":"M Lee","year":"2010","unstructured":"Lee, M., Hong, K. S., Chang, S. C., & Saver, J. L. (2010). Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: A meta-analysis. Stroke, 41(6), 1205\u20131212. https:\/\/doi.org\/10.1161\/STROKEAHA.109.573410.","journal-title":"Stroke"},{"issue":"5","key":"1798_CR19","doi-asserted-by":"publisher","first-page":"6261","DOI":"10.3892\/mmr.2018.8643","volume":"17","author":"B Li","year":"2018","unstructured":"Li, B., Gao, G., Zhang, W., Li, B., Yang, C., Jiang, X., Tian, Y., Liang, H. (2018). Metabolomics analysis reveals an effect of homocysteine on arachidonic acid and linoleic acid metabolism pathway. Molecular Medicine Reports, 17(5), 6261\u20136268. https:\/\/doi.org\/10.3892\/mmr.2018.8643.","journal-title":"Molecular Medicine Reports"},{"key":"1798_CR20","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jchromb.2018.05.013","volume":"1090","author":"Z Liu","year":"2018","unstructured":"Liu, Z., Liu, R., Chou, J., Yu, J., Liu, X., Sun, C., Li, Y., Liu, L. (2018). Targeted metabolomics analysis reveals the association between maternal folic acid supplementation and fatty acids and amino acids profiles in rat pups. Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 1090, 101\u2013109. https:\/\/doi.org\/10.1016\/j.jchromb.2018.05.013.","journal-title":"Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences"},{"issue":"1","key":"1798_CR21","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1161\/01.CIR.99.1.178","volume":"99","author":"MR Malinow","year":"1999","unstructured":"Malinow, M. R., Bostom, A. G., & Krauss, R. M. (1999). Homocyst(e)ine, diet, and cardiovascular diseases. Circulation, 99(1), 178\u2013182. https:\/\/doi.org\/10.1161\/01.CIR.99.1.178.","journal-title":"Circulation"},{"issue":"2","key":"1798_CR22","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1017\/S0007114507798999","volume":"99","author":"CJ Mcneil","year":"2008","unstructured":"Mcneil, C. J., Hay, S. M., Rucklidge, G. J., Reid, M., Duncan, G., Maloney, C. A., Rees, W. D. (2008). Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets. British Journal of Nutrition, 99(2), 262\u2013271. https:\/\/doi.org\/10.1017\/S0007114507798999.","journal-title":"British Journal of Nutrition"},{"key":"1798_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23154","author":"JN Peake","year":"2013","unstructured":"Peake, J. N., Copp, A. J., & Shawe, J. (2013). Knowledge and periconceptional use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: Systematic review and meta-analysis. Birth Defects Research Part A - Clinical and Molecular Teratology. https:\/\/doi.org\/10.1002\/bdra.23154.","journal-title":"Birth Defects Research Part A - Clinical and Molecular Teratology"},{"issue":"5","key":"1798_CR24","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.clnu.2012.12.009","volume":"32","author":"X Qin","year":"2013","unstructured":"Qin, X., Huo, Y., Xie, D., Hou, F., Xu, X., & Wang, X. (2013). Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: A meta-analysis of randomized controlled trials. Clinical Nutrition, 32(5), 722\u2013727. https:\/\/doi.org\/10.1016\/j.clnu.2012.12.009.","journal-title":"Clinical Nutrition"},{"key":"1798_CR25","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.164830","author":"RN Rodionov","year":"2008","unstructured":"Rodionov, R. N., & Lentz, S. R. (2008). The homocysteine paradox. Arteriosclerosis, Thrombosis, and Vascular Biology. https:\/\/doi.org\/10.1161\/ATVBAHA.108.164830.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"1798_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/2047-217X-2-13","author":"RM Salek","year":"2013","unstructured":"Salek, R. M., Steinbeck, C., Viant, M. R., Goodacre, R., & Dunn, W. B. (2013). The role of reporting standards for metabolite annotation and identification in metabolomic studies. GigaScience. https:\/\/doi.org\/10.1186\/2047-217X-2-13.","journal-title":"GigaScience"},{"key":"1798_CR27","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.5.4.511","author":"JA Schneider","year":"2006","unstructured":"Schneider, J. A., Tangney, C. C., & Morris, M. C. (2006). Folic acid and cognition in older persons. Expert Opinion on Drug Safety. https:\/\/doi.org\/10.1517\/14740338.5.4.511.","journal-title":"Expert Opinion on Drug Safety"},{"issue":"8","key":"1798_CR28","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.2337\/db09-0087","volume":"58","author":"Y Song","year":"2009","unstructured":"Song, Y., Cook, N. R., Albert, C. M., Van Denburgh, M., & Manson, J. A. E. (2009). Effect of homocysteine-lowering treatment with folic acid and B vitamins on risk of type 2 diabetes in women: A randomized, controlled trial. Diabetes, 58(8), 1921\u20131928. https:\/\/doi.org\/10.2337\/db09-0087.","journal-title":"Diabetes"},{"issue":"1","key":"1798_CR29","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.diabres.2012.05.027","volume":"98","author":"P Sudchada","year":"2012","unstructured":"Sudchada, P., Saokaew, S., Sridetch, S., Incampa, S., Jaiyen, S., & Khaithong, W. (2012). Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice, 98(1), 151\u2013158. https:\/\/doi.org\/10.1016\/j.diabres.2012.05.027.","journal-title":"Diabetes Research and Clinical Practice"},{"key":"1798_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2019.00049","author":"C Tinelli","year":"2019","unstructured":"Tinelli, C., Di Pino, A., Ficulle, E., Marcelli, S., & Feligioni, M. (2019). Hyperhomocysteinemia as a risk factor and potential nutraceutical target for certain pathologies. Frontiers in Nutrition. https:\/\/doi.org\/10.3389\/fnut.2019.00049.","journal-title":"Frontiers in Nutrition"},{"key":"1798_CR31","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.333s","author":"H Tsuge","year":"2000","unstructured":"Tsuge, H., Hotta, N., & Hayakawa, T. (2000). Effects of vitamin B-6 on (n-3) polyunsaturated fatty acid metabolism. Journal of Nutrition. https:\/\/doi.org\/10.1093\/jn\/130.2.333s.","journal-title":"Journal of Nutrition"},{"key":"1798_CR32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R700028200","author":"DE Vance","year":"2007","unstructured":"Vance, D. E., Li, Z., & Jacobs, R. L. (2007). Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology. Journal of Biological Chemistry. https:\/\/doi.org\/10.1074\/jbc.R700028200.","journal-title":"Journal of Biological Chemistry"},{"issue":"9871","key":"1798_CR33","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/S0140-6736(12)62001-7","volume":"381","author":"SE Vollset","year":"2013","unstructured":"Vollset, S. E., Clarke, R., Lewington, S., Ebbing, M., Halsey, J., Lonn, E., Armitage, J., Manson, J. E., Hankey, G. J., Spence, J. D., Galan, P., Bonaa, K. H., Jamison, R., Gaziano, J. M., Guarino, P., Baron, J. A., Logan, R. F. A., Giovannucci, E. L., Heijer, M. D., Ueland, P. M., Bennet, D., Collins, R., FMedSci,. Peto, R. (2013). Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: Meta-analyses of data on 50 000 individuals. The Lancet, 381(9871), 1029\u20131036. https:\/\/doi.org\/10.1016\/S0140-6736(12)62001-7.","journal-title":"The Lancet"},{"issue":"12","key":"1798_CR34","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1017\/S000711451200030X","volume":"108","author":"KE Vyncke","year":"2012","unstructured":"Vyncke, K. E., Libuda, L., De Vriendt, T., Moreno, L. A., Van Winckel, M., Manios, Y., Gottrand, F., Molnar, D., Vanaelst, B., Sjostrom, M., Gonzalez-Gross, M., Censi, L., Widhalam, K., Michels, N., Gilbert, C. C., Xatzis, C., Garcia, M. C., Heredia, F. P. D., Henauw, S. D., Huybrechts, I. (2012). Dietary fatty acid intake, its food sources and determinants in European adolescents: The HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. British Journal of Nutrition, 108(12), 2261\u20132273. https:\/\/doi.org\/10.1017\/S000711451200030X.","journal-title":"British Journal of Nutrition"},{"issue":"7374","key":"1798_CR35","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","volume":"325","author":"DS Wald","year":"2002","unstructured":"Wald, D. S., Law, M., & Morris, J. K. (2002). Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis. British Medical Journal, 325(7374), 1202\u20131206. https:\/\/doi.org\/10.1136\/bmj.325.7374.1202.","journal-title":"British Medical Journal"},{"issue":"10","key":"1798_CR36","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.numecd.2011.04.011","volume":"22","author":"ZM Wang","year":"2012","unstructured":"Wang, Z. M., Zhou, B., Nie, Z. L., Gao, W., Wang, Y. S., Zhao, H., Zhu, J., Yan, J. J., Yang, Z. J., Wang, L. S. (2012). Folate and risk of coronary heart disease: A meta-analysis of prospective studies. Nutrition, Metabolism and Cardiovascular Diseases, 22(10), 890\u2013899. https:\/\/doi.org\/10.1016\/j.numecd.2011.04.011.","journal-title":"Nutrition, Metabolism and Cardiovascular Diseases"},{"key":"1798_CR37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804093381507","author":"GN Welch","year":"1998","unstructured":"Welch, G. N., & Loscalzo, J. (1998). Homocysteine and atherothrombosis. New England Journal of Medicine. https:\/\/doi.org\/10.1056\/NEJM199804093381507.","journal-title":"New England Journal of Medicine"},{"key":"1798_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1579-y","author":"B Wen","year":"2017","unstructured":"Wen, B., Mei, Z., Zeng, C., & Liu, S. (2017). metaX: A flexible and comprehensive software for processing metabolomics data. BMC Bioinformatics. https:\/\/doi.org\/10.1186\/s12859-017-1579-y.","journal-title":"BMC Bioinformatics"},{"key":"1798_CR39","doi-asserted-by":"publisher","unstructured":"Wijekoon, E. P., Brosnan, M. E., & Brosnan, J. T. (2006). Homocysteine metabolism. In Biochemistry of Atherosclerosis (pp. 329\u2013357). https:\/\/doi.org\/10.1007\/0-387-36279-3_15.","DOI":"10.1007\/0-387-36279-3_15"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-021-01798-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-021-01798-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-021-01798-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T05:19:28Z","timestamp":1621833568000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-021-01798-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["1798"],"URL":"https:\/\/doi.org\/10.1007\/s11306-021-01798-z","relation":{},"ISSN":["1573-3882","1573-3890"],"issn-type":[{"type":"print","value":"1573-3882"},{"type":"electronic","value":"1573-3890"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"31 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare and certify that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the institutional ethical committee of Rajiv Gandhi Centre for Biotechnology (IHEC\/01\/2016\/13) and Medical Trust Hospital and Diabetes Care Centre. All procedures performed in the studies involving human participants were following the institutional and national research committee\u2019s ethical standards and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all the study participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"47"}}